• 한국IT서비스학회지
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• 제2권2호
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• pp.39-51
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• 2003

The Internet affects all economic activities. Physical world business must either adopt new digital strategies, launch new digital business to complement their physical world models, or be forced to completely revise their strategies. The purpose of this paper is to provide a framework that organizes the managerial decision-making process to assist managers in crafting and implementing e-business strategy. We applied the methodology to the case of KNK Educational Institute to explain the process. Core competence of KNK JUNIOR is researched according to our suggested methodology and activities and roles of KNK JUNIOR have been arranged.

• 천문학회지
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• 제38권2호
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• pp.169-172
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• 2005

We present CO(3-2), CO(2-1), and 230 GHz (1.3 mm) continuum images of nearby galaxies taken with the Submillimeter Array (SMA). Our main topic is to study the relation between higher-J molecular gas (e.g., CO J=3-2, 2-1) and nuclear activities (e.g., active galactic nuclei [AGNs] and starbursts). The nearby Seyfert 2 galaxy M51 shows strong CO(3-2) emission from the circumnuclear molecular gas, with an intensity twice as strong as that of the CO(1-0) emission. Strong CO(3-2) emission enhancement suggests that the circum nuclear molecular gas in M51 is warm and dense, which may be related to the AGN activities. Molecular gas in the nearby moderate starburst galaxy NGC 6946 is distributed along the large-scale bar or spiral arms and along the minibar, and the multi-J CO line images show very similar distribution to each other. For this galaxy, there is no clear enhancement in higher-J lines as seen in M51, which may be because NGC 6946 does not have clear AGN activities. Based on the results of these two galaxies, the physical conditions of the circum nuclear molecular gas may be related to the AGN activities. We also observed the nearby edge-on starburst galaxy NGC 3628 and the starburst/Seyfert composite galaxy NGC 4945 with the CO(2-1) line and 230 GHz (1.3 mm) continuum emission. These information will give us some hints for understanding the relation between nuclear activities and circum nuclear molecular gas and dust.

• Asian-Australasian Journal of Animal Sciences
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• 제29권2호
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• pp.204-210
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• 2016

This study examined the effect of supplementing exogenous cellulase on nutrient and energy utilization. Twelve desexed Boer crossbred goats were used in a replicated $3{\times}3$ Latin square design with 23-d periods. Dietary treatments were basal diet (control, no cellulase), basal diet plus 2 g unitary cellulase/kg of total mixed ration dry matter (DM), and basal diet plus 2 g compound cellulase/kg of total mixed ration DM. Three stages of feeding trials were used corresponding to the three treatments, each comprised 23 d, with the first 14 d as the preliminary period and the following 9 d as formal trial period for metabolism trial. Total collection of feces and urine were conducted from the 4th d of the formal trial, and gas exchange measures were determined in indirect respiratory chambers in the last 3 d of the formal trial. Results showed that cellulase addition had no effect (p>0.05) on nutrient digestibility. Dietary supplementation of cellulase did not affect (p>0.05) N intake and retention in goats. Gross energy (GE) intake, fecal energy and urinary energy excretion, heat production were not affected (p>0.05) by the cellulase supplementation. Total methane emission (g/d), $CH_4$ emission as a proportion of live weight or feed intake (DM, organic matter [OM], digestible DM or digestible OM), or $CH_4$ energy output ($CH_4$-E) as a proportion of energy intake (GE, digestible energy, or metabolizable energy), were similar (p>0.05) among treatments. There was a significant (p<0.001) relationship between $CH_4$ and live weight (y = 0.645x+0.2, $R^2$ = 0.54), $CH_4$ and DM intake (y = 16.7x+1.4, $R^2$ = 0.51), $CH_4$ and OM intake (y = 18.8x+1.3, $R^2$ = 0.51) and $CH_4$-E and GE intake. Results from this study revealed that dietary supplementation of cellulase may have no effect on nutrient digestibility, nitrogen retention, energy metabolism, and methane emission in goat.

• Journal of Radiation Protection and Research
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• 제43권1호
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• pp.29-38
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• 2018

Background: Radon contributing about 42% of annual average dose, mainly comes from soil. In this paper, standard measurement procedures for soil radon exhalation rate are suggested and their measurement uncertainties are analyzed. Materials and Methods: We used accumulation method for estimating surface exhalation rate. The closed-loop measurement system was made up with a RAD7 detector and a surface chamber. Radon activity concentrations in the system were observed as a function of time, with data collection of 5 and 15-minute and the measurement time of 4 hours. Linear and exponential fittings were used to obtain radon exhalation rates from observed data. Standard deviations of measurement uncertainties for two approaches were estimated using usual propagation rules. Results and Discussion: The exhalation rates (E) from linear approach, with 30 minutes measurement time were $44.8-48.6mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.14-2.32atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with relative measurement uncertainty of about 10%. The contributions of fitting parameter A, volume (V) and surface (S) to the estimated measurement uncertainty of E were 59.8%, 30.1% and 10.1%, in average respectively. In exponential fitting, at 3-hour measurement we had E ranged of $51.6-69.2mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.46-3.30atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with about 15% relative uncertainty. Fitting with 4-hour measurement resulted E about $51.3-68.2mBq{\cdot}m^{-2} {\cdot}s^{-1}$ or $2.45-3.25atom{\cdot}cm^{-2}{\cdot}s^{-1}$ with 10% relative uncertainty. The uncertainty contributions in exponential approach were 75.1%, 13.4%, 8.7%, and 2.9% for total decay constant k, fitting parameter B, V, and S, respectively. Conclusion: In obtaining exhalation rates, the linear approach is easy to apply, but by saturation feature of radon concentrations, the slope tends to decrease away from the expected slope for extended measurement time. For linear approach, measurement time of 1-hour or less was suggested. For exponential approach, the obtained exhalation rates showed similar values for any measurement time, but measurement time of 3-hour or more was suggested for about 10% relative uncertainty.

• BMB Reports
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• 제51권5호
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• pp.236-241
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• 2018

Anoctamin 1 (ANO1) is an anion channel that is activated by changes in cytosolic $Ca^{2+}$ concentration and noxious heat. Although the critical roles of ANO1 have been elucidated in various cell types, the control of its gating mechanisms by $Ca^{2+}$ and heat remain more elusive. To investigate critical amino acid residues for modulation of $Ca^{2+}$ and heat sensing, we constructed a randomized mutant library for ANO1. Among 695 random mutants, reduced $Ca^{2+}$ sensitivity was observed in two mutants (mutant 84 and 87). Consequently, the E143A mutant showed reduced sensitivity to $Ca^{2+}$ but not to high temperatures, whereas the E705V mutant exhibited reduced sensitivity to both $Ca^{2+}$ and noxious heat. These results suggest that the glutamic acids (E) at 143 and 705 residues in ANO1 are critical for modulation of $Ca^{2+}$ and/or heat responses. Furthermore, these findings help to provide a better understanding of the $Ca^{2+}$-mediated activation and heat-sensing mechanism of ANO1.

• Parasites, Hosts and Diseases
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• 제51권2호
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• pp.183-189
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• 2013

The occurrence of 37-collar spined echinostome metacercariae in freshwater snails was investigated in 6 districts of Chiang Mai Province, Thailand, from October 2011 to April 2012. A total of 2,914 snails that belong to 12 species were examined, and 7 snail species (Clea helena, Eyriesia eyriesi, Bithynia funiculata, Bithynia siamensis siamensis, Filopaludina doliaris, Filopaludina sumatrensis polygramma, and Filopaludina martensi martensi) were found infected with echinostome metacercariae. The prevalence of metacercariae was the highest in Filopaludina spp. (38.5-58.7%) followed by B. funiculata (44.0%), E. eyriesi (12.5%), B. siamensis siamensis (8.2%), and C. helena (5.1%). Metacercariae were experimentally fed to hamsters and domestic chicks, and adult flukes were recovered from both hosts at days 15 and 20 post-infection. The adult flukes were identified based on morphological features, morphometrics, host-parasite relationships, and geographical distribution. They were compatible to Echinostoma revolutum or Echinostoma jurini, with only minor differences. As the adults were recovered from both hamsters and chicks, our specimens were more compatible to E. revolutum rather than E. jurini (reported only from mammals). This is the first report for metacercariae of E. revolutum in the snail host, C. helena, and also confirmed that Filopaludina spp., E. eryresi, and Bithynia spp. act as the second intermediate hosts of E. revolutum under natural conditions, which are indigenously distributed in Chiang Mai province.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.550-558
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• 2020

To perform a systematic review of the data collected from case-control studies conducted earlier to investigate the correlation between E-selectin S128R polymorphism and ischemic stroke (IS) risk among the Chinese population. The PubMed, Web of Science, Chinese biomedical literature database (CBM), Chinese databases China National Knowledge Infrastructure (CNKI), WanfangData knowledge service platform (Wanfang Data), and information resource integration service platform (VIP) Databases were searched to retrieve case-control studies on the correlation between E-selectin gene S128R polymorphism and IS from the inception of the database till June 2019. The literature was screened, data were extracted, the risk of bias was reviewed, and the studies included were assessed independently by two reviewers. Stata ver. 12.0 software (Stata Corp LLC, College Station, TX, USA) was used to perform the meta-analysis. A total of 2907 cases from eight case-control studies involving 1478 IS patients and 1429 controls were included in this study. The R allele and RS genotype in E-selectin were found to be associated with the risk of IS as per the results of the meta-analysis (R vs. S : odds ratio [OR], 2.75; 95% confidence interval [CI], 2.15-3.51; p<0.00001; RS vs. SS : OR, 2.50; 95% CI, 1.95-3.19; p<0.00001; RR+RS vs. SS : OR, 2.85, 95% CI, 2.21-3.67; p<0.00001). The E-selectin gene S128R polymorphism is likely related to IS based on the results of a meta-analysis in the Chinese population, and the R allele and RS genotype of E-selectin may be IS risk factors.

• 한국군사과학기술학회지
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• 제27권2호
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• pp.304-310
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• 2024

Ricin is a highly toxic protein which is produced in the seeds of the castor oil plant. Ricin toxin A chain has ribosomal RNA N-glycosylase activity that irreversibly hydrolyses the N-glycosidic bond of the adenine residue at position 4324 within the 28S rRNA. In this study, we developed non-toxic recombinant ricin vaccine(R51) in E. coli expression system, and evaluated efficacy of the R51 according to adjuvants. When the R51 was administered using aluminum hydroxide as an adjuvant, the vaccine efficacy was higher than that of TLR agonists or aluminum phosphate. Because it is time-consuming to administer the vaccine three times at three-week intervals, we investigated the survival rate and antibody titer of mice according to the change of time interval of vaccination. Interestingly, there was no difference in survival rate and antibody titer when R51 was administered at 0, 1, and 3 weeks or 0, 2, and 4 weeks compared to when administered at 0, 3, and 6 weeks. Therefore, the developed R51 vaccine is promising to protect soldiers from Ricin attack.

• 환경위생공학
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• 제18권2호
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• pp.42-51
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• 2003

Public awareness of air pollution problem has increased the need for real time air pollution information system about changes in air pollution level. The purpose of this study is to construct e-AIR, a user-friendly air pollution information system for urban air quality using GIS(geographic information system) technology for windows. GIS was ideally suited featuring a geographical characteristics(e.g., road, traffics, buildings) and very effectively used in mapping and symbolization for the distribution of the spatial/periodic pollution status(e.g., pie or column chart, graduated symbols) which can be effectively applied to a information system on the web-site. And a user interface, GUI(graphic user interface) was designed very diversely and simply enabled the users connect with e-AIR and obtain a useful information of air quality. A interpretive technique, air pollution health index(e.g., PSI, AEI) was used also which transforms complex data on measured atmospheric pollutant concentrations into a single number or set of numbers in order to make the data more understandable. Eventually the final-step of this study was to construct e-AIR based on Web GIS could be assessed anywhere if internet is available and offer a very useful information services of the air pollution to the public like a weather news.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3247-3252
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• 2014

Background: Genetic factors have been shown to play an important role in the development of cancers. However, individual studies may fail to completely demonstrate complicated genetic relationships because of small sample size. Therefore, we performed a meta-analysis to evaluate the association of E-selectin Ser128Arg (S128R) with cancer risk. Materials and Methods: A literature search in PubMed, Embase, Web of Science, Science Direct, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure databases was carried out to identify studies of the association between E-selectin S128R polymorphism and cancer risk. The odds ratio (OR) with 95% confidence intervals (95%CIs) were used to assess the strength of association. Results: A total of eight studies involving 1,675 cancer cases and 2,285 controls were included in the meta-analysis. In overall populations, S128R polymorphism seemed to be associated with cancer risk (Arg allele vs Ser allele: OR=1.65, 95%CI =1.33-2.04, p<0.01; Arg/Arg+Arg/Ser vs Ser/Ser: OR=1.87, 95%CI =1.48-2.36, p<0.01; Arg/Ser vs Ser/Ser: OR=1.80, 95%CI =1.51-2.14, p<0.01). Similarly, subgroup analysis by ethnicity and source of control also revealed that this polymorphism was related to cancer risk. Conclusions: Our meta-analysis revealed that there was association between the E-selectin S128R polymorphism and the risk of cancer. Further large and well-designed studies are needed to confirm this association.