• Title/Summary/Keyword: OPT

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Induction of SOS Genes by a Low Dose of Gamma Radiation, 10 Gy, in Salmonella enterica Serovar Typhimurium

  • Lim, Sangyong;Joe, Minho;Seo, Hoseong;Kim, Dongho
    • Journal of Radiation Industry
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    • v.7 no.2_3
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    • pp.109-113
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    • 2013
  • In a previous study, a relatively high dose of gamma radiation (1 kGy) did not fully induce typical SOS genes such as sulA, recA, recN, and din in Salmonella Typhimurium (S. Typhimurium) (Lim et al. 2008, Gene expression profiles following high-dose exposure to gamma radiation in Salmonella enterica serovar Typhimuium. J. Radiat. Ind. 3:111-119). In this study, we examined changes in the transcriptional repertoire of S. Typhimurium after a dose of 10 Gy using DNA microarrays. It was found that more than half (~65%) of the 26 up-regulated genes belong to the SOS regulon: ten genes are typical SOS genes, and seven genes are Salmonella prophage genes, which are known to be activated by LexA cleavage. Among 29 down-regulated genes, the function of five genes with the most decreased expression is associated with carbohydrate transport and energy production. This suggests that upon exposure to gamma radiation cells may cease growing by reducing the metabolic activity, and repair DNA damage using a DNA repair system such as the SOS response system. The difference in expression of the SOS genes between a high (1 kGy) and low (10 Gy) dose of radiation shows the possibility that cells may opt for one of multiple regulatory circuits in response to the specific gamma radiation dose.

Things That Might Occur When Objects Show Up: A Story of Life of Things and Their Ethics in Wordsworth's Early Works

  • Joo, Hyeuk Kyu
    • Journal of English Language & Literature
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    • v.64 no.3
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    • pp.383-401
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    • 2018
  • Wordsworth is a poet who thought seriously about problems of human's relation to the world as perceiving subjects. What he calls "the life of things" illustrates the enabling power of things and their vitalities at play in excess of human elements. Drawing on this, he provides insights into vital materialities that act upon, and are acted upon by, the collaborative circulation between human and nonhuman agency. This paper aims to reinvigorate the debate about Wordsworth's ethics of things in terms of such critical notions as things, objects, agency, and nonhumans in an attempt to explain what he envisions as new environmental realities built upon nonhierarchical, collaborative relationships between all participants. From the vantage point of things, we see clearly what has been neglected in the New Historicist critical method. It holds fast to the conceit that humans are entitled to have sole agential legitimacy, disregarding the vibrancy of things. They opt for the objectified matter or the (re)presented state of things. But in terms of Wordsworth's life of things, all participants have equal amounts of agency regardless of their forms and for that reason humans are expected to respect other things' sovereignty. Through encounters with things, things in their thingness show up for us, only to reveal the ineradicable rupture between themselves and their objectified forms.

Encountering the Silk Road in Mengjiang with Tada Fumio: Korean/Japanese Colonial Fieldwork, Research, Connections and Collaborations

  • WINSTANLEY-CHESTERS, Robert;CATHCART, Adam
    • Acta Via Serica
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    • v.7 no.1
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    • pp.131-148
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    • 2022
  • While much has been written about Imperial Japan's encounter with geopolitics and developing ideas about Geography as a political and cultural discipline, little if anything has been written about relational and research Geographies between Japan and Silk Roads both ancient and modern. Memories of the ancient Silk Road were revivified in the late 19th century in tandem with the Great Game of European nations, as Japan modernized and sought new places and influence globally following the Meiji restoration. Imperial Japan thus sought to conquer and co-opt spaces imagined to be part of or influenced by the ancient Silk Road and any modern manifestation of it. This paper explores a particular process in that co-option and appropriation, research collaboration between institutions of the Empire. In particular it considers the exploration of Mengjiang/Inner Mongolia after its conquest in 1939/1940, by a collaborative team of Korean and Japanese Geographers, led by Professor Tada Fumio. This paper considers the making knowable of spaces imagined to be on the ancient Silk Road in the Imperial period, and the projecting of the imperatives of the Empire back into Silk Road history, at the same time as such territory was being made anew. This paper also casts new light on the relational and collaborative processes of academic exchange, specifically in the field of Geography, between Korean and Japanese academics during the Korean colonial period.

Solving the Travelling Salesman Problem Using an Ant Colony System Algorithm

  • Zakir Hussain Ahmed;Majid Yousefikhoshbakht;Abdul Khader Jilani Saudagar;Shakir Khan
    • International Journal of Computer Science & Network Security
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    • v.23 no.2
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    • pp.55-64
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    • 2023
  • The travelling salesman problem (TSP) is an important combinatorial optimization problem that is used in several engineering science branches and has drawn interest to several researchers and scientists. In this problem, a salesman from an arbitrary node, called the warehouse, starts moving and returns to the warehouse after visiting n clients, given that each client is visited only once. The objective in this problem is to find the route with the least cost to the salesman. In this study, a meta-based ant colony system algorithm (ACSA) is suggested to find solution to the TSP that does not use local pheromone update. This algorithm uses the global pheromone update and new heuristic information. Further, pheromone evaporation coefficients are used in search space of the problem as diversification. This modification allows the algorithm to escape local optimization points as much as possible. In addition, 3-opt local search is used as an intensification mechanism for more quality. The effectiveness of the suggested algorithm is assessed on a several standard problem instances. The results show the power of the suggested algorithm which could find quality solutions with a small gap, between obtained solution and optimal solution, of 1%. Additionally, the results in contrast with other algorithms show the appropriate quality of competitiveness of our proposed ACSA.

An Automated Production System Design for Natural Language Processing Models Using Korean Pre-trained Model (한국어 사전학습 모델을 활용한 자연어 처리 모델 자동 산출 시스템 설계)

  • Jihyoung Jang;Hoyoon Choi;Gun-woo Lee;Myung-seok Choi;Charmgil Hong
    • Annual Conference on Human and Language Technology
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    • 2022.10a
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    • pp.613-618
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    • 2022
  • 효과적인 자연어 처리를 위해 제안된 Transformer 구조의 등장 이후, 이를 활용한 대규모 언어 모델이자 사전학습 모델인 BERT, GPT, OPT 등이 공개되었고, 이들을 한국어에 보다 특화한 KoBERT, KoGPT 등의 사전학습 모델이 공개되었다. 자연어 처리 모델의 확보를 위한 학습 자원이 늘어나고 있지만, 사전학습 모델을 각종 응용작업에 적용하기 위해서는 데이터 준비, 코드 작성, 파인 튜닝 및 저장과 같은 복잡한 절차를 수행해야 하며, 이는 다수의 응용 사용자에게 여전히 도전적인 과정으로, 올바른 결과를 도출하는 것은 쉽지 않다. 이러한 어려움을 완화시키고, 다양한 기계 학습 모델을 사용자 데이터에 보다 쉽게 적용할 수 있도록 AutoML으로 통칭되는 자동 하이퍼파라미터 탐색, 모델 구조 탐색 등의 기법이 고안되고 있다. 본 연구에서는 한국어 사전학습 모델과 한국어 텍스트 데이터를 사용한 자연어 처리 모델 산출 과정을 정형화 및 절차화하여, 궁극적으로 목표로 하는 예측 모델을 자동으로 산출하는 시스템의 설계를 소개한다.

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The Maximum Scatter Travelling Salesman Problem: A Hybrid Genetic Algorithm

  • Zakir Hussain Ahmed;Asaad Shakir Hameed;Modhi Lafta Mutar;Mohammed F. Alrifaie;Mundher Mohammed Taresh
    • International Journal of Computer Science & Network Security
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    • v.23 no.6
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    • pp.193-201
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    • 2023
  • In this paper, we consider the maximum scatter traveling salesman problem (MSTSP), a travelling salesman problem (TSP) variant. The problem aims to maximize the minimum length edge in a salesman's tour that travels each city only once in a network. It is a very complicated NP-hard problem, and hence, exact solutions can be found for small sized problems only. For large-sized problems, heuristic algorithms must be applied, and genetic algorithms (GAs) are found to be very successfully to deal with such problems. So, this paper develops a hybrid GA (HGA) for solving the problem. Our proposed HGA uses sequential sampling algorithm along with 2-opt search for initial population generation, sequential constructive crossover, adaptive mutation, randomly selected one of three local search approaches, and the partially mapped crossover along with swap mutation for perturbation procedure to find better quality solution to the MSTSP. Finally, the suggested HGA is compared with a state-of-art algorithm by solving some TSPLIB symmetric instances of many sizes. Our computational experience reveals that the suggested HGA is better. Further, we provide solutions to some asymmetric TSPLIB instances of many sizes.

Anterior Open Bite with Temporomandibular Joint Osteoarthritis Treated with Skeletal Anchorage Device: A Case Report

  • Seo-Rin Jeong;So-Yoon Lee;Sung-Hoon Lim;Hye-Min Kim;Shin-Gu Kang;Hyun-Jeong Park
    • Journal of Oral Medicine and Pain
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    • v.48 no.3
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    • pp.123-130
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    • 2023
  • This case report describes the orthodontic treatment of a patient with severe anterior open bite and skeletal class II malocclusion with temporomandibular joint (TMJ) osteoarthritis (OA) of the left condyle. The 21-year-old male patient had open-bite malocclusion, mild crowding, and protrusion of the anterior teeth. Mild erosive changes were detected in the anterior part of the left mandibular condyle on cone-beam computed tomography; however, because no clinical symptoms were present, orthodontic treatment was performed. It is imperative to consider the potential implications of orthodontic treatment on the stability of the TMJ throughout the duration of treatment, as any instability can exacerbate TMJ OA. Hence, it is crucial to opt for the least invasive treatment modality available. In this regard, orthodontic treatment using a skeletal anchorage system as an alternative to conventional orthognathic surgery for patients with open bite holds great promise, as it not only ensures mandibular stability but also significantly ameliorates the open-bite condition.

Optimization of the Travelling Salesman Problem Using a New Hybrid Genetic Algorithm

  • Zakir Hussain Ahmed;Furat Fahad Altukhaim;Abdul Khader Jilani Saudagar;Shakir Khan
    • International Journal of Computer Science & Network Security
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    • v.24 no.3
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    • pp.12-22
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    • 2024
  • The travelling salesman problem is very famous and very difficult combinatorial optimization problem that has several applications in operations research, computer science and industrial engineering. As the problem is difficult, finding its optimal solution is computationally very difficult. Thus, several researchers have developed heuristic/metaheuristic algorithms for finding heuristic solutions to the problem instances. In this present study, a new hybrid genetic algorithm (HGA) is suggested to find heuristic solution to the problem. In our HGA we used comprehensive sequential constructive crossover, adaptive mutation, 2-opt search and a new local search algorithm along with a replacement method, then executed our HGA on some standard TSPLIB problem instances, and finally, we compared our HGA with simple genetic algorithm and an existing state-of-the-art method. The experimental studies show the effectiveness of our proposed HGA for the problem.

Gender Characteristics in Virtual Fashion Design -Virtual Avatars' Genders and Genderless Fashion Design Concepts-

  • Minji Lena Kim;Sang Ha Yun;Inzali Moe;Eun Kyoung Yang
    • Journal of the Korean Society of Clothing and Textiles
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    • v.48 no.3
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    • pp.397-416
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    • 2024
  • This study investigated gender characteristics in contemporary virtual fashion design, focusing on avatars and genderless fashion in recent collections from Auroboros, Republiqe, Placebo Digital Fashion House, RTFKT, and Tribute. Employing content analysis within a theoretical framework of gender-related research, the study coded virtual avatars in terms of biological sex, appearance, and sociological perspectives. The results showed a preference for female-type avatars, through which androgynous aesthetics were embraced and traditional gender norms were challenged. Male-type avatars reflected experimentation with blending masculine elements, emphasizing inclusivity. Human-like avatars indicated a preference for designs that promoted inclusivity and, in the process, challenged binary classifications. The examined brands strategically capitalized on compromise, sensuality, and playfulness, thereby breaking away from traditional values to opt for more diverse styles. Genderless features combined elements from traditional men's and women's clothing, espousing sensuality and playful exaggeration. These findings signify a dynamic shift away from conventional gender standards to foster inclusivity and experimentation. They can serve as a reference for promoting creative strategies and design innovation, challenging the traditional gender perspective in the fashion industry. Implementing these strategies can lead to a more inclusive representation of fashion styles, encouraging critical thinking about gender norms.

Effects of Sling Exercise on Spinal Flexibility and Dynamic Balance in Adolescent Scoliosis Patients (청소년기 척추측만증 환자에 대한 슬링운동이 척추유연성과 동적 균형에 미치는 영향)

  • Yoo, Dal-young;Choi, Jong-uk;Park, Seong-doo
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.26 no.1
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    • pp.19-26
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    • 2020
  • Background: The purpose of this study was compare and analyze the flexibility and dynamic balance in adolescents with idiopathic scoliosis and provide scientific basis for effectively treating idiopathic scoliosis. Methods: The subjects of this study were 20 members of adolescences. To measure the flexibility of the spine, a left buckling instrument was used, and it was measured using a modified sit and reach test. They were randomly divided into core exercise with sling program group (n=10) and general exercise program group (n=10), each consisting 50 minutes each for 4 times per week for 8 weeks. Results: The results of the study are as follows. First, Both groups were increased statistically significantly in spinal flexibility but no significant differences have been found between the two groups after 8 weeks of exercise. Second, Both groups were increased statistically significantly in balance ability of dynamic foot pleasure ratio but no significant differences have been found between the two groups after 8 weeks of exercise. Conclusion: In summarizing the results of this study, sling exercise with core exercise was effective in the decrease of flexibility and stability than general scoliosis exercise in adolescents with idiopathic scoliosis. It is also believed to be applicable to spinal diseases caused by muscular weakness since it is effective in strengthening core muscle strength.