• Journal of the Optical Society of Korea
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• v.10 no.3
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• pp.99-104
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• 2006

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter ${\sim}100nm$) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength ($B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

• Journal of Sensor Science and Technology
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• v.17 no.4
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• pp.317-324
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• 2008

This paper presents an optical doppler tomography(ODT) system using a speaker as a method to achieve depth measurement in a flowing sample. The use of the speaker provides easy implementation with a low cost. The nonlinear characteristics of the speaker has hindered its adaptation because it produces inconsistent fringe frequencies at different depths. This paper reports an adaptive algorithm to compensate the nonlinear characteristics, and could, resultantly, acquire the Doppler frequency shift caused by the sample. The experiment utilizes a flowing scattering particle solution in a capillary tube at a certain flow rate. The Doppler frequency profile over the lumen was calculated by using spectrogram method. and we obtained the velocity image of the sample.

• Journal of the Optical Society of Korea
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• v.16 no.2
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• pp.174-180
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• 2012

In this study, the feasibility of spectral domain optical Doppler tomography for measuring blood flow characteristics in a micro-tube was demonstrated through several experiments. The use of an SD-ODT system in blood flow measurement can provide high resolution images (5 microns resolution). We prepared three capillary tubes to reveal the effect of different concentrations of hematocrit ratio (HR). One tube serves as the control. The two other tubes contained different concentrations of HR (5%, 25%). Three different capillary tube inlet flow velocities were tested in the present study. The Reynolds number (Re) which is based on the capillary tube inner diameter ranges from Re=6 to 48. We calculated a Doppler shift of the power spectrum of the temporal interference fringes with Kasai autocorrelation function to achieve the velocity profile of the flow. As a result, SD-ODT systems could not detect the cell depletion layer in the present study due to the limitation of spatial resolution. Nevertheless, these systems were proven to be capable of observing the RBCs of blood.