• Journal of Yeungnam Medical Science
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• v.38 no.2
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• pp.160-164
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• 2021

Oculocutaneous albinism (OCA) is a group of rare genetically heterogeneous disorders, characterized by hypopigmentation of the eyes, skin, and hair, which result in ocular abnormalities and a risk of developing skin cancer. Currently, there is no ophthalmologic procedure or drug that prevents the clinical features of OCA. Here, we report a new type of OCA in two, unrelated Korean families with the same OCA2 mutation. Affected individuals in this study are different from those of previous reports in two aspects: an inheritance pattern and clinical presentation. All reported patients with OCA have shown an autosomal recessive inheritance pattern, while our patients showed an autosomal dominant inheritance pattern. Small amounts of pigment can be acquired with age in OCA, but there is no substantial variation from adolescence to adulthood in this regard. A case where the patient attained normal pigmentation levels has never been reported. However, our patients displayed completely normal pigmentation in their late twenties. Whole exome sequencing and in-silico analysis revealed a novel mutation, OCA2 c.2338G>A p.(G780S) (NM_000275) with a high likelihood of pathogenicity. Sanger sequencing of p.G780S identified the same mutation in the affected individuals, which was not found in the family members with normal phenotype. We hypothesize that OCA2 G780S not only acts as a pathogenic variant of OCA but also induces pigmentation by enhancing the melanogenesis gene expression of other modifier genes, such as SLC45A2 and TPC2. These findings may provide further understanding of melanin biosynthesis and new treatment methods for OCA.

• Medical Lasers
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• v.10 no.3
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• pp.146-152
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• 2021

Background and Objectives Although lasers have been widely applied in tissue treatment, the light penetration depth in tissues is limited by the tissue turbidity and affected by its absorption and scattering characteristics. This study investigated the effect of using an optical clearing agent (OCA) on tissue to improve the therapeutic effect of 1064 nm wavelength laser light by reducing the heat generated on the skin surface and increasing the penetration depth. Materials and Methods A diode laser (λ = 1064 nm) was applied to a porcine specimen with and without OCA to investigate the penetration depth of the laser light and temperature distribution. A numerical simulation using the finite element method was performed to investigate the temperature distribution of the specimen compared to ex-vivo experiments using a thermocouple and double-integrating sphere to measure the temperature profile and optical properties of the tissue, respectively. Results Simulation results showed a decrease in tissue surface temperature with increased penetration depth when the OCA was applied. Furthermore, both absorption and scattering coefficients decreased with the application of OCA. In ex-vivo experiments, temperatures decreased for the tissue surface and the fat layer with the OCA, but not for the muscle layer. Conclusion The use of an OCA may be helpful for reducing surface heat generation and enhance the light penetration depth in various near-infrared laser treatments.

• The korean journal of orthodontics
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• v.52 no.3
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• pp.172-181
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• 2022

Objective: The objectives of this study were to compare the time-dependent changes in occlusal contact area (OCA) and bite force (BF) of the deviated and non-deviated sides in mandibular prognathic patients with mandibular asymmetry before and after orthognathic surgery and investigate the factors associated with the changes in OCA and BF on each side. Methods: The sample consisted of 67 patients (33 men and 34 women; age range 15-36 years) with facial asymmetry who underwent 2-jaw orthognathic surgery. OCA and BF were taken before presurgical orthodontic treatment, within 1 month before surgery, and 1 month, 3 months, 6 months, 1 year, and 2 years after surgery. OCA and BF were measured using the Dental Prescale System. Results: The OCA and BF decreased gradually before surgery and increased after surgery on both sides. The OCA and BF were significantly greater on the deviated side than on the non-deviated side before surgery, and there was no difference after surgery. According to the linear mixed-effect model, only the changes in the mandibular plane angle had a significant effect on BF (p < 0.05). Conclusions: There was a difference in the amount of the OCA and BF between the deviated and non-deviated sides before surgery. The change in mandibular plane angle affects the change, especially on the non-deviated side, during the observation period.

• Radiation Oncology Journal
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• v.16 no.3
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• pp.225-231
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• 1998

Purpose : To determine whether TNF-$\alpha$ increases the antitumor effect of radiotherapy in murine syngeneic tumor system. Materials and Methods : Syngeneic murine tumors of MCa-K or MCa-4 (mammary carcinoma), OCa-I (ovarian carcinoma), or HCa-I(hepatocarcinoma were grown in hind legs of C3Hf/HeJ mice. When tumors were grown to 6 mm in mean diameter mice were treated with TNF-$\alpha$, radiation, or combination of the both. Gamma-radiation was given as a single dose of 30 Gy for HCa-I and 15 Gy for other tumors using Cobalt-60 teletherapy unit. A novel TNF-$\alpha$ mutein developed in Korea, was intraperitoneally administered daily at a dose of 10 ug per mouse for 7 days. In combination of radiation and TNF-$\alpha$, the drug was started 1 hour after radiation. Tumor growth delay assay was used to measure the tumor response to the treatment. Results : Among 4 tested tumors, TNF-$\alpha$ alone showed significant antitumor activity in MCa-K and OCa-I tumors, which showed absolute growth delay (AGD) of 5.0 days and 6.5 days, respectively. In combination with radiation, TNF-$\alpha$ showed significant delay of AGD (41.1 days) in OCA-I compared to AGDs of TNF-$\alpha$ alone and radiation, i.e., 6.5 days and 26.9 days, respectively(p<0.05). Enhancement factor was 1.29 in OCa-I, which showed supraadditive effect. TNF-$\alpha$ did not show significant delay of AGDs in the remaining 3 tumors compared to AGDs of TNF-$\alpha$ alone and radiation. Conclusions: TNF-$\alpha$ alone showed antitumor effects in MCa-K and OCa-I. In combination with radiation, TNF-$\alpha$ acted in supraadditive way in OCa-I only. The results of this study imply that the combination of TNF-$\alpha$ and radiation has different therapeutic potential depending on tumor model and further study is advocated.

• Journal of the Korean Institute of Gas
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• v.22 no.5
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• pp.31-37
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• 2018

The distrust about chemical plant safety have been increased by occurring the major industrial accidents. Chemical plants have become more and more enlarged and sophisticated to increase production amount and decrease cost. So hazard of industrial accidents also have been increased. In this situation, quantitative risk assessment is activated by introducing OCA(Off-site Consequence Analysis). So it is possible to analyze the objective hazard of chemical plant. Currently OCA focus on the end point of hazardous area by fire/explosion/dispersion. But in this case, it is possible to analyze the industrial accident effect to near the chemical plant but hard to consider the actual hazard by frequency and population density. This study analyzes the validity about application of F-N curve to OCA by compare end point with F-N curve about accident.

• Resources Recycling
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• v.29 no.6
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• pp.57-64
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• 2020

In this study, removal of OCA and organic impurities for recycling LCD touch panel glass was conducted by mechanical and chemical dissolution methode. Cut mill and oscillation mill were used for mechanical crushing of touch panel, and water, ethanol, dichloromethane were used to remove OCA and organic impurities. As a result of TGA, when applied only dicloromethane in the process, the efficiency of organic removal was to be best. In addition, removal effect of organic impurities increased as the cleaning temperature increased. As a result of zeta potential analysis to confirm the dispersion degree of touch panel glass in the solvent, the absolute value of the zeta potenial of water with the lowest cleaning effect was lower than other solvents, and it was confirmed that efficiency of organic removal is affected not only by the chemical dissolution properties but also the physical dispersion properties in the solvent.

• Radiation Oncology Journal
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• v.17 no.4
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• pp.307-313
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• 1999

Purpose : To investigate the Presence of adaptive response by low dose radiation in murine tumors in relation to radiation induced apoptosis as well as related mechanism. Materials and Methods : Syngeneic murine tumors, OCa-I and HCa-l, were given 0.05 Gy pretreatment followed by therapeutic dose of 25 Gy radiation. Induction of apoptosis was analyzed for each treatment group. Regulating molecules of apoptosis, p53, Bcl-2, Bax, Bcl-X, were also analyzed by Western blotting. Results : In 0.05 Gy pretreatment group of OCa-I, 25 Gy-induced apoptosis per 1000 cells was 229, which was estimated at $30\%$ lower level than the expected (p<0.05). In contrast, this reduction in radiation induced apoptosis was not seen in HCa-l. In the expression of apoptosis regulating molecules, p53 increased in both tumors in response to radiation. Bcl-2 and Bax did not show significant change in both tumors however, the expression of Bcl-2 surpassed that of Bax in 0.05 Gy pretreatment group of OCa-l. Bcl-X was not expressed in OCa-l. In HCa-l, Bcl-X showed increased expression even with 0.05 Gy. Conclusion : Adaptive response by low dose radiation Is shown in one murine tumor, OCa-l, in relation to radiation induced apoptosis. Apoptosis regulating molecules including Bcl-2/Bax and Bcl-X, appear to related. This study shows an evidence that adaptive response is present, but not a generalized phenomenon in vivo.

• Journal of the Semiconductor & Display Technology
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• v.17 no.3
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• pp.75-84
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• 2018

According to IHS, the overall display market is expected to grow at an average annual rate of 6% from $ 104 billion in 2016, to $ 138 billion in 2021. Among them, the OLED display panel will grow from $ 15 billion to $ 41 billion over the same period, forecasting a high annual growth rate of 22%. However, the refraction index, light leakage, bubble generation, adhesion deterioration, peeling phenomenon, moisture resistance, light transmittance, low turbidity. OCA (optically clear adhesive), which solves problems such as improving the resistance of the conductive film, is largely dependent on imported products. In addition, in 2016, the world market is worth KRW4.3 trillion, and the adhesive market has a large market effect. In this study, we tried to analyze the technical competitiveness of patent and thesis by classifying OCA (optically clear adhesive, optical adhesive) for display panel by curing method. As a result of the study, the amount of patents and papers in Korea was found to be superior to other competitors, but the quality level was low. In particular, it was found that the achievements of the papers in the hot melt field are lacking and the government should expand its support.

• Korean Architects
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• s.614
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• pp.34-43
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• 2020

• Proceedings of the Korean Information Science Society Conference
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• 2005.07b
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• pp.364-366
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• 2005

소프트웨어 개발시 요구사항 협의단계에서 WinWin 협의모델은 이해당사자들이 모두 만족할 수 있는 합의값물 결정하도록 도와준다. 이해당사자들은 각각의 Win 조건을 정의하고, 이것을 품질특성별로 규명한 수치화된 값으로 만든 후 이를 대상으로 협의하여 합의값을 도출한다. 하지만 이같은 합의값을 도출하는 과정에서 모든 이해당사자들이 Win 조건에 도달했는지 설명할 수 있는 방법은 없다. 본 논문은 WinWin 모델에서 이같은 합의값 도출 과정을 규명 가능한 수준으로 만들어 전체적으로 WinWin 모델의 성능이 개선될 수 있다는 것을 제시한다. 각 이해당사자들은 WinWin 모델 내의 합의값 도출과정을 퍼지 합의모델인 OCA(Opinion Changing Aversion)를 이용하여 산출된 합의값의 신뢰도를 평가한다. 평가된 신뢰도를 향상시킬 때까지 반복이 가능하므로 전체적으로 OCA는 WinWin 협의모델의 성능을 개선시킬 수 있다는 것을 증명한다.