• Title/Summary/Keyword: Nuclear industry

Search Result 6,226, Processing Time 0.033 seconds

Melanogenesis inhibition activity of floralginsenoside A from Panax ginseng berry

  • Lee, Dae Young;Lee, Jongsung;Jeong, Yong Tae;Byun, Geon Hee;Kim, Jin Hee
    • Journal of Ginseng Research
    • /
    • v.41 no.4
    • /
    • pp.602-607
    • /
    • 2017
  • Background: Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsenoside Re (GRE) were purified from P. ginseng berry. Methods: Chemical structures of FGA, GRD, and GRE were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy, ID-nuclear magnetic resonance, and infrared spectroscopy. Inhibitory activities of these compounds on melanogenesis were studied by measuring the expression of protein and melanin content in the melan-a cell line. This inhibitory activity was confirmed by observing pigmentation and tyrosinase activities of zebrafish. Results: GRD, GRE, and FGA were not cytotoxic at concentrations less than 20μM20μM, 80μM80μM, and 160μM160μM in melan-a cells, respectively. GRD, GRE, and FGA inhibited melanin biosynthesis in melan-a cells by 15.2%, 22.9%, and 23.9% at 20μM20μM, 80μM80μM, and 160μM160μM, respectively. FGA was observed to display the most potent inhibitory effect. In addition, FGA decreased microphthalmia-associated transcription factor protein expression in a dose-dependent manner. Moreover, FGA induced extracellular signal-regulated kinase phosphorylation level in melan-a cells. In addition, melanin pigment content and tyrosinase activity in zebrafish treated with FGA at 160μM160μM were reduced. Conclusion: FGA showed the most potent inhibition of melanogenesis in both in vitro and in vivo studies. This study suggests that FGA purified from P. ginseng may be an effective melanogenesis inhibitor.

Identification between Local Wall Thinning and Turbulent Velocity Components by Flow Acceleration Corrosion inside Tee of Pipe System (배관계 티에서 유동가속부식으로 인한 난류속도성분과 국부감육의 관계 규명)

  • Kim, Kyung-Hoon;Lee, Sang-Kyu;Cho, Yun-Su;Hwang, Kyung-Mo
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
    • /
    • v.23 no.7
    • /
    • pp.483-491
    • /
    • 2011
  • When pipe components made of carbon steel in nuclear, fossil, and industry are exposed to flowing fluid, wall thinning caused by FAC(flow accelerated corrosion) can be generated and eventually ruptured at the portion of pressure boundary. A study to identify the locations generating local wall thinning and to disclose turbulence coefficient related to the local wall thinning was performed. Experiment and numerical analyses for tee of down scaled piping components were performed and the results were compared. In particular, flow visualization experiment which was used alkali metallic salt was performed to find actual location of local wall thinning inside tee components. To disclose the relationship between turbulence coefficients and local wall thinning, numerical analyses were performed for tee components. The turbulence coefficients based on the numerical analyses were compared with the local wall thinning based on the measured data. From the comparison of the results, the vertical flow velocity component(Vr) flowing to the wall after separating in the wall due to the geometrical configuration and colliding with the wall directly at an angle of some degree was analogous to the configuration of local wall thinning.

Review on improving measurement of cyber terror management system

  • Park, Jong-Ryeol;Noe, Sang-Ouk
    • Journal of the Korea Society of Computer and Information
    • /
    • v.21 no.6
    • /
    • pp.89-96
    • /
    • 2016
  • Damage and attack size of cyber terror is growing to the national size. Not only targeting at a certain companies or individuals but number of cyber terror targeting government bodies or unspecific people is increasing. This is because compared to traditional weapon, input cost is very cheap but ripple effect and shock are much stronger, affecting not only certain groups but also each individuals. 'Anti-terror measurement for protection of nation and public safety' passed last month is one of the renowned measurement passed regardless of objection from opposition party. The opposition party went against this through filibuster for 192 hours but this finally passed National Congress due to lack of oppositions. Korean government is taking post actions after passage of anti-terror measurement. Legislation of enforcement ordinance and regulations is due by 6th of next month. This regulation will be executed from June 4th after legislation. Whenever there is any security issues such as hacking of Korea Hydro and Nuclear Power and National Intelligence Service happens, lot of attention is made to those hackers. However, social recognition or management of those hackers need lot more improvement. Especially, as market of internet of things is increasing, there is an increased anxiety on information security. But as we only rely on security solutions, this problems are keep happening. Therefore, active investment on nurturing hackers who play the role of 'spear and shield' shall be made. Government should put more efforts to allow white hackers to show their abilities. We should have a policy for supporting high-quality programs such as BoB. To make information protection industry into future growth engine, it is necessary to nurture professionals for information protection and white hackers through special programs. Politicians should make related regulations as soon as possible to remove factors that prevent swift management of cyber attack due to lack of legislation. Government should pay lot more financial investment to nurturing professional manpower than now. Protecting life and asset of nation is responsibility and duty of our government. We all should recognize that controlling cyber attack is a part of national defense.

Korean Costume's Figure and Means in the Coming-of-age Ceremony (한국성년례 복식의 형태와 의미)

  • Hwang, Mi-Sun;Lee, Un-Young
    • Journal of the Korea Fashion and Costume Design Association
    • /
    • v.15 no.1
    • /
    • pp.155-173
    • /
    • 2013
  • Recently, social problem of teens becomes one of the important social issues. Adolescence is the intermediate stages of childhood and adulthood. Teens have not find their identity at this time. That reason is why teens and the old generation are disconnect. That arise from the development of industry and the nuclear family, entrance examination-oriented education system. So they are wandering in the popular culture and the cyber-space. Therefore, families, schools and state should have interesting and understanding for teens, and should strive that teens establish a self established identity. Specially, ethics education using traditional culture will help to establish their identity, and that provide self-esteem and pride about korean traditional culture. This is the reason why culture contents that is based on Korean traditional culture have to make for teens. The purpose of this study is to provide the basic data that will help in the development Korean traditional cultural contents for teens. In this study, this researchers will search the following matters; first, what is ritual for Coming-of-age, second, various forms of ritual for Coming-of-age and Korean modern ritual in order to grasp the meaning of the ritual for Coming-of-age, third, costume and meaning of costume which has in both Kwan-Ryea as Korean traditional ritual for Coming-of-age and Korean modern ritual. This study will compare Kwan-Ryea with traditional ritual of modern.

  • PDF

A Qualitative Formal Method for Requirements Specification and Safety Analysis of Hybrid Real-Time Systems (복합 실시간 계통의 요구사항 명세와 안전성 분석을 위한 정성적 정형기법)

  • Lee, Jang-Soo;Cha, Sung-Deok
    • Journal of KIISE:Software and Applications
    • /
    • v.27 no.2
    • /
    • pp.120-133
    • /
    • 2000
  • Major obstruction of using formal methods for hybrid real-time systems in industry is the difficulty that engineers have in understanding and applying the quantitative methods in an abstract requirements phase. While formal methods technology in safety-critical systems can help increase confidence of software, difficulty and complexity in using them can cause another hazard. In order to overcome this obstruction, we propose a framework for qualitative requirements engineering of the hybrid real-time systems. It consists of a qualitative method for requirements specification, called QFM (Qualitative Formal Method), and a safety analysis method for the requirements based on a causality information, called CRSA (Causal Requirements Safety Analysis). QFM emphasizes the idea of a causal and qualitative reasoning in formal methods to reduce the cognitive burden of designers when specifying and validating the software requirements of hybrid safety systems. CRSA can evaluate the logical contribution of the software elements to the physical hazard of systems by utilizing the causality information that is kept during specification by QFM. Using the Shutdown System 2 of Wolsong nuclear power plants as a realistic example, we demonstrate the effectiveness of our approach.

  • PDF

Development and Application of RCM Process for the Optimized Maintenance of Railway Vehicle (철도차량의 유지관리 최적화를 위한 RCM 프로세스 개발 및 적용)

  • Shin, Kun Young;Lee, Hi Sung
    • Journal of Energy Engineering
    • /
    • v.24 no.1
    • /
    • pp.10-16
    • /
    • 2015
  • Recently, RCM(reliability centered maintenance) process is introduced and applied for the planning and implementing efficient and effective maintenance system in terms of optimal rolling stock maintenance. Particularly, cost-time benefits analysis associated with the implementation of RCM for rolling stock maintenance is necessary and required for railway operator in advance. The RCM process was primarily starting from military, airplane and nuclear industries and is now adapted in railway industry for local railway operators. This paper focuses on suggesting the way of connecting the RCM process with railway maintenance activities in the railway operation field. Thus, in order to introduce and establish reliability activities, it needs to review and evaluate the maintenance environment in the organizational point of view. Based on these reviews and evaluations, various maintenance methodologies are reviewed for customizing local railway field situations and establish specific process in the application of major systems on the reliability technology. In this paper, the railway RCM process is proposed for the establishment and construction of the systematic and optimal maintenance system.

Liposome-Mediated Electric Gene Delivery into Fetal and Adult Gonads (Liposome을 매개로 한 태아 및 웅성 생식선으로의 전기적 유전자 도입)

  • Choi, S. C.;S. K. Choi;S. S. Choi;S. U. Kim;N. N. Cho;J. Y. Jung;C. S. Park;S. H. Lee;S. H. Lee
    • Reproductive and Developmental Biology
    • /
    • v.28 no.1
    • /
    • pp.71-76
    • /
    • 2004
  • Gene delivery is one of the keen interests in animal industry as well as research on gene functions. Some of the in vivo gene delivery techniques have been successively used in various tissues for the gene therapy and transgenesis. Despite intensive efforts, it still remains to overcome problems of limited local and regional administration and low transgene expression. To improve the efficiency of gene delivery, a new procedure was tested. We injected exogenous DNA containing LacZ into the female or male gonads and then pulsed electric field. Electroporated gonads showed positive X-gal staining in many seminiferous tubules of the porcine fetal gonads. Exogenously introduced LacZ genes were also expressed in female porcine gonad. In addition, we demonstrated efficient gene delivery in gonad of adult mouse. Furthermore, we succeed to generate genetically modified germline cells showing GFP and positive X-gal signals. The results suggest that the newly developed gene delivery is an effective way of in vivo transfection in mammals. The developed gene delivery procedure should be useful in producing transgenic animals when combined with primary cell culture and nuclear transplantation.

A Study on the Design Concepts and Main Construction Processes of the Coal Shed at Thermal Power Plant (화력발전소 석탄저장고 설계개념과 시공과정 상의 주요 공정에 관한 연구)

  • Kim, Si-Hyun;Choi, Jang-Soon
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.16 no.5
    • /
    • pp.3619-3626
    • /
    • 2015
  • The coal shed at thermal power plant(T.P.P) is the biggest building on size among nuclear, coal and other power plant industry buildings. This the coal shed of indoor type is mass volume, the size of 6 soccer fields and 73 meter in height. Structural and functional elements take priority over aesthetic factors. The shed is built to make mighty space for structural safety and functional store by using the concrete, 75,000m375,000m3 on the total of central retaining wall and sub buttress, and the steel frame used by 11,744-ton P.E.B. system. The design requirement on its wall and frame, P.E.B. system's feature, and specific data of main process followed by construction are inquired. The aim of this study is to suggest the design requirement and guide for the indoor type of the coal shed.

Development of a Robust Polyvoltine Breed NP1 of the Mulberry Silkworm, Bombyx mori L.

  • Singh Ravindra;Rao D. Raghavendra;Sharma S.D.;Chandrashekaran K.;Basavaraja H.K.;Kariappa B.K.;Dandin S.B.
    • International Journal of Industrial Entomology and Biomaterials
    • /
    • v.12 no.1
    • /
    • pp.29-34
    • /
    • 2006
  • A breeding programme was initiated during 2001 utilizing two polyvoltine silkworm breeds viz. BL69, an evolved breed tolerant to high temperature and MAR, comparatively resistant to Bombyx mori nuclear polyhedrosis virus (BmNPV) with the objective to develop robust polyvoltine breeds and hybrids. The breed NP1 was developed by exposing the fifth instar larvae to high temperature (36±1C), high Relative Humidity (85±5 R.H.) and inoculating third instar larvae with BmNPV inoculum. At F12, the breed was tested for hybrid forming ability utilizing six bivoltine silkworm breeds viz. CSR2,CSR4,CSR17,CSR18,CSR19andNB4D2. The hybrid NP1×CSR17 exhibited its superiority by recording 97.2% survival, 1.892 g cocoon weight, 0.406 g cocoon shell weight, 21.5% cocoon shell ratio, 16.6% raw silk percentage and 890 m filament length whereas the control (PM×CSR2) has recorded 90.2% survival, 1.599 g cocoon weight, 0.304 g cocoon shell weight, 18.9% cocoon shell ratio, 13.1 % raw silk percentage and 768 m filament length. Commercial exploitation of the new polyvoltine×bivoltine hybrid in sericulture industry has been discussed.

Development of RCA Incident Investigation Method as Easily Adopted Industry Field (산업현장에서 쉽게 적용할 수 있는 근본원인 사고조사기법 개발에 관한 연구)

  • Kwon, Jae Beom;Kwon, Young Guk
    • Journal of the Korean Society of Safety
    • /
    • v.36 no.5
    • /
    • pp.43-51
    • /
    • 2021
  • Incident investigation is one of the most important processes among various other safety management methods to prevent industrial accidents. Finding the root causes of accidents, eliminating hazards, and improving safety are the most important purposes of investigating accidents. During the investigation process, root cause analysis (RCA) techniques are used to effectively identify RCA. Over the past few decades, over 30 RCA methods have been developed. These techniques are being widely used in some industries, such as the nuclear and aircraft industries; however, most of the RCA techniques require professional knowledge and special training, making it difficult for safety managers in their respective fields to understand and apply them. Therefore, managers of general industrial sites are rarely present at the scene of actual accident investigations, and they cannot contribute much to the purpose and effectiveness of these investigations. In this study, to address these issues, we developed an RCA technique to facilitate root cause investigation of accidents in real-world industrial sites. To develop new techniques, Systematic Cause Analysis Technique (SCAT), one of the RCA techniques, was used to investigate incidents in the enterprise over three years. We also utilized feature analysis and other papers from existing RCA techniques. To verify its effectiveness, the technique proposed was also applied to the accident case. The technique developed can easily identify and analyze the root cause of an accident and help industrial managers. It can also identify the root cause category where accidents are concentrated and use this data to establish guidelines for preventing future accidents and, thus, focus on prioritizing improvement initiatives.