• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(2)
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• pp.509-516
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• 1995

The uncertainty analysis for the in-vessel steam explosion during severe accidents at a nuclear power plant is performed using a probabilistic approach. This approach consists of four steps; 1) screening, 2) quantification of uncertainty 3) propagation of uncertainty, and 4) output analysis. And the specific methods which satisfy the sub-objectives of each step are prepared and presented. Compared with existing ones, the unique feature of this approach is the improved estimation of uncertainties through quantification, which ensures the defensibility of the resultant failure probability distributions. Using the approach, the containment failure probability due to in-vessel steam explosion is calculated. The results of analysis show that 1) pour diameter is the most dominant factor and slug condensed phase fraction is the least and 2) fraction of core molten is the second most dominant factor, which is identified as distinct feature of this study as compared with previous studies.

• 대한기계학회논문집A
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• 제20권6호
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• pp.1798-1809
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• 1996

The purpose of this paper is to develop new Z-Factors to evaluate the behavior of circumferential surface crack in ferritic steel piping including base metal and Submerged Arc Weld(SAW) metal in nuclear power plant. The Z-factor is a load multiplier to convert plastic load to elasto-plastic load. However the current Z-Factor is a load multiplier to convert plastic load to elasto-plastic load. However the current Z-Factor gives too conservative results. In this study, a J-estimation method, SC.TNP method, which is based on GE/EPRI expression, is used to develop new Z-Factors. The desirabilities of both the SC.TNP mehtod and the new Z-Factors are examined using the previous experimental results for the circumferential surface crack in ferritic steel pippings. The results are as follows ; (1) The SC.TNP mehtod is good for describing the circumferential surface crack behavior in farritic steel pipings, while the well-known R6 mehtod and DPFAD method give too conservative results. (2) The ASME-Z-Factor method using nwe Z-Factors well predicts the behavior of circumferential surface crack in ferritic steel pipings including base emtal and SAW metal.

• 한국생산제조학회지
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• 제22권3_1spc호
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• pp.518-524
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• 2013

Recently, probabilistic assessments of nuclear power plant components have generated interest in the nuclear industries, either for the efficient inspection and maintenance of older nuclear plants or for improving the safety and cost-effective design of newly constructed nuclear plants. In the present paper, the partial safety factor (PSF) of wall-thinned nuclear piping is evaluated based on a reliability index method, from which the effect of each statistical variable (assessment parameter) on a certain target probability is evaluated. In order to calculate the PSF of a wall-thinned pipe, a limit state function based on the load and resistance factor design (LRFD) concept is first constructed. As for the reliability assessment method, both the advanced first-order second moment (AFOSM) method and second-order reliability method (SORM) are employed to determine the PSF of each probabilistic variable. The present results can be used for developing maintenance strategies considering the priorities of input variables for structural integrity assessments of wall-thinned piping, and this PSF concept can also be applied to the optimal design of the components of newly constructed plants considering the target reliability levels.

• Journal of Microbiology and Biotechnology
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• 제28권8호
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• pp.1270-1281
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• 2018

Periodontal disease is triggered by the host immune response to pathogens in the microbial biofilm. Worsening of periodontal disease destroys the tooth-supporting tissues and alveolar bone. As oral inflammation can induce systemic diseases in humans, it is important to prevent periodontal disease. In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells. LPS-upregulated inflammatory factors, such as nuclear factor kappa B p65 and $interleukin-1{\beta}$, were prominently reduced by CXS and XAN. In addition, RANKL-induced osteoclastic factors, such as nuclear factor of activated T-cells c1, tartrate-resistant acid phosphatase, and cathepsin K, were decreased in the presence of CXS and XAN. CXS and XAN inhibited the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway. Collectively, these results provide evidence that CXS and XAN suppress LPS-induced inflammation and RANKL-induced osteoclastogenesis by suppressing the MAPK/AP-1 pathway.

• 대한의생명과학회지
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• 제29권3호
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• pp.137-143
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• 2023

Inflammation plays an important role in immune system's response to tissue injury and biological stimuli. However, excessive inflammation can cause tissue damage. Therefore, the development of naturally derived anti-inflammatory agents have received broad attention. In this study, we investigated the anti-inflammatory mechanism of Rubi Fructus (RF) extract on the mast cell-mediated inflammatory response. To determine the regulatory mechanism of RF in inflammatory reaction, we evaluated the effects of RF on secretion of interleukin (IL)-8, IL-6 and tumor necrosis factor (TNF)-α and activation of nuclear factor-κB (NF-κB) and caspase-1 in activated human mast cells-1 (HMC-1). The results showed that RF attenuated IL-8, IL-6 and TNF-α secretion in a concentration-dependent manner. Moreover, RF significantly attenuated caspase-1and NF-κB activation in activated HMC-1. Conclusively, the present results provide evidence that RF may be a promising agent for anti-inflammatory therapy.

• 대한통합의학회지
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• 제7권4호
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• pp.61-69
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• 2019

Purpose : Human gingival fibroblast cell is one of the the main cell types in periodontal tissue, which they can show anti-inflammatory activity through the production of numerous lines of inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and interleukins. Porphyromonas gingivalis, one of the oral pathogens, has reported to play a critical role in the development of periodontal diseases. This study aimed to investigate anti-inflammatory and antioxidative activities of Gracilaria textorii ethanol extract (GTEE) in P. gingivalis derived lipopolysaccharide (LPS-PG) stimulated human gingival fibroblast (HGF)-1 cell line. Methods : In order to analyze anti-inflammatory and antioxidative activities of GTEE in HGF-1 cell line, NOS enzyme activity, expression levels of iNOS, COX-2, NAD(P)H quinone dehydrogenase (NQO)1 and their transcription factors were estimated by Griess reaction and western hybridization. Results : LPS-PG induced overexpression of iNOS and COX-2, which was significantly attenuated by GTEE treatment in a dose-dependent manner without any cytotoxicity. In addition, intracellular NOS activity was in accordance with the result of iNOS expression. Due to important role in the regulation of inflammatory responses, phosphorylated status of p65 and c-jun, each subunit of nuclear factor (NF)-κB and activator protein (AP)-1, was also dose-dependently ameliorated by GTEE treatment. One of phase II enzymes, NQO1, and its transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), were analyzed since elevated phase II enzyme expression inhibited inflammatory response, which was significantly elevated by GTEE treatment in HGF-1 cell line. Conclusion : In conclusion, GTEE mitigated LPS-PG-stimulated inflammatory responses by attenuating NF-κB and AP-1 activation as well as accelerating NQO1 and Nrf2 expression in HGF-1 cell line. These results indicate that GTEE might be utilized a promising strategy for potential anti-inflammatory agent in periodontal diseases.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2001년도 춘계학술발표회요약집
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• pp.331.1-331
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• 2001

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 추계학술발표회요약집
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• pp.47.1-47
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• 1998

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2001년도 추계학술발표회요약집
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• pp.181.1-181
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• 2001

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1999년도 춘계학술발표회요약집
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• pp.226-226
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• 1999