• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.10a
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• pp.37-38
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• 2017

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.2
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• pp.161-168
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• 2016

Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated the antitumor effects of a novel reversible inhibitor of CRM1 on renal cancer cells. We found that S109 inhibits the CRM1-mediated nuclear export of RanBP1 and reduces protein levels of CRM1. Furthermore, the inhibitory effects of S109 on CRM1 is reversible. Our data demonstrated that S109 significantly inhibits proliferation and colony formation of renal cancer cells. Cell cycle assay showed that S109 induced G1-phase arrest, followed by the reduction of Cyclin D1 and increased expression of p53 and p21. We also found that S109 induces nuclear accumulation of tumor suppressor proteins, Foxo1 and p27. Most importantly, mutation of CRM1 at Cys528 position abolished the effects of S109. Taken together, our results indicate that CRM1 is a therapeutic target in renal cancer and the novel reversible CRM1 inhibitor S109 can act as a promising candidate for renal cancer therapy.

• Journal of the Korean Professional Engineers Association
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• v.44 no.6
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• pp.40-44
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• 2011

Nuclear energy in Korea began in 1958, when the Korea's atomic energy act was formulated and the relevant organizations were founded. Since then, notwithstanding the two catastrophe like TMI and Chernobyl accident, Korea made a wise decision to expand the peaceful uses of the nuclear energy as well as to localize the essential nuclear design technology of fuel and nuclear steam supply system. This decision resulted in the success of export of nuclear power plants as well as research reactor in 2010s. The Korea's nuclear policy, which well utilized 'international crisis in nuclear business' as 'opportunity of Korea to get. nuclear technology', is believed nice policy as a role model of nuclear new-comer countries. Based upon the success story of localization of nuclear technology, Korea had an eye for a niche market, which was a basis of development of SMART, Korea-made integral PWR. The operation of a SMART plant can sufficiently provide not only electricity but also fresh water for 100,000 residents. Last two years, Korea's nuclear industry team led by the Korea Atomic Energy Research Institute completed the standard design of SMART and applied to the Korea's regulatory body for standard design approval. Now the Korea's licensing authority is reviewing the design with the relevant documents, and the design team is doing its best to realize its hope to get the approval by the end of this year. From next year, the SMART business including construction and export will be explored by the KEPCO consortium.

• Proceedings of the Korean Nuclear Society Conference
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• 1999.10a
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• pp.387.1-387
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• 1999

• Proceedings of the Korean Nuclear Society Conference
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• 1999.10a
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• pp.387.2-387
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• 1999

• Asia-Pacific Journal of Business
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• v.9 no.2
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• pp.105-121
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• 2018

In 1995, the WTO started to ease the trade barriers. Globalization has accelerated. The opening of the agricultural products market is rapidly gaining momentum with the conclusion of an FTA. The acceleration of this FTA is expected to be a threat to Korea's agriculture, and a new strategy is needed. At the beginning of the nuclear accident, mainly radioactive materials are found in the surface layer of the soil. Over time, the concentration of the plant gradually increases. After 5 years, it becomes noticeable. In March 2016, it will be five years after the nuclear accident. Radioactive contamination is very likely to occur in agricultural products produced in the Fukushima area at this time. In this period, agricultural products produced in the Fukushima region are expected to generate supply disruptions in Japan, and imports to replace them will increase. Therefore, it is necessary to establish a mid- and long-term strategy for exporting to Japan by analyzing the competitiveness of Korean agricultural products. In this study, standardization index was derived by using agricultural price ratio, TSI, export CAC. Based on this, we analyzed the competitiveness of each item in the Japanese market. The analysis shows that garlic is the most competitive product in the Japanese market. Also, strawberry, tomato, and cucumber were found to be competitive. On the other hand, Kiwi, pineapple, soybean, onion, potato, etc. As a result of the analysis, the following strategies were proposed for the export of agricultural products with high competitiveness. First, it is necessary to develop technology to suppress deterioration of export transportation quality. Second, continuous supply of local consumption pattern information is required. Third, it is necessary to expand exports by processing fresh food. Fourth, it suggested the establishment of export base and strengthening of support system.

• Molecules and Cells
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• v.22 no.2
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• pp.133-140
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• 2006

Jun activation domain-binding protein 1 (Jab1) is involved in various cellular mechanisms including development in Drosophila and mouse, cell cycle control and signal transduction pathways. Recent studies also determined that Jab1 functions as a nuclear exporter and inducer of cytoplasmic degradation for several proteins including p53, p27, capsid of West Nile virus, and Smad4/7 proteins. In particular, p53 is shown to bind to and to be exported into the cytoplasm by Jab1, which helps to maintain low levels of p53 under normal conditions. This review was undertaken in an effort to understand the biological significance of the homeostasis of p53 as maintained in the presence of Jab1. Based on our observations, we have provided potential mechanistic hypotheses for the nuclear export of p53 in coordination with Jab1 and the role of other factors in these processes.

• Nuclear industry
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• v.37 no.7
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• pp.66-71
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• 2017

• Journal of Technology Innovation
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• v.20 no.3
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• pp.1-28
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• 2012

This study conducted a qualitative analysis on the Korea's nuclear energy sector in 2030 through scenario-based strategic foresight method. Specifically, the relationships between environmental influencing factors of the future nuclear energy sector was examined from a multi-dimensional perspective on the basis of STEEP analysis and network analysis. In addition, scenario planning method was used with key uncertainty factors (KUF) to create three predictable strategic scenarios including optimistic, business as usual, and pessimistic. Common strategies that need to be urgently pursued as well as the maximum risk avoidance strategies for each scenario were also presented. This study further identified energy pricing, global economic trend, competitiveness in nuclear technology, and marketing capability as key uncertainty factors in the future nuclear energy industry sector. In order to furnish effective export strategy in the future nuclear energy sector, it was also suggested that government policy should adopt following measures as top priorities: securing nuclear safety technology, educating nuclear engineers, securing nuclear resources such as uranium, increasing nuclear capability and so on. The implications and limitations of this study were then discussed based on research findings.

• Korean Journal of Microbiology
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• v.54 no.2
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• pp.91-97
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• 2018

The evolutionally conserved TREX complex member, Yra1/ALY, belongs to the REF (RNA and export factor binding proteins) family of hnRNP-like proteins, which has been implicated in multiple processes including transcription, nuclear RNA stability, and mRNA export. Fission yeast, Schizosaccharomyces pombe, genome encodes two members of REF proteins. In addition to Mlo3 known previously as an mRNA export factor, there is the other REF protein, Tho4, which is predicted as a component of THO complex. Here we showed that deletion of tho4 (SPBC106.12c) gene does not inhibit both growth and nuclear mRNA export. However, overexpression of tho4 displays growth retardation and slight accumulation of $poly(A)^+$ RNA in the nucleus. Neither ${\Delta}tho4$ ${\Delta}mlo3$ nor ${\Delta}tho4$ ${\Delta}mex67$ double mutants exhibit additive growth defect. Moreover, yeast two-hybrid and co-immunoprecipitation analysis did not show that the Tho4 protein interacted with any members of TREX complex and mRNA export factor Rae1. Contrary to expectation, these observations support that the S. pombe Tho4 is not a component of TREX complex, and not directly involved in bulk mRNA export from the nucleus.