• Title/Summary/Keyword: Nuclear Medicine

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Quantitation of In-Vivo Physiological Function using Nuclear Medicine Imaging and Tracer Kinetic Analysis Methods (핵의학 영상과 추적자 동력학 분석법을 이용한 생체기능 정량화)

  • Kim, Su-Jin;Kim, Kyeong-Min;Lee, Jae-Sung
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.2
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    • pp.145-152
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    • 2008
  • Nuclear medicine imaging has an unique advantage of absolute quantitation of radioactivity concentration in body. Tracer kinetic analysis has been known as an useful investigation methods in quantitative study of in-vivo physiological function. The use of nuclear medicine imaging and kinetic analysis together can provide more useful and powerful intuition in understanding biochemical and molecular phenomena in body. There have been many development and improvement in kinetic analysis methodologies, but the conventional basic concept of kinetic analysis is still essential and required for further advanced study using new radiopharmaceuticals and hybrid molecular imaging techniques. In this paper, the basic theory of kinetic analysis and imaging techniques for suppressing noise were summarized.

Diagnosis of Coronary Artery Disease Using Myocardial Perfusion SPECT (심근 SPECT를 이용한 관상동맥질환의 진단)

  • Won, Kyoung-Sook;Kim, Hae-Won
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.3
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    • pp.196-202
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    • 2009
  • Myocardial perfusion scintigraphy is currently by far the most commonly performed cardiac nuclear study, constituting approximately one third of all nuclear medicine procedure. It plays an important role in the diagnosis, prognosis, risk assessment and management of heart disease. Aim of this review is to describe recent evolution of myocardial perfusion imaging on the focus of diagnosis of coronary artery disease. In addition, current status of other imaging modalities will be reviewed.

Regional Myocardial Blood Flow Estimation Model Using Rubidium-82 Dynamic Myocardial PET and Modified Double Integration Method (Rubidium-82 심근 Dynamic PET 영상과 변형이중적분법을 이용한 국소 심근 혈류 예측 모델)

  • Park, Yong-Woo;Lee, Jae-Sung;Lee, Tae-Hoon;Kwak, Cheol-Eun;Lee, Dong-Soo;Kang, Keon-Wook;Park, Jae-Hyung;Jeong, Jae-Min;Chung, June-Key;Lee, Myung-Chul;Seo, Joung-Don;Min, Byoung-Goo;Koh, Chang-Soon
    • Proceedings of the KOSOMBE Conference
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    • v.1995 no.11
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    • pp.157-158
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    • 1995
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High FDG Uptake in Sclerosing Hemangioma (경화성 혈관종에서의 높은 FDG 섭취)

  • Lee, Jong-Jin;Kang, Won-Jun;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.3
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    • pp.212-213
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    • 2005
  • A 42 years old woman underwent F-18 FDG PET because of the incidentally detected lung mass on chest X-ray. PET/CT showed hypermetabolic lesion in the lung right upper lobe and the lung cancer was suspected because of the high FDG uptake. However, pathologic diagnosis was sclerosing hemangioma. There are few reports on the evaluation of sclerosing hemangioma using FDG PET. A report showed a slightly increased uptake (standardized uptake ratio of 1.8) (1), and another report showed unsatisfactory result (2). We suggest that sclerosing hemangioma could be seen as hypermetabolic lesion on the FDG PET.

Conventional Ultrasonography and Real Time Ultrasound Elastography in the Differential Diagnosis of Degenerating Cystic Thyroid Nodules Mimicking Malignancy and Papillary Thyroid Carcinomas

  • Wu, Hong-Xun;Zhang, Bing-Jie;Wang, Jun;Zhu, Bei-Lin;Zang, Ya-Ping;Cao, Yue-Long
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.935-940
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    • 2013
  • Background: To evaluate the diagnostic utility of conventional ultrasonography and real time ultrasound elastography in differentiating degenerating cystic thyroid nodules mimicking malignancy from papillary thyroid carcinoma. Methods: We retrospectively analyzed conventional ultrasonographic and elastographic characteristics of 19 degenerating cystic thyroid nodules mimicking malignancy in 19 patients, with 30 surgically confirmed PTCs as controls. Based on size, the nodules had been grouped into less than 10mm (group A) and greater than 10 mm (group B). We evaluated conventional parameters and elasticity pattern. Color-scaled elastograms were graded as to stiffness of nodules using an elasticity pattern from I (soft) to IV (stiff). Results: Degenerating cystic thyroid nodules were similar to PTCs in conventional ultrasonographic findings, but the former frequently showed oval to round in shape (group A, 69.2% vs 18.8%, P=0.017; group B, 66.7% vs 7.14%, P=0.017) and punctuate hyperechoic foci (group A, 61.5% vs 0, P<0.001; group B, 50% vs 0, P<0.001). On real time ultrasound elastography, 7 of 13 degenerating cystic thyroid nodules in group A were pattern I, 5 were pattern II, 1 was pattern III. One degenerating cystic thyroid nodule in group B was pattern II, 5 were pattern III. The area under the curve for elastography was 0.98 in group A (sensitivity 92.3%, specificity 100%, P = 0.002), and 0.88 in group B (sensitivity 16.7%, specificity 100%, P = 0.014). Conclusions: As a dependable imaging technique, elastography helps increase the performance in differential diagnosis of degenerating cystic thyroid nodule and malignancy.