• Title/Summary/Keyword: Nuclear Medicine

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Recent Developments in Nuclear Medicine Instrumentation (최근 핵의학 영상 기기 발전 동향)

  • Kim, Joon-Young;Choi, Yong;Kim, Jong-Ho;Im, Ki-Chun;Choe, Yearn-Seong;Lee, Kyung-Han;Kim, Sang-Eun;Kim, Byung-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.6
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    • pp.471-481
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    • 1998

  • The goals of developments in nuclear medicine instrumentation are to offer a higher-quality image and to aid diagnosis, prognosis assessment or treatment planning and monitoring. It is necessary for physicists and engineers to improve or design new instrumentation and techniques, and to implement, validate, and apply these new approaches in the practice of nuclear medicine. The researches in physical properties of detectors and crystal materials and advances in image analysis technology have improved quantitative and diagnostic accuracy of nuclear medicine images. This review article presents recent developments in nuclear medicine instrumentation, including scatter and attenuation correction, new detector technology, tomographic image reconstruction methods, 511 keV imaging, dual modality imaging device, small gamma camera, PET developments, image display and analysis methods.

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Tumor Imaging by Monoclonal Antibodies Labeled with Radioactive Metal Ions

  • Endo, K.;Sakahara, H.;Nakashima, T.;Koizumi, M.;Kunimatsu, M.;Ohta, H.;Furukawa, T.;Ohmomo, Y.;Arano, Y.;Yokoyama, A.;Okada, K.;Yoshida, O.;Hosoi, S.
    • The Korean Journal of Nuclear Medicine
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    • v.18 no.2
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    • pp.77-85
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    • 1984

  • Monoclonal antibodies have become widely investigated in the Nuclear Oncology, especially in the radioimmunosassay of tumor markers and in vivo radioimmunoimaging of cancer. However, there are numerous factors as to whether radioimmunoimaging will ultimately successful. For imaging of tumors, metallic radionuclides such as In-111, Ga-67, Tc-99m have favorable nuclear properties than widely used I-131. These radioistopes have characteristics of the useful radiation for imaging, convenient short half-lives and the simple and rapid radiolabeling of monoclonal antibodies by using bifunctional chelaing agents. The obtained chelate-tagged antibodies are quite stable both in vitro and in vivo, without interfering antibody activities and animal experiments provided a good basis for its clinical applicability for the radioimmunoimaging of cancer. Much attention has also been given to the possibility, only beginning to be exploited, of the specific treatment of malignant neoplasms with these agents. Although specific antibody has not been developed that is uniquely specific for cancer alone and there are still many questions to be answered and problems to be overcome before radioimmunoimaging can be successfully used in ptients with cancer, these methods can be applied to the coupling of monoclonal antibodies with anti-neoplastic drugs or radionuclides suitable for internal radiation therapy of cancer.

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