• 대한핵의학회지
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• 제26권1호
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• pp.86-94
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• 1992

Quantitative analysis of gallbladder emptying is important in diagnosis of motility disorder of gallbladder and in studies of biliary physiology. However, the normal range of gallbladder ejection fraction (GBEF) has not been determined yet and the best method for stimulating the gallbladder to contract has not been elucidated adequately. The purpose of this study was to compare the gallbladder emptying effect of the fatty meal ingestion with that of the continuous infusion of cholecystokinin (CCK) and to establish the normal GBSF values of normal subjects. Quantitative hepatobiliary scan with $^{99m}Tc-DISIDA$ after a fatty meal was performed for 22 normal healthy volunteers. Among them, 10 subjects repeated the test with a fatty meal. Again, for 7 subjects quantitative heaptobiliary scan with an infusion of CCK (sincalide) at a rate of 20 ng/kg/hr for 45 minutes was performed repeatedly. The results were as follows. 1) With a fatty meal, the mean GBEF was $89.6{\pm}8.2%$ in 22 normal subjects, and there was no difference between subjects. 2) With a continuous infusion of CCK, the mean GBEF was $62.4{\pm}16.6%$ in 7 normal subjects, and there was a significant difference between subjects(p<0.05). 3) The reproducibility of GBEF by a fatty meal was significantly higher than by an infusion of CCK (p < 0.05). 4) The mean GBEF by a fatty meal was significantly higher than that by an infusion of CCK (p < 0.05). We concluded that a fatty meal is superior to a continuous infusion of CCK for inducing gall-bladder contraction because that induces more complete emptying and the response is more reproducible and constant.

• 한국안광학회지
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• 제15권3호
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• pp.287-291
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• 2010

목적: 정상안과 폭주부족안에서 폭주근점, AC/A비, 사위량, 조절력, 조절래그, 상대조절, 상대폭주 등의 양안시기능 검사값을 비교해 보고자한다. 방법: 사시나 약시 및 안질환이 없는 86명(남 45명, 여 41명 평균연령 $23.27{\pm}2.85$세)을 AC/A비와 원 근거리 사위량을 기준으로 정상안 43명과 폭주부족안 43명으로 분류하여 연구하였다. 두 그룹의 양안시기능은 포롭터를 이용 측정하였다. 결과: 정상안과 폭주부족안은 폭주근점 5.71 cm, 7.07 cm로, 거리차 AC/A비 5.28, 2.81, 원근거리 사위량 0.92 exo/3.36 exo, 2.17 exo/10.84 exo, 양성상대폭주 15.49/23.30/13.30, 13.50/20.02/9.09 등으로 차이가 있었으나, 조절력, 조절래그, 양성상대조절, 음성상대조절, 원거리 개산여력, 폭주여력, 음성상대폭주 등은 현저한 차이가 없었다. 결론: 두 그룹은 차폐검사, 폭주근점, 거리차 AC/A, 원 근거리 사위량, 양성상대폭주 파괴점과 회복점 등에서 유의한 차이가 있었다.

• The Korean Journal of Physiology
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• 제9권1호
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• pp.33-37
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• 1975

Adult rabbits were anesthetized with nembutal, 30 mg/kg. Carotid artery and jugular vein were exposed surgically and cannulated with polyethylene tubing. Arterial blood pressure was recorded via pressure transducer on the physiograph and $100{\mu}g/ml$ of histamine solution was infused through the jugular vein by using the constant infusion pump with a rate of 0.92 ml/min or 1.40 ml/min. Mean arterial blood pressure was maintained at $40{\sim}70 mmHg$ and hypotension was kept for 2 hours. After the termination of this period, blood was taken and osmotic fragility was mea sured immediately. Also, every sample of normal blood and shocked blood was incubated for 1 hour or 2 hours at $37^{\circ}C$ in order to see whether or not there was some influence of incubation. Furthermore to clarify which component was responsible for the change on the fragility, the mixtures of normal blood cells with shocked plasma and shocked blood cells with normal plasma were also incubated at $37^{\circ}C$ for one or two hours and fragility in such cases was measured. The data obtained were analysed by probit-plot method and the concentration of saline solution at which the hemolysis started to occur, 50% of blood cells were hemolysed and that at which the red blood cells hemolysed completely were determined. The values for the blood of hypotension stage were compared with those of the control blood. The results obtained were as fellows: 1. Osmotic fragility of red blood cell was increased in hypotensive state induced by histamine. 2. The differences of osmotic fragility after two hours of incubation were negligible both in normal blood and in that of hypotensive state. 3. Osmotic resistance of normal red blood cell incubated in shock plasma was less than that of shock red blood cell incubated in normal plasma. It was suggested that plasma in hypotensive state caused by histamine might be primarily responsible for the alteration of red blood cell fragility.

• 한국식품영양과학회지
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• 제25권6호
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• pp.1045-1049
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• 1996

고혈압은 한국인에 있어서 발병율이 높은 성인병이며 또한 식이 중 Na 섭취와 관련이 있는 질병으로 알려져 있는바, 본 연구는 건강한 구성원만을 가진 정상인군과 고혈압 환자가 있는 가족의 구성원을 대상으로(환자 자신은 제외 ) 이들이 섭취하는 음식물, 소변 중의 Na 및 K과 혈압을 측정함으로서 이들 항목이 고혈압과 어떤 상관관계가 있는지를 알아보고자 하였다. 고혈압 환자의 수축기 $혈압(126\pm18.0mmHg)과$ 이완기 $혈압(77.6\pm14.6mmHg)은$ 정상인 가족의 수축기 $혈압(119.3\pm17.2mmHg)과$ 이완기 $혈압(71.6\pm12.5mmHg)$ 보다 유의적으로 높은 수치를 보였다. 수축기 혈압과 조사 항목간의 상관관계는 다음과 같다. 정상인군에서는 나이, 체중, 된장내 Na, 된장내 Na는 양의 상관관계를 보였고, 고추장내 K, 된장내 K, 고기반찬류내 K 등과 부의 상관관계를 나타냈다. 고혈압 환자 가족군에서는 나이, 체중, 소금 섭취량, 된장내 Na 등과 양의 상관관계를, 소변내 K배설량과 부의 상관관계를 보였다.

• 대한핵의학회지
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• 제19권1호
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• pp.127-136
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• 1985

To evaluate change of serum $beta_2-microglobulin$ concentration$(s\beta_2-MG)$ and the usefulness of $s\beta_2-MG$ and $s\beta_2-MG/serum$ creatinine concentration(sCr) ratio in various renal diseases, $s\beta_2-MG$ and sCr were measured in 25 normal controls and 90 patients of various renal diseases(16 cases of glomerulonephritis, 12 cases of acute renal failure, 8 cases of chronic renal failure, 24 cases of nephrotic syndrome, 15 cases of tubulointerstitial diseases and 15 cases of lupus nephritis) using $Phadebas^\circledR$ $Beta_2-Micro$ Test kits. The results were as follows; 1) In normal control, the mean value of $s\beta_2-MG$ was $1.65{\pm}0.41mg/l$ and the mean value of $s\beta_2-MG/sCr$ ratio was $0.14{\pm}0.05$. 2) In various renal diseases, the mean value of $s\beta_2-MG$ was $6.74{\pm}5.47mg/l$. The mean value of $s\beta_2-MG/sCr$ ratio was $0.24{\pm}0.11$ and significantly elevated than that of normal control. (p<0.05) 3) The correlation between $s\beta_2-MG$ and sCr in glomerular and tubulointerstitial disease was log $s\beta_2-MG-0.90$ log sCr-0.48 and its correlation coefficient was 0.78(p<0.05). 4) In glomerular disease, the correlation between $s\beta_2-MG$ and sCr was log $s\beta_2-MG-0.89$ log sCr-0.46(r - 0.76) and in tubulointerstitial disease, it was log, $s\beta2-MG-0.95$ log sCr-0.59 (r-0.87). There was no significant difference between the two groups(p<0.05). 5) Among 32 cases of glomerular and tubulointerstitial disease patients, whose sCr was within normal range, 17 cases showed elevated $s\beta_2-MG$. The mean values of $s\beta_2-MG/sCr$ ratio in these patients was $0.30{\pm}0.14$ and significantly elevated than that of normal control(p<0.05). 6) In 15 cases of lupus nephritis, 12 cases showed elevated $s\beta_2-MG$ with normal sCr and 12 cases showed elevated $s\beta_2-MG/sCr$ ratio. With above results, it was found that the $s\beta_2MG$ can be used as an index of glomerular filtration rate as in the case of sCr and that $s\beta_2-MG/sCr$ ratio can be used as a tool in early detection of slightly decreased glomerular filtration rate and in detection of the renal disease of increased $\beta_2-MG$ production.

• 대한족부족관절학회지
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• 제14권1호
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• pp.41-46
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• 2010

Purpose: Anterior drawer and varus stress test are commonly used for radiologic evaluation of chronic lateral ankle instability. However, there are controversies regarding the method of measurement and the normal value. This study was performed to investigate radiologic normal values in normal Korean adults and to analyze differences by age and gender. Materials and Methods: Sixty Korean adults were recruited and divided in three groups (20 in their twenties, 20 in their thirties, 20 in their forties). There were 10 males and 10 females in each group. The selection criteria were no history of ankle injury and no evidence of instability on physical examination. Radiologic measurement of varus talar tilt and anterior talar translation were performed through anterior and varus stress radiographs using Telos device (150N force). The measurement was repeated twice by three researchers, and intraobserver reproducibility and interobserver reliability were analyzed. The average talar tilt and anterior talar translation were obtained. Results: Talar tilt and anterior talar translation on ankle stress radiographs had good intraobserver reproducibility and interobserver reliability. Talar tilt was average $3.7^{\circ}$ and $5.1^{\circ}$ in male and female of twenties of age, $3.9^{\circ}$ and $4.8^{\circ}$ in their thirties, $3.4^{\circ}$ and $4.5^{\circ}$ in their forties. Anterior talar translation was average 3.5 mm and 4.2 mm in their twenties, 4.1 mm and 3.8 mm in their thirties, 3.6 mm and 4.1 mm in their forties. There was no significant difference in talar tilt and anterior talar translation by age. However, there was significant difference in talar tilt by gender. Conclusion: Normal range of talar tilt angle in Korean adults was below $8.3^{\circ}$, and normal range of anterior talar translation was below 7.6 mm. It seems to be able to serve as a good reference for radiologic evaluation and for treatment of chronic lateral ankle instability.

• 대한예방한의학회지
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• 제7권2호
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• pp.13-22
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• 2003

Objectives: CRATAEGII FRUCTUS(山査) is known as the substance which decreases concentration of sarum lipid. The purpose of this study is to investigate the effects of CRATAEGII FRUCTUS(山査) on decreasing concentration of sarum lipid which are triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol in rat high cholesterol diet inducede hyperlipide rats. Methods: Sprague-Dawley rats were divided into 3 groups, Normal group(supplied enough water and feeds only. Normal Group), high fat diet administered group(AIN-76 high fat diet #100496 used beef tallow for 4 weeks, Control Group) and CRATAEGII FRUCTUS(山査) administered group(AIN-76 high fat diet #100496 used beef tallow and CRATAEGII FRUCTUS(山査) extracts 85.0mg/200g 1time/day for 4 weeks. SS Group). Rats were sacrificed and concentration of triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol were measured in rat's sarum lipid Results: There was no significant difference in the level of waight between each experimental group(F=0.243, p=0.787, ANOVA test), Concentration of triglyceride has no significant difference in each group(F=0.210, p=0.813, ANOVA test). There was significant increase of total cholesterol in the Control group compared to those of Normal but there was no significant difference in the SS group compared to the Control group(F=5.237, p=0.0l9, ANOVA test). There was a significant increase of HDL-cholesterol in the SS group compared to the Control group and decrease in Control group compared Normal group(F= 11.437, p=0.001, ANDYA test). Concentration of LDL -cholesterol was significantly different in each group(F= 16.377, p=0.0001, ANDYA test). It was significantly increased in the Control group compared with the Normal group and it has no difference in the SS group compared to the control group. TBARS values(Thiobarbituric Acid Reactive Substances) were significantly different in each group(F=5.242, p=0.0019, ANDYA test). It was significantly increased in the Control group compared with the Normal group and significantly decreased in SS group compared with the Control group. Conclusions: According to the above results, it is considered that CRATAEGII FRUCTUS(山査) is effective in decreaseing concentration of sarum lipid in high cholesterol diet induced hyperlipidemic rats.

• 한국식품과학회지
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• 제35권2호
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• pp.206-210
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• 2003

DFD육의 가공적성과 NaCl 농도에 따른 batter의 이화학적 변화를 연구하기 위하여 NaCl 농도$(0{\sim}3%)$를 다르게 하여 DFD육 batter와 정상육 batter를 제조한 후 pH, 가열감량, 직경감소율, 단백질용해성, 유화안정성, 점도 및 경도를 조사하였다. DFD육 batter와 정상육 batter는 NaCl 농도가 0%에서 3%로 증가함에 따라 가열전 pH가 DFD육은 0.23, 정상육은 0.2 unit 감소하였으며, 가열후 batter의 pH는 정상육과 DFD육 모두 가열전에 비해 다소 증가하였다. DFD육 batter의 가열감량과 직경감소율은 정상육 batter보다 낮았으며 NaCl 농도가 증가함에 따라 감소하였다. 단백질 용해성은 DFD육과 정상육 모두 NaCl 농도가 증가함에 따라 증가하였으며 DFD육의 단백질용해성이 정상육보다 높은 것으로 나타났다. 유화안정성에 있어서 DFD육 batter는 NaCl 농도가 증가함에 따라 지방분리가 급격히 감소하였으며, 정상육 batter에 비교하여 유화안정성이 다소 우수한 것으로 평가되었다. DFD육 batter의 점도는 정상육 batter보다 높게 나타났으며 NaCl 농도가 증가함에 따라 증가하였다. 또한 DFD육 batter의 경도는 NaCl 농도가 증가함에 따라 증가하였으며, 정상육 batter보다 높았다. 본 실험의 결과를 종합해 볼 때 육제품 원료육으로서 DFD육의 이용가치는 매우 우수한 것으로 사료된다.

• 대한원격탐사학회지
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• 제35권6_2호
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• pp.1133-1148
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• 2019

산림지역은 계절에 따라 생장 및 활력 특성이 변화하기 때문에 산림피해를 정확하게 탐지하기 위해서는 과거 동일한 계절적 시기의 영상정보 확보가 필요하다. 그러나 고해상도 또는 중해상도 영상은 영상촬영주가 높지 않아 동일 시기의 영상 정보들을 확보하는 것은 쉽지 않다. 따라서 본 연구에서는 산림생태계의 피해를 평가하기 위해 시계열 영상정보를 통해 피해발생 이전 과거 동일 시점의 분광정보를 추정하여 산림피해 평가의 기준정보로 활용하는 방법을 연구했다. 연구대상지는 2017년 우박과 가뭄으로 인해 대규모 산림피해가 발생한 전라남도 화순지역이며, 과거 3년간 해당 지역에서 촬영된 모든 Landsat 8 영상의 시계열 식생지수(NDVI, EVI, NDMI) 자료를 구축하고 이를 일별 연속자료로 자료보간을 실시하였다. 그리고 이를 통해 교란 발생 이전의 정상적인 일별 식생지수 추정 지도를 제작하였으며, 동일 날짜의 일별 평년 식생지수와 교란발생 이후의 식생지수의 차이값을 구하고 피해등급 기준을 적용하여 최종적인 위성자료 기반의 피해등급지도가 산출되었다. 위성기반 피해등급지도는 기존의 항공사진 기반 피해등급지도에 비해 미세한 식생활력도 변화를 효과적으로 탐지하였으며, 피해극심지역을 대상으로 비교하였을 때 SWIR 밴드를 이용한 식생지수(NDMI)가 기존의 피해등급평가 결과와 유사한 결과를 산출하여 활용도가 높은 것으로 평가되었다. 결과적으로, 일별 평년식생활력도 지도의 제작을 통해 신속하고 정확한 피해지 탐지가 가능해졌다.

• 응용통계연구
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• 제9권2호
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• pp.119-134
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• 1996

가속수명검사는 시간과 경비를 현실적인 여건에 맞추기 위하여 정상조건보다 열악한(강도가 높은) 조건에서 검사를 수행하여 그 결과를 정상조건에서의 수명분포와 관련된 관심사(기대수명, 신뢰도) 등을 추정하는 것을 목적으로 하는 검사 방법이다. 이 연구에서는 고장률이 다른 두 개의 부품이 직렬형으로 구성된 시스템의 가속수명검사 자료를 분석할 때 사용되는 하나의 모형을 제안하고 분석 과정 및 기존의 두 개의 부품이 서로 독립이라고 가정한 모형과 비교하는 것을 주요 내용으로 하였다. 시스템이 작동될 때 받는 관찰이 가능하지 않은 총체적인 환경의 효과를 동일 시스템내의 두 개의 부품이 공유하게 됨으로써 발생되는 두 부품의 수명의 의존성을 frailty 모형을 이용하여 모형화하였고, 분석 과정에서는 Profile 우도함수를 사용하여 최대 우도 추정 과정에서의 초기치 문제를 해결하는 방법을 제시하고 모의실험을 통하여 독립성의 가정을 검토하여 보았다.