• Genomics & Informatics
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• v.15 no.4
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• pp.156-161
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• 2017

Transcriptome analysis has been widely used to make biomarker panels to diagnose cancers. In breast cancer, the age of the patient has been known to be associated with clinical features. As clinical transcriptome data have accumulated significantly, we classified all human genes based on age-specific differential expression between normal and breast cancer cells using public data. We retrieved the values for gene expression levels in breast cancer and matched normal cells from The Cancer Genome Atlas. We divided genes into two classes by paired t test without considering age in the first classification. We carried out a secondary classification of genes for each class into eight groups, based on the patterns of the p-values, which were calculated for each of the three age groups we defined. Through this two-step classification, gene expression was eventually grouped into 16 classes. We showed that this classification method could be applied to establish a more accurate prediction model to diagnose breast cancer by comparing the performance of prediction models with different combinations of genes. We expect that our scheme of classification could be used for other types of cancer data.

• Journal of Veterinary Clinics
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• v.8 no.1
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• pp.11-26
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• 1991

The effects of intra-articula. sodium hyaluronate(SH) and polysulfated glycosaminoglycan(PSGAG) on degenerative joint disease of the carpus were compared each other In 20 racehorses. Ten horses were dosed with intra-articula. injection of 20mg SH(2 times/2 weeks interval) and ten horses were dosed with intra-articular injection of 250mg of PSGAG(4 times/1 week into.val). Synovial fluid analysis and clinical examination were made to evaluate the effects of the drugs on degenerative joint disease at before injection and 2 weeks after the last injection, respectively. Appearance and mucinous precipitate quality oi synovial fluids of the group injected with 58 and PSGAG were improved by 40～50% and 60～80%, respectively. The chemical values of alkaline phosphatase, lactic dehydrogenase, aspartate aminotransferase, total protein, A/G ratio and glucose of synovial fluid in the group injected with PSGAG were more clearly returned to the normal values than those of the group injected with SH. Relative viscosity and total white blood cells of synovial fluid were returned to the normal walues after the treatments in both groups. Clinical symptoms(swelling, heat and pain on carpal joint, and lameness) of the horses in the group injected with SH and PSGAG were disappeard by 56～67% and 67～80%, respectivelty. Conclusively, the PSGAG was superior to SH in the effects on treatment of the degenerative joint disease in the horses.

• Journal of Oral Medicine and Pain
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• v.14 no.1
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• pp.19-24
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• 1989

The purpose of this study was to investigate the reliability of electromyographic examination in a day and detect the objective measurement timing of electromyography. 18 normal students who were in dental collage of C national university were selected for this study. They had no symptoms on temporomandibular joint area, no restorations and missing tooth on dentition. Their molar relationship was normal or class I of Angle's classification. Electromyography had been taken every one hour from 9:00 A.M. to 5:00 P.M. in the state of clenching and rest by using Bioelectric processor EM2 interfaced with mandibular kinesiograph K-6 diagnostic system. We compared and analyzed the variances of electromyography values of each subjects. The obtained results were as follows : There were no significant differences on variability of electromyography values in each state clenching and rest. In the aspect of this circumstances, the use of electromyography could be a good objective procedure to diagnose the temporomandibular disorders and to detect the effect to the treatment of temporomandibular disorders at any time in a day from 9:00 A.M. to 5:00 P.M.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.10
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• pp.1353-1357
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• 2018

This paper compares and analyzes Fusarium wilt of radish by using an unmanned aerial vehicle(UAV) with the NDVI-7 camera. The UAV have taken near-infrared images of the Radish field in Gangwon area, which is affected by Fusarium wilt. Based on those images, we analyzed NDVI(Normalized difference vegetation index) and compared conditions of radish by using the Blue value among Regular Vegetation Index in NDVI. First, the radish field is divided into three fields for radish, soil and vinyl. Each field has separate Blue values that are radish 0.4890, soil 0.2959, vinyl -0.0605 respectively. Second, radish condition levels are divided into four stages which are normal, early, middle, and late stage of Fusarium wilt. The average values of each stage are normal 0.5165(100%), early 0.4565(88%), middle 0.3444(66%), and late 0.1772(34%) respectively. This result shows that this NDVI value is validated by measuring conditions of Radish and soil.

• Journal of Bio-Environment Control
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• v.23 no.3
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• pp.174-180
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• 2014

Standard weather data available to greenhouse environmental design are limited in most regions of the country. So, instead of using standard weather data, in order to find the method to build design weather data for greenhouse heating and cooling, design outdoor weather conditions were analyzed and compared by TAC method and frequency analysis using climatological normal and thirty years from 1981 to 2010 hourly weather data provided by KMA and standard weather data provided by KSES. Average TAC values of outdoor temperature, relative humidity and insolation using thirty years hourly weather data showed a good agreement with them using standard weather data. Therefore, in regions which are not available standard weather data, we suggest that design outdoor weather conditions should be analyzed using thirty years hourly weather data. Average of TAC values derived from every year hourly weather data during the whole period can be established as environmental design standards, and also minimum and maximum of them can be used as reference data.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.131-135
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• 2017

Background: Neuromuscular ultrasound can be used to assess the diaphragm. Before it can be used clinically, the reference ranges of diaphragm thickness and contractility must be determined. Methods: We measured the thickness of the diaphragm and the diaphragmatic thickening fraction (DTF) in 80 healthy volunteers with ultrasound and collected their demographic information to determine if age, sex, and body mass index (BMI) influence these measures. Results: The thickness of the diaphragm at resting end expiration was $0.193{\pm}0.044cm$ on the right side and $0.187{\pm}0.039cm$ on the left. The DTF was $104.8{\pm}50.6%$ on the right side and $114.9{\pm}49.2%$ on the left. Sex, weight, height, and BMI significantly affected the thickness of the diaphragm, but had little effect on the DTF. Conclusions: Normal reference values for the diaphragm should be helpful when evaluating the diaphragm. The DTF appears more useful than resting diaphragm thickness because it is affected less by individual variation.

• KCID journal
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• v.21 no.1
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• pp.78-88
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• 2014

This study is to analyze the 2012 spring drought of Korea using drought index and satellite image. The severe spring drought recorded in May of 2012 showed 36.4% of normal rainfall(99.5mm). The areas of west part of Gyeonggi-do and Chungcheong-do were particularly serious. The drought indices both the SPI(Standardized Precipitation Index) and WADI(WAter supply Drought Index) represented the drought areas from the end of May and to the severe drought at the end of June. The drought by SPI completely ended at the middle of July, but the drought by WADI continued severe drought in the agricultural reservoir watersheds of whole country even to the end of the July. On the other hand, the results by spatial NDVI(Normalized Difference Vegetation Index) and EVI(Enhanced Vegetation Index) data from Terra MODIS, both indices showed relatively low values around the areas of Sinuiju, Pyongyang, and west coast of North Korea and Gyeonggi-do and Chungcheong-do of South Korea indicating drought condition. Especially, the values of NDVI and EVI at Chungcheong-do were critically low in June compared to the normal year value.

• Journal of Ocean Engineering and Technology
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• v.34 no.1
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• pp.26-36
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• 2020

An extreme value analysis of metocean data which include wave, wind, and current data is a prerequisite for the operation and survival of offshore structures. The purpose of this study was to provide information about the return wave, wind, and current values for the Barents Sea using extreme value analysis. Hindcast datasets of the Global Reanalysis of Ocean Waves 2012 (GROW2012) for a waves, winds and currents were obtained from the Oceanweather Inc. The Gumbel distribution, 2 and 3 parameters Weibull distributions and log-normal distribution were used for the extreme value analysis. The least square method was used to estimate the parameters for the extreme value distribution. The return values, including the significant wave height, spectral peak wave period, wind speed and current speed at surface, were calculated and it will be utilized to design offshore structures to be operated in the Barents Sea.

• Speech Sciences
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• v.14 no.4
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• pp.179-200
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• 2007

In voice pathology, various measurements calculated from pitch values are proposed to show voice quality. However, those measurements frequently seem to be inaccurate and unreliable because they are based on some wrong pitch values determined from pathological voice data. In order to solve the problem, we compared several pitch estimation methods to propose a better one in pathological voices. From the database of 99 pathological voice and 30 normal voice data, errors derived from pitch estimation were analyzed and compared between pathological and normal voice data or among the vowels produced by patients with benign vocal fold lesions. Results showed that gross pitch errors were observed in the cases of pathological voice data. From the types of pathological voices classified by the degree of aperiodicity in the speech signals, we found that pitch errors were closely related to the number of aperiodic segments. Also, the autocorrelation approach was found to be the most robust pitch estimation in the pathological voice data. It is desirable to conduct further research on the more severely pathological voice data in order to reduce pitch estimation errors.

• The Korean Journal of Nuclear Medicine
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• v.3 no.2
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• pp.33-38
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• 1969

The serum thyroxine levels were measured by method of Tetrasorb Kit in 69 subjects including 13 subjects in euthyroid state, 31 with hyperthyroidism, 5 with hypothyroidism, 13 with nontoxic diffuse goiter, and 7 with nontoxic nodular goiter. Three parameters of the thyroid function test including thyroxine ($T_4$) levels, $^{131}I$ uptake (24 hrs) values and $PB^{131}I$ conversion ratio were correlated with clinical manifestations and courses of the disease. 1. The serum $T_4$ levels in the normal subjects were in range of $6.0{\mu}g/dl\;to\;14.4{\mu}g/dl$. (The mean $9.4{\mu}g/dl$). 2. The diagnostic compatibility of the serum $T_4$ was 93.5% in hyperthyroidism, 100% both in hypothyroidism and in nontoxic diffuse goiter, 86% in nontoxic nodular goiter, or 95.8% in the entire series. (Table 1). 3. The diagnostic compatibility of $^{131}I$ uptake (24 hrs) values and $PB^{131}I$ conversion ratio were less than the serum $T_4$ levels as summarized in Tables 2 & 3. The serum $T_4$ determination by Tetrasorb Kit is a simple, accurate and very useful test of the thyroid function.