• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.276.2-276.2
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• 2003

Simultaneous enantioseparation of nine racemic non-steroidal antiinflammatory drugs (NSAIDs) for their accurate chiral discrimination was achieved by cyclodextrin (CO) modified capillary electrophoresis in the normal polarity (NP) mode and in the reversed polarity (RP) mode. The NP mode employed neutral tri-O-methyl-${\beta}$-cyclodextrin (TM${\beta}$CD) as a selector dissolved in MES buffer (PH 6.0). (omitted)

• Journal of Audiology & Otology
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• 제25권4호
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• pp.199-208
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• 2021

Background and Objectives: No known studies have investigated the influence of stimulus polarity on the Auditory Brainstem Response (ABR) elicited from level-specific (LS) chirp. This study is important as it provides a better understanding of the stimulus polarity selection for ABR elicited from LS chirp stimulus. We explored the influence of stimulus polarity on the ABR from LS chirp compared to the ABR from click at 80 dBnHL in normal-hearing adults. Subjects and Methods: Nineteen adults with normal hearing participated. The ABRs were acquired using click and LS chirp stimuli using three stimulus polarities (rarefaction, condensation, and alternating) at 80 dBnHL. The ABRs were tested only on the right ear at a stimulus rate of 33.33 Hz. The ABR test was stopped when the recording reached the residual noise level of 0.04 μV. The ABRs amplitudes, absolute latencies, inter-peak latencies (IPLs), and the recorded number of averages were statistically compared among ABRs at different stimulus polarities and stimuli combinations. Results: Rarefaction polarity had the largest ABR amplitudes and SNRs compared with other stimulus polarities in both stimuli. There were marginal differences in the absolute latencies and IPLs among stimulus polarities. No significant difference in the number of averages required to reach the stopping criteria was found. Conclusions: Stimulus polarities have a significant influence on the ABR to LS chirp. Rarefaction polarity is recommended for clinical use because of its larger ABR peak I, III, and V amplitudes than those of the other stimulus polarities.

• 대한청각학회지
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• 제25권4호
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• pp.199-208
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• 2021

Background and Objectives: No known studies have investigated the influence of stimulus polarity on the Auditory Brainstem Response (ABR) elicited from level-specific (LS) chirp. This study is important as it provides a better understanding of the stimulus polarity selection for ABR elicited from LS chirp stimulus. We explored the influence of stimulus polarity on the ABR from LS chirp compared to the ABR from click at 80 dBnHL in normal-hearing adults. Subjects and Methods: Nineteen adults with normal hearing participated. The ABRs were acquired using click and LS chirp stimuli using three stimulus polarities (rarefaction, condensation, and alternating) at 80 dBnHL. The ABRs were tested only on the right ear at a stimulus rate of 33.33 Hz. The ABR test was stopped when the recording reached the residual noise level of 0.04 μV. The ABRs amplitudes, absolute latencies, inter-peak latencies (IPLs), and the recorded number of averages were statistically compared among ABRs at different stimulus polarities and stimuli combinations. Results: Rarefaction polarity had the largest ABR amplitudes and SNRs compared with other stimulus polarities in both stimuli. There were marginal differences in the absolute latencies and IPLs among stimulus polarities. No significant difference in the number of averages required to reach the stopping criteria was found. Conclusions: Stimulus polarities have a significant influence on the ABR to LS chirp. Rarefaction polarity is recommended for clinical use because of its larger ABR peak I, III, and V amplitudes than those of the other stimulus polarities.

• 대한화학회지
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• 제38권3호
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• pp.221-223
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• 1994

정상 액체크로마토그래피에서의 선형 용매화에너지 비교법 연구를 시도하였다. 용매를 고정시키고 여러 용질의 lnk'과 용질의 극성도 지수간의 상관관계를 조사한 회귀분석의 결과를 보면, 상관계수는 정상 액체크로마토그래피의 용질 머무름 메카니즘상의 복잡성으로 인하여 역상 액체크로마토그래피의 경우보다 낮은 결과를 보였고, 회귀계수의 용매조성 부피비(${\phi}$)에 따른 경향을 조사하여 정지상의 모든 극성도가 이동상의 그것보다 크며 그 극성도 차이는 극성이 더 큰 용매의 ${\phi}$가 증가함에 따라 감소하는 경향을 관찰하였다. 주어진 컬럼과 한 용질에 대해서 여러 다른 조성의 용매를 고려하여 수행한 lnk'과 용매 극성도 지수간의 다중 회귀분석은 용매 극성도 지수간의 직선상관성으로 인하여 의미있는 결과를 얻을 수 없었고, 대신 lnk'대 ${\pi}^*$간의 회귀분석은 용질 머무름 예측의 응용성이 있는 직선상관을 주었으며 이것은 lnk'대 ${\phi}$간의 직선상관성보다 우수하였다.

• Molecules and Cells
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• 제22권2호
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• pp.146-153
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• 2006

Cell polarity is critical for the division, differentiation, migration, and signaling of eukaryotic cells. RAX2 of budding yeast encodes a membrane protein localized at the cell cortex that helps maintain the polarity of the bipolar pattern. Here, we designate SPAC6f6.06c as $rax2^+$ of Schizosaccharomyces pombe, based on its sequence homology with RAX2, and examine its function in cell polarity. S. pombe $rax2^+$ is not essential, but ${\Delta}rax2$ cells are slightly smaller and grow slower than wild type cells. During vegetative growth or arrest at G1 by mutation of cdc10, deletion of $rax2^+$ increases the number of cells failing old end growth just after division. In addition, this failure of old end growth is dramatically increased in ${\Delta}tea1{\Delta}rax2$, pointing to genetic interaction of $rax2^+$ with $tea1^+$. ${\Delta}rax2$ cells contain normal actin and microtubule cytoskeletons, but lack actin cables, and the polarity factor for3p is not properly localized at the growing tip. In ${\Delta}rax2$ cells, and endogenous rax2p is localized at the cell cortex of growing cell tips in an actin- and microtubule-dependent manner. However, ${\Delta}rax2$ cells show no defects in cell polarity during shmoo formation and conjugation. Taken together, these observations suggest that rax2p controls the cell polarity of fission yeast during vegetative growth by regulating for3p localization.

• Journal of Advanced Marine Engineering and Technology
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• 제38권9호
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• pp.1146-1149
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• 2014

단자 표식이 불분명한 3상유도전동기에서 고정자 권선의 극성을 판별하는 데는 외부 여자전류에 의해 유도되는 기전력 특성에 기초하거나 또는 회전자의 잔류자기를 이용하는 방법이 가능하다. 회전자의 잔류자기로 유도되는 권선에서의 기전력은 자속 크기와 수동 구동의 회전자 속도 및 위상 관계에 따라 정해지며 이 같은 극성 판별이 작업현장에서 가능하려면 기전력의 크기가 멀티테스터로 확인될 수 있는 정도이어야 하고 또한, 코일 간 위상 특성이 극성 판별에 적합해야 한다. 잔류자기에 의한 기전력들이 3상 평형 관계에 있다면 전체 합성 전압은 권선들의 극성 연결 상태가 정상일 때 0이 되어야 하는 한편, 극성 연결의 오류 시에는 상대적으로 큰 출력 전압을 나타낸다는 점에서 본 연구에서는 각 경우에 대한 특성을 분석하였다. 또한, 잔류자기에 의한 판별 방식을 실험용 전동기에 적용하여 극성의 정상 및 이상 상태에서의 출력 파형을 비교함으로써 제시된 방식이 극성 판별 방법으로서 현장에서 용이하게 활용될 수 있는지를 확인한다.

• 자원환경지질
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• 제40권2호
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• pp.153-170
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• 2007

중력자료 및 자력자료를 이용하여 독도해산들의 지각평형 탄성판모델 및 VGP(Virtual Geomagnetic Pole)를 분석하여 해산들의 형성시기와 형성환경을 연구하였다. 후리에어중력이상은 독도와 이사부해산 최고치 사이에 약 50 mGal의 차이를 보이는데 이 두 화산체는 규모면에서 비슷하지만 후리에어중력이상에서 차이가 나는 것은 보상정도의 차이에 기인한다. 탄성판모델의 적용 결과는 해산 하부 지각의 강도(탄성두께)가 이사부해산에서 독도로 갈수록 강해짐(두꺼워짐)을 지시한다. 즉, 이사부해산이 생성될 당시의 해산 하부 지각의 연령이 가장 젊었고 독도가 생성될 때 하부 지각이 가장 오래 되었다는 것을 나타낸다. 자기이상은 독도해산들을 중심으로 복잡하게 나타난다. 고지자기 특성을 연구하기 위하여 자기 이상을 1500m 상향연속한 후 최소자승자화법 및 반놈자화법을 함께 이용하여 각 독도해산들의 VGP를 구하였다. 기존 독도암석의 연대측정, 탄성판 모델 및 VGP결과를 지자기 연대표와 비교하여 보면 울릉분지의 열개 종료 후에 이사부해산이 정자기극 시대에 가장 먼저 생성되었고 독도은 가장 후기에 생성되었으며 정자기극 시대에 첫 번째 대규모 분출이 있었고 그 후 역자기극 시대에 두 번째 대규모의 분출로 인하여 이루어졌을 것으로 생각된다. 심흥택 해산은 독도와 이사부해산의 생성시기 사이의 정자기극 시대에 형성되었을 것으로 사료된다. 이 해산들의 생성 시기는 동해 생성 후 압축응력이 작용하던 시기와 일치하며 이 압축력 시기의 화산활동에 의해 해산들이 생성되었을 가능성이 높은 것으로 판단된다.

• 조명전기설비학회논문지
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• 제20권9호
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• pp.70-77
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• 2006

We have fabricated an integrated three-phase flux-lock type SFCL, which consists of an YBCO($YB_a2Cu_3O_7$) thin film and a flux-lock reactor wound around an iron core of each phase. In order to apply the SFCL in a real power system, fault analyses for the three-phase system are essential. The short-circuit currents were effectively limited by adjusting the numbers of winding of each secondary coil and their winding directions. The flux flow generated in the iron core cancelled out under the normal operation due to the parallel connection between primary and secondary windings. However, the flux-lock type SFCL with same iron core was operated just after the fault due to the flux generating in the iron core. To analyze the current limiting characteristics, the additive polarity winding was compared with the subtractive one in the flux lock reactor. Whenever a single line-to-ground fault occurred in any phase, the peak value of the line current of the fault phase in the additive polarity winding increased up to about 12.87 times during the first-half cycle. On the other hand, the peak value in the subtractive polarity winding increased up to about 34.07 times under the same conditions. This is because the current flow between the primary and the secondary windings changed to additive or subtractive status according to the winding direction. We confirmed that the current limiting behavior in the additive polarity winding was more effective for a single-line-to-ground fault

• Molecules and Cells
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• 제20권2호
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• pp.256-262
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• 2005

The neuronal cytoskeleton is essential for establishment of neuronal polarity, but mechanisms controlling generation of polarity in the cytoskeleton are poorly understood. The nonreceptor tyrosine kinase, Fer, has been shown to bind to microtubules and to interact with several actin-regulatory proteins. Furthermore, Fer binds p120 catenin and has been shown to regulate cadherin function by modulating cadherin-${\beta}$-catenin interaction. Here we show involvement of Fer in neuronal polarization and neurite development. Fer is concentrated in growth cones together with cadherin, ${\beta}$-catenin, and cortactin in stage 2 hippocampal neurons. Inhibition of Fer-p120 catenin interaction with a cell-permeable inhibitory peptide (FerP) increases neurite branching. In addition, the peptide significantly delays conversion of one of several dendrites into an axon in early stage hippocampal neurons. FerP-treated growth cones also exhibit modified localization of the microtubule and actin cytoskeleton. Together, this indicates that the Fer-p120 interaction is required for normal neuronal polarization and neurite development.

• Applied Microscopy
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• 제22권2호
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• pp.46-65
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• 1992

In this study, we have made morphological and cytochemical observations to investigate the type of Golgi apparatus around the bile canaliculus. The animal (Wister, $220{\sim}250gm$) were divided into 4 groups; normal, hydrochol, colchicine and hydrochol-colchicine. The Golgi apparatus is classified into 16 different types from 4 different groups. In the normal group, we could observe 12 different types of the sixteen. Type I which showed convexed cisterns facing the bile canaliculi was most abundant of the types. In the hydrochol group, 14 types were observed. Type VII and type I showed convexed cisterns facing the bile canaliculus and were abundant. In the colchicine group, 11 different types were viewed and type XIV which showed intensely dilated cisterns without the polarity was predominant. In the hydrochol-colchicine group, we observed 3 different types. Type XIV clearly showed the highest percentage, although that type was less numerous in this group than in the colchicine group. In the hydrochol group, the Golgi apparatus showed a tendency to increase in numbers, while in the hydrochol-colchicine group the Golgi apparatus showed a tendency to decrease in numbers. The reactive products of thiamine pyrophosphatase and acid phosphatase were apparent over the distal Golgi cistern in the normal and hydrochol groups, but were decreased or not observed in the colchicine and hydrochol-colchicine groups. From the results, it is assumed that with the presence of the microtubule, Golgi cisterns are dilated with polarity after stimulation of secretion. Without the microtubule, the cistern becomes more intensely dilated and none polaric. Also the enzymes within the cisternal membrane become decreaed or absent and the Golgi apparatus decreases in numbers after activation of secretion.