• 대한한의학회지
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• 제25권3호
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• pp.160-168
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• 2004

Background and Objectives: Tinnitus is on the increase due to the increase in the elderly population, industrial pollution and noise pollution. This symptom is especially marked in patients with a hearing problem and the relationship between cause, mechanism and treatment is poorly understood. The characteristics of tinnitus and other hearing problems are well brought out using an animal model with salicylate ototoxicity. Therapeutic effects of Uncariae Ramulis and Testudinis Plastrum were expected in tinnitus and hearing problems; therefore we experimented on an animal model with salicylate ototoxicity. Salicylate is one of the most commonly prescribed drugs, although it has been recognized that salicylate induces hearing loss and tinnitus reversibly. The purpose of this study was to find the therapeutic effects of this by the morphologic study using salicylate ototoxicity. Materials and Methods : Twelve healthy Sprague-Dawley rats were divided into three groups: normal, control and sample. The sample group was treated with the extract of Uncariae Ramulis and Testudinis Plastrum (1cc/100g, once a day for 6 days). Then, to induce the salicylate ototoxicity in the control and sample groups, rats were injected intraperitoneally with sodium salicylate (500mg/kg). We observed the morphologic changes in the cochlea of the rats every 2, 3, 4 and 5 hours after injection. Results : The outer hair cells showed marked changes. Vacuolization formed in the cuticular plate and the endoplasm of the control group. The endoplasm and the cuticular plates of the sample group after 2 hours were similar to the control group, but the cuticular plates of the sample group observed after 3, 4 and 5 hours were not similar. Conclusions : The results suggest that an extract of Uncariae Ramulis and Testudinis Plastrum has therapeutic effects on an animal model with salicylate ototoxicity.

• 대한한방내과학회지
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• 제28권3호
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• pp.624-631
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• 2007

Hypothyroidism is a common disease of the endocrinal system, characterized by fatigue, cold intolerance, bradycardia, and so on. Subclinical hypothyroidism is a common biochemical abnormality which can be found in routine screening tests of thyroid function. It is defined as an asymptomatic state which characterized by normal free thyroxine(FT4) and elevated thyroid stimulating hormone(TSH) levels. The purpose of this study was to evaluate the effect of treatment with palmijihwang-tang and to observe the changes in triiodothyronine(T3), free thyroxine(FT4), thyroid stimulating hormone(TSH) level and VAS of cold intolerance, hoarseness, dry skin. After the treatment, triiodothyronine(T3) increased from 57.12ng/dl to 120.53ng/dl. Free thyroxine(FT4) increased from 12.59pg/ml to 14.21pg/ml. Thyroid stimulating hormone(TSH) decreased from 10.61mU/L to 1.57mU/L. Cold intolerance, hoarseness and dry skin changed for the better. These results support a role for oriental medical therapy in treating subclinical hypothyroidism. Further case studies of herbal treatment of this ailment are needed.

• 감성과학
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• 제5권2호
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• pp.1-9
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• 2002

향-냄새에 대한 감수성은 종족, 성에 따라 상이하며 냄새에 대한 인지력과 식별력은 가령화에 따라 쇠퇴한다고 한다. 가령화에 따른 향의 평가에 관한 선행보고들은 그 대상이 유아에서 노인에 이르기까지 다양함에도 불구하고 제시 향에 단순 알코올이나 단순 초산염이 주로 사용되었으며, 냄새 인지력이나 식별력 둥 지성적인 측면에서의 평가가 대부분이었다. 본 연구에서는 후각기능이 정상인 19～68세 50명을 대상으로 6종의 천연향에 대해 안정/폐안 상태에서 ECG, 피부저항, 그리고 주관평가를 실시하여 서로 다른 연령층에 따른 변화를 살펴보고자 하였다. 그 결과, 20대, 40대의 청\ulcorner중년층은 lemon을, 60대는 Lavender를 긍정적으로 반응\ulcorner평가하였다. 특히 40대 그룹은 평균 RR 간격, 심박수, 피부저항, 주관평가의 결과에서 가장 높은 상관성을 보여 후각기능이 가장 성숙한 연령대임이 확인되었다. 제시 향에 대해 연령별로 상이하게 반응/평가한 본 연구결과는 연령별로 차별화된 향장품 개발뿐만 아니라 인공냄새 그리고 맛의 개발에도 응용이 가능할 것으로 여겨진다.

• 한국전문물리치료학회지
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• 제13권4호
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• pp.79-86
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• 2006

The purpose of the current experiment was to describe interlimb coordination when swing limb conditions are being manipulated by constraining step length or by adding a 5 or 10 pound weight to the swing limb distally. Subjects were asked to begin walking with the right limb to land on the primary target (normal step length) that is 10 cm in diameter. However, if, during movement, the light was illuminated, then the subject had to step on one of the secondary targets (long and short step length). These three step length conditions were repeated while wearing a 5 pound ankle weight and then when wearing a 10 pound ankle weight. Ground reaction force (GRF) data indicated that there were changes in the forces and slopes of the swing and stance Fx GRFs. Long stepping subjects had to increase the propulsive force required to increase step length. Consequently, swing and stance toe-off greatly increased in the long step length condition. Short step length subjects had to adequately adjust step length, which decreased the speed of gait initiation. Loading the swing limb decreased the force and slope of the swing limb. Swing and stance toe-off was longest for the long step length condition, but there was a small difference of temporal events between no weight and weight condition. It appears that subjects modulated GRFs and temporal events differently to achieve the peak acceleration force of the swing and stance limb in response to different tasks. The findings from the current study provide preliminary data, which can be used to further investigate how we modulate forces during voluntary movement from a quiet stance. This information may be important if we are to use this or a similar task to evaluate gait patterns of the elderly and patient populations.

• 전기학회논문지
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• 제59권11호
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• pp.2114-2118
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• 2010

The purpose of this study was to analyze bradykinesia of toe tapping movement in patients with Parkinson's disease (PD) as compared to those of normal subjects. 39 PD patients (age: $65.5{\pm}11.2$ yrs, H&Y stage:$2.3{\pm}0.5$), 14 eldelry subjects with comparable mean age ($65.0{\pm}3.9$ yrs) and 17 healthy young subjects ($24.1{\pm}2.1$ yrs) participated in this study. Angular velocity during repetitive toe tapping movement was measured in both feet using a gyro sensor system. Suggested quantitative measures of bradykinesia were root-mean-squared (RMS) angular velocity, RMS angle, peak power and total power which were derived from the angular velocity signal. ANOVA showed that all measures were significantly different among three groups (p<0.001). Subsequent post-hoc test revealed that all measures in PD patients were significantly smaller than in healthy elderly and healthy young subjects (p<0.02). All measures were significantly correlated with UPDRS scores(r=-0.689~-0.825). These results suggest that the developed system can be used as quantitative measures of the lower limb bradykinesia in PD patients.

• 한국정보통신학회논문지
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• 제10권11호
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• pp.2107-2112
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• 2006

노년층의 인구비율이 늘어나면서 IT 기술을 활용한 상시 건강관리 시스템에 관한 관심과 연구가 크게 증가하고 있다. 본 연구에서는 소형 저 전력 센서 노드와 핸드폰을 이용한 유비쿼터스 헬스케어 시스템을 설계하고 구현하였다. 본 연구에서 제안하는 시스템은 소형 저전력 센서노드간의 네트워크가 가능하며 핸드폰과의 인터페이스로 장소에 구애받지 않고 자신의 현재 건강상태를 확인해 볼 수 있다. WIPI기반으로 만들어진 휴대폰 어플리케이션을 통해 간단한 건강상태 확인이 가능하고 또한 웹과의 연동을 통해 의료서비스 서버에서 자신의 생체신호에 대한 좀 더 자세하고 정확하게 분석 된 결과를 받아볼 수 있도록 하며 검사된 생체신호 데이터는 DB에 저장이 가능하도록 하여 전문의료진을 통해 확인이 가능하도록 하였다. 본 논문에서는 IEEE 802.11b/g 방식과 IEEE 802.15.4 방식을 선택사용 할 수 있는 센서 노드 및 베이스 스테이션을 제안하였으며 또한 휴대폰을 통한 데이터통신 및 모니터링을 위한 WIPI기반의 휴대폰 어플리케이션을 구현하였다. 또한 웹서버에서의 생체신호 분석 및 모니터링 프로그램, 데이터베이스관리 프로그램이 구동되어 핸드폰과 연동되어 동작하는 전체 서비스모델을 구현하였다.

• Journal of Chest Surgery
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• 제39권3호
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• pp.230-235
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• 2006

폐에 체동맥이 분포하는 선천성 기형은 드문 질환으로 하폐엽의 기저분절에 폐동맥 대신 대동맥에서 1개 이상의 체동맥이 나오는데 정상적인 기관지와 연결 유무에 따라 폐 분획증과 좌측 폐동맥 이상 기시증(Anomalous Origin of Left Pulmonary Artery, AOLPA)으로 구분된다. 한일병원 흉부외과에서는 하행 흉부 대동맥에서 시작되는 비정상적인 체동맥을 가진 두 예의 폐동맥 기형을 경험하고, 1예는 기저분절절제술을, 다른 예는 동맥색전술을 시행하였고, 2년간 관찰한 결과 양호하였다. 이 결과를 바탕으로 외과적 수술이 이 기형의 근본적인 치료법이지만, 전신상태가 불량하거나 폐기능이 저하된 고위험군에서 동맥색전술도 선택적으로 시행할 수 있는 가능한 치료법으로 생각된다.

• Journal of Preventive Medicine and Public Health
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• 제40권2호
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• pp.162-168
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• 2007

Objectives : This prospective population-based cohort study was conducted to evaluate the risk factors of cognitive impairment and the degree of cognitive function change through a 5-year follow-up. Methods : The baseline and follow-up surveys were conducted in 1998 and 2003, respectively, Among 176 subjects who had normal cognitive function in the baseline study, 136 were followed up for 5 years. The cognitive function was investigated using the Korean version of the Mini-Mental State Examination (MMSE-K). The collected data were analyzed using SPSS and Stata. Results : Of the 136 subjects analyzed, 25 (18.4%) were cognitively impaired. Old age and low social support in the baseline survey were risk factors for cognitive impairment after 5 years. In the generalized estimating equation for 128 subjects except severe cognitive impairment about the contributing factors of cognitive function change, the interval of 5 years decreased MMSE-K score by 1.02 and the cognitive function was adversely affected with increasing age, decreasing education and decreasing social support. Conclusions : Although the study population was small, it was considered that the study results can be used to develop a community-based prevention system for cognitive impairment.

• 한국정밀공학회지
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• 제28권12호
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• pp.1425-1433
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• 2011

We investigated an early rehabilitation training system that increase the intensity of patient rehabilitation training to shorten the time it takes for patients to progress to a secondary rehabilitation training stage by allowing patients incapable of self-ambulation. It consisted of tilting bed, unstable platform using strong springs and training program for lower limb rehabilitation. We performed experimental study on the muscular activities of tibialis anterior(TA), soleus(SO), gastrocnemius(GA) in the lower extremities during training of straight line, circle, quardrangle pattern during tilting angle of $30^{\circ}$, $60^{\circ}$. The muscle activities were higher during tilting angle of $30^{\circ}$ than $60^{\circ}$. In straight line pattern, the muscle activities were higher by SO, GA and TA during medio-lateral direction, however, by TA, SO and GA during anterio-posterior direction. In circle and quardrangle pattern, the muscle activities were higher by TA, SO and GA during clockwise and counterclockwise direction. The results indicate that the early rehabilitation training system could be applied to improve the lower extremity muscular strength for elderly and patients, especially, stroke.

• 한국식품영양과학회지
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• 제44권1호
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• pp.49-56
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• 2015

본 연구는 지역사회에서 거주하고 있는 재가노인을 대상으로 삼킴장애 위험군을 선별하여 위험 실태를 파악하고 관련인자를 조사하고자 하였다. 서울, 경기 및 충북 지역에 거주하는 65세 이상 재가노인 419명을 대상으로 2012년 9월에서 12월까지 일대일 면접방법으로 설문자료를 수집하였다. 주요 연구 결과는 다음과 같다. 첫째, 전체 응답자 가운데 과반수(53.50%)가 삼킴장애 위험군으로 판정되었고 삼킴장애 위험점수는 평균 13.17점으로 국내외 선행연구보다 높은 수준이었다. 둘째, 노인의 삼킴장애 위험도는 65~74세군보다 75세 이상군에서 높았고, 의치를 하는 경우와 일상생활에서 독립성이 떨어지는 경우에 유의하게 높았다. 셋째, 삼킴장애 위험군과 비위험군에서 노인의 식품섭취 문제와 그에 따른 향후 섭취 문제 위험 여부를 조사한 결과 삼킴장애 위험군은 비위험군보다 식욕부진, 식사량 감소, 잦은 결식, 입맛이 나쁘다고 응답한 경우가 많았으며 이에 따라 향후 섭취 문제 위험도가 유의하게 높은 것으로 나타났다. 결론적으로 국내 재가노인의 삼킴장애 실태는 간과하기 어려운 수준이며 향후 지역사회의 다양한 환경에 있는 노인들을 대상으로 연구가 확대되어야 할 것이다.