• Proceedings of the Korean Geotechical Society Conference
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• 2004.03b
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• pp.391-398
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• 2004

The propagation mechanism of a detonation pressure with fully coupled charge is clarified and the blasting pressure propagated in rock mass is derived from the application of shock wave theory. Probabilistic distribution is obtained by using explosion tests on emulsion and rock property tests on granite in Seoul and then the probabilistic distribution of the blasting pressure is derived from their properties. The probabilistic distributions of explosive properties and rock properties show a normal distribution so that the blasting pressure propagated in rock can be also regarded as a normal distribution. Parametric analysis was performed to pinpoint the most influential parameter that affects the blasting pressure and it was found that the detonation velocity is the most sensitive parameter. Moreover, uncertainty analysis was performed to figure out the effect of each parameter uncertainty on the uncertainty of blasting pressure. Its result showed that uncertainty of natural rock properties constitutes the main portion of blasting pressure uncertainty rather than that of explosive properties.

• Applied Microscopy
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• v.21 no.2
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• pp.1-13
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• 1991

In order to investigate the factors of the control mechanism of somitogenesis, early chick embryos (H-H stage $8{\sim}13$) were treated with heat shock, ${\alpha}$-amanitin and cycloheximide and morphological changes of somite were examined by light microscopy, transmission and scanning electron microscopy. In normal chick embryo, somites were formed from the somitomere which preexisted in segmental plate. Somites were wrapped with extracellular collagen fibrils and connected with neural tube, notochord and ectoderm. And then, somites were differentiated to sclerotome, dermatome and myotome by the interaction of nervous tissue. Abnormal somites were observed after formation of six or seven so mites in heat shock treated group. Amounts of collagen fibrils were obviously decreased in this group. In cycloheximide treated group, most so mites were smaller and neural tube formation was incomplete. Chromatins were condenced and formed several heterochromatins in the nucleus of somite cells. Lipid like cytoplasmic dense mass and lipid droplets were also observed. Segmentation of somites seemed to be normal progress in ${\alpha}$-amanitin treated group. Center of somite, however, hollowed in longitudinal sectioned samples. These results suggested that so mites were already existed in the segmental plate as the form of somitomere. Segmented somites were contacted with neural tube or notochord and the somites were tightly connected with each other by the extracellular collagen fibrils which were secreted from neuroepithelium and somite cells. Somites are thought to differentiate into sclerotome, dermatome and myotome by these interactions.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.4
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• pp.63-72
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• 2013

A Mach 5 nozzle and a diffuser of the Scramjet Engine Test Facility (SETF) were made for a hydrocarbon-fueled scramjet engine. SETF, attached with a diffuser guide, started with a model of 60% blockage, though the model engine could not start by over expansion of the facility nozzle. The model was moved into the nozzle to escape the shock generated from the nozzle exit, both SETF and the engine could start. The pitot rake experiments (blockage of 2.3%) were done for measuring the core flow in the test section. From the pitot experiments, the core flow was expanded by an under expansion. It means that the core flow in the test section was related with a model blockage. SETF and the engine with a blockage of 33% work normally. From a series of experiments, SETF started with a normal shock efficiency of 58%, regardless of a blockage ratio.

• Journal of Astronomy and Space Sciences
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• v.28 no.1
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• pp.17-26
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• 2011

Bow shock, formed by the interaction between the solar wind and a planet, is generated in different patterns depending on the conditions of the planet. In the case of the earth, its own strong magnetic field plays a critical role in determining the position of the bow shock. However, in the case of Mars of which has very a small intrinsic magnetic field, the bow shock is formed by the direct interaction between the solar wind and the Martian ionosphere. It is known that the position of the Martian bow shock is affected by the mass loading-effect by which the supersonic solar wind velocity becomes subsonic as the heavy ions originating from the planet are loaded on the solar wind. We simulated the Martian magnetosphere depending on the changes of the density and velocity of the solar wind by using the three-dimensional magnetohydrodynamic model built by modifying the comet code that includes the mass loading effect. The Martian exosphere model of was employed as the Martian atmosphere model, and only the photoionization by the solar radiation was considered in the ionization process of the neutral atmosphere. In the simulation result under the normal solar wind conditions, the Martian bow shock position in the subsolar point direction was consistent with the result of the previous studies. The three-dimensional simulation results produced by varying the solar wind density and velocity were all included in the range of the Martian bow shock position observed by Mariner 4, Mars 2, 3, 5, and Phobos 2. Additionally, the simulation result also showed that the change of the solar wind density had a greater effect on the Martian bow shock position than the change of the solar wind velocity. Our result may be useful in analyzing the future observation data by Martian probes.

• The Korean Journal of Physiology
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• v.9 no.1
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• pp.57-61
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• 1975

A study was designed to clarify the influence of the hippocampus upon tolerance by electric shock. Forty-eight male rats were used, of which 14 rats had their hippocampal tissue on both sides removed through an opening in the parieto-occipital cortex (hippocampal group), 17 rats received damage to the parieto-occipital cortex only (cortical control group), and 17 rats served as normal control animals. After 24 hours' fasting with water ad libitum, each animal was restrained on a plate with added electric shock (4 mA A.C., 1.5 sec in a duration, and once per minute in average) to the tail for the last 24 hours without food and water. The mortality in each animal group and the mean survival time of the dead animal during the repitition of electric shock were calculated. Results obtained were as follows: 1. The mortality was lower significantly in the hippocampal group than in the two control groups. 2. The mean survival time of the dead animal was longer insignificantly in the hippocampal group than in the two control groups. The inference from the above results is that the hippocampus exerts a inhibitory influence upon tolerance by electric shock.

• International Journal of Industrial Entomology and Biomaterials
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• v.9 no.2
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• pp.235-239
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• 2004

Drosophila melanogaster heat shock protein 70 gene promoter (Dhsp70p) is widely used in transgenic insect to drive exogenous gene, and the homologous region 3 from Bombyx mori nucleopolyhedrovirus (BmNPVhr3) functions as an enhancer for several promoters. To test whether BmNPVhr3 can enhance the Dhsp70ps transcriptional activity, the reporter plasmids, which contain the Dhsp70p, the reporter $\beta$-galactosidase gene with SV40 terminator and BmNPVhr3 fragment, are constructed and transfected into the insect cell lines (Bm-N cells and Sf-21 cells) by lipofectin-mediated method. The results from the transient expression assay show that BmNPVhr3 significantly increases transcriptional activity of Dhsp70p both under the normal condition and under the heat-shock treatment, although the effects are significantly different between in Bm-N cells and in sf-21 cells. The enhancing behavior of BmNPVhr3 on the Dhsp70p is in an orientation-independent manner. Meanwhile, the effects of heat-shock treatment on Dhsp70p alone or Dhsp70p/BmNPVhr3 combination present no significant difference, indicating that BmNPVhr3 only enhances the transcriptional activity of Dhsp70p, but cant alter its characteristic of the response to the heat-shock stress. The above results suggest that the Dhsp70p/BmNPVhr3 combination is more effective one to drive exogenous gene for transgene or stable cell expression system in insects.

• Korean Journal of Applied Biomechanics
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• v.31 no.2
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• pp.113-118
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• 2021

Objective: The purpose of this study was to investigate differences of landing strategy between people with or without chronic ankle instability (CAI) during double-leg drop landing. Method: 34 male adults participated in this study (CAI = 16, Normal = 18). Participants performed double-leg drop landing task on a 30 cm height and 20 cm horizontal distance away from the force plate. Lower Extremities Kinetic and Kinematic data were obtained using 8 motion capture cameras and 2 force plates and loading rate was calculated. Independent samples t-test were used to identify differences between groups. Results: Compared with normal group, CAI group exhibits significantly less hip internal rotation angle (CAI = 1.52±8.12, Normal = 10.63±8.44, p = 0.003), greater knee valgus angle (CAI = -6.78±5.03, Normal = -12.38 ±6.78, p = 0.011), greater ankle eversion moment (CAI = 0.0001±0.02, Normal = -0.03±0.05, p = 0.043), greater loading Rate (CAI = 32.65±15.52, Normal = 18.43±10.87, p = 0.003) on their affected limb during maximum vertical Ground Reaction Force moment. Conclusion: Our results demonstrated that CAI group exhibits compensatory movement to avoid ankle inversion during double-leg drop landing compared with normal group. Further study about how changed kinetic and kinematic affect shock absorption ability and injury risk in participants with CAI is needed.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1997.04a
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• pp.43-51
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• 1997

Steady and unsteady numerical simulations are conducted for the experiments performed to investigate the ram accelerator flow field by using the expansion tube facility in Stanford University. Navier-Stokes equations for chemically reacting flows are analyzed by fully implicit and time accurate numerical methods with Jachimowski's detailed chemistry model for hydrogen-air combustion involving 9 species and 19 reaction steps. Although the steady state assumption shows a good agreement with the experimental schlieren and OH PLIF images for the case of $2H_2$+$O_2$+$17N_2$, it fails in reproducing the combustion region behind the shock intersection point shown in the case of $2H_2$+$O_2$+$12N_2$, mixture. Therefore, an unsteady numerical simulation is conducted for this case and the result shows all the detailed flow stabilization process. The experimental result is revealed to be an instantaneous result during the flow stabilization process. The combustion behind the shock intersection point is the result of a normal detonation formed by the intersection of strong oblique shocks that exist at early stage of the stabilization process. At final stage, the combustion region behind the shock intersection point disappears and the steady state result is retained. The time required for stabilization of the reacting flow in the model ram accelerator is found to be very long in comparison with the experimental test time.

• Korean Journal of Biological Psychiatry
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• v.14 no.4
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• pp.221-231
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• 2007

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

• Journal of computational fluids engineering
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• v.6 no.3
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• pp.32-40
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• 2001

Viscous solutions of supersonic jet impinging on a flat plate normal to the flow are simulated using three-dimensional Navier-Stokes solver. The jet impinging flow structure exhibits such complex nature as shock shell, plate shock and Mach disk depending on the flow parameters. Among others, the dominant parameters are the ratio of the nozzle exit pressure to the ambient pressure and the distance between the nozzle exit plane and the impinging plane. In the present study, the nozzle contour and the pressure ratio are held fixed, while the jet impinging distance is varied to illuminate the characteristics of the jet plume with the distance. As the plate is placed close to the nozzle at 3D high, the computed wall pressure at or near the jet center oscillates with large amplitude with respect to the mean value. Here D is the nozzle exit diameter. The amplitude of wall pressure fluctuations subsides as the distance increases, but the maximum mean pressure level at the plate is achieved when the distance is about 4D high. The frequency of the wall pressure is estimated at 6.0 kHz, 9.3 kHz, and 10.0 kHz as the impinging distance varies from 3D, 4D, to 6D, respectively.