• Nutrition Research and Practice
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• 제12권3호
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• pp.222-232
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• 2018

BACKGROUND/OBJECTIVES: Since gain or loss of skeletal muscle mass is a gradual event and occurs due to a combination of lifestyle factors, assessment of dietary factors related to skeletal muscle is complicated. The aim of this study was to investigate the changes in total energy intake according to the level of skeletal muscle mass. SUBJECTS/METHODS: A total of 8,165 subjects ${\geq}30years$ of age from the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011 were included in the analysis, and multivariate-adjusted regression analyses were performed to analyze the association of the quartiles of sarcopenia index (SI) with energy intake of the study population after adjusting for age and metabolic parameters. RESULTS: The increase in SI quartile was in proportion to the gradual decrease in systemic lipids and the anthropometric measurement of fat accumulation (P < 0.001). Subjects in higher SI quartiles tended to consume more total energy and energy-producing nutrients than those in lower quartiles (P < 0.001). After age, body weight, alcohol consumption, and metabolic parameters were adjusted in the analysis, total energy intake gradually increased according to the increase in SI quartile, and the association between total energy intake and SI was more pronounced in men. However, the risk (odd ratio) of having a low SI was not affected by any single macronutrient intake. CONCLUSION: In this study, total energy intake was positively associated with SI and relative skeletal mass in both men and women. However, no significant association or a weak association was observed between any single macronutrient intake and skeletal muscle mass. The data indicated that acquiring more energy intake within the normal range of energy consumption may help to maintain skeletal muscle mass.

• 한국산학기술학회논문지
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• 제16권5호
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• pp.3633-3642
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• 2015

단기추진제는 Nitrocellulose를 주요 에너지원으로 사용하는 추진제이다. 추진제의 정확한 저장 수명 예측은 인적, 물적 자원의 비용 절감 효과를 기대할 수 있다. 본 연구에서는 안정제 함량 변화모사에 대해 n차 반응속도 모델을 적용하여 최적의 반응차수를 도출하고, 이에 따른 저장 수명을 예측하였다. 고온가속노화시험 결과로부터 최적의 반응차수는 1.15481로 도출되었으며, 이때의 추정표준오차(${\times}100$ 기준)는 16.284로 나타났다. 일반 저장온도 범위를 $21^{\circ}C$에서 $30^{\circ}C$로 가정하면, 본 시험에 사용된 단기추진제는 약 35년에서 최대 140년까지 저장 수명이 예측되었다. 정확한 저장 수명을 예측하기 위해서는 탄약 저장고내 온도 분포를 데이터화하여 적용하는 것이 타당할 것으로 판단된다.

• 한국구조물진단유지관리공학회 논문집
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• 제20권2호
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• pp.18-25
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• 2016

하천 또는 해안의 선박운항을 위한 도개교는 그 희소성으로 인해 최근에는 랜드마크로의 역할을 인정받으면서, 국외의 경우 세심한 유지관리로 수십 년 이상 공용기간을 지속하고 있는 사례가 적지 않다. 국내 유일의 도개교인 영도대교는 부식과 노화로 철거 후, 2013년에 재가설 되었으며, 현재 1일 1회 도개를 실시하고 있다. 최근 교량의 안전과 유지관리에 대한 요구가 높아지면서 주기적인 안전진단이 수행되지만 도개교에 대한 계측 및 분석 사례는 거의 없는 실정이다. 이에 본 연구에서는 도개교가 상승 및 하강하는 도개과정과 상시 사용상태에서의 계측자료를 토대로 구조해석을 실시하여 도개교의 응력, 진동, 반력 등 실제 거동을 분석하고자 하였으며, 이 결과는 추후 공용연수의 증가 및 도개횟수의 증가에 따른 교량거동의 변동 추세를 분석하기 위한 초기 자료로 활용될 수 있을 것으로 기대된다.

• Biomolecules & Therapeutics
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• 제20권4호
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• pp.357-370
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• 2012

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.140-148
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• 2017

Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggested as a novel strategy, because hyperlipidemia is closely associated with inflammation and immune dysfunction. In this study, the effects of an aqueous extract of Rubus occidentalis (RO) in obese mice were investigated using immunological indexes. The mice were fed a high-fat diet (HFD) to induce hyperlipidemia, which was confirmed by biochemical analysis and examination of the mouse physiology. Two different doses of RO and rosuvastatin, a cholesterol synthesis inhibitor used as a control, were orally administered. Disturbances in immune cellularity as well as lymphocyte proliferation and cytokine production were significantly normalized by oral administration of RO, which also decreased the elevated serum tumor necrosis factor $(TNF)-{\alpha}$ level and total cholesterol. The specific immune-related actions of RO comprised considerable improvement in cytotoxic T cell killing functions and regulation of antibody production to within the normal range. The immunological evidence confirms the significant cholesterol-lowering effect of RO, suggesting its potential as a novel therapeutic agent for hyperlipidemia and associated immune decline.

• Restorative Dentistry and Endodontics
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• 제23권1호
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• pp.223-235
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• 1998

The recognition of the esthetics as well as their function of the teeth in the dental field is growing. Evaluating the esthetics of a tooth concerns shape, texture, and color. And among these, color has been the most difficult element to make natural expression. Color is a very subjective element affected by many different factor like light source, object, observer. Numerous efforts to quantifying color has been made. Currently the use of colorimeter and spectrophotometercolor that the color measuring device has been suggested. In this study, the normal range of the tooth color in canines, lateral incisors and central incisors for Koreans was evaluated with a modified spectrophotometer for intraoral use. The color differences in terms of teeth positions, age and area within the tooth was evaluated and comparatively analyzed. Results were as follow ; 1. In all age groups, the central incisors are most bright and least yellowish opposit to the canines are most dark and yellowish. The central incisors and lateral incisors showed the similar color patterns. 2. In the comparison between gender, it showed that in the 10' s group male have more yellowish, the 20's female have lighter and more redness, the 30's indicated more redness in female and in the 40's the lightness is more in female. 3. With aging, there was no significant change in $L^*$ and $a^*$ coordinates but a shift was in $b^*$ to yellowish in the 30' sand 40's in central incisors. Lateral incisors and canines showed a lighter and more yellowish tooth color with an irregular change of color coordinate in $a^*$. 4. In all teeth the middle and cervical portion showed close correlation with over 0.7(0.05>p) but color ($a^*$, $b^*$) showed higher correlation than lightness($L^*$). 5. It has been shown that through the regression test the cervical color could be calculated by the middle color value.

• Journal of the Optical Society of Korea
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• 제17권4호
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• pp.344-349
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• 2013

This paper proposes a simulation algorithm to assess the gradual yellowing vision of the elderly, which refers to the predominance of yellowness in their vision due to aging of the ocular optic media. This algorithm employed the spectral transmittance property of a yellow filter to represent the color appearance perceived by elderly people with yellow vision, and modeled the changes in the color space through a spectrum change in light using the yellow filter effect. The spectral reflectivity data of 1269 Munsell matte color chips were used as reference data. Under the standard conditions of a D65 illuminant and a $10^{\circ}$ observer of 1964 CIE, the spectrum of the 1269 Munsell colors were processed through the yellow filter effect to simulate yellow vision. Various degrees of yellow vision were modeled according to the transmittance percentage of the yellow filter. The color differences before and after the yellow filter effect were calculated using the DE2000 formula, and the color pairs were selected based on the color difference function. These color pairs are distinguishable through normal vision, but the color difference diminishes as the degree of yellow vision increases. Assuming 80% of yellow vision effect, 17 color pairs out of $(1269{\times}1268)/2$ pairs were selected, and for the 90% of yellow vision effect, only 3 color pairs were selected. The result of this study can be utilized for the diagnosis system of gradual yellow vision, making various types of test charts with selected color pairs.

• 대한지역사회작업치료학회지
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• 제8권3호
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• pp.91-106
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• 2018

이 논문은 노인의 균형문제를 해결하기 위해 안뜰눈반사와 안뜰재활운동에 대해 고찰하고자 한다. 낙상은 노화와 관련된 주요한 문제이다. 낙상과 결과적으로 일어나는 일은 가장 흔하면서 심각한 문제이다. 균형의 결함은 낙상의 가장 높은 위험 요소 중 하나이다. 균형을 조절하고 협응하는데 사용되고 통합되는데 세 가지 신경계가 필요하다. 정상적인 이동과 머리운동을 하는 동안, 안뜰눈반사는 주시를 안정화시키고 망막의 상을 유지하도록 돕는다. 안뜰눈반사의 결함과 낙상간에 직접적인 관계가 있다. 노인들은 안뜰눈반사를 억제하고 강화시키는 능력이 감소된다. 안뜰재활운동은 중추신경계 보상을 목적으로 시작한 운동에 근거한 단체 치료법이다. 안뜰재활운동은 머리와 눈의 반복적인 운동을 사용해서 안뜰눈반사의 이득을 회복시키고 오류를 줄인다. 많은 연구들이 안뜰재활운동을 한 단체가 균형과 보행 검사에서 월등함을 보였다. 이 논문은 노인의 낙상을 방지하기 위한 운동법으로 안뜰재활운동을이 도움이 될 것으로 사료된다.

• 융합정보논문지
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• 제11권2호
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• pp.201-210
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• 2021

본 연구는 메밀 추출물과 비텍신을 이용하여 UVB 손상 개선에 대한 효과를 알아보기 위해 Microarray 분석, 세포의 증식, 세포 상처 회복, 세포주기, 마이크로파지의 생성 양상, 단백질 분석 등을 실시하였다. Microarray 분석 결과는 DRAM1, Atg2a 및 Atg13 유전자에서 UVB에 의해 증가 된 양상을 메밀 에탄올추출물과 비텍신에서 감소시켰다. 세포의 증식, 상처 회복, 주기 및 마이크로파지 양상에서는 메밀 에탄올추출물과 비텍신에서 정상 세포와 유사하게 개선되었으며, 단백질 분석에서 DRAM1, Beclin-1 및 LC3 I/II 모두 비텍신 처리군에서 감소하였고, p-mTOR 및 Survivin은 모두 증가 되었다. UVB에 의한 손상에서 메밀 에탄올추출물과 비텍신은 DRAM1, Atg2a 및 Atg13을 같이 컨트롤 하고 세포 증식, 상처 회복 및 주기를 정상으로 회복하며 UVB에 의한 세포 노화 발생원인 중 하나인 오토파지를 조절하여 세포의 사멸억제 및 재생하므로 기능성 화장품 성분으로 활용가능할 것으로 사료 된다.

• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.318-326
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• 2021

본 연구는 고령화 및 저출산에 따라 보건의료분야의 만성질환의 증가 및 전문 인력부족 등의 문제를 해결하고 효율적인 헬스케어를 제공하고자 VR 콘텐츠를 이용한 신체검사의 효과성을 연구하였다. 이에 본 연구는 HTC VIVE Pro VR과 스틱 컨트롤러를 착용하여 원스톱 VR 콘텐츠 신체검사 시스템을 구현하였다. 시스템은 1단계부터 5단계까지이며, 색각테스트, 기억력테스트, 청력테스트, 반응속도테스트, 순간인지능력테스트의 5단계를 순차적으로 거쳐 최종 신체 나이를 판별하는 솔루션으로 구성된다.또한 본 연구가 개발한 원스톱 VR 콘텐츠 신체검사 시스템에 대해 대전 소재 A 상급종합병원 건강검진센터 및 VR/AR 임상시험 센터에 내원한 정상인을 대상으로 사용자 만족도를 검증한 결과, 전체적인 만족도와 재이용의사가 높게 나타났고, 성별에 따라 5단계 순간인지테스트는 유의한 차이가 있었으며, 연령에 따라서 4단계 반응속도테스트, 5단계 순간인지테스트에서 유의한 차이가 나타났다.