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Thromboxane A2 Synthetase Inhibitor Plus Low Dose Aspirin : Can It Be a Salvage Treatment in Acute Stroke Beyond Thrombolytic Time Window

  • An, Gyu-Hwan;Sim, Sook-Young;Jwa, Cheol-Su;Kim, Gang-Hyeon;Lee, Jong-Yun;Kang, Jae-Kyu
    • Journal of Korean Neurosurgical Society
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    • v.50 no.1
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    • pp.1-5
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    • 2011
  • Objective : There is no proven regimen to reduce the severity of stroke in patients with acute cerebral infarction presenting beyond the thrombolytic time window. Ozagrel sodium, a selective thromboxane A2 synthetase inhibitor, has been known to suppress the development of infarction. The antiplatelet effect is improved when aspirin is used together with a thromboxane synthetase inhibitor. Methods : Patients with non-cardiogenic acute ischemic stroke who were not eligible for thrombolysis were randomly assigned to two groups; one group received ozagrel sodium plus 100 mg of aspirin (group 1, n=43) and the other 100 mg of aspirin alone (group 2, n=43). Demographic data, cardiovascular risk factors, initial stroke severity [National Institute of Health Stroke Scale (NIHSS) and motor strength scale] and stroke subtypes were analyzed in each group. Clinical outcomes were analyzed by NIHSS and motor strength scale at 14 days after the onset of stroke. Results : There were no significant differences in the mean age, gender proportion, the prevalence of cardiovascular risk factors, stroke subtypes, and baseline neurological severity between the two groups. However, the clinical outcome for group 1 was much better at 14 days after the onset of stroke compared to group 2 (NIHSS score, p=0.007, Motor strength scale score, p<0.001). There was one case of hemorrhagic transformation in group 1, but there was no statistically significant difference in bleeding tendency between two groups. Conclusion : In this preliminary study, thromboxane A2 synthetase inhibitor plus a low dose of aspirin seems to be safe and has a favorable outcome compared to aspirin alone in patients with acute ischemic stroke who presented beyond the thrombolytic time window.

The Impact of COVID-19 Pandemic on Stock Markets: An Empirical Analysis of World Major Stock Indices

  • KHAN, Karamat;ZHAO, Huawei;ZHANG, Han;YANG, Huilin;SHAH, Muhammad Haroon;JAHANGER, Atif
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.7
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    • pp.463-474
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    • 2020
  • This study aims to investigate the impact of COVID-19 pandemic on the stock markets of sixteen countries. Pooled OLS regression, conventional t-test and Mann-Whitney test are used to estimate the results of the study. We construct a weekly panel data of COVID-19 new cases and stock returns. Pooled OLS estimation result shows that the growth rate of weekly new cases of COVID-19 negatively predicts the return in stock market. Next, the returns on leading stock indices of these countries during the COVID-19 outbreak period are compared with returns during the non-COVID period. We use a t-test and Mann-Whitney test to compare the returns. The results reveal that investors in these countries do not react to the media news of COVID-19 at the early stage of the pandemic. However, once the human-to-human transmissibility had been confirmed, all of the stock market indices negatively reacted to the news in the short- and long-event window. Interestingly, we noticed that the Shanghai Composite Index, which was severely affected during the short-event window, bounced back during the long-event window. This indicates that the Chinese government's drastic measures to contain the spread of the pandemic regained the confidence of investors in the Shanghai Stock Market.

A Study on the Optimum Design of a Facade with Shading-type BIPV in Office Building (차양형 BIPV가 적용된 사무소 건물의 외피 최적 설계에 관한 연구)

  • Park, Se-Hyeon;Kang, Jun-Gu;Bang, Ah-Young;Kim, Jun-Tae
    • Journal of the Korean Solar Energy Society
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    • v.35 no.2
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    • pp.93-101
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    • 2015
  • Zero energy building is a self sufficient building that minimizes energy consumption through passive elements such as insulation, high performance window system and installing of high efficiency HVAC system and uses renewable energy sources. The Korea Government has been strengthening the building energy efficiency standard and code for zero energy building. The building energy performance is determined by the performance of building envelope. Therefore it is important to optimize facade design such as insulation, window properties and shading, that affect the heating and cooling loads. In particular, shading devices are necessary to reduce the cooling load in summer season. Meanwhile, BIPV shading system functions as a renewable energy technology applied in solar control facade system to reduce cooling load and produce electricity simultaneously. Therefore, when installing the BIPV shading system, the length of shadings and angle that affect the electricity production must be considered. This study focused on the facade design applied with BIPV shading system for maximizing energy saving of the selected standard building. The impact of changing insulation on roof and walls, window properties and length of BIPV shading device on energy performance of the building were investigated. In conclusion, energy consumption and electricity production were analyzed based on building energy simulations using energyplus 8.1 building simulation program and jEPlus+EA optimization tool.

A Stability of P-persistent MAC Scheme for Periodic Safety Messages with a Bayesian Game Model (베이지안 게임모델을 적용한 P-persistent MAC 기반 주기적 안정 메시지 전송 방법)

  • Kwon, YongHo;Rhee, Byung Ho
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.38B no.7
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    • pp.543-552
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    • 2013
  • For the safety messages in IEEE 802.11p/WAVE vehicles network environment, strict periodic beacon broadcasting requires status advertisement to assist the driver for safety. In crowded networks where beacon message are broadcasted at a high number of frequencies by many vehicles, which used for beacon sending, will be congested by the wireless medium due to the contention-window based IEEE 802.11p MAC. To resolve the congestion, we consider a MAC scheme based on slotted p-persistent CSMA as a simple non-cooperative Bayesian game which involves payoffs reflecting the attempt probability. Then, we derive Bayesian Nash Equilibrium (BNE) in a closed form. Using the BNE, we propose new congestion control algorithm to improve the performance of the beacon rate under saturation condition in IEEE 802.11p/WAVE vehicular networks. This algorithm explicitly computes packet delivery probability as a function of contention window (CW) size and number of vehicles. The proposed algorithm is validated against numerical simulation results to demonstrate its stability.

Effect of Nitrogen, Titanium, and Yttrium Doping on High-K Materials as Charge Storage Layer

  • Cui, Ziyang;Xin, Dongxu;Park, Jinsu;Kim, Jaemin;Agrawal, Khushabu;Cho, Eun-Chel;Yi, Junsin
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.33 no.6
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    • pp.445-449
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    • 2020
  • Non-volatile memory is approaching its fundamental limits with the Si3N4 storage layer, necessitating the use of alternative materials to achieve a higher programming/erasing speed, larger storage window, and better data retention at lower operating voltage. This limitation has restricted the development of the charge-trap memory, but can be addressed by using high-k dielectrics. The paper reviews the doping of nitrogen, titanium, and yttrium on high-k dielectrics as a storage layer by comparing MONOS devices with different storage layers. The results show that nitrogen doping increases the storage window of the Gd2O3 storage layer and improves its charge retention. Titanium doping can increase the charge capture rate of HfO2 storage layer. Yttrium doping increases the storage window of the BaTiO3 storage layer and improves its fatigue characteristics. Parameters such as the dielectric constant, leakage current, and speed of the memory device can be controlled by maintaining a suitable amount of external impurities in the device.

Several systems for 1Giga bit Modem

  • Park, Jin-Sung;Kang, Seong-Ho;Eom, Ki-Whan;Sosuke, Onodera;Yoichi, Sato
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.1749-1753
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    • 2003
  • We proposed several systems for 1Giga bit Modem. The first, Binary ASK(Amplitude Shift Keying) system has a high speed shutter transmitter and no IF(Intermediate Frequency) receiver only by symbol synchronization. The advantage of proposed system is that circuitry is very simple without IF process. The disadvantage of proposed system are that line spectrum occurs interference to other channels, and enhancement to 4-level system is impossible due to its large SNR degradation. The second, Binary phase modulation system has a high speed shutter transmitter and IF-VCO(IF-Voltage Controlled Oscillator) control by base-band phase rotation. Polarity of shutter window is changed by the binary data. The window should be narrow same as above ASK. The advantage of proposed system is which error rate performance is superior. The disadvantage of proposed system are that Circuitry is more complex, narrow pull-in range of receiver caused by VCO and spectrum divergence by the non-linear amplifier. The third, 4-QAM(Quadrature Amplitude Modulation)system has a nyquist pulse transmitter and IF-VCO control by symbol clock. The advantage of proposed system are that signal frequency band is a half of 1GHz, reliable pull-in of VCO and possibility of double speed transmission(2Gbps) by keeping 1GHz frequency-band. The disadvantage of proposed system are that circuit complexity of pulse shaping and spectrum divergence by the non-linear amplifier.

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TFT-LCD Defect Detection Using Mean Difference Between Local Regions Based on Multi-scale Image Reconstruction (로컬 영역 간 평균 화소값 차를 이용한 멀티스케일 기반의 TFT-LCD 결함 검출)

  • Jung, Chang-Do;Lee, Seung-Min;Yun, Byoung-Ju;Lee, Joon-Jae;Choi, Il;Park, Kil-Houm
    • Journal of Korea Multimedia Society
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    • v.15 no.4
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    • pp.439-448
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    • 2012
  • TFT-LCD panel images have non-uniform brightness, noise signal and defect signal. It is hard to divide defect signal because of non-uniform brightness and noise signal, so various divide methods have being developed. In this paper, we suggest method to divide defective regions on TFT-LCD panel image by estimating a menas of two different size of windows, which is suggested by Eikvil et al., and using difference of them. But in this method, the size of detectable defects is restricted by the size of window, hence it has inefficient problem that the size of window have to increase to divide a large defect region. To solve this problem we suggest an algorithm which can divide various size of defects, by using Multi-scale and restrict a detectable size of defects in each scale. To prove an efficiency of suggested algorithm, we show that resulting images of real TFT-LCD panel images and an artificial image with various defects.

A Study on SONOS Non-volatile Semiconductor Memory Devices for a Low Voltage Flash Memory (저전압 플래시메모리를 위한 SONOS 비휘발성 반도체기억소자에 관한 연구)

  • 김병철;탁한호
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.7 no.2
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    • pp.269-275
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    • 2003
  • Polysilicon-oxide-nitride-oxide-silicon(SONOS) transistors were fabricated by using 0.35${\mu}{\textrm}{m}$ complementary metal-oxide-semiconductor(CMOS) process technology to realize a low voltage programmable flash memory. The thickness of the tunnel oxide, the nitride, and the blocking oxide were 2.4nm, 4.0nm, and 2.5nm, respectively, and the cell area of the SONOS memory was 1.32$\mu$$m^2$. The SONOS device revealed a maximum memory window of 1.76V with a switching time of 50ms at 10V programming, as a result of the scaling effect of the nitride. In spite of scaling of nitride thickness, memory window of 0.5V was maintained at the end of 10 years, and the endurance level was at least 105 program/erase cycles. Over-erase, which was shown seriously in floating gate device, was not shown in SONOS device.

ESTIMATION OF ERRORS IN THE TRANSVERSE VELOCITY VECTORS DETERMINED FROM HINODE/SOT MAGNETOGRAMS USING THE NAVE TECHNIQUE

  • Chae, Jong-Chul;Moon, Yong-Jae
    • Journal of The Korean Astronomical Society
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    • v.42 no.3
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    • pp.61-69
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    • 2009
  • Transverse velocity vectors can be determined from a pair of images successively taken with a time interval using an optical flow technique. We have tested the performance of the new technique called NAVE (non-linear affine velocity estimator) recently implemented by Chae & Sakurai using real image data taken by the Narrowband Filter Imager (NFI) of the Solar Optical Telescope (SOT) aboard the Hinode satellite. We have developed two methods of estimating the errors in the determination of velocity vectors, one resulting from the non-linear fitting ${\sigma}_{\upsilon}$ and the other ${\epsilon}_u$ resulting from the statistics of the determined velocity vectors. The real error is expected to be somewhere between ${\sigma}_{\upsilon}$ and ${\epsilon}_u$. We have investigated the dependence of the determined velocity vectors and their errors on the different parameters such as the critical speed for the subsonic filtering, the width of the localizing window, the time interval between two successive images, and the signal-to-noise ratio of the feature. With the choice of $v_{crit}$ = 2 pixel/step for the subsonic filtering, and the window FWHM of 16 pixels, and the time interval of one step (2 minutes), we find that the errors of velocity vectors determined using the NAVE range from around 0.04 pixel/step in high signal-to-noise ratio features (S/N $\sim$ 10), to 0.1 pixel/step in low signa-to-noise ratio features (S/N $\sim$ 3) with the mean of about 0.06 pixel/step where 1 pixel/step corresponds roughly to 1 km/s in our case.

Study on Insulation Standards at Passive Level of Non-Residential Buildings by Regional Climate (지역별 기후에 따른 비주거 건축물 패시브 수준 단열기준 연구)

  • Kim, Yeweon;Yu, Ki-Hyoung
    • Journal of the Korean Solar Energy Society
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    • v.37 no.6
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    • pp.51-58
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    • 2017
  • This study proposes an appropriate level of insulation standards by region through annual heating energy requirements according to regional climate. The reference buildings out of non-residential buildings approved by the energy saving design standard for buildings were derived in the previous study, in which the annual heating energy requirements for each building were as follows when the insulation standard for building members in four regions (Pyeongchang, Seoul, Gwang-ju, and Jeju) suggested by the energy saving design standard for buildings: $29.8kWh/m^2$ in Pyeongchang, $17.5kWh/m^2$ in Seoul, $14.4kWh/m^2$ in Gwangju, and $16.7kWh/m^2$ in Jeju. To satisfy the passive level of insulation standards for these buildings, in case that roof/floor of buildings in Pyeongchang and Seoul was $0.2W/m^2K$, the minimum window thermal transmittance should satisfy $0.9W/m^2K$ and the minimum wall thermal transmittance should satisfy $0.1W/m^2K$ in the case of Pyeongchang. On the other hand, the minimum window thermal transmittance should satisfy $1.5W/m^2K$ and the minimum wall thermal transmittance should satisfy $0.14W/m^2K$ in the case of Seoul. For Jeju regions, the minimum wall thermal transmittance should satisfy $0.34W/m^2K$ to meet the passive level of buildings. Based on the above results, the thermal transmittance of each member by region should take the outdoor climate condition of the region into consideration to satisfy the passive level of buildings.