• Journal of Applied Biological Chemistry
• /
• v.57 no.4
• /
• pp.379-386
• /
• 2014

Chromatin is an instructive DNA structure that can widely respond to external signals. An important change of chromatin is the modifications of histone for this regulation. There are accumulating lists of these modifications and the complexity of their action is gradually understood. It is evident that histone modifications play important roles in most biological processes that are involved in the expression or repression of DNA. The surface of nucleosomes is susceptible to multiplicity of modifications. Chromatin modifications can play either by eliminating chromatin contacts or by recruiting non-histone proteins to chromatin. Many of these regulations seem to be epigenetically inherited. Thus, histone modifications are closely correlated with many fundamental biological processes in animal, plant and microbial kingdoms. Failures of histone modification lead, in general, to defective chromosome condensation or decondensation, impeding many biological functions including development, maturation, and protection against various diseases.

• Proceedings of the Korean Society for Agricultural Machinery Conference
• /
• 2017.04a
• /
• pp.34-34
• /
• 2017

목질계바이오매스 중 목재펠릿은 '탄소중립(Carbon Neutral)' 연료로써 온실가스 감축 의무에 대응 가능한 에너지원이다. 하지만 목질계바이오매스 연소 시 발생되는 타르는 보일러 내부에 누적되어 효율을 감소시킨다. 타르 및 연소 불꽃에 의한 효율 감소를 최소화하기 위해 반대측면에 내화재(Castable)를 적용하여 실험하였으며 시뮬레이션을 이용하여 구조변경 분석이 실시되었다. 적용된 내화재는 비중이 낮고 단열성이 우수하여 열손실을 막아 연료비 절감의 효과를 가져 오며, 연소실 내부 청소 면적 감소로 인한 경제적 효과도 기대 할 수 있다. 분석결과를 이용하여 최적화된 펠릿보일러가 제작되었으며, 실험을 통하여 200시간 가동 후 열효율 감소량이 나타났다. 단위시간별 동일한 외부환경(산화제량, 부하, 주변 온도, 펠릿소비량)에서 실험이 진행 되었으며, 타르생성이전(Non-tar), 이후(Tar-existence) 보일러의 열효율 성능 비교실험이 실시되었다. 실험결과 타르생성이전 조건에서 구조변경 전 후 보일러의 열효율은 각각 91.87%, 90.73%로 확인되었으며, 타르생성이후 조건에서 각각 82.68%, 83.27%의 열효율을 확인하였다. 타르생성이전 대비 이후 조건에서 열효율 감소량은 각각 9.19%p, 7.46%p로 구조변경 전 대비 변경 후 보일러의 열효율이 약 1.73%p 더 적게 감소됨을 확인되었으며, 시뮬레이션 결과 타르생성이전 조건에서 구조변경 전 후 보일러의 효율은 각각 91.83%, 92.05%로 확인되었으며 타르 생성이후 조건에서 각각 85.25%, 87.43%의 열효율을 확인하였다. 타르생성이전 대비 이후 조건에서 열효율 감소량은 각각 6.58%, 4.62%로 구조변경 전 대비 변경 후 보일러의 열효율이 약 1.96%p 더 적게 감소됨을 확인하였다.

• Proceedings of the Korean Society for Agricultural Machinery Conference
• /
• 2017.04a
• /
• pp.85-85
• /
• 2017

무동력 복합작업기는 치즐쟁기와 디스크의 배열에 따라 작업성능이 좌우된다. 프레임과 디스크, 치즐쟁기에 가해지는 기본적인 힘의 상태를 확인하기 위한 정적 구조해석을 수행하였다. 복합작업기는 디스크는 $18^{\circ}$가 경사진 형태로 전면9개 후면9로 총 18개, 치즐쟁기(Chiselplow)는 4개로, 디스크는 모두 18개이다. 정적인 상태에서 끄는 견인력은 100마력, 150마력, 200마력으로 하였으며 Inventor의 해석 시스템은 힘을 N으로 사용하기 때문에 각 마력에 부가되는 하중을 N으로 치환하여 사용하였다. 구속조건은 frame과, disc, chisel plow에 맞닿는 면을 구속하고, 힘의 방향은 프레임과 트랙터의 연결면, 디스크 날과 땅의 접촉면에 적용했다. front /rear 디스크는 이론상으로는 양 디스크가 쌍으로 마주하고 있어서 스캔데이타를 중심으로 모델링한 결과를 바탕으로, 전후면 디스크해로우의 해석을 수행하였다. 조립 또는 사용상의 문제점이나 자연적인 유격에 의해 어느 정도 대칭이 되지 않을수 있으나 그 정도에 따라 진동과 내구성에 문제가 될 수도 있기에 한쌍에 대해 모델링을 통한 해석을 수행하였다. 해석결과에 따르면 디스크에 작용하는 폰미세스 응력은 극한강도에 미치지 않은 것으로 나타났으며 Frame의 최대 폰 미세스 응력을 제외하면, 대부분의 응력은 항복강도에 현저히 미치지 못하는 수치이고, 프레임의 경우는 150마력, 200마력으로 힘을 가할 때 항복강도는 넘는 수치이지만 극한인장강도에는 미치지 못하는 수치인 것을 알 수 있었다. 100마력에 폰 미세스 응력의 최대값은 0.161918 MPa이고 프레임 강의 항복강도인 207MPa와 디스크의 항복강도인 250MPa에 못 미치는 수치이다. 150마력과 200마력의 힘으로 회전할 때의 폰 미세스 응력의 최대값은 0.286425MPa과 0.381921 MPa로 항복강도인 250MPa에 크게 못 미치는 수치이다. 그 이유는 디스크해로우 방식의 복합작업기는 견인저항력이 작게 설계되고 작업속도를 개선하기 위한 목적으로 사용되기 때문으로 사료된다. 벤치마킹 기대의 Rear 디스크도 마찬가지로 각도는 $18^{\circ}$이며, 동일한 구속조건을 적용하여 시뮬레이션을 수행하였으며 해석결과는 모두 항복강도 이내로 예측 되었다. 디스크에 최대로 응력이 미치는 부분은 디스크와 프레임이 연결되는 허브 부분이다. 각도가 커짐에 따라 응력이 증가하므로 이를 감안한 설계인자 도출이 가능하다. 마력과 각도가 증가함에 따라 디스크 해로우에 작용하는 폰미세스 응력과, 접촉압력이 증가하므로 이에 대한 검토와 동적하중인 로드프로파일을 적용한 해석을 수행하여 내구수명 특성에 대한 연구를 수행할 계획이다.

• Strategy21
• /
• s.31
• /
• pp.57-84
• /
• 2013

North Korea's continuous threats and provocative behaviors have aggravated tension on the Korean peninsula particularly with the recent nuclear weapons test. South Korea's best way to cope with this situation is to maintain the balance among three policy directions: dialogue, sanctions, and deterrence. Among the three, I argue that deterrence should be prioritized. There are different sources of deterrence such as military power, economic power, and diplomatic clouts. States can build deterrence capability independently. Alternatively, they may do so through relations with other states including alliances, bilateral relations, or multilateral relations in the international community. What South Korea needs most urgently is to maintain deterrence against North Korea's local provocations through the enhancement of independent military capability particularly by addressing the asymmetric vulnerability between militaries of the South and the North. Most of all, the South Korean government should recognize the seriousness of the negative consequences that North Korea's 'Nuclear shadow strategy' would bring about for the inter-Korea relations and security situations in Northeast Asia. Based on this understanding, it should develop an 'assertive deterrence strategy' that emphasizes 'multi-purpose, multi-stage, and tailored deterrence whose main idea lies in punitive retaliation.' This deterrence strategy requires a flexible targeting policy and a variety of retaliatory measures capable of taking out all targets in North Korea. At the same time, the force structures of the army, the air force, and the navy should be improved in a way that maximizes their deterrence capability. For example, the army should work on expanding the guided missile command and the special forces command and reforming the reserve forces. The navy and the air force should increase striking capabilities including air-to-ground, ship-to-ground, and submarine-to-ground strikes to a great extent. The marine corps can enhance its deterrence capability by changing the force structure from the stationary defense-oriented one that would have to suffer some degree of troop attrition at the early stage of hostilities to the one that focuses on 'counteroffensive landing operations.' The government should continue efforts for defense reform in order to obtain these capabilities while building the 'Korean-style triad system' that consists of advanced air, ground, and surface/ subsurface weapon systems. Besides these measures, South Korea should start to acquire a minimum level of nuclear potential within the legal boundary that the international law defines. For this, South Korea should withdraw from the Nuclear Non-proliferation Treaty. Moreover, it should obtain the right to process and enrich uranium through changing the U.S.-South Korea nuclear cooperation treaty. Whether or not we should be armed with nuclear weapons should not be understood in terms of "all or nothing." We should consider an 'in-between' option as the Japanese case proves. With regard to the wartime OPCON transition, we need to re-consider the timing of the transition as an effort to demonstrate the costliness of North Korea's provocative behaviors. If impossible, South Korea should take measures to make the Strategic Alliance 2015 serve as a persisting deterrence system against North Korea. As the last point, all the following governments of South Korea should keep in mind that continuing reconciliatory efforts should always be pursued along with other security policies toward North Korea.

• Journal of Korean Academy of Nursing
• /
• v.10 no.2
• /
• pp.95-115
• /
• 1980

Current statistics reveal remarkable prolongation of the average longevity in this country for the past decade. Welfare of the aged is no longer sole concern of the person or/and family. but has aroused social concern on the community and national level. This study was designed to assess social, economic and emotional needs of the aged. and to identify problems they are confronting. Data were gathered through questioning 273 subjects living in Seoul from July 25, to August 31. 19 80. Frequencies and percentile scores were analysed to describe the fact. and the significance of int or-variable differences was tested by Chi-square method. Results are : 1. Majority of the subjects (male : 65.38%). (female : 62.13%)“talk about past experiences”to re-collect their past days, the difference between male and female respondents was not significant. 2. Except few who earn their pocket money (4.21%). majority were doing household errands (34.52% ) and looking after their garnd children (29.26 ％）. Main sources of their pocket money revealed to be their children (84.02%) and their own savings (24.64% ). Except few (15％）engaged with social activities directly or indirectly. leisure hours are spent in chatting with aged neighbors (44.81%). Highest in the rank order on the joyous moments for the aged revealed to be when the members of family living apart paying a visit (male : 37.5%, female : 63.72%)difference of male and female was significant ( P<0.05). Among female respondents. significant difference between age group was revealed (p<0.05). 3. Majority prefered sin91e houses (84.30% ). as residential environment. the suburban (36.26% ) area was the filet in the rank order : difference between age group and the educational status were not significant. Majority of respondents revealed to have their own room in the house. The first preference was given to live with their children (68.86%). Memory of the past (37.36% )revealed to be the highest in the rank order among the reasons why they dislike moving the house. 4. Majority favored current welfare benefts provided for the old age. however. the ideal way to live at their old age they responded was to live on their own savings (50.54%). 5. Majority revealed to be daunted occasionally (62.27%) by not being less active (34.16%) socially and by poor physical health(29.75%). Male and female differ in the causes of loneliness significantly (P <0.001) : retirement (37.89%) in ale and helpessness (43.05%) in female revealed the highest in the rank order. Majority talk over their feelings with aged neighbors to overcome the loneliness. 6 Majority were in favor of planting and looking after pet animal in the house. however. male and female differ in the kind significantly (p <0.001), 7. Majority think about death and dying occasionally or more (84.11% ). Many of the respondents believes in the life after life (53.49%) : female revealed to be significantly higher (p <0.01). and subjects with christian belief were significantly higher than non-christians (P<0.001). Attitude towards death and dying differs significantly between male and female (P <0. 001) and between christians ans and nonchristians (p <0.001). Highest preference was given to simple funeral (69.85%). Precious heritage that they would pass on to their descendants was onoscience and ethical value(57. 51%) : christian response as the first value was christian belief (52.38%).

• Journal of Periodontal and Implant Science
• /
• v.29 no.3
• /
• pp.507-519
• /
• 1999

The ultimate objective of periodontal treatment is to stop disease progression and to regenerate destroyed periodontal tissues and thereby regain normal function. Growth factors are naturally found polypetides which stimulate many cellular activities pertaining to wound healing by acting as signal molecule in controlling cell movement, proliferation, and matrix production. Platelet derived growth factor (PDGF) is 28,000-35,000 Da molecular weight dimeric protein with 2 long positively charged polypeptide chains connected by sulfide bonds. The purpose of this study is to evaluate histologically the initial guided tissue regeneration in a periodontal defect f a beagle dog treated with a biodegradable membrane formed with polylactic acid (poly-L-lactic acid) and polyglycolic acid loaded with 200ng/$cm^2$ platelet derived growth factor. 2 beagle dogs were used in he experiment. $5mm{\times}6mm$ alveolar bone defect was formed in upper and lower canines and third premolars and a reference notch was placed. PDGF-BB non-containing membrane was used as control. Each defect was randomly assigned to the test roup or the control group. The dogs were sacrificed 3 weeks after membrane placement. Toluidine blue and multiple staining was done for histological analysis. In the 3 week specimen in the control group, no new one formation could be seen. Small amount f bone resorption below the notch could be seen. In the notch, loose connective tissue with infiltration of inflammatory cells could be seen. Also thin discontinuous new cementum could be seen and the membrane still retained its structure. Where PDGF-BB containing membrane was used, new bone formation could be seen in the notch at weeks and also continuous thin cementum could be seen. PDL cells were observed between new bone and new cementum and some were attached to bone and cementum. These results suggest that new bone and cementum formation seen when PDGF-BB loaded membrane was used was due to inhibition of downgrowth of epithelial cells and also due to continuous release of the growth factor. Further study on the resorption characteristics of the membrane nd the release characteristics of the PDGF-BB is necessary. Also, development of a membrane easier to use clinically is necessary.

• Journal of Biomedical Engineering Research
• /
• v.30 no.1
• /
• pp.49-55
• /
• 2009

Purpose : The aim of this study is to evaluate a possibility of clinical application for the effects of low intensity ultrasound stimulation (LIUS) in morphological characteristics (i.e., structure, bone mineral density) of bone on osteoporotic fracturesprevention. Materials and Methods : Eight virgin 14-week-old ICR mice (approximate weight 25g) were used and ovariectomized (OVX) to induce osteoporosis. Right tibia (US) for each mouse served as the LIUS (1.5MHz frequency, 1.0 kHz pulse repetition on frequency, $30mW/cm^2$ intensity, $200{\mu}s$ pulse length, and stimulation for 20 minutes a day and 5 days a week over a 6-week period). Left tibia (CON) for each mouse served as the non-stimulated controls. Structural parameters and bone mineral density ($g/cm^3$) on trabecular bone of tibiae were calculated and measured from images derived in-vivo micro computed tomography (micro-CT) at 0 week and after 6weeks. Results : The BV/TV and Tb.N in US group were significantly bigger than those in CON group. The Tb.Pf in US group, moreover, was significantly smaller than that in CON group (p<0.05).For the others structural parameters and BMD, however, there were no significant difference between US group and CON group (p>0.05). Conclusion : The LIUS might prevent bone loss and keep bone connectivity in osteoporotic bones. Therefore, the LIUS might prevent effectively the osteoporotic fractures in clinics.

• Journal of Korea Water Resources Association
• /
• v.36 no.3 s.134
• /
• pp.507-520
• /
• 2003

A V-shaped riffle is an artificial hydraulic structure haying two wings from the streamside with a narrow opening in between. It is usually made of crushed stones or large boulders. It limits channel width and accelerates the flow through the constricted section causing a local scour just downstream. The V-shaped riffle provides with a unique aquatic habitat by forming a pool and sandbars around the pool edge, increasing local morphologic, hydraulic and sedimentological diversity. This study investigates experimentally the scour characteristics of the V-shaped riffle in the sandbed stream and proposes a predictive equation for the scour. Total 45 cases of experiments were conducted to examine the effect of hydraulic factors and configuration of V-shaped riffle on the geometry of scour holes. From the comparison of the experimental results of this study with the predictive equation of spur dike by Breusers and Raudkivi(1991), it is found that their predictive equation of spur dike underestimates the maximum scour depth downstream of the V-shaped riffle. h new predictive equation for the maximum scour depth was developed using the non-dimensional hydraulic and geometrical variables. The parameters used in the proposed equations were determined using the experimental data. The analysis reveals that the scour depth is dependent dominantly on the Froude number at the opening of the V-shaped riffle, while the angle of riffle and the opening width also affect the scour depth. The proposed equation for the scour of V-shaped riffle well agrees with the experimental data. It can be used for estimating the scour of the V-shaped riffle in sandbed streams.

• Journal of the Korean Crystal Growth and Crystal Technology
• /
• v.21 no.5
• /
• pp.187-192
• /
• 2011

Tilt angle of r-plane wafer is a one of the important factors related with the quality of the GaN epi, so the fine control of the tilt angle is important for the growing of high quality non-polar a-GaN epi. We prepared the R-plane sapphire wafers with slight tilt angles for nonpolar a-plane GaN. The target tilt angles of ${\alpha}$ and ${\beta}$ were 0, -0.1, -0.15, -0.2, -0.4, $-0.6^{\circ}$ and -0.1, 0, $0.1^{\circ}$, respectively. The tilt angles of sliced R-plane sapphire wafers were measured by x-ray and the statistical evaluation of reliability of tilt angles of wafers were performed. The tolerance of the tilt angle was ${\pm}0.03^{\circ}$. R-plane sapphire wafers have relatively large distributions of BOW and TTV data than c-plane sapphire wafers due to the large anisotropy of R-plane. As the tilt angle ${\alpha}$ was increased from -0.1 to $-0.6^{\circ}$, the step widths and heights were decreased from 156 nm to 26 nm and 0.4 nm to 0.2 nm, respectively. The growth and qualities of GaN epi seems to be largely affected by the change of step structure of R-plane sapphire wafers with tilt angle.

• Journal of Technologic Dentistry
• /
• v.31 no.1
• /
• pp.55-61
• /
• 2009

Passive fitting of meso-structure and super-structures is a predominant requirement for the longevity and clinical success of osseointegrated dental implants. However, precision and passive fitting has been unpredictable with conventional methods of casting as well as for corrective techniques. Alternative to conventional techniques, electro discharge machining(EDM) is an advanced method introduced to dental technology to improve the passive fitting of implant prosthesis. In this technique material is removed by melting and vaporization in electric sparks. Regarding the efficacy of EDM, the application of this technique induces severe surface morphological and elemental alterations due to the high temperatures developed during machining, which vary between $10,000{\sim}20,000^{\circ}C$. The aim of this study was to investigate the morphological and elemental alterations induced by EDM process of casting dental gold alloy and non-precious alloy used for the production of implant-supported prosthesis. A conventional clinical dental casting alloys were used for experimental specimens patterns, which were divided in three groups, high fineness gold alloy(Au 75%, HG group), low fineness gold alloy(Au 55%, LG group) and nonprecious metal alloy(Ni-Cr, NP group). The UCLA type plastic abutment patterns were invested with conventional investment material and were cast in a centrifugal casting machine. Castings were sandblasted with $50{\mu}m\;Al_2O_3$. One casting specimen of each group was polished by conventional finishing(HGCON, LGCON, NPCON) and one specimen of each group was subjected to EDM in a system using Cu electrodes, kerosene as dielectric fluid in 10 min for gold alloy and 20 min for Ni-Cr alloy(HGEDM. LGEDM, NOEDM). The surface morphology of all specimens was studied under an energy dispersive X-ray spectrometer (EDS). The quantitative results from EDS analysis are presented on the HGEDM and LGEDM specimens a significant increase in C and Cu concentrations was found after EDM finishing. The different result was documented for C on the NPEDM with a significant uptake of O after EDM finishing, whereas Al, Si showed a significant decrease in their concentrations. EDS analysis showed a serious uptake of C and Cu after the EDM procedure in the alloys studied. The C uptake after the EDM process is a common finding and it is attributed to the decomposition of the dielectric fluid in the plasma column, probably due to the development of extremely high temperatures. The Cu uptake is readily explained from the decomposition of Cu electrodes, something which is also a common finding after the EDM procedure. However, all the aforementioned mechanisms require further research. The clinical implication of these findings is related with the biological and corrosion resistance of surfaces prepared by the EDM process.