• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.477-480
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• 2008

In tunnel, though the frequency of fire occurrence is relatively lower than other structures, the characteristics of sealed space tends to cause the temperature to rapidly rise to more than $1000^{\circ}C$ within 5 minutes after fire, which might eventually lead to a large fire that usually results in a loss of lives and the damage to the properties, not to mention a huge cost necessary for repair and maintenance after fire. Referring to foreign tunnel fire scenarios, it clarified the heat transfer characteristics of concrete PC panel lining depending on fire intensity (ISO, MHC, RWS), and to identify the range of thermal damage, the evaluation was carried out using ITA standard. As a result, 39mm under ISO fire condition, 50mm under MHC and 100mm under RWS were measured. And when it comes to spalling, 30mm was measured under RWS. When PC panel was designed to serve the support, a fire resistance to the minimum depth of 100mm of the concrete that might be damaged under the fire shall be maintained, and in case of a non-support structure, PC lining shall have at least 100mm thickness.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.12
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• pp.3056-3068
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• 1996

This papre presents the RDM algorithm for composition of bit. After this, we propose a digital signature scheme for facsimile document using RDM algorithm. We modify the even-odd feature in distance of changing pel between coding line and multiple reference line which have been scanned before, and run-length in coding line. The time to take in signature is reduced by spreading of signature. Non-repudiation in origin, the 3rd condition of digital signature is realized by proposed digital signature scheme. The transmitter embeds the signature secretly and tensfers it, and the receiver makes a check of any forgery on the signature and the document. This scheme is compatible with the ITU-T.4(G3 or G4 facsimile standard). The total amount of data transmitted and the quality of image are about the same to that of the original document, thus a third party does not notics signature embeded on the document.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.195-200
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• 2016

Background: Venous thromboembolism (VTE) is a common and life-threating condition in cancer patients. Low molecular weight heparins (LMWH), such as dalteparin, are recommended in the treatment of VTE. Also, rivaroxaban, an orally administered direct factor Xa inhibitor, was approved for the treatment of VTE. It showed similar efficacy to standard therapy (LMWH or warfarin) and was associated with significantly lower rates of major bleedings. However, in the real world, bleeding has been reported to occur frequently in cancer patient receiving rivaroxaban. The goal of this research was to analyze bleeding risks between rivaroxaban and dalteparin for treatment of VTE in cancer patients. Methods: Medical records of oncology patients who were treated with rivaroxaban or dalteparin for VTE from July 2012 to June 2014 were retrospectively reviewed. Data collected were as follows: age, sex, weight, height, cancer types and stages, ECOG (eastern cooperative oncology group) PS (performance score), VTE types, concurrently used medications, study drug information (dose and duration of therapy), INR (international normalized ratio), PT (prothrombin time), and platelet counts. Bleeding was classified into major bleedings, clinically relevant non-major bleedings, and minor bleedings. Results: A total of 399 patients were included in the study. Of these patients, 246 were treated with rivaroxaban and 153 with dalteparin. Bleeding rates were significantly higher in the rivaroxaban group than in the dalteparin group (adjusted odds ratio (AOR) 2.09, 95% CI 1.22-3.60) after adjusting for confounders. In addition, rivaroxaban remained independently associated with 1.78-fold (95% CI 1.14-2.76) shorter time to bleeding compared to dalteparin after adjusting other factors known to be associated with poor outcomes. Conclusion: This study suggested that rivaroxaban was associated with an increased risk of bleedings in cancer patients.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.327-330
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• 2006

This paper represents the numerical analysis on effects of radius ratio in a concentric annulus with a rotating inner cylinder. The numerical model consisted of two cylinder which inner cylinder is rotating and outer cylinder is fix, and the axial direction is used the cyclic condition because of the length for axial direction is assumed infinite. The diameter of inner cylinder is assumed 86.8mm, the numerical parameters are angular velocity and radius ratio. Also, the whole walls of numerical model have no-slip and the working fluid is used water at $20^{\circ}C$. The numerical analysis is assumed the transient state to observe the flow variations by time and the 3-D cylindrical coordinate system. The calculation grid adopted a non-constant grid for dense arrangement near the wall side of cylinder, the standard $k-{\omega}$ high Reynolds number model to consider the effect of turbulence flow and wall, the fully implicit method for time term and the quick scheme for momentum equation. The numerical method is compared with the experimental results by Wereley and Lueptow, and the results are very good agreement. As the results, TVF isn't appeared when Re is small because of the initial flow instability is disappear by effect of the centrifugal force and viscosity. The vortex size is from 0.8 to 1.1 for TVF at various $\eta$, and the traveling distance for wavy vortex have the critical traveling distance for each case.

• Journal of Plant Biotechnology
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• v.35 no.1
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• pp.13-21
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• 2008

Final regulatory steps for commercialization of transgenic crops are risk assessment and variety registration. The risk assessment of transgenic crops requires broad network of scientists, high cost and long term. Developers of transgenic crops, therefore, face to additional challenges to consider theoretical and strategic aspects on risk assessment. The general concept for risk assessment of genetically modified organisms was derived from chemical risk assessment. Due to the complexity of organisms, however, comparative approaches that are substantial equivalence and familarity have been developed. In practical view, the integration of risk assessment is more difficult than the evaluation of each risk factors involving gene flow, toxicity and allergenicity. Variety registration of transgenic crops requires the results of risk assessment compared with non-GM crops and agronomic data analyzed with standard varieties. For economic and fast commercialization, risk assessment process should combined with condition of cultivation test for variety registration.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.10 no.2
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• pp.117-128
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• 2007

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated hypersensitivity disorder, which is associated with mainly gastrointestinal symptoms and has a delayed onset. The vomiting and/or diarrheal symptoms of FPIES typically begin in the first month of life in association with a failure to thrive, metabolic acidosis, and shock. Therefore, the differential diagnosis of FPIES and neonatal or infantile sepsis-like illnesses or gastroenteritis is difficult. The early recognition of indexes of suspicion for FPIES may help in the diagnosis and treatment of this disorder. The diagnosis of FPIES is generally made through clinical practice and food-specific IgE test findings are typically negative in this condition. Therefore, oral cow's milk challenge (OCC) remains the valid diagnostic standard for FPIES. An investigation of positive OCC outcomes helps to find out a diagnostic algorithm of criteria of a positive challenge in FPIES. Moreover, it has not been clearly determined in infantile FPIES when $1^{st}$ follow up-oral food challenge (FU-OFC) should be performed, with what kind of food protein (e.g., cow's milk, soy), and how much protein should be administered. Hence, to prevent the risk of inappropriate FU-OFC or accidental exposure and achieve appropriate dietary management, it is necessary to identify tolerance rates to major foods under the careful follow up of infantile FPIES patients. On the other hand, small intestinal enteropathy with villous atrophy is observed in FPIES and this enteropathy seems to be in part induced by both of epithelial apoptosis and intercellular junctional complex breakdown. The purpose of this report is to introduce an update on diagnostic and therapeutic approaches in FPIES and suggest the possible histopathological evidences in this disorder.

• Clinical and Experimental Reproductive Medicine
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• v.44 no.1
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• pp.40-46
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• 2017

Objective: To describe in vitro development of human embryos derived from an individual with a homozygous pathogenic variant in NLRP7 (19q13.42) and recurrent hydatidiform mole (HM), an autosomal recessive condition thought to occur secondary to an oocyte defect. Methods: A patient with five consecutive HM pregnancies was genomically evaluated via next generation sequencing followed by controlled ovarian hyperstimulation, in vitro fertilization (IVF) with intracytoplasmic sperm injection, embryo culture, and preimplantation genetic screening. Findings in NLRP7 were recorded and embryo culture and biopsy data were tabulated as a function of parental origin for any identified ploidy error. Results: The patient was found to have a pathogenic variant in NLRP7 (c.2810+2T>G) in a homozygous state. Fifteen oocytes were retrieved and 10 embryos were available after fertilization via intracytoplasmic sperm injection. Developmental arrest was noted for all 10 embryos after 144 hours in culture, thus no transfer was possible. These non-viable embryos were evaluated by karyomapping and all were diploid biparental; two were euploid and eight had various aneuploidies all of maternal origin. Conclusion: This is the first report of early human embryo development from a patient with any NLRP7 mutation. The pathogenic variant identified here resulted in global developmental arrest at or before blastocyst stage. Standard IVF should therefore be discouraged for such patients, who instead need to consider oocyte (or embryo) donation with IVF as preferred clinical methods to treat infertility.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.453-458
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• 2001

This study was performed to reuse the dyeing wastewater sludge treated by Fenton process through the solidification/stabilization technique. To solidify the dyeing sludge the industrial by-products such as blast furnace slag, fly ash and waste sand with cement were used. The laboratory scale and pilot scale test were conducted at room temperature to make construction brick which has high compressive strength and low leaching of heavy metals. The experimental results showed that blast furnace slag and fly ash could be used instead of cement and the products satisfied the regulation of Korean Standards. The blast furnace slag increased the compressive strength and the optimum ratio of slag/dyeing sludge on dry basis was found 0.4. The solidifying agent of SB series could increase rapidly the compressive strength and the optimum ratio of solidifying agent/sludge on dry basis was 0.26 at which the strength was two times compared with non-added condition. The portion of waste and industrial by-products in matrix was over 80%. From the pilot test the optimum pressure in molding was 100kg/$\textrm{cm}^2$ at which the compressive strength was over 100kg/$\textrm{cm}^2$. And the strength increased continuously to 160kg/$\textrm{cm}^2$ until 120 days curing time due to pozzolanic reaction. When SB-20 as a solidifying agent was used, the unconfined compressive strength of dyeing sludge could be obtained 110kg/$\textrm{cm}^2$ which satisfied the regulation of cement brick in Korea Standard(KS).

• Journal of the Korean Geotechnical Society
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• v.33 no.8
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• pp.29-40
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• 2017

In this study, the dynamic compaction method was selected by analyzing field situation, soil condition data and compaction test characteristics of the special selected soils, and the compaction method for using the selected soils as the site restoration soil of the ${\bigcirc}{\bigcirc}$ city non-sanitary landfill maintenance project. The N value in the standard penetration test (SPT) before and after dynamic compaction increased by an average of 89% over the range 12~18, and the allowable bearing capacity of the plate bearing test (PBT) was ranged $150{\sim}227kN/m^2$, at least 80% higher than that before test. As a result, it can be seen that the same tendency as the dynamic compaction effect applied to the existing dredging and waste landfill is shown.

• Journal of the Korean Society of Safety
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• v.32 no.5
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• pp.62-68
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• 2017

It is necessary to analyze on the compressive strength among material properties of concrete for confirming damages of architectures due to large explosion. A non destructive test is known as the representative methods estimating compressive strength and ultrasonic pulse velocity, rebound hardness test are widely used because of their simplicity, convenience. But combined method supplementing two types is applied at now as they are affected by the characteristics of test specimen. In this research to check damages on the members of structure before and after explosion, the characteristics of compressive strength are compared and analyzed through a real explosion test prior to full scale structures. The test results showed that the larger the TNT powder and the shorter the distance, the greater the decrease in strength before and after the explosion and that the largest displacement and moment for the explosive load and the greatest decrease in the strength at the central part. Due to the surface condition and the thickness variation of the concrete specimens, the standard deviation value is the smallest in the combining method of fusion of the ultrasonic method and rebound hardness method. Thus, the combining method can be one of appropriate methods to evaluate the strength in the reinforced concrete structures damaged by the explosion.