• Journal of the Korea Convergence Society
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• v.11 no.7
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• pp.223-230
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• 2020

The purpose of this study was to identify the characteristics of college graduates who obtain qualifications, and to check the economic and ineffectiveness of qualifications through the analysis of employment and job relevance according to their school area. For the main research, the "2016 Graduates Occupational Mobility Survey (GOMS)" data was used to perform basic statistics and logistic regression analysis using SPSS 25. This study reaffirmed the effectiveness of employment as stated in the preceding study, and in particular, the qualification of non-Seoul area colleges students had some positive effects on employment and job compatibility. In conclusion, the effectiveness of qualifications according to individual attributes and location of school may differ, but it suggests that proper qualification encouragement and acquisition support can help the employment and job convergence of college graduates.

• Structural Engineering and Mechanics
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• v.21 no.4
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• pp.437-450
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• 2005

In this study, a complete analysis of soil-structure interaction problems is presented which includes a modelling of the near surrounding of the building (near-field) and a special description of the wave propagation process in larger distances (far-field). In order to reduce the computational effort which can be very high for time domain analysis of wave propagation problems, a special approach based on similarity transformation of the infinite domain on the near-field/far-field interface is applied for the wave radiation of the far-field. The near-field is discretised with standard Finite Elements, which also allows to introduce non-linear material behaviour. In this paper, a new approach to calculate the involved convolution integrals is presented. This approximation in time leads to a dramatically reduced computational effort for long simulation times, while the accuracy of the method is not affected. Finally, some benchmark examples are presented, which are compared to a coupled Finite Element/Boundary Element approach. The results are in excellent agreement with those of the coupled Finite Element/Boundary Element procedure, while the accuracy is not reduced. Furthermore, the presented approach is easy to incorporate in any Finite Element code, so the practical relevance is high.

• Safety and Health at Work
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• v.8 no.2
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• pp.206-211
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• 2017

Background: Self-reported low back pain (LBP) has been evaluated in relation to material handling lifting tasks, but little research has focused on relating quantifiable stressors to LBP at the individual level. The National Institute for Occupational Safety and Health (NIOSH) Composite Lifting Index (CLI) has been used to quantify stressors for lifting tasks. A chemical exposure can be readily used as an exposure metric or stressor for chemical risk assessment (RA). Defining and quantifying lifting nonchemical stressors and related adverse responses is more difficult. Stressor-response models appropriate for CLI and LBP associations do not easily fit in common chemical RA modeling techniques (e.g., Benchmark Dose methods), so different approaches were tried. Methods: This work used prospective data from 138 manufacturing workers to consider the linkage of the occupational stressor of material lifting to LBP. The final model used a Bayesian random threshold approach to estimate the probability of an increase in LBP as a threshold step function. Results: Using maximal and mean CLI values, a significant increase in the probability of LBP for values above 1.5 was found. Conclusion: A risk of LBP associated with CLI values > 1.5 existed in this worker population. The relevance for other populations requires further study.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.175-179
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• 2015

Rad51, a key factor in the homologous recombination pathway for the DNA double-strand break repair, plays a vital role in genesis of non-small-cell lung cancer (NSCLC). In recent years, more and more studies indicate that high expression of Rad51 is of great relevance to resistance of NSCLC to chemotherapeutic agents and ionizing radiation. However, the underlying molecular mechanisms are poorly understood. In this study, we investigated the role of single Rad51 on cell viability in vitro. Our results show that depletion of endogenous Rad51 is sufficient to inhibit the growth of the A549 lung cancer cell line, by accumulating cells in G1 phase and inducing cell death. We conclude that independent Rad51 expression is critical to the survival of A549 cells and can be an independent prognostic factor in NSCLC patients.

• Journal of the Korean Society of Food Culture
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• v.28 no.5
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• pp.533-538
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• 2013

The side effects, such as belching and headache, after Makgeolli intake are an obstacle to the development of the Makgeolli industry. The side effects of drinking Makgeolli have many causes. The possibility of BA production by incorrect storage conditions cannot be excluded. This study analyzed the BA contents produced in non-sterilized Makgeolli after 5 days storage at 4 and $20^{\circ}C$. BA was not detected in Makgeolli stored at $4^{\circ}C$, but putrescine and tyramine were detected in $20^{\circ}C$. A drinking test was performed to determine the relevance of the BA contents and hangover symptoms. The results revealed no significant difference in the taste score and symptoms score between 4 and $20^{\circ}C$ storage. Therefore, the results suggest that the presence of BA in Makgeolli produced during room temperature storage for 5 days does not induce or strengthen hangover symptoms. On the other hand, the alcohol and BA dose may be insufficient to represent the normal symptoms of a hangover.

• Journal of Life Science
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• v.11 no.3
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• pp.279-283
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• 2001

Amyotrophic lateral sclerosis(ALS) is a progressive neurologic disorder resulting from the degeneration of upper and lower motor neurons, and is inherited in 10% of cases. About 20% of familial ALS, clinically indistinguishable from sporadic ALS, is caused by mutations of Cu/Zn superoxide dismutase on chromosome 21q22.21 inherited as an autosomal dominant trait. We now report a new locus in the non-SOD1 dominantly inherited ALS. We screened a large ALS family with 11 affected individuals and one obligate gene carrier with genome-wide ABI polymorphic markers using the ABI 377 automated system. No evidence of linkage was obtained with the autosomal markers. We next screened this family with X chromosome markers as there was no evidence of male-to-male tran-smission of the disease. Linkage was established with several X chromosome markers with a lod score up to 3.8; almost the maximum possible score in this family. Our finding imply that a gene for the dominant expression of a neuronal degeneration is coded on X chromosome and raise the question of the role of X-linked genes that escape inactivation in this pathogenesis. More importantly, our finding that a gene causing ALS is localized on X-chromosome has direct investigational relevance to sporadic ALS, where epidemiological studies show male gender predominance(1.3:1) and earlier onset in men by 5-10 years.

• Structural Engineering and Mechanics
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• v.39 no.4
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• pp.599-620
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• 2011

The investigation on possible causes of failures related to documented collapses is a complicated issue, primarily due to the scarcity and inadequacy of information available. Although several studies have tried to understand which are the inherent structural deficiencies or circumstances associated to failure of the main structural elements in a reinforced concrete frame, to the authors knowledge a uniform approach for the evaluation building static vulnerability, does not exist yet. This paper investigates, by means of a detailed case study, the potential failure mechanisms of an existing reinforced concrete building. The linear elastic analysis for the three-dimensional building model gives an insight on the working conditions of the structural elements, demonstrating the relevance of a number of structural faults that could sensibly lower the structure's safety margin. Next, the building's bearing capacity is studied by means of parametric nonlinear analysis performed at the element's level. It is seen that, depending on material properties, concrete strength and steel yield stress, the failure hierarchy could be dominated by either brittle or ductile mechanisms.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.2
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• pp.142-148
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• 2010

Purpose: This study was done to determine how a hospital life guidance movie enhanced the understanding of hospital life by elderly in-patients. Method: A non-equivalent control group post-test design was used for the study. The experimental group watched a movie on guidance for hospital life while an in-patient control group read corresponding guidance booklets. The understanding and satisfaction from the respective programs for the two groups were surveyed with a questionnaire. The data were analyzed using SPSS. Results: The group which watched the movie had a better understanding of hospital life than the group which read the booklets. The patients who watched the movie also expressed more satisfaction with their guide program than the patients who only read the booklets. Understanding of hospital life had relevance to satisfaction with the given program. Conclusion: The results of this study suggests that a movie on hospital life provides better guidance which helps the prospective patients understand and adapt better to their hospital life. Therefore, this type of movie is considered to be an effective medium to provide guidance to elderly in-patients.

• BMB Reports
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• v.53 no.1
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• pp.10-19
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• 2020

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood cells. Inflammatory mediators such as cytokines and complements are also linked to AD pathogenesis. Despite increasing evidence supporting the association between abnormal inflammation and AD, no well-established inflammatory biomarkers are currently available for AD. Since many reports have shown that abnormal inflammation precedes the outbreak of the disease, non-invasive and readily available peripheral inflammatory biomarkers should be considered as possible biomarkers for early diagnosis of AD. In this minireview, we introduce the peripheral biomarker candidates related to abnormal inflammation in AD and discuss their possible molecular mechanisms. Furthermore, we also summarize the current state of inflammatory biomarker research in clinical practice and molecular diagnostics. We believe this review will provide new insights into biomarker candidates for the early diagnosis of AD with systemic relevance to inflammation during AD pathogenesis.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.6 no.1
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• pp.81-109
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• 1984

The purpose of this research is (i) to establish the principles particularly appropriate for the arrangement of archival collections is korea, and (ii) to produce a workable model of classification scheme in conformity with the established principles. The archival collections in korea are roughly devided into two groups as follows. (1) The collections of professional institutions of archives such as Korean National Archives. (2) The collections preserved by libraries, museums, and other similar institutions as a secondary collection, and these groups of collections are generally non-systematic collecting. For the arrangement of the former collections, the concept of "respect des fonds" which is universally accepted principies in archives are also applicable. But in case of the arrangement of the latter collections, the above mentioned principles are inappropriate because its collections a re built in separate pieces of documents and records without any relevance to the original function or structure of the corporation. Consequantly it is badly needed to make some devices for the arrangement of these archival collections since the archival collections of korea, in the majority of cases, belong to the latter. The author produced a tentative classification scheme, and adapted the korean traditional form (or type) of documents and records as a cardinal principle of the classification. The scheme is presented at the end of this paper.