• International Journal of Aeronautical and Space Sciences
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• v.18 no.4
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• pp.729-739
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• 2017

The objective of this study was to optimize minimum-energy impulsive spacecraft intercept using genetic algorithms. A mathematical model was established on two-body system based on f and g solution and universal variable to address spacecraft intercept problem for non-coplanar elliptical orbits. This nonlinear problem includes many local optima due to discontinuity and strong nonlinearity. In addition, since it does not provide a closed-form solution, it must be solved using a numerical method. Therefore, the initial guess is that a very sensitive factor is needed to obtain globally optimal values. Genetic algorithms are effective for solving these kinds of optimization problems due to inherent properties of random search algorithms. The main goal of this paper was to find minimum energy solution for orbit transfer problem. The numerical solution using initial values evaluated by the genetic algorithm matched with results of Hohmann transfer. Such optimal solution for unrestricted arbitrary elliptic orbits using universal variables provides flexibility to solve orbit transfer problems.

• Toxicological Research
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• v.22 no.1
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• pp.23-30
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• 2006

Among poly aromatic hydrocarbons, dioxin and PCBs are the most controversial environmental pollutants in our modern life. These pollutants are known as human carcinogens, and liver is the most sensitive target in animal cancer models. Specific aims of the study were focused on the mechanism of carcinogenesis in hepatocytes and the structure-activity relation among these diverse environmental chemicals. Because key mechanisms of dioxin-induced carcinogenesis in human epithelial cell model are the alteration of signal transduction pathway and PKC isoforms, the alteration of the signal transduction pathways and other factors associated with carcinogenesis were studied. Rat hepatocytes cultured under the sandwich protocols were exposed with the various concentration of dioxins and PCBs, and signal transduction pathway, protein kinase C isoforms, oxidant stress, and apoptotic nuclei were evaluated. Since it is important to understand the structure-activity relation among these chemicals to properly assess the carcinogenic potentials, the study analyzed the parameters associated with carcinogenic processes, based on their structural characteristics. In addition, signal transduction pathways and PKC isoforms involved in inhibition of UV-induced apoptosis were also analyzed to elaborate the tumor promotion mechanism of these chemicals. Induction of apoptosis by UV irradiation was optimal at $60\;J/m^2$ in primary hepatocyte in culture. Compared to non coplanar PCBs such as PCB 114 and PCB 153, coplanar PCBs such as PCB 77 and PCB126 showed a stronger inhibition of apoptosis induced by UV irradiation. Production of reactive oxygen species (ROS) was more stimulated by non-coplanar PCBs than coplanar PCBs with the most potent induction of ROS by chlorinated non-coplanar PCB. As compared to the level of induction by PCB126, non-coplanar PCB153 showed a higher increase of intracellular concentrations. Besides the alteration of intracellular calcium concentration, translocation of PKC from cytosolic fraction to membrane fraction was clearly observed upon the exposure of non-coplanar PCB. Taken together, the present study demonstrated that there is a potent structure-activity relationship among PCB congeners and the mechanism of PAH-induced carcinogenesis is structure-specific. The study suggested that more diverse pathways of PAH-induced carcinogenesis should be taken into account beyond the boundary of Ah receptor dogma to assess the health impact of PAH with more accuracy.

• The Journal of Korean Society for Radiation Therapy
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• v.29 no.1
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• pp.57-68
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• 2017

Purpose: The purpose of this study was to compare volumetric modulated arc therapy(VMAT) with fixed-field intensity modulated radiation therapy(IMRT) using non-coplanar beam when the shape of target is irregular and the location is adjacent to organ at risk(OAR). Materials and Methods: The subjects of this study were a total of 6 patients who had radiation therapy for whole scalp(2 patients), partial scalp(2 patients), and whole ventricle(2 patients) by True Beam STX(Varian Medical Systems, USA). VMAT plans consisted of coplanar or non-coplanar arcs which can minimize the volume of OAR included in beamlets. All fixed-field IMRT plans consisted of non-coplanar beams using more than 2 angles of Couch. Results: The VMAT and IMRT plans were compared with regard to the maximum dose of both lens, both optic nerves, optic chiasm, and brain stem and the mean dose of both eyeballs and hippocampus. VMAT plans showed higher dose than ncIMRT plans at more than 6 of all OARs in every patient, and the ratio was from 1.1 times to 8.2 times. In case of total scalp and partial scalp, the volume of brain which received more than 20 Gy in the VMAT plans was 2 times larger than the volume in the ncIMRT plans. In case of whole ventricle, there was no significant difference. Target coverage was satisfied in both plans($PTV_{100%}=95%$). The maximum dose in target volume and required monitor unit(MU) of ncIMRT were higher than them of VMAT plans. Conclusion: Even though ncIMRT is less efficient than VMAT with regard to required MU and treatment time, the dose to OARs is much lower than VMAT and PTV Coverage is similar with VMAT. If the shape of target is irregular and location is adjacent to OAR, comparison VMAT plan with ncIMRT plan deserves to be considered.

• Journal of the Korean Society of Radiology
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• v.18 no.3
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• pp.249-256
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• 2024

The study aimed to evaluate the efficacy of treatment plans using full Arc and Partial Arc Coplanar volumetric modulated arc therapy and Non-Coplanar volumetric modulated arc therapy to minimize radiation treatment side effects, such as pneumonia, and protect normal organs in esophageal cancer radiotherapy. 30 patients who underwent Concurrent Chemoradiotherapy for esophageal cancer were included. Compared planning target volume, lung, heart, spinal cord and total monitor units among three treatment plans: fVMAT(2 Full Arc), pVMAT(4 Partial Arc), and ncVMAT(2 Partial Arc + 2 Non-Coplanar Arc). All plans met the PTV criteria, showing uniform distribution. The average dose to the heart was 5.8 Gy for fVMAT, 6.97 Gy for pVMAT, and 7.6 Gy for ncVMAT, with the lowest value in fVMAT, which was statistically significant. However, the average lung dose was 9.01 Gy for fVMAT, 7.71 Gy for pVMAT, and 7.12 Gy for ncVMAT, with V_5Gy(%) values of 52.22%, 38.61%, 36.35% and V_10Gy(%) values of 37.8%, 27.33%, 24.15% respectively. ncVMAT showed the lowest values, while fVMAT had the highest, with statistical significance. In conclusion, ncVMAT effectively reduces lung radiation exposure in esophageal cancer radiotherapy, potentially reducing the incidence of side effects such as pneumonia. However, considering factors like setup accuracy and treatment time, applying an appropriate treatment plan may lead to better outcomes.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.03a
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• pp.140-140
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• 2003

Ti:LiNbO$_3$ 광 도파로를 이용한 광 변조기의 마이크로파 손실을 감소시키고 RF와 광파의 속도정합의 조건하에서 초고속 광변조의 제작을 위해서는 두꺼운 TW(travelling wave) 전극이 필수적이다 또한, 두꺼운 Au 전극이 우수한 RF 특성을 갖기 위해서는 도금된 Au 전극이 고순도의 작은 grain size를 갖는 도금 층을 제조하여야 하며, 도금 후 Au 층의 뒤틀림 현상이 작아야 한다. 따라서, 본 연구에서는 LiNbO$_3$ 기판 위에 30nm Ni-Cr과 50nm의 Au의 기저 막을 올렸으며 감광제를 이용한 photo-lithography 공정으로 CPW(coplanar waveguide) 구조의 패턴을 약 13$\mu\textrm{m}$의 두께로 형성 한 후 non-cyanidic 액을 이용하여 전류밀도 0.02 - 0.06 mA, bubble 및 non-bubble flow를 조건으로 하여 도금된 Au 전극의 특성을 관찰하였다.

• Journal of Yeungnam Medical Science
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• v.36 no.1
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• pp.36-42
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• 2019

Background: The purpose of this study was to evaluate the efficacy and feasibility of non- coplanar whole brain radiotherapy (NC-WBRT) for parotid sparing. Methods: Fifteen cases, previously treated with WBRT were selected. NC-WBRT plans were generated. The beam arrangement for the non-coplanar plans consisted of superior anterior, right, and left beams. After generation of the non-coplanar plans a field-in-field technique was applied to the bilateral parallel opposed beams in order to reduce maximum dose and increase dose homogeneity. The NC-WBRT plans were subsequently compared with the previously generated bilateral WBRT (B-WBRT) plans. A field-in-field technique was also used with the B-WBRT plans according to our departmental protocol. As per our institutional practice a total dose of 30 Gy in 10 fractions of WBRT was administered 5 days a week. Results: The mean dose to the parotid gland for the two different plans were 16.2 Gy with B-WBRT and 13.7 Gy with NC-WBRT (p<0.05). In the NC-WBRT plan, the V5Gy, V10Gy, V15Gy, V20Gy, and V25Gy of the parotid were significantly lower (p<0.05) than those of the B-WBRT plan. The $D_{max}$ of the lens was also lower by 10% with NC-WBRT. Conclusion: The use of NC-WBRT plans could be a simple and effective method to reduce irradiated volumes and improve the dose-volume parameters of the parotid gland.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.11
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• pp.902-910
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• 2018

This paper deals with spacecraft intercept problem on non-coplanar elliptical obit considering J2 perturbation. This disturbance addressed in this work is a major factor changing the trajectory of a spacecraft orbiting the Earth. To resolve this issue, a real-time intercept method is proposed. This method is based on the optimization problem which consist of the equation of motion considering spherical earth and impulse, and the optimal solution numerically obtained is set as the direction of the thrust of the interceptor. The position error is resolved by iteratively solving the optimization problem and modifying the direction of thrust of interceptor. The proposed method in this paper is verified by using various numerical examples.

• Journal of The Korean Radiological Technologist Association
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• v.25 no.1
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• pp.63.2-64
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• 1999

• The Journal of Korean Society for Radiation Therapy
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• v.11 no.1
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• pp.115-119
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• 1999

• Proceedings of the IEEK Conference
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• 1999.06a
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• pp.639-642
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• 1999

There exist geometrically invariant relations in single-view images under a specific geometrical structure. This invariance may be utilized for 3D object recognition. Two types of invariants are compared in terms of the robustness to the variation of the feature points. Deviation of the invariant relations are measured by adding random noise to the feature point location. Zhu’s invariant requires six points on adjacent planes having two sets of four coplanar points, whereas the Kaist method requires four coplanar points and two non-coplanar points. Experimental results show that the latter method has the advantage in choosing feature points while suffering from weak robustness to the noise.