• Korean Journal of Environmental Agriculture
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• v.5 no.1
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• pp.67-72
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• 1986

The nitrofen adsorption on several clay minerals was determined by sludge method to know the effect of clay minerals on the nitrofen activity. The bioassay was conducted with wheat seedlings to study the influence of the adsorbed nitrofen on the nitrofen activity. It is apparant that a four hours shaking was enough to reach the equilibrium concentration. The more the amount of sample, the more nitrofen was adsorbed by clay minerals, whereas the more nitrofen adsorption per unit gram of sample was observed at a 200 mg addition than a 400 mg in the same nitrofen solution. A little amount of nitrofen was adsorbed on Ca-zeolite or Ca-kaolinte, and much more nitrofen was adsorbed on Na-montmorillonite than the other clay minerals in the experiment. Little effect of pH on the adsorption would be attributed to physical adsorption between nitrofen molecule and clay surface. Na-and Ca-montmorillonite were the most effective in reducing the phytotoxicity of nitrofen to the growth of wheat seedlings among clay minerals which nitrofen was added to the growth media.

• Korean journal of applied entomology
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• v.10 no.1
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• pp.31-38
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• 1971

Tolerance test in plastic vat, pot and fold tests were carried out to investigate the selective herbicides for soybean culture in sandy loam. The soybean plants showed great tolerance against herbicides such as Tri-allate (Avadex-BW), Alachlor (Lasso), Butachlor (Machete), Propachlor (Ramrod), Nitrofen (TOK), MO, HE-314, Nitrofen/Dinoseb(TOK/DNBP), and Chlo.oxu.on (Tenoran), and the growth was normal even when each was treated with the herbicides up to 2ft3 times of the recommended concentrations. Soybean plants showed a slight tolerance against Prometryne (Gesagard), Propazine (Gegamil), Diuron (Karmex), Metabromuron (Patoran), Linuron (Lorox) and Swep when each was treated with herbicides up to 1-2 times of the recommended concentrations. Great injury or withering was noticed due to the high sensitivity of soybean to Simazine (CAT) and to Floumetron (Cotoran). In pot and field experiments with herbicides such as Butachlor (Machete), Alachlor (Lasso), Nitrofen (TOK), Kerb, Nitrofen/Dinoseb (TOK/DNBP), Swep, Linuron (Lorox), Simazine (CAT) and PCP, the following results were obtained: Great injuries were noticed with Simazine (CAT). Also, Linuron (Lorox) and Kerb showed a slight injury at early growth stage of soybean, Nitrofen (TOK) , Nitrofen/Dinoseb (TOK/DNEP), Alachlo. (Lasso), Butachlo. (Machete) and Swep had high selectivities for soybean and no injury was noticed. With respect to herbicidal effects there was a greatly significant difference between treated plots and non-treated plots with the exception of Simaaine (CAT) plot in field test. E. crusgalli and C. sanguinalis were tolerant against Simazine(CAT) and Linuron(Lorox). Cyperus and E. annuus were tolerant against Kerb. Great herbicidal effects on grasses were observed in Alachlor (Lasso) and Butachlor (Machete) plots. Among broad-leaf weeds, P. hydropiper and C. album were tolerant against Butachlor (Machete) and Alachlor (Lasso). When soybean was treated with the herbicides such as Alachlor (Lasso) (ai. 150g/10a), Butachlor (Machete) (ai. 300g/10a), Nitrofen (TOK) (ai. 250g/10a), Linuron (Lorox) (ai. 75g/10a) once after seeding, no additional wording was required till harvest.

• Journal of Chest Surgery
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• v.20 no.4
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• pp.659-672
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• 1987

Nitrofen [2,4-dichlorophenyl-P-nitrophenyl ether] is a diphenyl ether herbicide used for pre and post-emergent control of broad leafed weeds. This chemical was known to induce a variety of congenital cardiovascular anomalies with diaphragmatic hernia and hydronephrosis in the rate fetuses. The present study was conducted to produce congenital cardiovascular anomalies in the rat fetuses by oral nitrofen administration at the indicated doses and days of gestation, and to find the characteristics of nitrofen-induced cardiovascular anomalies. All the observed fetuses were removed from the pregnant Sprague-Dawley rats sacrificed on the twenty-first day of gestation. They were preserved in 10 per cent formalin and dissection for examination were carried out under a dissecting microscope using forceps and scissors. Following results and conclusion were based on dissecting microscopic findings on 482 offsprings. 1. The eleventh day of gestation was the most sensitive day for nitrofen induction of congenital cardiovascular anomalies in the rat. This incidence was dose-related in rats exposed on the eleventh day of gestation. 2. Ventricular septal defect was the most common single anomaly that represented more than half of the total cardiovascular anomalies, followed by aortic arch anomalies and tetralogy of Fallot. 3. Cardiac anomalies derived from infundibular maldevelopment such as tetralogy of Fallot and pulmonary atresia with ventricular septal defect were only observed in the eleventh gestation day treated group. 4. Aortic arch anomalies were found in high frequency and the great majority were characteristically anomalous right subclavian artery with left aortic arch. Key words; nitrofen, congenital cardiovascular anomalies.

• Korean Journal of Weed Science
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• v.4 no.2
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• pp.154-162
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• 1984

The persistence of butachlor and nitrofen in different soil conditions applied organic matter, lime, and other pesticides was studied under submerged and field moisture capacity. Degradation of the herbicides in soil was significantly retarded by autoclaving the soil and half-life of nitrofen was much longer than that of butachlor under this condition. Submerging the soil enhanced degradation of the herbicides, in particular that of nitrofen. On the other hand, half-life of nitrofen under field moisture capacity was twice longer than that of butachlor. Increased amendment of rice straw to the soil shortened the half-life of nitrofen under submerged soil, however it prolonged that of butachlor when the amendment was exceeded 1000kg/10a level. Liming the soil stimulated herbicide decomposition in the soil, which appears to be pH independent. Butachlor degradation in submerged soil was slightly stimulated by simultaneous application of fungicides and insecticides, but nitrofen persistence was not influenced.

• Applied Biological Chemistry
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• v.18 no.1
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• pp.30-41
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• 1975

A substituted diphenyl ether herbicide(MC-4379) was studied on the decomposition by some environmental factors; sunlight, microorganisms, and the crude enzyme in rice plant extract. All the decomposition products were confirmed by means of TLC, GLC, and IR. The parent compound and the decomposition products were put to the test for the effect on the growth of some plants. The results obtained are summarized as follows: 1. Photolysis Amino-MC-4379, 2,4-dichloro-3'-carboxyl-4'-nitrodiphenyl ether, Nitrofen, 2,4-dichloro-3'-carboxyl-4'-amino-diphenyl ether, amino-Nitrofen, 3-carboxymethyl-4-nitrophenol, p-nitrophenol, p-aminophenol, etc. were confirmed as photoproducts, in addition to a relatively small amount of an unknown compound. It was confirmed that the solution-phase photolysis of MC-4379 was accelerated much more by the aid of a photosensitizer benzophenone. 2. Degradation by the crude extract of germinating rice seeds Nitrofen was confirmed as a major degradation product, in addition to a relatively small amount of and unknown compound. Most of the parent compound remained unchanged. 3. Degradation by microorganisms Nitrofen and amino-MC-4379 were confirmed as the major products. in addition to a small amount of an unknown compound. 4. The germinating rice seeds and soybean were grown in the 1,000 ppm emulsions of some chemicals, respectively. The effect on rice plant growth was in the inhibitory order of p-nitrophenol > C-6989> Nitrofen > amino-Nitrofen > MC-4379. The effect on soybean was in the order of Nitrofen > amino-Nitrofen > MC-4379. Two weeds, Amantus blitum and Setaria viridis were grown in the 500 ppm emulsions containing the compounds, respectively. After incubation for 3 days, it was observed that all the shoots had been dead.

• Toxicological Research
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• v.2 no.1
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• pp.37-50
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• 1986

This paper describes the effects of nitrofen (Hi-TOK), a herbicide on the fetuses of rats. The results were observed as follows: The internal soft tissue anomalies were classified as diaphragmatic hernia, cardiac malformation (T.G.V., V.S.D., S.V.), dilatation of ventricle in brain, dilatation of renal pelvis, underdevelopment of fetal lung, shortening of cortex length and increasing of immatured glomeruli counts in the fetal kidney. The heart and diaphragm appear to be the target organs.

• Applied Biological Chemistry
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• v.24 no.2
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• pp.112-119
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• 1981

The persistence of preemergence herbicides, butachlor [2-chloro-2,6-diethyl-N(butoxymethyl) acetanilide] and nitrofen(2,4-dichlorophenyl-4-nitrophenyl ether), at 10 ppm level in different soil conditions amended with organic matter and lime was studied under flooded and field moisture capacity. The microbial breakdown played a major role in the dissipation of the herbicides in soil. Nitrofen degradation in flooded soil was greatly accelerated, while it was slowed down in field moisture capacity as compared with butachlor. Increased amendment of rice straw to the soil shortened the half-life of butachlor under flooded condition, however it prolonged that of butachlor when the amendment was exceeded over 1% on dry weight basis. Liming the soil stimulated decomposition of the herbicides in the soil systems, which ap pears to be pH independent.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.26 no.4
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• pp.287-292
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• 1981

The field studies were carried out in paddy field over a four year period in order to find out the effects of butachlor, nitrofen, oxadiazon or CG 102, benthiocarb-S, and bentazon applied successively to the same paddy field for four years on weed succession and rice yields under different fertilized conditions including compost, chemical fertilizer and straw application. Total dry weight of weeds was steadily increased yearly over 4 year period regardless of fertilized conditions, and significantly higher increase of weed dry weight was observed on non-fertilized and compost plots. The most dominant weed species was Scirpus hotarui, and Potamogeton distinctus, Eleocharis kuroguwai and Cyperus serotinus were predominated on compost plot, E. kuroguwai and E. aclularis on non-fertilized plot, E. kuroguwai, C. serotinus, and Monochoria vaginalis on chemical fertifizer plot, and C. serotinus on straw plot. When the same herbicides were used continuously on the same plots, weed control effect was decreased and thus weed population was greatly increased particularly on butachlor and nitrofen treated plots. P. distinctus, E. kuroguwai, and C. serotinus were predominated on butachlor treated plot, P. distinctus and C. serotinus on nitrofen treated plot, C. serotinus on benthiocarb-S treated plot, C. serotinus and P. distinctus on oxadiazon or CG 102 treated plot and P. distinctus on bentazon treated plot. Annual weeds were slightly increased by repeated annual application of oxadiazon or CG 102 and benthiocarb-S, whereas perennial weeds were predominated by successive application of butachlor, nitrofen. and bentazon for 4 years. Yield reduction of rice became prominent by successive application of same herbicides. particularly butachlor and nitrafen. This results suggested that successive annual application of same herbicides should be limited and herbicide combination or herbicide rotation should be applied to control the remaining weed species.

• Korean Journal of Weed Science
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• v.3 no.1
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• pp.69-74
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• 1983

The behaviour of mixtures of herbicides was determined to obtain the basic informations about effective herbicide use, enhancing herbicidal efficacy and reducing the chemical cost. Fourteen herbicides with 91 mixed combinations were evaluated by Limpel et al method at the Echinochloa crus galli Beauv-Monochuria vaginalis Presl.-Scirpus hotarui Ohwi (importance values of these weeds were 63%, 16% and 10%, respectively) community type. Thirty eight mixed combinations showed the antagonistic response. Among these 14 mixed combinations including chlormethoxynil + naproanilide mixture were greater than 11% in antagonistic effect. On the other hand, 40 mixed combinations including chlormethoxynil + SW751 mixture showed additive response (${\pm}2%$). For synergistic response, 13 mixed combinations were belonged to this group. Particularly, 3 mixed combinations, chlormethoxynil + butachlor, chlormethoxynil + bifenox and nitrofen + ACN/MCPB/nitrofen mixtures were greater than 11% in synergistic effects. The mixture of thiobencarb + oxyfluorfen was analyzed by isobole technique. This mixture showed the synergistic response and the interaction index was approximately 2. The most optimum mixtur for inducing 90%n weed suppression was 0.012 kg ai/ha for oxyfluorfen and 0.45 kg ai/ha for thiobencarb.

• Korean journal of applied entomology
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• v.16 no.3 s.32
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• pp.149-154
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• 1977

Effect of Simazine(2-chloro-4,6-bis (ethylamino)-s-triazine), Nitrofen (2, 4-dichloro-4' -nitrodi­phenylether), Propanil (:3, 4-dichloropropionanilide), and Butachlor (2-chloro-2, 6-diethyl N-(buthoxy­menthyl) acetanilide on urea hydrolysis and subsequent nitrification was investigated in an upland soil incubated at $20\pm1^{\circ}C$. 1. All the herbicides tested had no effect on the hydrolysis of urea to ammonia at the recommended rates. Butachlor, at ten and fifty times the recommended rate, and Nitrofen, at fifty times the recommeded rate, depressed urea hydrolysis, resulting in reduction of ammonia. But the depressive effects were temporary, disappearing soon. Simazine and Propanil had no detrimental effect on urea decomposition at all the treated rates. 2. Also, all the chemicals tested had no effect on the nitrification process at the recommended rates. At higher concentrations of ten and fifty times the recommended rate Butachlor and Nitrofen inhibited the oxidation of nitrite, and propanil long inhibited the oxidation of ammonium to nitrite, but was inactive against nitrite oxidizer. These inhibitive effects of the chemicals, however, disappeared in the later period of incubation. Simazine had no effect on the nitrification process at all the treated rates. 3. The trend of change in soil pH of both the treated and untreated plots well reflected the change of soil nitrogen forms during incubation. No direct effect of the chemicals on soil pH was obserbed.