• 대한방사성의약품학회지
• /
• 제3권2호
• /
• pp.113-115
• /
• 2017

Since the nitrile group is commonly found in natural products and bioactive molecules, many scientists' interest has been focused on the usage of nitrile group. Novel reactions for $^{11}C-labelling$ using nitrile group have been developed, and novel preparation protocols of biomolecules labeled with $^{11}C$ have been studied. In this highlight review, recent researches for the novel labeling reactions using nitrile group are illustrated.

• 한국응용과학기술학회지
• /
• 제31권2호
• /
• pp.225-230
• /
• 2014

Several nitrile-functionalized ionic liquids have been prepared and characterized. An attempt was made to systematically characterize nitrile-functionalized ionic liquids on the basis of a few kinds of cations and anions. The detailed comparison of the differences in physicical characteristics such as UV-Vis spectroscopy, thermal stability, viscosity, solubility property, and electrochemical property before and after incorporation of a nitrile group were studied. The results showed that the incorporation of a nitrile group to cations could result in remarkable changes in these properties.

• Fibers and Polymers
• /
• 제1권2호
• /
• pp.111-115
• /
• 2000

The effects of nitrile group substitution onto aromatic polyamide backbone on the gas permeability and permselectivity of the polymers are examined. The gas permeability of aromatic polyamides increase with increasing the content of nitrile group substitution, whereas the permselectivity decreases with increasing the nitrile group contents. The effects of chain linrearity on the permeability and permselectivity are also examined. The non-linearity of the polymers increases the permeability. These behaviors are interpreted in terms of chain packing and crystallinity of the aromatic polyamides.

• Archives of Pharmacal Research
• /
• 제11권4호
• /
• pp.285-291
• /
• 1988

2-mercaptoethanol, thioglycolic acid, glutathione, 3-mercapto-1, 2-propanediol and 3-mercapto-2-butanol showed catalytic activities on the hydrolysis of $\alpha$-amino-phenylacetonitrile to phenylglycineamide at the rate of 12.19 $\times$ $10^{-2}$, 8.03 $\times$ $10^[-2}$, 6.83 $\times$ $10^{-2}$, 8.60 $\times$ $10^{-2}$ and 6.04 $\times$ $10^{-2}$ mM $min^{-1}$, respectively. hte hydrolysis rate was faster in buffer than in water. The hydrolysis of the nitrile compound to phenylglycine was limited.

• Bulletin of the Korean Chemical Society
• /
• 제31권8호
• /
• pp.2351-2356
• /
• 2010

Various dienamide derivatives were synthesized in reasonable yields from benzonitriles having an amide moiety at the ortho-position, via the sequential (i) In-mediated allylation of nitrile moiety to form an imine intermediate, (ii) intramolecular quenching of an acyl group by the imine intermediate, and (iii) a proton transfer to dienamide.

• 한국재료학회지
• /
• 제9권4호
• /
• pp.373-377
• /
• 1999

The cure mechanicsm and cure kinetics of diglycidyl ether of bisphenol A(DGEBA)/4,4'-methylene dianiline(MDA)/nitrile(MN, SN, GN) systems were studied by FT-IR and DSC to develop new applications in the biomedical polymer fields. The network structure of the DGEBA/MDA system was changed to the chain-extended network structure by the addition of nitriles. The reactions contributed to the chain extension were the primary amine-nitrile and hydroxyl-nitrile reactions. The chain-extended network structure could be indirectly proved by the decrement of T\ulcorner and the increment of impact strength with the increasing nitrile content. The cure rate of DGEBA/MDA/nitrile system was lower than that of DGEBA/MDA system due to the disturbance of nitrile group in the reaction of primary amine and epoxide groups.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2000년도 제1회 학술대회 논문집
• /
• pp.191-192
• /
• 2000

New copolyimides containing nitrile side group were synthesized from copolymerization of pyromellitic dianhydride, m-phenylene diamine and 3,5-diaminobenzonitrile and subsequent thermal imidization of the resulting poly(amic acid). Crystallinity, glass transition temperature and initial decomposition temperature of copolyimides were almost identical to those of homo polyimide prepared from PMDA and m-PDA. Change of pretilt angle induced by the orientation layer of resulting copolyimide was investigated by using a nitrile-containg nematic liquid crystal cell after rubbing. As the content of polar nitrile group was increased in the copolymer, pretilt angle was increased from $3.65^{\circ}$ to $6.49^{\circ}$. The mechanism of this was speculated as the dipolar interaction between the liquid crystal and nitrile groups in copolyimide.

• 대한화학회지
• /
• 제38권3호
• /
• pp.179-185
• /
• 1994

니트릴기의 라만 신축진동 파수는 용매 변화에 의해 영향을 받고 또한, 동일한 용매에서 농도변화에 의해 영향을 받았다. 아세토니트릴의 경우에는 니트릴기 신축진동 파수들이 다양한 용매들에서 2247.3~2254.9 $ cm^{-1}영역에 나타났다. 반면에 벤조니트릴에서는 2226.1∼2230.3 cm-1영역에서 나타났다.아세토니트릴에서는 물의 첨가로, νC≡N은 메틸프로톤들과 물 사이에서의 더 많은 수소결합으로 순수한 아세토니트릴의 2250.1cm^{-1}로부터 90% 물의 2257.7 cm^{-1}까지 높은 파수쪽으로 이동하였다. 니트릴기에 대한 νC≡N파수는 혼합용매 (CHCl_3/CCl_4)의$ 몰비가 증가함에 따라 용매 유발효과에 의해 높은 파수쪽으로 이동하였다.

• 한국재료학회지
• /
• 제3권3호
• /
• pp.272-275
• /
• 1993

To modify the toughness of epoxy for matrix, succinonitrile(SN) was introduced to diglycidy1 ether of bisphenol-A (DGEBA)/methylene dianiline(MDA)system. Cure reaction mdchanism of the DGEBA/MDA/SN system was strdied through Fourier transform infrared(FT-IR) spectrometry. As a result, the reaction of nitrile group of SN with secondary amine and with hydroxy1 group prevented the reaction of hydroxy1 group with epoxide group from crossoinding. Nitrile groups produced amide group by reacting with hydroxy1 groups and made a lowered crosslind density in chain networks.

• Archives of Pharmacal Research
• /
• 제9권1호
• /
• pp.45-47
• /
• 1986

Phenylglycine was obtained as the sole metabolite when .alpha.-aminophenylacetonitrile was ted to the culture broth of Aspergillus furmigatus furmigatus. The isolated phenylglycine showed L-configuration with 80% optical purity. Examination of the hydrolysis of the substrate to phenylglycine with cell free extracts, and the supernatant fraction and the particulate fraction both of which were obtained after ultracentrifugation of the cell free extract at 100,000g, indicated that the nitrile group hydrolyzing enzymes, nitrilase existed not only in cytoplasm, but in microsome fractions.