• Toxicological Research
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• v.30 no.3
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• pp.149-157
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• 2014

Smoking is one of the most serious but preventable causes of cardiovascular disease (CVD). Key aspects of pathological process associated with smoking include endothelial dysfunction, a prothrombotic state, inflammation, altered lipid metabolism, and hypoxia. Multiple molecular events are involved in smoking-induced CVD. However, the dysregulations of reactive oxygen species (ROS) generation and metabolism mainly contribute to the development of diverse CVDs, and NADPH oxidase (NOX) has been established as a source of ROS responsible for the pathogenesis of CVD. NOX activation and resultant ROS production by cigarette smoke (CS) treatment have been widely observed in isolated blood vessels and cultured vascular cells, including endothelial and smooth muscle cells. NOX-mediated oxidative stress has also been demonstrated in animal studies. Of the various NOX isoforms, NOX2 has been reported to mediate ROS generation by CS, but other isoforms were not tested thoroughly. Of the many CS constituents, nicotine, methyl vinyl ketone, and ${\alpha}$,${\beta}$-unsaturated aldehydes, such as, acrolein and crotonaldehyde, appear to be primarily responsible for NOX-mediated cytotoxicity, but additional validation will be needed. Human epidemiological studies have reported relationships between polymorphisms in the CYBA gene encoding p22phox, a catalytic subunit of NOX and susceptibility to smoking-related CVDs. In particular, G allele carriers of A640G and $-930^{A/G}$ polymorphisms were found to be vulnerable to smoking-induced cardiovascular toxicity, but results for C242T studies are conflicting. On the whole, evidence implicates the etiological role of NOX in smoking-induced CVD, but the clinical relevance of NOX activation by smoking and its contribution to CVD require further validation in human studies. A detailed understanding of the role of NOX would be helpful to assess the risk of smoking to human health, to define high-risk subgroups, and to develop strategies to prevent or treat smoking-induced CVD.

• Journal of Forest and Environmental Science
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• v.39 no.4
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• pp.225-234
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• 2023

This study verified the effect of a combined forest/thermal therapy (FT/TT) program on participants with depressive symptoms and smoking or alcohol dependence. The participants included 20 people in the experimental group and 18 people in the control group. The experimental group participated in the FT/TT program for 2 nights and 3 days at the National Center for Forest Healing, in Hoengseong (National Hoengseong Supchewon), and a charcoal kiln operated by the Gangwon Charcoal Farming Association. The control group carried out their daily life for the same period. Psychological, physiological, and biochemical tests were conducted to determine the effect of the program. The results showed that there were significant improvements in stress, anxiety, depression, sleep quality, sleep satisfaction, and IL-6 levels. However, no significant difference was found in the cortisol, serotonin and melatonin levels between the experimental and control groups. Thus, the FT/TT therapy had psychological and biochemical effects on individuals with depression and nicotine or alcohol dependency. Further studies should be conducted to verify the effect of forest healing in various conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4575-4581
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• 2014

Turkey protects its entire population of 75 million people with all the MPOWER measures at the highest level. The aim of this study is to make a comparison of smoking and addiction data obtained from Sakarya University students in 2005-6 and 2012-13. A total of 4,200 (2,500 and 1,700 for each academic year) students at Sakarya University in Sakarya, Turkey, were randomly selected for sampling purposes. The selected participants represented Sakarya University students. Data were collected using a pretested anonymous and confidential, self-completed questionnaire which took 15-20 minutes to complete and Fagerstrom Test for nicotine dependence. Chi-squared, Spearman correlation, and binary logistic regression tests were used to define associations, if any. The level of significance was kept at alpha=0.05. Smoking prevalance dropped by 8.5% (from 26.9% to 18.5%). Male gender, older age, high family smoking index, low self-rated school success, and high peer smoker proportion were common variables that have correlation with smoking status. In the binary logistic regression test the highest contributor to "being a smoker" was found to be the rate of peer smokers. Having all friends smoking puts the student a a 47.5 and 58.0 times higher risk for smoking for males and females, respectively. Our results suggest an admirable diminution of smoking prevalance among Sakarya University students, which can be attributed to MPOWER protection.

• Journal of dental hygiene science
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• v.21 no.3
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• pp.133-139
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• 2021

Background: Smoking in adolescence leads to an intensified addiction to nicotine when physical and mental growth has not yet been completed. With the advent of e-cigarettes, the rate of e-cigarette use among Korean adolescents has been steadily increasing. To date, studies on e-cigarettes and oral health, especially on the relationship between smoking styles and oral health in adolescents, are limited. Therefore, this study aimed to identify the risk factors for oral health problems caused by the repeated use of conventional cigarettes and e-cigarettes. Methods: This explanatory research study compared the adolescents' experiences of periodontal disease symptoms according to smoking type through a secondary analysis of the original data from the 15th Adolescent Health Behavior Survey (2019). Cross-analysis was performed to compare the smoking patterns according to the adolescents' general characteristics. Finally, a binary logistic regression analysis was performed to determine how smoking characteristics affect the adolescents' experience of periodontal disease symptoms. Results: In terms of patients' general characteristics, significant differences were observed in sex, school level, grades, household economic status, type of residence, and father's education level between adolescents who smoked conventional cigarettes alone and those who smoked both conventional cigarettes and e-cigarettes (p<0.05). After checking the factors affecting the smoking pattern and the experience of periodontal disease symptoms in adolescents, it was found that the duplicate smoking group was more likely to experience periodontal disease symptoms (odds ratio, 1.20) than the group that smoked conventional cigarettes alone (p<0.05). Conclusion: Duplicate smokers experienced more symptoms of periodontal disease than those who smoked cigarettes alone. Based on the findings of this study, smoking cessation counseling according to the smoking type and differentiated education for oral health promotion should be provided.

• Journal of Environmental Health Sciences
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• v.29 no.3
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• pp.43-49
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• 2003

ETS concentrations in the PC game rooms and factors affecting ETS concentrations were measured. Nicotine, 3-EP, respirable dust and UVPM were used as tracers for ETS. ETS concentrations are 2-3 times higher than those of other results. The concentration of ETS at the commercial district was higher than that of the residential district. The correlations between these tracers and SD/ ACH, a factor affecting to ETS concentration, were calculated. The correlation between 3-ethenylpyridine among tracers and SD/ACH was highest. The correlation between respirable dust and SD/ ACH was lowest. It was difficult to recommend respirable dust as a tracer of ETS.

• The Korean Nurse
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• v.36 no.5
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• pp.91-100
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• 1998

This study aims to investigate smoking patterns in high school student and to give student smoker effective information. The sample of 250 male highschool students out of two different schools in Tae-Jon was questioned from July 10th to 15th. 1995. In analyzing these date. the statistics shows the realities by means of number of students. The results are summarized into 17 items as follows. Regarding the level of smoking. 140 students out of 250 admit that they have ever smoked. 52.1% of smoking students say that the motivation of beginning smoking is mainly curiosity. The survey shows that 22.9% of smoking students feel very good when smoking. It also shows that 30.0% of smoking students began smoking in the first grade of high school. With regard to the volume of smoking per day. 41.4% of smoking students smoke variably. 42.1% drink when smoking. 15.0% spend more than W 70.000 a month. About the question who knows the fact of their smoking. 51.5% answer that their friends know the fact of their smoking. In regard to the resaltionship between smoking and school per-formance. 18.2% of non smoking students make poor grades as compared with 40% of smoking students. 9.3% of smoking students say that they are satisfied with the school life. but 35.7% of them are not satisfied. Regarding the attitude to smoking teachers. 35% of smoking students state that they are affected by them. 69.3% of smoking students say that they will stop smoking. while the remaining 30.7% say that they will keep smoking. The reason of 63.9% to stop smoking is that smoking is bad for the health. The reason of 46. 5% to keep smoking is the acquired habit of smoking. 97.2% know the fact that the major element of cigarettes is nicotine and it is very harmful to the health. 40.8% recognize the harmful effect of smoking by TV and radio programs. 97.2% know that smoking could cause lung cancer. From the above results. I propose as follows We should make specific plan to keep smoking by simple curiosity from being developed into habitual smoking. We should teach them how harmful smoking is and make them stop smoking by themselves. It is very essential for family members and teachers to give continuous interest since childhood. As the teacher affect the students very much, they should give up smoking first. The incidence of smoking should be identified in each of the middle and high schools. smoking prohibition programs relevant to each school should be developed and implemented. The local community should ban cigarette vending machines. Cigarettes should not be sold to adolescents. By setting every place where adolescents gather including schools nonsmoking area. we should decrease their impulse to smoke. then smoking opportunities. and harmful effects to them caused by passive smoking.

• Tuberculosis and Respiratory Diseases
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• v.62 no.3
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• pp.197-202
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• 2007

Background: Cigarette smoking is an important risk factor for chronic bronchitis and COPD. Airway epithelial cells exposed to cigarette smoke components such as nicotine, cotinine and benzopyrene can generate reactive oxygen species (ROS) and be subject to oxidative stress. This oxidative stress can induce the inflammatory response in the lung by the oxidant itself or by the release of proinflammatory cytokines. It has been reported that nicotine stimulates ROS, which are associated with NF-${\kappa}B$. Methods: Beas2B cells were treated with nicotine, cotinine and benzopyrene. RT PCR was used to measure the expression of several antioxidant factors using the total RNA from the Beas2B cells. The level of superoxide dismutase(CuZnSOD), thioredoxin, glutathione reductase expression was examined. Results: 0.5 to 4 hours after the benzopyrene, nicotine and cotinine theatments, the level of thioredoxin and glutathione reductase expression decreased. Longer exposure to these compounds for 24 to 72 hours inhibited the expression of most of these antioxidant factors. Conclusion: During exposure to smoke compounds, thioredoxin and glutathione reductase are the key antioxidant factors induced sensitively between 0.5 and 4 hours but the levels these antioxidants decrease between 24 hour and 72hours.

• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.119-124
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• 1999

This study was done to examine whether cigarette smoking improved smooth pursuit eye movement(SPEM) abnormalities in chronic schizophrenic inpatients. Fifteen schizophrenic and twelve alcoholic subjects abstained from their usual cigarette smoking for a minimum of nine hours and their baseline performances during the constant velocity smooth pursuit tasks were assessed. Then, the subjects smoked as much as they desired in a 10 minutes period and were retested immediately after smoking and 15 minutes after smoking. Electrooculographic recordings during the eye movements were converted and saved as digitized files. Power spectral density curves and natural logarithm value of signal/noise(Ln S/N) ratios were computed from them. In the schizophrenic patients, Ln S/N ratios increased significantly immediately after smoking compared to baseline. But, Ln S/N ratios showed no statistically significant changes after 15 minutes compared to baseline. In alcoholic subjects, Ln S/N ratios showed no statistically significant changes immediately after smoking and after 15 minutes compared to baseline. In conclusion, SPEM was improved in schizophrenic patients immediately after smoking and we hypothesized that nicotinic receptor dysfunction maybe a candidate mechanism for smooth pursuit eye movement abnormalities in schizophrenia.

• Journal of Korean Academy of Nursing
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• v.35 no.7
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• pp.1285-1294
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• 2005

Purpose: This study was done to evaluate the predictive value of aspects of the Transtheoretical model (TTM) of behavior change as applied to smoking cessation in a rural population. Method: A convenience sample was recruited from a public health center in a community. A total of 484 participants were recruited, including 319 smokers, 116 ex-smokers and 49 non-smokers. A cross-sectional and descriptive design was used in this study. Data was analyzed using descriptive statistics, frequency statistics, ANOVA and Logistic regression. Result: The major findings were 1) The participants were assessed at baseline for their current Stage of Change resulting in a distribution with $42.1\%$ in Precontemplation, $24.1\%$ in Contemplation, $9.7\%$ in Preparation, $6.2\%$ in Active, and $17.9\%$ in the Maintenance stage. 2) There were statistically significant differences of processes of change, decisional balance and situational temptation across the stages of change. 3) The main factors that affect smoking cessation were age, number of years smoking, age when began smoking, self-liberation and negative/affective situations, which combined explained $33.2\%$ of the smoking cessation. Conclusion: TTM variables measured prior to a smoking cessation program added little predictive value for cessation outcome beyond that explained by demographic and smoking history variables.

• Journal of Korean Public Health Nursing
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• v.18 no.2
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• pp.330-341
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• 2004

Parental smoking status and smoking environment do not only affect children's health through exposure to nicotine, but are also related to children's smoking attitude, intention and knowledge of smoking. Since this study was conducted to examine a relationship between family members smoking and smoking attitude, intention and knowledge of their children, little is known about psychosocial factors influencing smoking among Korean preschool children. This study aimed to determine the psychosocial factors (sociodemographic factors, education for smoking cigarette, knowledge about smoke cigarette) influencing smoking attitude and smoking intention, with a purpose of providing directions for future education programs for Korean preschool children. A cross sectional sample of 840 children, ages 4-7 years, living in a rural district were interviewed during August 6 - November 14, 2003. Among them, 834 children whose missing data were less than $10\%$ were included the analysis. The independent variables included sociodemographic characteristics and education for smoking cigarette, while the dependent variables were knowledge about smoking, the children's smoking attitude and their intention of smoking. The data on sociodemographic characteristics were analyzed using descriptive statistics including frequency, percentage, mean, and standard deviation. The correlations between the independent variables and attitude and intention of smoking were analyzed using chi-square test, t-test, and logistic regression. The results of this study were s follows. The factors that were found to be significantly correlated to smoking attitude include mother's smoking $(x^2=4.86,\;p=.03)$, grandmother's smoking $(x^2=5.56,\;p=.02)$, and knowledge of smoking cigarette $(x^2=-5.13 p<.01)$. The factors that were significantly correlated to the intention of smoking include gender $(x^2=.08,\; p=.02)$, education for smoking$(x^2=17.65,\;p<.01)$, mother's smoking $(x^2=19.05,\; p<.01)$, grandmother's smoking $(x^2=17.67,\; p<.01)$, and knowledge$(x^2=-2.17,\;p=.03)$. The children who had non smoking mother were more likely to have negative attitude (OR=2.29). The children who had a higher knowledge about smoking were more likely to have negative attitude (OR=1.58). The findings suggest that a smoking prevention program specific for preschool children is necessary to prevent early onset of smoking. The findings also suggest that the program should involve children's family members who influence their smoking attitude and intention.