• Korean Journal of Health Education and Promotion
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• v.30 no.1
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• pp.53-64
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• 2013

Objectives: In this study, a multilevel analysis model has been designed to investigate the effect of personal characteristics associated with smoking cessation on anti-smoking determinants with a goal of finding out the factors which have influence on smoking cessation among the entrants of smoking cessation clinic in a public health center. Methods: A total of 253,136 male smokers who received smoking cessation services for more than six(6) months in a smoking cessation clinic of public health center from July 16, 2007 to July 15, 2008 were examined. For technical analysis, SPSS Version 2.0 has been used. For multilevel analysis on smoking cessation determinants, in addition, HLM 7.0 has been adopted. Results: According to the unconditional model of multilevel analysis, the success rates of smoking cessation among the entrants of a smoking cessation clinic were 47.3%. In an unconditional slope model test to which regional variables were added, a negative effect was observed in average smoking amount, total smoking period, nicotine dependence and services while a positive effect was found in age, stress and type of social security in terms of the log of the odds of smoking cessation. In a conditional model test, a positive effect was observed in Non-Smoking Campaigns (NSC) and Frequency of Counseling (FC) in terms of the log of the odds of smoking cessation in regional variables. Conclusions: It is important to approach smokers individually and, at the same time, build healthy environment for a local community to increase smoking cessation rates among the entrants of smoking cessation clinic in a public health center.

• Journal of the Korean Society of Tobacco Science
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• v.31 no.1
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• pp.58-67
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• 2009

Biomarkers could be critical and useful tools for assessing the biological effects of smoking and detecting differences between potentially reduced exposure product (PREP) and conventional cigarettes. Smoking-related biomarkers can be classified into three categories as biomarkers of exposure, biomarkers of effects, and biomarkers of potential harm. When compared with the biomarkers of effects or harm, the biomarkers of exposure for chemical constituents of cigarette smoke are well established and characterized. In addition, they could offer the important information in understanding how cigarette smoke interacts with biological molecules and causes the disease to human. Therefore, we provide an overview of 6 biomarkers of exposure (Nicotine and nicotine metabolites, Carboxyhaemoglobin, NNAL (4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol) and NNAL - glucuronide, 3-Hydroxypropyl-mercapturic acid, and Monohydroxy-butenyl-mercapturic acids, and Urine mutagenicity) which were validated through extensive research and clinical experience. These reliable biomarkers could help identify the efficacy of PREP by predicting early toxicological effects and lead to improve it.

• Development and Reproduction
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• v.26 no.4
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• pp.155-163
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• 2022

Human pluripotent stem cells (hPSCs) can give rise to a vast array of differentiated derivatives, which have gained great attention in the field of in vitro toxicity evaluation. We have previously demonstrated that hPSC-derived alveolar epithelial cells (AECs) are phenotypically and functionally similar to primary AECs and could be more biologically relevant alternatives for assessing the potential toxic materials including in fine dust and cigarette smoking. Therefore, in this study, we employed hPSC-AECs to evaluate their responses to exposure of various concentrations of diesel particulate matter (dPM), cigarette smoke extract (CSE) and nicotine for 48 hrs in terms of cell death, inflammation, and oxidative stress. We found that all of these toxic materials significantly upregulated the transcription of pro-inflammatory cytokines such as IL-1α, IL-β, IL-6, and TNF-α. Furthermore, the exposure of dPM (100 ㎍/mL) strongly induced upregulation of genes related with cell death, inflammation, and oxidative stress compared with other concentrations of CSE and nicotine. These results suggest that hPSC-AECs could be a robust in vitro platform to evaluate pulmotoxicity of various air pollutants and harmful chemicals.

• Korean Journal of Acupuncture
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• v.24 no.1
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• pp.13-25
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• 2007

목 적 : 흡연에 따른 건강적 피해가 많이 알려져 있음에도 불구하고 특히 여성 및 청소년 계층의 흡연이 증가하고 있으며 폐암 사망자수는 급격히 늘어나고 있는 상황이다. 완전한 금연이 실패하는 주요 이유는 담배의 중독성에서 비롯되며 금단현상을 극복하지 못해 일어나는 것으로 알려져 있다. 흡연의 중독성은 담배 주요성분 중의 하나인 니코틴(nicotine)에 의해 유발되며 따라서 모든 금연 요법 및 금연 치료보조제 들은 이 니코틴 작용을 어떻게 효과적으로 억제 또는 대체하느냐에 초점을 맞추고 있다. 최근 금연치료 요법으로 한방 침이 주목 받고 있으며 본 논문을 통해 한방 침의 금연효과에 대한 신경학적 기전을 고찰하고자 한다. 방 법 : 금연을 돕는 전형적인 보조 치료제 및 치료법이 몇 종류 개발되어 사용 중에 있으며 대표적으로 니코틴 대체 요법(nicotine replacement therapy, NRT)이나 항우울제로 사용되는 bupropion 등을 들 수 있다. 이 치료 방법들은 뇌의 도파민계 신경전달 체계에 영향을 미쳐 금연 효과를 발휘하게 되는데 실질적인 금연성공확률은 그리 높지 않은 것으로 알려져 있다 따라서 침의 자극에 대한 도파민계 신경전달 조절효과를 중심으로 고찰함으로써 침의 금연효과에 대한 의과학적 기전을 설명하고자 하였다. 결 과 : 침자극은 우수한 금연효과를 가져올 수 있는 치료법으로 기존의 금연 치료요법 및 치료제 들을 보완할 수 있는 보다 확실한 치료요법 중의 하나이며 특히 금연 후에 오는 금단현상을 효과적으로 완화시키는 작용을 한다. 그리고 이 같은 효과는 부분적으로 도파민계를 비롯한 신경전달계를 조절함으로써 가능한 것으로 판단된다. 결 론 : 본 논문을 통해 니코틴에 의한 금단현상의 신경학적 기전과 금연과 관련된 신경전달체계에 대한 침자극의 효능에 대해 고찰하였으며 기존의 금연보조치료법을 대체할 수 있는 우수한 의학적 치료법으로써의 침치료법을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4963-4968
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• 2014

Background: We evaluated whether providing health risk appraisal for Koreans (KHRA) in terms of 'health age' during smoking cessation program would effectively help smokers quit smoking or not. Materials and Methods: A total of 332 male smokers aged between 30-65 years old, registered for a smoking cessation program in a public health center in a city, were recruited and underwent a baseline survey from January 2010 to February 2011. They were then prospectively randomized to a conventional counseling group (n=165) or a KHRA group (n=167), and received conventional counseling or KHRA-based counseling for six months. Abstinence rates were identified through carbon monoxide measurement (at the $4^{th}$ and $24^{th}$ weeks) or urinary cotinine level (at the $12^th$ week). Results: The abstinence rate confirmed by exhaled carbon monoxide was significantly higher in the KHRA group (61.1%) than the control group (49.1%) at the $4^{th}$ week (absolute difference 12.0%, 95% CI: 1.4%-22.6%). However, there was no difference in abstinence rates between the two groups at the 12th and 24th weeks. The predicting factors of 24 week's smoking cessation success were age, older than 50 years old (OR 2.02, 95% CI: 1.16-3.52), lower Fagerstr$\ddot{o}$m Test for Nicotine Dependence score less than 4 (OR 1.84, 95% CI: 1.03-3.29), and higher Self Efficacy/Temptation score (OR 1.79, 95% CI: 1.05-3.06). Conclusions: Smoking cessation counseling with KHRA could be effective compared to conventional counseling in the short period of smoking cessation. Further study is needed to evaluate the long-term efficacy of KHRA in tobacco dependence treatment and to establish the indication and target population of this tool.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.516-524
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• 2012

The purpose of this study was to examine the relationship between the smoking experience of some middle school students and their oral health behavior in an effort to provide information on how to teach students to abstain from smoking and improve their oral health behavior to maintain or promote their oral health. The subjects in this study were the students who were in their first, second and third years in four different middle schools located in the city of Iksan, North Jeolla Province. A survey was conducted from June 14 to July 12, 2011, and the collected data were analyzed. The findings of the study were as follows: 1. The students who smoked accounted for 10.6 percent. Out of them, the rates of the boys and the girls respectively stood at 16.0 and 5.4 percent (p<0.001). 2. As for the life satisfaction of the smoker students, 9.5 percent were satisfied, and 15.0 percent were unsatisfied (p<0.05). 3. Concerning a plan for quitting smoking, 71.4 percent of the boys and 45.5 percent of the girls planned to give up smoking (p<0.01). 4. Regarding the links between smoking experience and oral health behavior, the students who had smoking experience got 2.19 in the use of oral hygiene supplies, and the others who hadn't got 1.97 (p<0.01). 5. As to the connections between nicotine dependence and oral health behavior, the students who replied they depended on nicotine got 2.68 in education and concern, and those who answered they never did got 3.21 (p<0.05).

• The Korean Society of Law and Medicine
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• v.12 no.2
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• pp.317-338
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• 2011

The World Health Organization (WHO) tries to accomplish the goal of 'smoke free society', and developed countries regard the nicotine as an addictive drug. In order to better protect human health, all parties are required to adopt and implement effective legislative, executive, administrative or other measures for tobacco control in accordance with Article 4 the Framework Convention on Tobacco Control (FCTC). In order to achieve the objective of the FCTC and its protocols and to implement its provisions, Korea need to take an attention on the U.S. Family Smoking Prevention And Tobacco Control Act of 2009 and Final Rule. It is need to integrate and centralize of tobacco safety administration and smoking prevention for the national health promotion.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10841-10846
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• 2015

Background: Smoking is a primary risk factor for cancer development. While most research has focused on smoking cigarettes, the increasing popularity of shisha or water pipe smoking has received less attention. This study measured the prevalence and risk factors for shisha and cigarette smoking and related knowledge. Materials and Methods: This cross-sectional analytical study was conducted in Shah Alam, Malaysia. Participants aged ${\geq}18years$ were selected from restaurants. Data regarding demographic variables, smoking patterns, and knowledge about shisha smoking were collected in local languages. Logistic regression was performed to assess risk factors. Results: Of 239 participants, 61.9 % were male and 99.2% revealed their smoking status. Some 57.4% were smokers: 50.7% only cigarettes, 5.9% only shisha and 42% both. Mean age of starting cigarette smoking was $17.5{\pm}2.4years$ and for shisha smoking $18.7{\pm}2.0years$. In a univariate model, male gender, age 33-52 years and monthly income > MYR 4,000 increased the risk and unemployment and being a student decreased the risk. In a multivariate model, male gender increased the risk of smoking, while being a student decreased the risk, adjusting for age and income. The perception of shisha being less harmful than cigarettes was present in 14.6% and 7.5% had the opinion that shisha is not harmful at all, while 21.7% said that it is less addictive than cigarettes, 39.7% said that shisha did not contain tar and nicotine, 34.3% said that it did not contain carbon monoxide and 24.3% thought that shisha did not cause health problems. Conclusions: Prevalence of shisha and cigarette smoking is high in the general population in Malaysia and knowledge about shisha smoking is relatively low. The findings of our study might have implications for understanding similarities and differences in incidence of shisha and cigarette smoking in other cultural/geographic regions.

• Korean Journal of Health Education and Promotion
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• v.35 no.5
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• pp.47-56
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• 2018

Objectives: This study was performed to investigate trends of smoking characteristics and to identify the relationship between smoking characteristics and obesity among military personnel in Korea. Methods: The study participants were 50,680 military personnel who participated smoking cessation clinic from January in 2009 to December in 2017(excluded in 2011). Obesity was defined as body mass index${\geq}25kg/m2$. Smoking characteristics was included cigarettes of smoked per day, age of initial smoking, smoking duration, and nicotine dependence. Binominal logistic regression analysis was performed to confirm the relationship of smoking and obesity among military personnel. Results: The prevalence of obesity of study subjects was 20.4%. The military personnel were more likely to be obese if they who smoked more than 20 cigarettes per day(adjusted OR 2.271, CI 2.027-2.545), who smoked for more than 10 years(adjusted OR 2.046, CI 1.820-2.299), and who smoked their initial smoking at later than 20 years(adjusted OR 1.357, CI 1.223-1.493). Conclusions: Obesity is closely related to cigarettes of smoked per day, age of initial smoking and smoking duration among military personnel. Thus, intervention included both smoking cessation and weight control are necessary for smokers with obese who are interested in losing weight among military personnel.

• Journal of Oral Medicine and Pain
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• v.36 no.4
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• pp.225-234
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• 2011

Tobacco smoking is a major risk factor of systemic health and also impairs oral health, which is related to development of oral cancers, periodontitis, delayed wound healing, tooth loss, failure of implant, etc. Aside from smoking, many other risk factors can be related to oral health and long-term effects of smoking on salivary flow and taste threshold are still in controversy. Authors considered dental students to be an appropriate group with good oral hygiene for a long-term study to reveal effects of smoking on oral health. This study was performed to compare smoking patterns and current oral health conditions between smokers and nonsmokers in dental students prior to long-term evaluation. 192 volunteers (85.7%) of 224 male dental students in Dankook University were evaluated through questionnaires and clinical examination in 2010. Questionnaires included smoking pattern, alcohol use, nicotine dependence, preventive care, psychological profile and clinical examinations comprised assessment of teeth or periodontal status, nicotine pigmentation, salivary flow, electrical taste thresholds and halitosis. From the study, (current) smokers were older, and drank more frequently with more alcohol intake compared to former smokers and nonsmokers(p<0.05). There was no significant difference among them in salivary flow rate, halitosis and electrical taste threshold. However, there was significant difference in DMFT rate, periodontal treatment need, nicotinic pigmentation between smokers and nonsmokers(p<0.05), irrespective of their levels of preventive care. The smokers in this study, who are young dental students with relatively shorter duration of smoking, less use of cigarettes and low level of nicotine dependence, did not reveal significant impairment of oral health. However, their oral health was found to be relatively impaired compared to nonsmokers', which suggests negative effect of smoking on the oral health and a need of smoking cessation.