• Korean Journal of Psychosomatic Medicine
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• v.21 no.2
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• pp.81-92
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• 2013

Newer antidepressants are commonly used in clinical practice to treat psychiatric disorder and psychosomatic disorder including chronic pain syndrome, fibromyalgia, headache. However there are many unexpected adverse effects of these drugs such as nausea and vomiting, weight gain, sexual dysfunction. These are 3 most well-recognized common adverse effects of newer antidepressant and are most common causes of treatment failure. I reviewed mechanisms, epidemiology, and pharmacological management of these adverse effects of newer antidepressants. In this paper, newer antidepressants include selective serotonin reuptake inhibitor(fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine), serotonin norepinephrine reuptake inhibitor(venlafaxine, duloxetine), norepinephrine and dopamine reuptake inhibitor(bupropion), noradrenergic and specific serotonergic antidepressant(mirtazapine), and reversible inhibitor of MAO-A(moclobemide). I suggest that psychiatrists and clinicians in the psychosomatic field should know mechanisms, epidemiology, and management of these common and well-recognized adverse effects of newer antidepressants. Therefore it will be helpful to recognize easily and treat well for patients with psychiatric disorder and psychosomatic disorder using newer antidepressants.

• Journal of Environmental Science International
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• v.19 no.1
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• pp.1-8
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• 2010

Only limited information is available on the measured exposure levels of residents according to the construction age of apartments. As such, present study was conducted to measure and to compare the bedroom, living-room, and outdoor air levels of MTBE and benzene, toluene, ethyl benzene and m,p-xylene(BTEX) in both newer and older apartments. For both newer and older apartments, all the compounds except for MTBE showed significantly higher levels in bedrooms or living-rooms as compared to the outdoor concentrations. The ratio of bedroom or living-room median concentration to outdoor concentration was close to 1 for MTBE, whereas it was larger than 1 for other target compounds. It was also found that the bedroom and living-room appeared to have similar indoor sources and sinks for BTEX, but not for MTBE. The median concentration ratios of the newer apartments to the older apartments ranged from 1.63 to 1.81, depending upon the compounds. In contrast, the MTBE concentrations did not differ significantly between the newer and older apartments, thereby suggesting that although newer buildings could emit more VOCs, this is not applicable to all VOCs. Conclusively, the findings of present study should be considered, when designing exposure studies associated with VOC emissions in buildings and/or managing indoor air quality according to construction age of buildings.

• Korean Journal of Biological Psychiatry
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• v.6 no.1
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• pp.34-40
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• 1999

New antidepressants have become available for clinical use in the 1990s. Before this decade, the drugs available to treat depression consisted essentially of monoamine oxidase inhibitors, tricyclic antidepressants, and lithium. Following the introduction of SSRIs, the options have expanded and now include SSRIs, nefazodone, venlafaxine, mirtazapine, reboxetine, tianeptine. Newer antidepressants possess a variety of pharmacological characteristics that are relevant to the choice of an antidepressant for clinical use. This review summarizes some of the major pharmacological characteristics among the drugs.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2781-2784
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• 2007

Early detection of a disease is important to tackle treatment issues in a better manner. Several diagnostic techniques are in use, these days; for such purpose and tremendous research is going on to develop newer and newer methods. However, more work is required to be done to develop cheap and reliable early detection techniques. Micro-fluidic chips are also playing key role to deliver new devices for better health care. The present study focuses on a review of recent developments in the interrogation of different techniques and present state-of-the-art of microfluidic sensor for better, quick, easy, rapid, early, inexpensive and portable POCT (Point of Care testing device) device for a particular study, in this case, bone disease called osteoporosis. Some simulations of the microchip are also made to enable feasibility of the development of a blood-chip-based system. The proposed device will assist in early detection of diseases in an effective and successful manner.

• Membrane Journal
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• v.2 no.1
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• pp.1-20
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• 1992

Classical membrane processes like microfiltration (MF), ultrafiltration (UF) and reverse osmosis (RO) are being applied in the last years more frequently in environmental and effluent process problems. Newer technologies and developments like pervaporation (PV) and gas sepaxation (GS) recently found commercial applications in the treatment of waste waters and gas streams. The incentive here is either the clean-up from organic components to comply with federal emission regulations or the recovery of the organics for economical reasons. Processes still in their development stage are combinations of chemical reactions with membrane processes to separate and treat $SO_x$ and $NO_x$ laden waste gas streams in the clean-up of stack-gases. In this paper we will first give a short overview of the more recent developments in MF, UF and RO. This is followed by a closer look on newer technologies applied in environmental problems. The applications looked at are the recovery of organic components from solvent laden gas streams and the separation of organic volatiles from aqueous waste waters via pervaporation. Technical solutions, the advantages and disadvantages of the processes and. where possible, cost estimations will be presented.

• Journal of the Institute of Convergence Signal Processing
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• v.12 no.2
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• pp.119-127
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• 2011

The paper surveys various analytical models for IEEE 802.11 medium access control protocols and critically discusses recent issues developing in wireless mobile ad hoc networks and their MACs. The surveyed MAC protocols include the standard IEEE 802.11 MAC suites such as IEEE 802.11 DCF, IEEE 802.11 PCF, IEEE 802.11e EDCA, and IEEE 802.11 ad hoc mode; and also the newer, de facto MAC protocols. We study the analytic models of the standard MAC suites followed by the newer analytic models that have been published in recent years. Also, the paper tries to include most of current literatures discussing analytic modeling of MAC in conjunction to some critical issues such as contention among ad hoc nodes, hidden terminal problems, and real-time service support.

• Journal of Dental Anesthesia and Pain Medicine
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• v.23 no.6
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• pp.303-315
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• 2023

Painless treatment determines the quality of pediatric dental care. Although local anesthesia has been used to manage pain in dentistry, children often cite traditional aspirating syringes as a symbol of fear and pain. Adequate pain control during dental procedures may help alleviate fear and anxiety and instill positive oral health attitudes in children. Newer approaches such as intranasal spray, centbucridine, jet injectors, buzzy devices, and acupressure have been developed to help dentists provide near-painless injections while reducing dental anxiety. This review aims to summarize newer approaches to alleviate pain and anxiety in children.

• Archives of Pharmacal Research
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• v.14 no.3
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• pp.195-198
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• 1991

As potential antibacterial agents, several antipyrine derivatives were synthesized from 4-formylantipyrine and antibacterial activities of the synthesized compounds were also examined.

• Journal of Gifted/Talented Education
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• v.7 no.2
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• pp.69-92
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• 1997

The purpose of the study was to evaluate the effects of the enrichment program for the gifted on gifted childrens development of the logical thinking and science process skills. The enrichment program consists of 200 enrichment courses in language arts, mathematics, sciences, social sciences and thinking for children at the age of 30 months to Grade 8. Enrichment programs are characterized as process-oriented, student-choice available, activities-oriented, open-ended, and interdisciplined. Subjects were 123 gifted children from Grade 1 to 3 at the Korean Academy of Gifted Education (KAGE), whose IQ scores were above 130 at their entry point to KAGE. Children were divided into two groups depending the duration of the program participation. Older Group participated in the program for longer than 13 months, while Newer Group did for shorter than 12 months. Mean of IQs of the two groups were not significantly different. They were tested on Logical Thinking Test and Integrated Process Skills Test revised by KEDI into Korean version in 1991. Descriptive statistics were calculated and group differences were analyzed with t-test, and scheffe test. The main finding were as follows: There were not significant differences between gender. Children in higher grades showed higher level of development. Older groups showed significantly higher level of logical thinking level of development. Older group showed significantly higher level of logical thinking and process skills than the Newer group inspite of the similar IQ levels to each other. The longer the gifted child participate in the enrichment program, the higher the development of childrens thinking skills.

• Journal of Pharmacopuncture
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• v.22 no.4
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• pp.210-224
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• 2019

Rheumatoid arthritis is a severe autoimmune disorder, related to joints. It is associated with serious cartilage destruction. This causes disability and reduces the excellence of life. Numerous treatments are existed to combat this disease, however, they are not very efficient and possess severe side effects, higher doses, and frequent administration. Therefore, newer therapies are developed to overcome all these limitations. These include different monoclonal antibodies, immunoglobulins, small molecules used for immunotherapy and transgenes for gene therapy. One of the main goals of these new generation therapeutics is to address the underlying distressing biological processes by specifically targeting the causative agents with fewer systemic side effects and greater patient console. It is very fortuitous that loads of progressive investigations are going on in this field and many of them have entered into the successful clinical trial. But till date, a limited molecule has got FDA clearance and entered the market for treating this devastating disease. This review highlights the overview of conventional therapy and advancements in newer therapeutics including immunotherapy and gene therapy for rheumatoid arthritis. Further, different novel techniques for the delivery of these therapeutics of active and passive targeting are also described.