• Toxicological Research
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• 제13권1_2호
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• pp.139-147
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• 1997

Four-week toxicity of EPO(erythropoietin) was investigated using New Zealand White rabbits according to the established regulations of Korean National Institute of Safety Research. Rabbits were administered intravenously seven days per week for 28 days with dosage of 0, 80, 400 and 2000IU/kg B. W./day. Animals administered with EPO showed no significant changes of body weight, water consumption and feed consumption, and no clinical signs and death. They were not significantly different from the control group in hematological and serum biochemical analysis, urinalysis, prothrombin time, and partial thromboplastin time. In this study, we concluded that EPO had no toxic effect in the New Zealand White rabbits when they were administered intravenously below 2000IU/ kg B.W./ day for 28 days.

• Biomolecules & Therapeutics
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• 제4권4호
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• pp.415-418
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• 1996

This study was conducted to investigate the skin irritation toxicity of Syndella gel, a combination topical drug containing a deproteinised dialysate of calf's blood and micronomicin sulfate in the ratio of 20 to 1, in New Zealand White rabbits. In the primary skn irritation test with male New Zealand White rabbits, there was no treatment-related effect on clinical sign, nd body weight was not significantly changed. The Primary Irritation index (PII) was 0.33, indicating that Syndella gel was a mildly irritating formulation.

• Toxicological Research
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• 제12권1호
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• pp.53-58
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• 1996

Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and Primary Irritation Index (PII) was O.47, indicating Aloewhite as mildly irritating material. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea pig after intradermal and epicutaneous induction and graded 1 with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.

• 한국임상수의학회지
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• 제27권4호
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• pp.411-414
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• 2010

Rabbit's cornea is the most common thing that used for researches in ophthalmology, so many experimentations have done. The purpose of this study was to survey the corneal pachymetry, tonometry and specular microscopy in New Zealand white rabbits. Three months old male rabbits ($2.9{\pm}0.2\;kg$) were examined with contact the specular microscope to evaluate the endothelial cell density, coefficiency of variation and the percentage of hexagonal cells in the central cornea. For the pachymetry, ultrasonic pachymeter was used for central cornea in each twenty rabbits, and tonometry was performed forty rabbit's eyes to evaluate the intraocular pressure. Corneal endothelial cell density in New Zealand white rabbit was $3304{\pm}354\;cell/mm^2$. Coefficiency of variation was $45.8{\pm}2$ and the percentage of hexagonal cells in the central cornea was $44.4{\pm}11%$. The pachymetry of cornea was $346.1{\pm}21\;{\mu}m$ and tonometry of eye was $14.3{\pm}2\;mmHg$. It is considered that normal New Zealand white rabbit's pachymetry, specular microscopy and tonometry were useful basic data of rabbit's cornea for research and clinic in veterinary ophthalmology.

• 한국식품위생안전성학회지
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• 제6권3호
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• pp.171-177
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• 1991

New Zealand White에 대한 피부 자극성 시험을 6마리의 수컷 토끼를 이용하여 7일간 피부 1차 자극성 실험을 국립보건안전 연구원 예규에 따라 실시하였으며, 전 동물에서 시험 전 기간을 토해 본 시험 물질에 의한 것이라고 인정되는 임상증상, 체중변화 및 부검소견등이 관찰되지 않았다. 그리고 시험 물질 도포부위의 홍반과 가피형성 및 부종등의 자극성은 인정되지 않았으며, Draize의 P.I.I(primary irritation index)의 산출에 의한 피부 1차 자극율은 "0"으로 평가되었다. Zealand White Rabbit에서 BST-SR에 대한 안점막 자극 시험을 국립보건 안전연구원 예규에 따라 토끼 9마리를 가지고 시험하였다. 검체를 모든 토끼의 오른쪽 눈에 0.1ml을 투여하고 3마리의 토끼는 20~30초 후에 미온수로 1분간 세척해 주고 나머지 6마리의 토끼는 그대로 두어 각막, 홍채, 결막에 각각 나타나는 병변을 등급표에 따라 계산해 보았으나, 안점막에 대해서 무자극물로 판단되었다. 따라서 BST-SR는 토끼의 안점막 및 피부 에 자극성이 없는 것으로 생각되어진다.

• Asian-Australasian Journal of Animal Sciences
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• 제21권8호
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• pp.1171-1177
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• 2008

The performance of growing rabbits fed Ruzi grass (Brachiaria ruziziensis), head lettuce (Lactuca sativa) residue, Mimosa pigra and water spinach (Ipomoea aquatica) was studied in an experiment using 64 rabbits (4 males and 4 females per treatment) of 2 breeds, New Zealand White and a crossbred between New Zealand White and native breed. The rabbits had an average initial weight of 668 g, were about 6 weeks old and were housed in individual pens. The foliages were fed ad libitum and a commercial concentrate was fed at a restricted level of 2% of body weight on a dry matter (DM) basis. In the digestibility experiment, the rabbits, 4 per foliage and males only, were fed the same foliages as in the growth experiment but without concentrate. Daily weight gain was lower in the group fed Ruzi grass, 14.8 g/d (p<0.001) compared to 17.6, 18.5 and 18.4 g/d for head lettuce, Mimosa pigra and water spinach, respectively. Feed intake and feed conversion ratio were lowest for the rabbits fed water spinach, 66 g DM/d and 3.6 kg DM/kg live weight, respectively. The New Zealand White breed had a higher daily gain than the crossbred rabbits (p<0.05), 18.0 and 16.7 g/d, respectively. There were no significant differences in feed intake, growth or feed conversion ratio due to sex. The digestibility coefficients of DM, organic matter, crude protein, crude fiber, neutral detergent fiber and acid detergent fiber were significantly lower (p<0.001) in the rabbits fed Ruzi grass. Breed and sex had no effect on digestibility. In conclusion, feeding head lettuce residue, Mimosa pigra and water spinach resulted in higher growth rate and digestibility than feeding Ruzi grass and can be recommended as alternative feeds.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.250-250
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• 1996

Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and primary Irritation Index(PII) was 0.47, indicating Aloewhite as mildly irritating material, In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea Peg after intradermal and epicutaneous induction and graded I with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.

• Toxicological Research
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• 제13권1_2호
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• pp.161-165
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• 1997

This study was conducted to investigate the skin irritation by transdermal administration of the three dyes. These dyes were originated from onion by using extraction method. By the order of extraction from onion, A-dye was obtained from onion by using water at 90-100$\circ$C. B-dye was extracted from A-dye with ethylacetate. After ethylacetate extraction from A-dye, the lower layer named as C-dye. Twenty-four New Zealand white rabbits were divided into three groups. The each groups was consisted of two subgroups according to high dose (extracted dyes) and low dose (the 100-fold dilutions of A-, Band C-dye). In primary skin irritation test of male New Zealand White rabbits, body temperature and weights were not significantly changed and blood cells were positioned in normal blood cell ranges of health rabbits. Primary irritation index was "0" in the test and control sites of all animals used in this study. By the results obtained in the present test, all dyes were evaluated as a non-irritant on the basis of the criteria of Draize.of Draize.

• Toxicological Research
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• 제19권1호
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• pp.39-44
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• 2003

Two local irritation and skin sensitization studies of nonspecific immunostimulator, $BARODON^{\circledR}$ were carried out with New Zealand White rabbits and Hartley guinea pigs. In skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and there were no responses after treatment for 24 or 72 hours and the Primary irritation index (P.1.1.) was '0'. And, in the eye irritation test, there were chemosis in some of rabbits. One of 3 rabbits in washing group was detected chemosis after 24 and 72 h following treatment and 2 of 6 rabbits in non-washing group were detected chemosis after 24h and 7 days following treatment. Therefore, total score is '4' after 24 h and '2' after 72 h following treatment by conforming article "some blood vessel are clearly hyperemic" . However evaluation value is non-irritant because M.O.I. (Mean ocular irritation index) score is below during the all experimental period and no significance through individuals and exposure time. In skin sensitization, the score of skin reaction was graded 1 with 0% sensitization rate. Taken together, these results indicate that $BARODON^{\circledR}$ may be non-irritant material. material.

• Journal of Nutrition and Health
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• 제27권4호
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• pp.323-335
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• 1994

The present study was carried out in normocholesterolemic New Zealand white(NZW) rabbit, to evaluate the effect of dietary supplementation with Korean pinenut oil, on plasma lipids, plasma lipoproteins, liver lipids and platelet aggregation. NZW rabbits were fed for 80 days on a commercial chow diet supplemented with 5% of energy as fats(soybean oil or pinenut oil) or 10% of energy as fats(soybean oil or pinenut oil). A control group was fed a commercial stock diet. There were no significant effects of pinenut oil on plasma free cholesterol, HDL-cholesterol, triglycerides, glucose and lecithin-cholesterol acyltransferase, as compared with those obtained from rabbits fed the soybean oil diet. After 80 days, the concentration of plasma free fatty acid in only the pinenut oil group was significantly decreased by about 50% relative to the control diet. At the end of the dietary treatment, liver triglycerides and phospholipids were significantly decreased in the pinenut oil group, compared to the how diet, whereas the soybean oil-consuming rabbits had only significantly decreased phospholipid levels. Cholesterol contents of liver were unaffected by type of dietary fat. At the end of 80 days, a diet containing pinenut oil resulted in a decrease in apolipoprotein B and the apo B/apo AI ratio as compared with the stock diet or soybean oil diet. Platelet aggregation induced by collagen or arachidonic acid was depressed significantily in pinenut oil diet.