• Geomechanics and Engineering
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• 제22권2호
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• pp.119-132
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• 2020

In this study a new innovative three unknowns trigonometric shear deformation theory is proposed for the buckling and vibration responses of exponentially graded sandwich plates resting on elastic mediums under various boundary conditions. The key feature of this theoretical formulation is that, in addition to considering shear deformation effect, it has only three unknowns in the displacement field as in the case of the classical plate theory (CPT), contrary to five as in the first shear deformation theory (FSDT) and higher-order shear deformation theory (HSDT). Material characteristics of the sandwich plate faces are considered to vary within the thickness direction via an exponential law distribution as a function of the volume fractions of the constituents. Equations of motion are obtained by employing Hamilton's principle. Numerical results for buckling and free vibration analysis of exponentially graded sandwich plates under various boundary conditions are obtained and discussed. Verification studies confirmed that the present three -unknown shear deformation theory is comparable with higher-order shear deformation theories which contain a greater number of unknowns.

• Steel and Composite Structures
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• 제24권2호
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• pp.227-237
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• 2017

This paper presents optimization of a long-span portal steel frame under dynamic wind loads using a surrogate-assisted evolutionary algorithm. Long-span portal steel frames are often used in low-rise industrial and commercial buildings. The structure needs be able to resist the wind loads, and at the same time it should be as light as possible in order to be cost-effective. In this work, numerical model of a portal steel frame is constructed using structural analysis program (SAP2000), with the web-heights at five locations of I-sections of the columns and rafters as the decision variables. In order to evaluate the performance of a given design under dynamic wind loading, the equivalent static wind load (ESWL) is obtained from a database of wind pressures measured in wind tunnel tests. A modified formulation of the problem compared to the one available in the literature is also presented, considering additional design constraints for practicality. Evolutionary algorithms (EA) are often used to solve such non-linear, black-box problems, but when each design evaluation is computationally expensive (e.g., in this case a SAP2000 simulation), the time taken for optimization using EAs becomes untenable. To overcome this challenge, we employ a surrogate-assisted evolutionary algorithm (SAEA) to expedite the convergence towards the optimum design. The presented SAEA uses multiple spatially distributed surrogate models to approximate the simulations more accurately in lieu of commonly used single global surrogate models. Through rigorous numerical experiments, improvements in results and time savings obtained using SAEA over EA are demonstrated.

• 한국컴퓨터그래픽스학회논문지
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• 제6권1호
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• pp.37-50
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• 2000

본 논문에서는 R. T. Farouki에 의하여 소개된 평면 곡선들에 대한 복소수화된 표현법을 사용하여 주어진 임의의 평면 다항식 곡선을 복소수 계수를 갖는 한 다항식으로 나타내고 이 식을 대수학의 기본정리에 따라 복소수체 상에서 완전히 인수분해한 다음 그 근들을 관찰하여 주어진 곡선이 평면 다항식 피타고리안 호도그라프(PH) 곡선이 되기 위하 필요충분 조건을 새로운 방법으로 밝히고, 이를 3차원 민코브스키 공간 $R^{2,1}$ 상의 다항식 곡선에 적용, 이 곡선이 PH 곡선이 되기 위한 필요충분을 보다 간결한 형태로 나타내고 이를 통하여 3차원 민코브스키 공간 $R^{2,1}$ 상의 가능한 다항식 PH 곡선들의 유형이 모두 결정된다는 것을 보인다.

• 한국미생물·생명공학회지
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• 제26권4호
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• pp.358-364
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• 1998

본 연구에서는 새로 분리된 B. thuriniensis(Bt) NT0423 균주를 이용하여 효과적인 미생물 살충제를 개발하고 그 효력을 검정하였다. 농업부산물인 저가의 대두박과 밀기울을 이용한 새로운 SW32 배지로 Bt NT0423 균주를 대량배양하여 BioBact 10%, 20% 및 40%로 명명된 세 종류의 미생물 살충제를 수화제 제형으로 제조하였다. 제조된 세 종의 BioBact 제제는 수화성, 현수성, 입도 및 부착성에서 우수한 물성을 보였고 또한 SDS-PAGE분석 결과,약 130kDa의 내독소 단백질도 안정적으로 존재하였다. 세 종의 BioBact로 명명된 제제중, BioBact 10%는 독성이 낮았지만, BioBact 20%와 40%는 배추좀나방을 공시충으로하여 시판중인 Bt 제제인 subsp. kurstaki 균주를 사용한 A 제품, Bt subsp. aizawai 균주를 사용한 B 제품 및 화학살충제와 더불어 실내 및 야외 독성검정 실험을 비교 수행한 결과, 각각 100%와 80% 이상의 매우 높은 살충력을 보였다. 또한 야외에서 독성의 지속성도 다른 제제에 비해 최소 7일 이상 살충력이 유지되었다.

• 한국임상수의학회지
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• 제28권4호
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• pp.394-398
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• 2011

Mesenchymal stem cells (MSC) are pluripotent cells that can be found in umbilical cord blood from new borne babies as well as placenta, bone marrow, adipose tissue, amniotic fluid, muscle, et al. MSC are capable of renewing themselves without differentiation in long-term culture, also can be differentiated into various tissues under specific condition. Formulating a cryopreservation protocol for the MSC is required because these cells cannot survive for long periods under in vitro culture conditions and a new formulation of harmless cryoprotectant is needed for the direct injection of MSC into patients. The undifferentiated MSC were frozen with a vitrification solution of 40% ethylene glycol, 20% Ficoll-70 and 0.3M sucrose. The survival rate after thawing and their proliferation rate were examined and compared with slow rate cooling methods using dimethylsulfoxide (DMSO). The vitrification method showed high survival rate after thawing and proliferation capacity comparable to DMSO. It can be suggested that ultra-rapid cooling method by vitrification is reliable methods for long term preservation of MSC and the vitrification solution with ethylene glycol, Ficoll-70 and sucrose will be more beneficially used for direct transplantation of MSC into patients than DMSO solution.

• 터널과지하공간
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• 제9권4호
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• pp.296-305
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• 1999

많은 터널 현장에서 계측을 수행하고 있지만, 일반적인 역해석 방법으로 이 계측자료를 통해 라이닝에 작용하는 변형율과 응력 등의 역학량을 추정하기는 어렵다. 그 이유는 현장에서 계측이 가능한 적은 변위수로부터 라이닝의 응력상태를 추정할 수 없기 때문이다. 계측의 시간과 비용을 고려해 볼 때, 계측자료를 이용할 수 있는 기법의 개발은 시급한 연구과제라 할 수 있다. 본 연구에서는 터널계측에서 계측 가능한 소수의 변위로 전테 라이닝의 변위와 응력 등의 역학량을 계산할 수 있는 역해석 모델을 개발하였다. 역해석 방법으로서 복공 외면에 작용하는 외력의 자승이 최소화될 때 해를 구하는 방법을 사용하였다. 라이닝 외면에 작용하는 하중을 가정하여 유한요소법으로 변위와 응력을 계산하고, 여기서 얻은 몇개의 변위를 계측 변위로 가정하여 역해석 모델에 입력함으로써 절점 변위, 요소의 변형율 및 응력 등을 다시 구하였다. 처음 계산된 변위와 역계산으로 구한 변위를 비교함으로써 모델의 신뢰성을 평가하였다. 자동계측으로 라이닝의 비교적 정확한 계측을 수행하고 있는 지하철 한강 하저터널 현장에서 얻은 계측변위를 개발한 역해석 모델을 적용하여 실제 계측한 응력과 유사한 결과를 얻었다.

• 복식
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• 제51권2호
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• pp.181-192
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• 2001

Men study the nature in two ways. Scientists and mathematicians inquire a branch of those two ways. Mathematical formulations are the tools and the expressions of their nature. Meanwhile, the other branch, the art, alms for different inquiry. Instead of formulating the nature, the artists create their masterpieces from their ultimate source, the Mother Nature. For thousands of years these two branches have grown together, influencing each others work. Some mathematicians find that formulation, are not enough to fully express the beauty of nature. It is believed that such a simple expression, formula, easily omits the careful details of nature. The nature is simply too chaotic to be shaped with a formula. Of those mathematicians, Mandelbrot, one of the first to realize this matter, introduced the world of fractal geometry. Fractals give new possibilities. It allows us not to limit ourselves to linear prospect, rather a whole new view of this chaotic beauty of the nature. A popular practice to understand fractals is in costume design. The artistic characteristic and organization mechanism is appalled to costumes. Meanwhile, another practice, rather aggressive, is using computer to create an image of fractals. This image is then used for motives to generate artistic expressions. Computer and paper ironing technique is used for fashion illustration in this research. The works were synthesized arid transformed from computer programs. To add more traditional painting touch to this work, Paper ironing technique was used. Since the of effect of this technique is so random, irregular, and unordered, it corresponds to fractal consideration. This thesis asserts an another prospect to fractal as a structural way of describing nature ailed fashion illustration, rather than restricting it to only mathematical theory.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.115-115
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• 1997

A new capsaicin analog modified with 4-hydroxyl and alkyl chain of capsaicin was a very potent antiinflammatory analgesic drug and may be clinically useful for those who have rheumatoid arthritis, diabetic neuropathy and cancer. The purpose of this study was to investigate histopathology after short and long term application of poloxamer-based gels, and percutaneous absorption of various topical formulations. Poloxamer-based gel was prepared by cold method using poloxamer 407. The poloxamer gels was applied to dorsal sites of hairless mouse skin during one week or one month for the evaluation of skin irritation. The applied site was then sectioned for histopathologic examination. The topical formulations were also prepared using CMC, HPMC, MC, carbopol and glycerylmono stearate. Skin variation of poloxamer gels was studied using excised hairless mouse, rat, hamster and human penis skin. Franz-type diffusion cells were used far skin penetration of drug against receptor phase filled with about 10$m\ell$ of 0.9% saline solution kept at 32$^{\circ}C$. The concentration of drug was determined by the reverse phased C18, Symmetry HPLC with fluorometeric detector. No skin erythema was observed after dorsal application of poloxamer-based gels for one week or one month. No histopathologic changes was also examined, suggesting no skin toxicity of poloxamer-based gels. The order of flux rate was HPMC > MC ( CMC > poloxamer >> glycerylmono stearate ( carbopol. There was a skin variation of poloxamer gels. The flux rate of poloxamer gels was highest in case of hairless mouse followed by rat, human and hamster skin. The Partial support-Ministry of Science and Engineering (HAN project).

• Structural Engineering and Mechanics
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• 제68권4호
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• pp.385-398
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• 2018

In the present paper, we offer a new flat shell finite element. It is the result of the combination of a membrane element and a bending element, both based on the strain-based formulation. It is known that $C^{\circ}$ plane membrane elements provide poor deflection and stress for problems where bending is dominant. In addition, they encounter continuity and compliance problems when they connect to C1 class plate elements. The reach of the present work is to surmount these problems when a membrane element is coupled with a thin plate element in order to construct a shell element. The membrane element used is a triangular element with four nodes, three nodes at the vertices of the triangle and the fourth one at its barycenter. Each node has three degrees of freedom, two translations and one rotation around the normal. The coefficients related to the degrees of freedom at the internal node are subsequently removed from the element stiffness matrix by using the static condensation technique. The interpolation functions of strain, displacements and stresses fields are developed from equilibrium conditions. The plate element used for the construction of the present shell element is a triangular four-node thin plate element based on Kirchhoff plate theory, the strain approach, the four fictitious node, the static condensation and the analytic integration. The shell element result of this combination is robust, competitive and efficient.

• Asian-Australasian Journal of Animal Sciences
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• 제28권9호
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• pp.1317-1326
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• 2015

This study investigated the metabolizable energy (ME) intake, net energy of production (NEp), heat production (HP), efficiencies of ME use for energy, lipid and protein retention as well as the performance of broiler chickens fed diets based on cassava chips or pellets with or without supplementation with an enzyme product containing xylanase, amylase, protease and phytase. The two products, cassava chips and pellets, were analysed for nutrient composition prior to feed formulation. The cassava chips and pellets contained 2.2% and 2.1% crude protein; 1.2% and 1.5% crude fat; and 75.1% and 67.8% starch, respectively. Lysine and methionine were 0.077%, 0.075%, and 0.017%, 0.020% protein material, respectively, while calculated ME was 12.6 and 11.7 MJ/kg, respectively. Feed intake to day 21 was lower (p<0.01) on the diet containing cassava chips compared to diets with cassava pellets. Enzyme supplementation increased (p<0.01) feed intake on all diets. Live weight at day 21 was significantly (p<0.01) reduced on the diet based on cassava chips compared to pellets, but an improvement (p<0.01) was noticed with the enzyme supplementation. Metabolizable energy intake was reduced (p<0.01) by both cassava chips and pellets, but was increased (p<0.01) on all diets by enzyme supplementation. The NEp was higher (p<0.01) in the maize-based diets than the diets containing cassava. Enzyme supplementation improved (p<0.01) NEp in all the diets. Heat production was highest (p<0.01) on diets containing cassava pellets than on cassava chips. It is possible to use cassava pellets in diets for broiler chickens at a level close to 50% of the diet to reduce cost of production, and the nutritive value of such diets can be improved through supplementation of enzyme products containing carbohydrases, protease, and phytase.