• KIEAE Journal
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• 제17권1호
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• pp.5-13
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• 2017

Purpose: This study, by comprehensively the characteristics of new Hanok application techniques with the proposed site application technology in the course of the design changes that have been accumulated through Hanok technology development the second stage business, by analyzing the range of reflection, new Considering the direction reflects the efficiency of the new Hanok application techniques. Method: new Hanok application technology, it was been established through research and development of large 1 new Hanok technology it has been proposed through the "site-specific application techniques" and 2 builders and designers "space-time proposed technique" Analysis of the case, at the center of the design changes, the land the body of laws and regulations, the requirements of the public buildings, compared to the construction method and the like for the reduction of construction costs, new Hanok applied technology in the process of change by it There was analyzed whether acceleration on the range and step which is reflected in the design Result: The result of new Hanok applied technology was built through the demonstration build business case, process another major technology, foundation, woodwork, walls, roof, has been reflected in the ceiling construction, the inclusion of items in the proposed technique of construction , it was applied to the main steps in general, except for other construction work landscaping. Application techniques and construction proposal technology research team has presented, show the difference between the scope and method. With significance effort to improve the unreasonable traditional methods of these core processes that can be reflected in the field repeated the construction proposed technique as a result of the utility that can be applied for substantial construction.

• 한국농공학회논문집
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• 제61권2호
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• pp.51-61
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• 2019

In this study, interest in rural life of good natural environment rather than busy life is increasing as human life is extended by scientific and medical technology and society has improved. The reckless development of rural villages has caused social problems as the natural environment has been damaged, failing to function as a pleasant home. To address these problems, the government has implemented a rural village development project, but if the site is selected incorrectly, the residents may not be recruited, or applicants may lose their status, or the portion of the infrastructure building fee may increase. In order to prepare objective and clear assessment methods for the target site not to cause such problems, a layering analysis method (AHP: Analytic Method) was used to identify the current status of the rural village formation project, draw assessment items, and determine the importance of each item.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2006년도 춘계학술대회
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• pp.323-324
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• 2006

In the present paper a forecasting system of wind power generation for Walryong Site, Jejudo is presented, which has been developed and evaluated as a first step toward establishing Korea Forecasting Model of Wind Power Generation. The forecasting model, KIER forecaster is constructed based on statistical models and is trained with wind speed data observed at Gosan Weather Station nearby Walryong Si to. Due to short period of measurements at Walryong Site for training statistical model, Gosan wind data were substituted and transplanted to Walryong Site by using Measure-Correlate-Predict technique. Three-hour advanced forecast ins shows good agreement with the measurement at Walryong site with the correlation factor 0.88 and MAE(mean absolute error) 15% under.

• 대한방사성의약품학회지
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• 제6권1호
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• pp.46-52
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• 2020

Radiopharmaceuticals that can be consumed in specific disease site play a key role In order to diagnose and treat the diseases. In addition, radiopharmaceuticals can be used for diagnostic or therapeutic purposes depending on the type of the labeled radioactive isotope. Recently, theragnostic radiopharmaceuticals that can simultaneously diagnose and treat are developed. Therefore, the development of target-specific radiopharmaceuticals is a very important research topic in the field of molecular imaging and therapy. This review paper summarizes the basic considerations for the development of radiopharmaceuticals. For new researchers or students who are now beginning in the field of radiopharmaceuticals, we intend to assist in the development of radiopharmaceuticals by describing the definition of radiopharmaceuticals, the ideal radiopharmaceutical conditions, the considerations for developing new radiopharmaceuticals, the factors affecting the design of radiopharmaceuticals, the requirements of radioisotope labeling reactions, and finally the definition and importance of molar activity in radiopharmaceuticals.

• The Korean Journal of Ecology
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• 제23권2호
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• pp.141-147
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• 2000

The Long-Term Biodiversity Research Programme (LTBRP) for Mindanao is envisioned to be a collaborative programme of the Philippines. It will be a programmatic research on biodiversity - its status, threats. and conservation and management. The chosen research site is Mt. Malindang in Misamis Occidental of Mindanao. The BRP will support a set of research projects that will generate knowledge on biological and ecological, socio-economic. cultural and policy aspects of biodiversity conservation. It will also enable researchers to develop and try new methods for research on these aspects, separately or crossing boundaries of academic disciplines. Moreover. the BRP will implement support programmes which will provide the linkages of research activities to development issues and needs in the research site. The support programmes will also draw from the research projects, the knowledge that can be lent or immediately available to policy and programme formulation. The support programmes will comprise: human resource development or capability-building; information, education and communication; database; networking; community organizing: and development action. The BRP will be undertaken by a group of academie and research institutions from the Philippines, in partnership with their respective government entities and local government units in Mindanao. The Biodiversity Research Programme (BRP) will comprise a set of research projects to be undertaken by small research teams in the site. Researchable areas have been identified initially through the National Biodiversity Research Agenda. and later enriched in the Participatory Rural Appraisal (PRA) Analysis workshops by the Mindanao researchers and Philippine resource persons. Results of the PRA are presented in the paper.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 춘계학술대회 초록집
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• pp.171.1-171.1
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• 2010

Riverbank filtration wells have been developed to supply a heat source/sink of water in the alluvium aquifer to ground water heat pumps for cooling and heating of a green house. In order to look for an appropriate site to carry out the research, two sites of Jinju and Gumi areas were investigated. In the results of the electrical resistivity surveys, Jinju and Gumi areas have the alluvium aquifer in the depth of 6~17 m and 10~20 m under the ground respectively. Two boreholes have been drilled in each site of both areas. The averaged water level at Jinju site is about 3 m under the ground, and 3.5 m and 6.5 m of sandy gravel aquifer layers are existed in each site. While Gumi site has 10 m water level and 2.5 m and 4.6 m of sandy gravel aquifer. Therefore, it is expected that $1,000m^3$/day of water could be withdrawn at Jinju site rather than Gumi site.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• Journal of Microbiology and Biotechnology
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• 제24권11호
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• pp.1551-1558
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• 2014

The esterase gene Est8 from the thermophilic bacterium Bacillus sp. K91 was cloned and expressed in Escherichia coli. The monomeric enzyme exhibited a theoretical molecular mass of 24.5 kDa and an optimal activity around $50^{\circ}C$ at pH 9.0. A model of Est8 was constructed using a hypothetical YxiM precursor structure (2O14_A) from Bacillus subtilis as template. The structure showed an ${\alpha}/{\beta}$-hydrolase fold and indicated the presence of a typical catalytic triad consisting of Ser-11, Asp-182, and His-185, which were investigated by site-directed replacements coupled with kinetic characterization. Asp-182 and His-185 residues were more critical than the Ser-11 residue in the catalytic activity of Est8. A comparison of the amino acid sequence showed that Est8 could be grouped into the GDSL family and further classified as an SGNH hydrolase. Est8 is a new member of the SGNH hydrolase subfamily and may employ a different catalytic mechanism.

• The Plant Pathology Journal
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• 제34권3호
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• pp.191-198
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• 2018

Fast and accurate diagnosis is needed to eradicate and manage economically important and invasive diseases like fire blight. Loop-mediated isothermal amplification (LAMP) is known as the best on-site diagnostic, because it is fast, highly specific to a target, and less sensitive to inhibitors in samples. In this study, LAMP assay that gives more consistent results for on-site diagnosis of fire blight than the previous developed LAMP assays was developed. Primers for new LAMP assay (named as DS-LAMP) were designed from a histidine-tRNA ligase gene (EAMY_RS32025) of E. amylovora CFBP1430 genome. The DS-LAMP amplified DNA (positive detection) only from genomic DNA of E. amylovora strains, not from either E. pyrifoliae (causing black shoot blight) or from Pseudomonas syringae pv. syringae (causing shoot blight on apple trees). The detection limit of DS-LAMP was 10 cells per LAMP reaction, equivalent to $10^4$ cells per ml of the sample extract. DS-LAMP successfully diagnosed the pathogens on four fire-blight infected apple and pear orchards. In addition, it could distinguish black shoot blight from fire blight. The $B{\ddot{u}}hlmann$-LAMP, developed previously for on-site diagnosis of fire blight, did not give consistent results for specificity to E. amylovora and on-site diagnosis; it gave positive reactions to three strains of E. pyrifoliae and two strains of P. syringae pv. syringae. It also, gave positive reactions to some healthy sample extracts. DS-LAMP, developed in this study, would give more accurate on-site diagnosis of fire blight, especially in the Republic of Korea, where fire blight and black shoot blight coexist.

• 한국농림기상학회지
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• 제8권2호
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• pp.97-106
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• 2006

Site index is an essential tool to estimate forest productivity. Generally, a site index equation is developed and used from the relationship between stand age and dominant tree heights. However, there is a limit to the use of the site index equation in the application of variable ages, environmental influence, and estimation of site index for the unstocked forest. Therefore, it has been attempted to develop a new site index equation based on various environmental factors including site, climate, and topographical variables. This study was conducted to develop a site index equation based on the relationship between site index and environmental factors for the species of Pinus koraiensis in Yangpyung-Gun, Gyunggi Province. The influence of climatic factors (temperature and solar irradiation ratio), topographical factors (elevation, slope, ratio of slope to valley and aspect) and soil profiles (soil depth by layer and soil consistency) on site index were evaluated by multiple regression analysis. Five environmental factors were selected in the final site index equation for Pinus koraiensis. The site index equation developed in this study was also verified by three evaluation statistics: model's estimation bias, model's precision, and mean square error of measurement. Based on the site index equation, the number of productive areas for Pinus koraiensis were estimated by applying GIS technique to digitized forest maps. In addition, the distribution of productive areas was compared with the areas of current distribution of Pinus koraiensis. It is expected that the results obtained in this study could provide valuable information about the amount and distribution of productive areas for Pinus koraiensis reforestation.