• Title/Summary/Keyword: Neurophysiology

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Skin biopsy: an emerging method for small nerve fiber evaluation

  • Sohn, Eun Hee
    • Annals of Clinical Neurophysiology
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    • v.20 no.1
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    • pp.3-11
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    • 2018
  • Skin biopsy and staining the specimens with immuno-reactive markers has been proven to be a useful method to demonstrate the pathologic status of small nerve fibers. Quantification of intraepidermal nerve fiber density using anti-protein gene product 9.5 antibody is a standard method to diagnose small fiber neuropathy. Skin biopsy also makes it possible to differentiate the nerve fibers according to their function by using different markers. Quantification of dermal structures with different types of nerve fibers could reveal the pathophysiologic mechanism of the disease state.

Vestibular-evoked myogenic potentials: principle and clinical findings

  • Choi, Jeong-Yoon
    • Annals of Clinical Neurophysiology
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    • v.22 no.2
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    • pp.67-74
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    • 2020
  • Vestibular-evoked myogenic potentials (VEMPs) are useful for evaluating the vestibulocollic reflex arising mostly from the saccule and the vestibuloocular reflex originating from the utricle. VEMPs can vary with the characteristics of the applied stimuli and the effects of aging and diseases. VEMPs have been found to be useful for diagnosing superior canal dehiscence, but their usefulness for other clinical disorders remains unclear. This review discusses the principles of VEMP tests and summarizes the findings for VEMPs in common vestibular disorders.

Delayed diagnosis of intramedullary spinal cord germinoma

  • Kim, Haelim;Lee, Eung-Joon;Sung, Jung-Joon
    • Annals of Clinical Neurophysiology
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    • v.22 no.2
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    • pp.109-111
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    • 2020
  • Germ-cell tumors (GCTs) are common in the central nervous system. GCTs are highly sensitive to radiotherapy and chemotherapy and can be cured without radical surgery. However, this tumor produces nonspecific imaging findings, and its rarity can make diagnosis challenging. Here we report a case in which the first diagnosis was uncertain and follow-up imaging revealed intramedullary germinoma. The patient underwent chemotherapy and radiotherapy after the diagnosis.