• 대한치매학회지
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• 제22권3호
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• pp.100-108
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• 2023

Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name-were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.

• Annals of Clinical Neurophysiology
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• 제14권1호
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• pp.45-48
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• 2012

Neurolymphomatosis is a complication of lymphoma and initial presentation of cranial nerve involvement has been rarely reported. We describe a patient with neurolymphomatosis who presented as facial palsy mimicking steroid responsive Bell's palsy, a common and benign condition. This case shows that even minor neurologic deficit of lymphoma patient should not be absolutely regarded as a benign condition.

• Journal of Korean Medical Science
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• 제33권53호
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• pp.343.1-343.8
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• 2018

Background: Linkage of public healthcare data is useful in stroke research because patients may visit different sectors of the health system before, during, and after stroke. Therefore, we aimed to establish high-quality big data on stroke in Korea by linking acute stroke registry and national health claim databases. Methods: Acute stroke patients (n = 65,311) with claim data suitable for linkage were included in the Clinical Research Center for Stroke (CRCS) registry during 2006-2014. We linked the CRCS registry with national health claim databases in the Health Insurance Review and Assessment Service (HIRA). Linkage was performed using 6 common variables: birth date, gender, provider identification, receiving year and number, and statement serial number in the benefit claim statement. For matched records, linkage accuracy was evaluated using differences between hospital visiting date in the CRCS registry and the commencement date for health insurance care in HIRA. Results: Of 65,311 CRCS cases, 64,634 were matched to HIRA cases (match rate, 99.0%). The proportion of true matches was 94.4% (n = 61,017) in the matched data. Among true matches (mean age 66.4 years; men 58.4%), the median National Institutes of Health Stroke Scale score was 3 (interquartile range 1-7). When comparing baseline characteristics between true matches and false matches, no substantial difference was observed for any variable. Conclusion: We could establish big data on stroke by linking CRCS registry and HIRA records, using claims data without personal identifiers. We plan to conduct national stroke research and improve stroke care using the linked big database.

• 대한신경과학회지
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• 제36권4호
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• pp.337-340
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• 2018

Human immunodeficiency virus (HIV) infection can result in ischemic stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. HIV-vasculopathy is related to endothelial dysfunction, stenosis and aneurysm formation, infectious vasculitis, dissection and accelerated atherosclerosis during highly active antiretroviral therapy (HAART). We represent a case of HIV infection manifested as an acute ischemic stroke attack. After 4 months during HAART, our patient experienced a recurrent ischemic stroke with progression of middle cerebral artery stenosis.

• Journal of Information Science Theory and Practice
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• 제3권3호
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• pp.45-63
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• 2015

The word ‘growth’ represents an increase in actual size, implying a change of state. In science and technology, growth may imply an increase in number of institutions, scientists, or publications, etc. The present study demonstrates the growth of neurology literature for the period 1961-2010. A total of 291,702 records were extracted from the Science Direct Database for fifty years. The Relative Growth Rate (RGR) and Doubling Time (Dt.) of neurology literature have been calculated, supplementing with different growth patterns to check whether neurology literature fits exponential, linear, or logistic models. The results of the study indicate that the growth of literature in neurology does not follow the linear, or logistic growth model. However, it follows closely the exponential growth model. The study concludes that there has been a consistent trend towards increased growth of literature in the field of neurology.

• 대한임상검사과학회지
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• 제45권3호
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• pp.124-129
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• 2013

Separating of the facial nerve caused by compression near the blood vessels that cause the blood vessels and surgery when the hemifacial spasm, facial spasms, will disappear. These impacts have occurred very rarely and seen in this paper as facial spasms due to a brain tumor. The size of a brain tumor grows, which will put pressure on the surrounding facial spasm. Treated hemifacial spasm symptoms disappear through the removal of a brain tumor that occurs because saw.

• Annals of Clinical Neurophysiology
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• 제6권1호
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• pp.57-60
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• 2004

The sixty two-year-old woman was admitted with facial diplegia and ataxic gait. Neurological examination revealed areflexia and sensory ataxia with decreased sensation of position and vibration in both lower extremities. Electrophysiologic study suggest motor dominant demyelinating polyneuropathy and bilateral facial neuropathy. CSF study revealed no cells and increased proteins. After intravenous immunoglobulin therapy, sensory ataxia and electrophysiological study had markedly improved for 3 months.

• Annals of Clinical Neurophysiology
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• 제6권1호
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• pp.61-63
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• 2004

The copy numbers of the CTG repeats are known to relate to the severity of clinical symptoms for myotonic dystrophy. The positive correlation between clinical manifestations and CTG repeat size has been demonstrated previously. A genetically confirmed myotonic dystrophy patient with 90 CTG repeat number had more severe clinical manifestation than brother with 120 CTG repeats, in adulthood.

• Annals of Clinical Neurophysiology
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• 제22권1호
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• pp.24-28
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• 2020

Hashimoto's encephalopathy (HE) is a heterogeneous encephalopathy with diverse clinical presentations. Here we report on a 69-year-old woman who presented with confusion, aphasia, fever, and focal ictal discharges. Cerebrospinal fluid analysis and a workup for other fever origins revealed no abnormality and a high level of thyroperoxidase antibody was detected, which findings led to a diagnosis of HE. The symptoms subsided after treatment. This study highlights the importance of considering HE in patients presenting with fever and abnormal EEG findings.

• Annals of Clinical Neurophysiology
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• 제9권1호
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• pp.39-41
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• 2007