• 한국융합학회논문지
• /
• 제12권2호
• /
• pp.61-66
• /
• 2021

본 연구의 목적은 지연성근육통의 통증 변화가 자율신경계와 뇌파에 미치는 영향을 알아보고자 하였다. 지연성 근육통이 유발된 28명을 대조군(n=14)과 실험군(경피신경자극과 키네시오테이핑 적용, n=14)으로 구분하였다. 중재는 지연성근육통 유발 1일 후부터 5일 동안 실시하였다. 평가는 VAS(visual analog scale), 심박변이, 뇌파를 사용하여 지연성근육통 유발 전, 유발 24시간 후, 5일 치료 후, 치료 중단 3일 후에 측정하였다. 실험 결과 지연성근육통이 발생하면 교감신경계의 활성 증가 또는 부교감신경계 활성 억제가 되며, 중재로 인한 통증 감소는 반대의 활동이 나타났다. 통증 발생 시 alpha파의 감소가 나타났으나 유의하지 않았다. 본 연구 결과 통증 변화는 자율신경계와 뇌파에 영향을 미침을 알 수 있었으며, 이러한 결과는 통증 관리와 치료 전략 개발 및 연구에 도움이 될 것이다.

• Biomolecules & Therapeutics
• /
• 제30권4호
• /
• pp.360-367
• /
• 2022

Tropomyosin receptor kinase A (TrkA) protein is a receptor tyrosine kinase encoded by the NTRK1 gene. TrkA signaling mediates the proliferation, differentiation, and survival of neurons and other cells following stimulation by its ligand, the nerve growth factor. Chromosomal rearrangements of the NTRK1 gene result in the generation of TrkA fusion protein, which is known to cause deregulation of TrkA signaling. Targeting TrkA activity represents a promising strategy for the treatment of cancers that harbor the TrkA fusion protein. In this study, we evaluated the TrkA-inhibitory activity of the benzoxazole compound KRC-108. KRC-108 inhibited TrkA activity in an in vitro kinase assay, and suppressed the growth of KM12C colon cancer cells harboring an NTRK1 gene fusion. KRC-108 treatment induced cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 suppressed the phosphorylation of downstream signaling molecules of TrkA, including Akt, phospholipase Cγ, and ERK1/2. Furthermore, KRC-108 exhibited antitumor activity in vivo in a KM12C cell xenograft model. These results indicate that KRC-108 may be a promising therapeutic agent for Trk fusion-positive cancers.

• 한국전문물리치료학회지
• /
• 제29권3호
• /
• pp.241-248
• /
• 2022

Background: The PyeongChang 2018 Winter Paralympic Games (WPG) being one of the most successful Paralympic Games (PG) in modern athletic world history, hosted the largest number of elite athletes representing 49 National Paralympic Committees (NPCs). Objects: The present investigation highlighted the demographic and clinical characteristics of injured athletes and non-athletes and the physiotherapy services provided during the PyeongChang 2018 WPG. Methods: Prospective descriptive epidemiology study, in which the study group comprised of 201 participants (51 athletes and 150 non-athletes) who were admitted to and utilized the polyclinic physiotherapy service of 2018 PyeongChang WPG in Physiotherapy Department of Paralympic Village from March 1, 2018 to March 20, 2018. Results: Qualitative frequency analysis of injury type demonstrated highest number of chronic injuries (51%, n = 100) in athletes and non-athletes. Anatomical injury site analysis revealed that the spine and shoulder areas were affected with equal frequency for athletes (54.9%, n = 14), whereas for non-athletes, the frequencies of spine and shoulder area injuries were 36.7% (n = 55) and 26% (n = 39), respectively. The Pyeongchang WPG showed a high rate of athletes visiting the physiotherapy service during the pre-competition period (33.3%, n = 50), which may have led to smaller incidence rate of traumatic injury. The physiotherapy treatment service analysis demonstrated that manual therapy (35.4%, n = 230) was most commonly utilized, followed by transcutaneous electrical nerve stimulation/interference current therapy (TENS/ICT), therapeutic massage and therapeutic exercise. Conclusion: We established the importance of prophylactic and preventive physiotherapy services to reduce the risk of sports injuries during WPG.

• Journal of Acupuncture Research
• /
• 제40권3호
• /
• pp.238-244
• /
• 2023

Background: Occipital neuralgia (ON) is an established risk factor for headaches in the posterior cervical region. Several conservative treatments by nerve decompression and pain relief are available for ON, but these treatments have limitations. Acupuncture treatment, which is known to demonstrate analgesic effects, involves various stimulation methods, and several studies have reported their clinical benefit. No recent systematic review (SR) has compared each acupuncture type for ON treatment. Thus, this SR aims to investigate the clinical effectiveness of each acupuncture type for treating ON. Methods: We will identify relevant studies using electronic databases, including EMBASE, MEDLINE, Cochrane Library, China National Knowledge Infrastructure (CNKI), Korean Studies Information Service System (KISS), Korean Medical Database, KoreaMed, and National Digital Science Library (NDSL) from the inception until August 2023. The primary outcome will include the numerical change of pain symptoms (visual analog scale and numerical rating scale) and effective rate. Safety and secondary outcomes will include adverse events and quality of life. We will compare the conservative treatment with the acupuncture treatment using network meta-analysis. The Cochrane Collaboration "risk of bias" tools will be used to assess the quality of included trials. The Grades of Recommendation, Assessment, Development, and Evaluation will be used to examine the evidence level. Conclusion: This study will provide clinical evidence of several acupuncture types for ON and help clinicians decide on the best.

• 대한한방내과학회지
• /
• 제44권2호
• /
• pp.158-166
• /
• 2023

Background: Adductor spasmodic dysphonia (ASD) is caused by the involuntary contraction of laryngeal muscles due to dystonia localized to the larynx. In the case of ASD, conventional treatment is mainly performed with a botulinum toxin injection. However, the botulinum toxin injection has a short-lasting effect and requires repeated injections. Alternatives are needed due to concerns over adverse effects, such as general weakness and airway aspiration caused by the botulinum toxin injection. Case report: A 46-year-old female patient with ASD complained of voice tremor and hoarseness. The combined Korean medical treatments-Ukgan-san-gami, Jakyakgamcho-tang, acupuncture, and transcutaneous electrical nerve stimulation (TENS)-were administered on the first day the patient was hospitalized. The Voice Handicap Index (VHI) was evaluated during the treatment. The VHI taken on the second day totaled 92 points. On the ninth day, 81 points were recorded. Total score gradually improved, and on the 16th day, 62 points were recorded. Combined Korean medical treatment lasted 19 days. Conclusion: The present case report suggests that a combined Korean medical treatment approach with Ukgan-san-gami, Jakyakgamcho-tang, acupuncture, and TENS might be effective for symptoms such as voice tremors and hoarseness. Combined Korean medical treatment can be a therapeutic option for patients with ASD.

• 대한중풍순환신경학회지
• /
• 제19권1호
• /
• pp.41-48
• /
• 2018

■ Objectives The purpose of this case report is to show the effect of Traditional Korean Medicine (TKM) on a patient with horizontal eye movement disorder due to Foville syndrome. ■ Methods A patient with horizontal eye movement disorder as Foville syndrome was treated with herbal medication, acupuncture, electro-acupuncture and transcutaneous electrical nerve stimulation. Then we evaluated the improvement with mobility impairment, length of movement and House-Brackmann scale before and after treatment ■ Results Improvements of mobility impairment, distance at left gaze and House-Brackmann scale were observed after the TKM treatment. ■ Conclusion This case report shows the effect of TKM treatment on horizontal eye movement disorder due to Foville syndrome.

• Physical Therapy Rehabilitation Science
• /
• 제12권2호
• /
• pp.185-191
• /
• 2023

Objective: Transcutaneous electrical nerve stimulation (TENS) is a treatment method for pain, and it can be divided into conventional TENS (C-TENS) and acupuncture-like TENS (A-TENS). More recently, high power lasers have increasingly been used to reduce pain caused by arthritis, residual neuralgia, and musculoskeletal disorders. The aim of this study was to compare the laser needle with C-TENS and A-TENS in terms of pain and blood flow in healthy people, as well as to confirm that the laser needle can replace TENS to treat pain. Design: A randomized controlled trial. Methods: The selected participants were divided using Minimize computer software into a laser group (n=13), a C-TENS group (n=13), and an A-TENS group (n=14); they underwent a pre-test for blood flow and pain in their forearm. The three groups received their respective interventions; they then underwent a second pain and blood flow test on the same spot. Results: No significant differences were observed in the A-TENS group between the pre- and post-tests, and a comparison among the three groups revealed no significant differences between the laser needle group and the C-TENS group in terms of pain. Regarding blood flow, no significant differences were found between the pre- and post-tests in the laser needle group; a comparison among the three groups only revealed a significant between the laser needle and A-TENS groups. Conclusions: This study confirmed that the laser needle can be used to treat pain when it is necessary to control blood flow.

• 대한족부족관절학회지
• /
• 제27권4호
• /
• pp.137-143
• /
• 2023

Purpose: Autologous osteochondral transplantation (AOT) is indicated for patients with a large osteochondral lesion of the talus (OLT), accompanying subchondral cyst, and the failure of bone marrow stimulation (BMS) procedures. Despite the many reports on the clinical results of surgical treatment for medial osteochondral lesions, those of lateral lesions are rare. This paper reports the intermediate-term clinical outcomes after AOT for lateral OLTs. Materials and Methods: Twenty-one patients with lateral OLTs were followed up for at least three years after AOT. The clinical evaluations comprised the Foot and Ankle Outcome Score (FAOS) and Foot and Ankle Ability Measure (FAAM). The radiographic assessment included the irregularity of the articular surface (subchondral plate), the progression of degenerative arthritis, and the changes in talar tilt angle and anterior talar translation. Results: The mean FAOS and FAAM scores improved significantly from 42.1 to 89.5 and 39.5 to 90.6 points, respectively, at the final follow-up (p<0.001). The radiological evaluation revealed two cases (9.5%) of articular step-off ≥2 mm and 1 case (4.8%) of progressive arthritis. The mean talar tilt angle and anterior talar translation improved significantly. As postoperative complications, there was one case of a local wound problem, one case of superficial peroneal nerve injury, and one case of donor site morbidity. At a mean follow-up of 62.3 months, no patient showed a recurrence of instability or required reoperation for OLT. Conclusion: AOT for the lateral OLTs demonstrated satisfactory intermediate-term clinical outcomes, including daily and sports activity abilities. Most OLT could be accessed through lateral ligament division and capsulotomy, and the incidence of iatrogenic complications, such as recurrent sprains or chronic instability, was minimal. AOT appears to be an effective and relatively safe treatment for patients with large lateral osteochondral lesions unresponsive to conservative therapy, with subchondral cysts, or with failed primary BMS.

• Journal of Yeungnam Medical Science
• /
• 제14권1호
• /
• pp.111-122
• /
• 1997

정상 성인에서 상지로 부터 H-반사가 유발될수 있는지를 알아보고, 또 상지에서의 H-반사 검사가 경수 신경근병증의 진단에 유용한지를 알고자 본 연구를 실시하였다. 정상 성인 31명을 대상으로 좌우 62개의 요측수근굴근, 요측수근신근, 상완요골근, 소지외전근의 H-반사를 검사하여 잠복기와 interlatency time을 구하였고 경수 신경근병변을 가진 환자 12명을 대상으로 H-반사를 검사하였다. 정상군에서 요측수근신근의 H-반사의 잠복기의 평균은 $15.99{\pm}1.25$ msec, 양측 차이의 평균치는 $0.68{\pm}0.71$ msec이었으며 interlatency time은 평균치가 $13.93{\pm}1.32$ msec, 양측 차이의 평균치는 $0.73{\pm}0.62$ msec 이었다 요측수근굴근의 H-반사의 잠복기의 평균은 $16.16{\pm}1.65$ msec, 양측 차이의 평균치는 $0.47{\pm}0.48$ msec이었고 interlatency time의 평균치는 $13.91{\pm}0.99$ msec, 양측 차이의 평균치는 $0.49{\pm}0.47$ msec 이었다. 상완요골근의 경우는 H-반사의 잠복기의 평균치가 $16.47{\pm}1.59$ msec, 양측 차이의 평균치가 $0.63{\pm}0.43$ msec 이었고 interlatency time의 평균치는 $14.68{\pm}1.61$ msec, 양측 차이의 평균치는 $0.79{\pm}0.71$ msec 이었다. 소지외전근에서의 H-반사의 잠복기의 평균치는 $24.46{\pm}1.42$ msec, 양측 차이의 평균치는 $0.59{\pm}0.42$ msec, 양측 차이의 평균치는 $0.59{\pm}0.42$ msec이고 interlatency time의 평균치는 $22.31{\pm}1.24$ msec, 양측 차이의 평균치는 $0.19{\pm}0.44$ msec를 보였다. 정상군에서는 팔 길이와 키가 커짐에 따라서 H-반사의 잠복기가 길어지는 양상을 보였다. 경수 신경근병변을 가진 12명중 11명에서 H-반사 검사상 이상 소견을 보였으며 제 6,7 경수 신경근 병변을 보인 5명중 4명에서 요측수근굴근의 H-반사의 이상 소견을 보였고, 제 7 경수 신경근병변을 보인 4명 모두에서 요측수근굴근과 요측수근신근에서의 이상 소견을 보였다. 제 5 신경근병변을 보인 환자 1명에서 상완요골근에서의 이상 소견을 보였다. 본 연구를 통하여 정상 성인에서 상지로부터 H-반사가 측정할 수 있으며, H-반사의 잠복기는 팔 길이와 키에 연관이 있음을 알았다. 또 경수 신경병증의 진단에 H 반사가 적용될 수 있음을 확인 하였다.

• Journal of Acupuncture Research
• /
• 제26권6호
• /
• pp.67-76
• /
• 2009

Objectives : The purpose of this study is to examine if Radix Aconiti herbal acupuncture may be effective to the neuropathic pain(mechanical allodynia, cold allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic pain, under isoflurane 2.5% anesthesia, L5 spinal nerve was ligated by 6-0 silk thread. After neurophathic surgery, the author examined if the animals exhibited the behavioral sign of allodynia. The allodynia was assessed by stimulating the medial malleolus with von frey filament and acetone. Three days after the neuropathic surgery, Radix Aconiti herbal acupuncture was injected at Hwando($GB_{30}$) one time per two days for 2 weeks. After that, the author examined the withdrawal response of neuropathic rats' legs by von frey filament and acetone stimulation. And also the author examined c-Fos in the midbrain central gray of neuropathic rats and the change of WBC, RBC, HGB, HCT count in the blood of neuropathic rats. Results : The Radix Aconiti herbal acupuncture injected Hwando($GB_{30}$) decreased the withdrawal response of mechanical allodynia that assessed with von frey filament in RA1-$GB_{30}$, RA2-$GB_{30}$ group as compared with control group. The Radix Aconiti herbal acupuncture injected Hwando($GB_{30}$) decreased the withdrawal response of chemical allodynia(cold allodynia) that assessed with acetone in RA1-$GB_{30}$, RA2-$GB_{30}$ group as compared with control group. The Radix Aconiti herbal acupuncture injected Hwando($GB_{30}$) showed the significant between control group and RA2-$GB_{30}$ group in the c-Fos expression. The Radix Aconiti herbal acupuncture injected Hwando($GB_{30}$) did not show the significant between control group and RA1-$GB_{30}$ group, RA2-$GB_{30}$ group and RA3-$GB_{30}$ group in the WBC, RBC, HGB, HCT count. Conclusions : We have noticed that Radix Aconiti herbal acupuncture at Hwando($GB_{30}$) decreased mechanical allodynia and cold allodynia in the model of neuropathic pain compared with the control group. C-fos expression in the central gray of that group was also decreased compared with the control group. This study can be used as a basic resource on a study and a treatment of pain.