• Clinical and Experimental Pediatrics
• /
• 제46권2호
• /
• pp.192-194
• /
• 2003

가정분만으로 태어난 후 생후 6일된 신생아에서 전신성 강직-간대 경련이 발생하여 내원한 환아에서, 병력과 진찰 소견상 신생아 파상풍으로 진단하여 근이완제 및 인공환기요법으로 치료한 1례를 경험하였기에 보고하는 바이다.

• Journal of Oral Medicine and Pain
• /
• 제36권2호
• /
• pp.117-121
• /
• 2011

파상풍은 손상부위에 Costridium tetani 감염으로 발생하는 근육의 경련성 마비와 근육의 통증, 및 자율신경계증상을 동반하는 치명적인 신경학적인 질환이다. C. tetani는 오염된 상처에서 산소부족 상태에서 임상적 파상풍으로 발생하며, 상처의 크기보다는 혈액과 산소의 공급장애에 의해 발행한다. 파상풍은 전신형, 국소형, 두개형 신생아형으로 분류되며 잠복기는 보통 7일이다. 파상풍의 전형적인 임상 증상은 근육의 지속적인 경련과 경직이며, 안면근 경련으로 인해 경련미소나 등쪽의 경련 지속으로 인해 활모양강직이 나타난다. 파상풍 환자의 75%가 안면부 근육에 증상 즉, 개구제한을 보여 초기에 치과로 내원 할 가능성이 높다 본 증례에서는 손상후에 개구제한을 주소로 본과로 내원한 환자가 파상풍으로 진단됨에 따라 이 환자의 증례를 살펴 파상풍으로 인한 개구 제한에 대해 고찰하고자 한다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제11권3호
• /
• pp.79-84
• /
• 2007

Because synaptic refinement of medial nucleus of trapezoid body (MNTB) - lateral superior olive (LSO) synapses is most active during the first postnatal week and the long term depression (LTD) has been suggested as one of its mechanisms, LTD of MNTB-LSO synapses was investigated in neonatal rat brain stem slices with the whole cell voltage clamp technique. In $Mg^{2+}$ free condition, tetanus (10 stimuli at 10 Hz for 2 min) in the current clamp mode induced a robust LTD of isolated D, L-APV-sensitive postsynaptic currents (PSCs) for more than 30 min ($n=6,\;2.4{\pm}0.4%$ of the control), while isolated CNQX-sensitive PSCs were not suppressed ($n=6,\;95.3{\pm}1.6%$). Tetanus also elicited similar LTD in the isolated GABAergic/glycinergic PSCs ($n=6,\;3.6{\pm}0.5%$) and mixed PSCs (GABAergic/glycinergic/glutamatergic) ($n=4,\;2.2{\pm}0.7%$). However, such a strong LTD was not observed in the mixed PSCs when 10 mM EGTA was added in the internal solution (n=10), indicating that postsynaptic $Ca^{2+}$ rise is needed for the strong LTD. This robust LTD might contribute to the active synaptic refinement occurring during the first postnatal week.

• Journal of Preventive Medicine and Public Health
• /
• 제10권1호
• /
• pp.142-149
• /
• 1977

To use basic data for health planning and evaluation of Kangwha community health project of Yonsei University, a study on death rates and causes of death were investigated in two townships (Naega and Sunwon Myuns) in Kangwha County from April 1, 1975 to March 31, 1977 All death was identified and reported by family health workers who are living in each village and 2 trained public health nurses confirmed the death. The causes of death were investigated by 2 public physicians. Total number of deaths for 2 years was 230 and the followings are brief summary of the study. 1. Age-adjusted crude death rates of study area were 8.69 per 1,000 population in 1975 and 7.18 per 1,000 population in 1976. Age-adjusted crude death rates for male were 9.18 in 1975 and 6.38 in 1976 and for female were 8.33 and 7.80 per 1,000 population 2. Age specific death rate curves by year and sex showed 'U' shapes. 3. Infant and neonatal death rates were 30.08 and 22.56 per 1,000 live births in 1975, and the rates in 1976 were 18.18 and 13.64. 4. The most common cause of death was cerebrovascular disease and average cause specific death rate for the disease was 215.5 per 100,000 population. 5. Four leading causes of death were non-infectious origin; cerebrovascular disease, malignant neoplasms, senility and suicide. Pulmonary tubeculosis and pneumonia occupied 5th and 9th causes of death. 6. Stomach cancer and hepatoma occupied 61.3% of total death due to malignant neoplasms. 7. Most frequent cause of neonatal death was birth injury. Two deaths due to tetanus were found in 1975, but no death due to this disease was found in 1976. 8. About half of deceased received care from physician before death.