• 대한지역사회영양학회지
• /
• 제12권2호
• /
• pp.133-141
• /
• 2007

Minerals play important roles in biological processes. Hair mineral analysis has the advantages of conveniences in sampling and observing the profiles of multiple minerals simultaneously. The purpose of this study was to compare hair mineral contents between urban and local middle school students, and to find out the relation with nutrient intakes and clinical symptoms. Ten nutritional minerals and 7 environmental mineral contents were analyzed in the hair samples of 44 and 37 male students who resided in urban and local area, respectively. And their nutrient intake and clinical symptom score were estimated from questionnaire. The average age, height, and weight were 15.1 years, 168.4 cm, 56.8 kg in urban subjects and 15.4 years, 169.1 cm, 61.9 kg in local subjects, respectively. The residence types were apartment (63.6%) and small-sized apartment (22.7%) in urban subjects and apartment (51.4%) and house (37.8%) in local subjects. The primary water sources were purified water (38.3%), running water (18.2%) in urban subjects and purified water (32.4%), underground water (27.0%) in local subjects, respectively. Daily energy and nutrient intakes were not significantly different between two groups. Among the surveyed 17 clinical symptoms, the scores of constipation, cold, anxieties and total score of clinical symptoms in urban subjects were significantly love. than those in local subjects. Hair contents of Na, Mg, Ca, Cu, V Al, As were significantly higher, while U was lower in urban subjects compared to those in rural subjects. Hair contents of Ni and U were significantly correlated with food intake, and Cr, V, Al, Sb, As, U showed a correlation with energy intake. Hair Mg level showed significantly negative correlation with total clinical symptom score. In conclusion, hair mineral profile between urban and local students was significantly different. And some of these minerals were significantly correlated with food and nutrient intakes. Especially hair magnesium was significantly correlated with total clinical symptom score. Therefore, hair mineral levels would be needed for more systematic study elucidating potentiality as a useful clinical tool.

• Clinical and Experimental Pediatrics
• /
• 제56권1호
• /
• pp.32-36
• /
• 2013

Purpose: Chronic day-to-day symptoms of orthostatic intolerance are the most notable features of postural orthostatic tachycardia syndrome (POTS). However, we have encountered patients with such symptoms and excessive tachycardia but with no symptoms during the tilt-table test (TTT). We aimed to investigate whether POTS patients with chronic orthostatic intolerance always present orthostatic symptoms during the TTT and analyze the factors underlying symptom manifestation during this test. Methods: We retrospectively examined patients who presented with POTS at the Gyeongsang National University Hospital between 2008 and 2011. Diagnosis of POTS was based on chronic day-to-day orthostatic intolerance symptoms as well as excessive tachycardia during the TTT. The patients were divided two groups depending on the presentation of orthostatic symptoms during the TTT. Clinical data and the results of the TTT were compared between these groups. Results: In 22 patients, 7 patients (31.8%) did not present orthostatic symptoms during the test. Diastolic blood pressure (BP) was significantly lower in the symptom-positive group. The head-up tilt resulted in a significant increase in diastolic BP in the symptom-negative group (P=0.04), while systolic BP had a tendency to decrease in the symptom-positive group (P=0.06). Conclusion: Significant patients with POTS did not present orthostatic symptoms during the TTT despite having chronic daily symptoms. This finding may be important for establishing definitive diagnostic criteria for pediatric POTS. Development of symptoms during TTT might be related to low diastolic BP and abnormal compensatory responses to orthostasis.

• 한국직업건강간호학회지
• /
• 제8권1호
• /
• pp.56-67
• /
• 1999

This study was designed to identify the relationships of role-conflict and role-overload, coping strategies, and stress response of clerical workers. The subjects were 115 clerical workers from two company. The instruments were the role-conflict and role-overload scale developed by Lee(1989), coping scale developed by Latack(1986), and the stress response scale developed by Chang(1993). Analysis of data was done by descriptive statistics, Cronbach's $\alpha$, Pearson correlation coefficietnt, ANOVA. The results of this study were summarized as follows ; 1. The average score for the level of stress response was $83.6({\pm}9.1)$. The high risk stress group was 86.1% of the clerical workers, the latent stress group members was 13.9%, and healthy group was 0%. The overall stress level was very high. 2. Considering the coping strategies by sociodemographic factors, the use of control coping strategies showed significant differences by work-time. The use of symptom management coping strategies showed significant differences by sex, age, married status, year of career, pay, and type of work. The organizational coping strategies showed significant differences by year of education and type of work. 3. The clerical workers who had worked below 44 hours per week complained significantly lower stress response(F=4.942, p<.05). 4. Above 65% of all respondents answered that they needed all of organizational level coping strategies. 5. The role-confilct positively related to escape and organizational level coping strategies(r=.562, r=.495, p<.05). The role-overload didn't related to individual level coping strategies, but positively related to organizational level coping strategies(r=.320, p<.05). 6. The control coping strategies and the escape coping strategies positively related to symptom management, organizational level coping strategies(r=.409, r=.324, r=.316, r=.339, p<.05). 7. The relationship between role-related stress and stress response revealed positive correlation(r=.482, r=.431, p<.05), and the relationship between stress response and control, symptom management coping strategies revealed negative cor-relation(r=-.3204, r=-.3146, p<.05). In conclusion, this study revealed that relationship of role related stress, coping strategies, stress response was statistically significant. The result of this study support that coping strategies vary across situation of stress. Based on survey results, future studies should consider coping strategies in specific stress situation and concept of symptom management coping strategy. Also organizational or training interventions could be developed and initiate to help to increase the use of adaptive coping strategies in light of individual and situational differences.

• 한국산학기술학회논문지
• /
• 제14권1호
• /
• pp.214-222
• /
• 2013

본 연구는 노인의 감각처리유형과 통증 파국화 수준과의 상관관계에 대하여 알아보고, 이를 통해 재활중재를 위한 기초자료로 제시하고자 하였다. 연구대상은 65세 이상 노인 216명으로 하였다. 감각처리의 유형은 청소년/성인 감각프로파일을 사용하여 측정하였고, 통증의 심리적인 변인들은 통증파국화척도를 사용하여 측정하였다. 성별과 연령에 따른 차이는 t-검정을, 감각처리유형과 통증파국화와의 상관관계를 피어슨 상관분석을 실시하였다. 감각처리유형은 여성이 남성에 비해 '감각민감', '감각회피'의 경향이 높았으며(p<.05), 연령이 75세 이상인 군이 65~74세 군에 비해 '감각회피', '등록저하', '감각찾기'의 경향이 높은 것으로 나타났다(p<.05). 감각처리유형이 '등록저하'일 때 통증파국화의 '반추적사고'와 그리고 '감각찾기'일 때 통증 파국화의 '무력감'과 음의 상관관계를 나타내었다. '감각민감', '감각회피' 일 때 통증파국화의 모든 항목에서 양의 상관관계를 나타내었다. 65세 이상 노인의 감각처리 유형은 통증에 대한 심리적인 변인과 관련되어 있으며, 성별과 연령에 따라 차이가 있음을 알 수 있었다. 앞으로는 노인의 감각처리 유형 및 통증관련 요인들에 관한 더 진전된 연구가 이루어지기를 기대한다.

• 동의신경정신과학회지
• /
• 제22권2호
• /
• pp.15-25
• /
• 2011

Objectives : The aim of this study was to find correlations between characteristics of Four constitution and Hwa-byung. Methods : Clinical data were collected from Hwa-byung Epidemiologic study data. we selected 130 self-labelled Hwa-byung patients data and 83 of them were diagnosed as Hwa-byung by SCID. We used Hwa-byung SCID, Hwa-byung scale, CES-D, STAI, STAXI and Personality and Physiological Symptom Questionnaire(PPSQ) as evaluation tools. We performed statistical analysis of each 2 groups, self-labelled Hwa-byung group(N=130) and diagnosed Hwa-byung group(N=83). Results : 1. In self-labelled Hwa-byung group, Greater yin score showed significant negative correlation with 3 indices of Hwa-byung scale and significant positive correlation with 1 index. Lesser yin score showed significant positive correlation with 6 indices. In diagnosed Hwa-byung group, Greater yin score showed significant negaitive correlation with 5 indices. In both groups, Lesser yang score showed no significant correlation with any indices of Hwa-byung scale. 2. In self-labelled Hwa-byung group, Greater yin score showed significant negative correlation with both trait anger score and state anger score of STAXI. Lesser yin score showed significant positive correlation with trait anxiety score, state anxiety score and CES-D score self-labelled Hwa-byung group. Lesser yang score showed significant positive correlation with anger-out score of STAXI. But Lesser yin score showed significant negative correlation with same index diagnosed Hwa-byung group. Conclusions : 1. The higher Greater yin score, suppression or denial, psychological defense mechanism, become more stronger. 2. The higher Lesser yin score, anger-out tendency become more weakened and increased prevalence of Hwa-byung symptoms. 3. The higher Lesser yang score, anger-out tendency become more stronger.

• 생물정신의학
• /
• 제16권3호
• /
• pp.170-180
• /
• 2009

Objectives : To assess clinical improvement and change in plasma brain-derived neurotrophic factor(BDNF) level after repetitive transcranial magnetic stimulation(rTMS) in patients with treatment-resistant schizophrenia. Methods : Seven patients with DSM-IV schizophrenia, who were proven to be treatment-resistant, were treated with 15 sessions of rTMS for three weeks as an adjuvant therapy to antipsychotic treatment. Clinical improvement and change in plasma BDNF level were measured after the treatment period. The symptom severity was assessed with the Positive and Negative Syndrome Scale(PANSS) and the Korean Version of Calgary Depression Scale for Schizophrenia(K-CDSS) at baseline and 7 days after the treatment. Plasma BDNF level was measured by enzyme-linked immunosorbent assay(ELISA) at baseline and 7 days after the treatment. Results : After the rTMS treatment, there was no significant improvement in PANSS total score(Z=-1.693, p=0.090) and no significant change in plasma BDNF was found(Z=-1.183, p=0.237). Negative correlations were found between percentage change in PANSS positive subscale score and duration of illness(rho=-0.991, N=7, p<0.0005, two-tailed), and PANSS negative subscale score at baseline and percentage change in plasma BDNF level(rho=-0.821, N=7, p=0.023, two-tailed). Conclusion : This preliminary study suggests that rTMS didn't make a significant change in clinical symptoms nor in plasma BDNF level in treatment-resistant schizophrenia. Percentage change in plasma BDNF, however, might be correlated with treatment resistance in schizophrenic patients. This is a pilot study with a small sample size, therefore, a further study with a larger sample size is needed.

• 기본간호학회지
• /
• 제6권1호
• /
• pp.35-50
• /
• 1999

The purpose of this study was to compare the climacteric symptoms and emotion of Korean women living in the United States and Korea. The 195 subjects consisted of 81 women who have lived for more than 10 years in the United States and 114 women who live in Korea. All the subjects were from 40 to 60 years of age. Data were collected by convenience sampling using a questionaire in the west and mid-west regions of the United States and in Kyungbuk province in Korea. The results of this study are as follows : 1. Both subjects in the United States and Korea showed the highest negative emotions according to the following ; in the 50-54 years of age group, divorced, less than high school graduation, lower income level and Protestant in religion. So we concluded that the cultural differences between the United States and Korea did not exert an important influence on the women's emotional tendency, but personal characteristics and background did. 2. Emotional tendency of Korean women from 40 to 60 years of age living in United States and Korea was slight negative (Korean-American ; $3.97{\pm}.94$, Korean ; $3.90{\pm}.71$) 3. The emotions of women living in the United States showed a significant difference according to the state of health(F=3.7726, p<.05).The emotions of women living in Korea showed a significant difference according to marrital status(F=6.4733, p<.05). 4. There were negative correlations between the number of climacteric symptoms and emotions.

• Neurospine
• /
• 제15권4호
• /
• pp.383-387
• /
• 2018

Objective: Lower back pain (LBP) is a worldwide health problem, and magnetic resonance imaging (MRI) is a common modality used to aid in its diagnosis. Although specific guidelines for assessing the necessity of MRI usage exist, the use of MRI as the initial imaging method for LBP seems to be more common than necessary in general practice. Methods: We conducted a retrospective chart review of 313 patients who had undergone MRI of the lumbosacral spine during 2014-2015. We recorded and compared various factors, including age, sex, body mass index, current smoking status, race, symptoms, MRI findings, and progression to surgery within the next year. All rates were compared according to whether the MRI results showed radiographically significant findings (MRI-positive) or not (MRI-negative) using the chi-square or Fisher exact tests (if the expected cell count was <5). All analyses were performed using SAS version 9.4. Results: There were no statistically significant differences in the rates of each symptom between the MRI-positive and MRI-negative groups, which accounted for 58.5% (183 of 313) and 41.5% (130 of 313) of the MRIs, respectively. The difference in the rate of surgery in the next year (18% among MRI-positive patients and 8.5% among MRI-negative patients) was found to be statistically significant (p<0.05). Conclusion: Based on our findings, 41.5% of patients underwent lumbar MRI unnecessarily and 81% of patients with positive MRIs did not have surgery within the next year. Further physician training is needed to avoid unnecessary investigations and expenditures.

• Toxicological Research
• /
• 제13권1_2호
• /
• pp.153-156
• /
• 1997

The antigenicity of EPO (erythropoietin) was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA) of this materials were performed according to the established Regulation of Korean National Institute of Safety Research (1996, 4, 16). The results were followed: 1. After sensitizaion with EPO emulsified with complete Freund's adjuvant (CFA), guinea pigs didn't show any anaphylatic shock symptom in the ASA test 2. After sensitization with antisera of EPO sensitized mice, blue spots were observed on the hypodermis of back of rats in the PCA test, but diameter of each spot was smaller than 5 mm. From the results of this investigation, the antigenicity of EPO was negative under the present experimental condition.

• 한국임상약학회지
• /
• 제11권2호
• /
• pp.89-96
• /
• 2001

Ziprasidone is equally effective as haloperidol in treating schizophrenia with fewer side effects and drug interactions. Ziprasidone is an atypical antipsychotic agent and works by blocking serotonin and dopamine receptors in the central nervous system, specifically 5-HT2A and D2 receptors. Low anticholinergic side-effects and low EPS would recommend the drug for use in the elderly. Ziprasidone inhibits reuptake of norepinephrine and serotonin at neurojunction sites in vitro, indicating a potential efficacy for depression and negative symptoms which often follow after exacerbation of schizophrenia. Patients with recent acute myocardial infarction and uncompensated heart failure are contraindicated to the drug due to a possibility of QT prolongation. Although ziprasidone is metabolized by cytochrome P450 3A4, there is no significant drug interaction with the drugs that induce or inhibit the isoenzyme. Ziprasidone is safe with coadministration of lithium and there has been no significant drug interaction reported with oral birth control pills.