• Journal of Ginseng Research
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• v.45 no.1
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• pp.149-155
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• 2021

Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1-infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs. Methods: The vif-vpr genes over 26 years in 20 hemophiliacs infected with HIV-1 from a single source were sequenced to investigate whether vif-vpr genes were affected by KRG and KRG plus highly active antiretroviral therapy (ART) (hereafter called GCT) and compared the results with our previous data. Results: A significantly higher number of in-frame small deletions were found in the vif-vpr genes of KRG-treated patients than at the baseline, in control patients, and in ART-alone patients (p < 0.001). These were significantly reduced in GCT patients (p < 0.05). In contrast, sequences harboring a premature stop codon (SC) were more significant in GCT patients (10.1%) than in KRG-alone patients, control (p < 0.01), and ART-alone patients (p = 0.078 for peripheral blood mononuclear cells). The proportion of SC in Vpr was similar to that in Vif, whereas the proportion of sequences revealing SC in the env-nef genes was significantly lower than that in the pol-vif-vpr genes (p < 0.01). The genetic distance was 1.8 times higher in the sequences harboring SC than in the sequences without SC (p < 0.001). Q135P in the vif gene is significantly associated with rapid progression to AIDS (p < 0.01). Conclusion: Our data show that KRG might induce sD in the vif-vpr genes and that vif-vpr genes are similarly affected by lethal mutations.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.229-229
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• 2006

WECPNL(Weighted Equivalent Continuous Perceived Noise Level) which designated currently in Domestic 'The Stanrd Method of Measuring Noise and Vibration' is composed of different factor with WECPNL that published in ICAO. Domestic WECPNL is concerned in application of $L_{MAX}$ measurement. On the other hand, ICAO's WECPNL is based on EPNL that includes factors of the pure tone correction and the duration time. NNI and NEF also are each based on PNL and EPNL. Because a military aircraft noise, especially, has the pure tone of high frequency and the irregular duration, it seems to be undesirable to estimate aircraft noise for using Domestic WECPNL. Therefore, this study was performed to detect a flaw of Korean WECPNL, through comparison of the trend of each other aircraft noise index by using equivalent rawdata.

• Bulletin of the Korean Mathematical Society
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• v.31 no.1
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• pp.15-23
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• 1994

Throughout this paper, we are working on the complex number field C. The aim of this paper is to explain the applications of Theorem 2 in .cint. 1. In the surface theory, the adjoint linear system has played important roles and many tools have been developed to understand it. In the cases of higher dimensional varieties, we don't have any useful tools so far. Theorem 2 implies that it is enough to compute the dimension of the adjoint linear system to check the birationality. We can compute, somehow, the dimension of the adjoint linear system. For example, we can get an information about $h^{0}$ (X, $O_{x}$( $K_{x}$ + D)) from Euler characteristic of vertical bar $K_{X}$ + D vertical bar and some vanishing theorems. We are going to show the applications of Theorem 2 to smooth three-folds and smooth fourfold, specially, of general type with a nef canonical divisor, smooth Fano variety, and Calabi-Yau manifold. Our main results are Theorem A and Theorem B. Most of birationality problems in Theorem A and Theorem B have been studied. (see Ando [1] and Matsuki [4] for the detail matters.) But Theorem 2 gives short and easy proofs in the cases of dimension 3 and improves the previously known results in the cases of dimension 4.4. 4.4.

• Resources Recycling
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• v.8 no.3
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• pp.37-42
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• 1999

Ths sludy was canied out to recover gold and sllics from abandoned gold mine talings with about 4.5 ghonAu and 84.88 wt% SOz. Tl~bee nef~cialiop~ro~c esses including crushing, screening, magnelic and gravity (humprey sp~rals,h aking table) separation \ulcornervex employed. Results were Feasible to rccovn h e gold concentrates (307.1 gltoilon .4u . 0.60 wr%, 97.7 giton Au : 0.27 wl%, 15.3 &/ton Au . 5.23 wt%, 21.2 g/ton Au : 2.42 wl%) and silica (96.40 wi% SiO\ulcorner yield 60 65 ~ 1 % )

• Biomolecules & Therapeutics
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• v.3 no.3
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• pp.210-216
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• 1995

Partially purified water-soluble extract mixture from Ricini and Coptidis (named as RIC) showed to be a potent inhibitor of human immunodeficiency virus-1 (HIV-1) replication. RIC was evaluated for in vitro anti-HIV activity using SupTl and H9 cells infected by a recombinant virus (pSVCAT) containing chloramphenicol acetyltransferase (CAT) gene substituted for nef gene in the HIV-1 genome. RIC inhibited syncytiaformation of SupTl cells with a half maximal effective concentration, $IC_{50}$/, of 2.5 $\mu\textrm{g}$/mι and showed marked inhibition of CAT activity in the infected H9 cells and also suppressed reverse transcriptase (RT) activity in the supernatant of the infected H9 culture. However, RIC did not inhibit the activity of reverse transcriptase directly when it was mixed with the enzyme or with viral particles. Berberine, one of components of RIC, also showed similar anti-HIV activity as RIC did. The data suggest that there are active ingredients which mediate anti-HIV activity in RIC.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.738-741
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• 2009

본 논문에서는 RAW 이미지 포맷 중 PEF, MRW에 대한 분석 결과와 RAWImage Viewer에 대해 소개한다. DSLR 디지털 카메라로 촬영되는 이미지 파일은 범용의 JPEG 포맷이나 제조사별 독자적인 RAW 이미지 포맷으로 저장된다. 이러한 RAW 이미지 파일을 PMP 등의 휴대용 멀티미디어 기기나 디지털액자에서 재생 및 확인하기 위한 요구가 증대되고 있다. 하지만, RAW 이미지 포맷이 디지털 카메라 제조사별로 다르고, 해당 포맷에 대한 구체적인 정보가 공개되지 않아 대부분의 휴대용 멀티미디어 기기에서 RAW 이미지 파일 재생 기능을 완벽하게 지원하지 못하고 있다. 본 논문에서는 RAW 이미지 파일 포맷을 분석하여 다양한 임베디드 멀티미디어 기기에서 모든 RAW 이미지 파일을 지원할 수 있는 라이브러리 구축을 위한 연구 결과 중 일부를 소개한다. Cannon의 CRW, CR2 포맷과 Nikon의 NEF 분석 결과에 이어 PEF, MRW에 대한 분석 결과와 RAW 이미지 출력 및 분석 기능이 포함된 RAWImage Viewer에 대해 설명한다. 연구 결과는 RAW 파일을 재생할 수 있는 임베디드 장비 및 PC용 RAW 이미지 파일 재생 라이브러리를 구축 및 응용 프로그램 개발시 활용될 것이다.

• Proceedings of the Microbiological Society of Korea Conference
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• 2006.05a
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• pp.129-131
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• 2006

Through molecular phylogenetic analysis using the nef gene sequences of HIV-l isolated from Korean registered in the NCBI GenBank together with 41 reference strains and 94 foreign isolates, we verified that most (${\sim}80%$) of Korean isolates belonged to subtype B and 78% of subtype B were clustered together exclusively of foreign isolates, and this cluster was named Korean clade subtype B ($K_cB$). Similarity study suggested that the $K_cB$ cluster was more homogeneous than and clearly distinctive from the non-Korean subtype B ($NK_cB$). Comparison of the consensus amino acid sequences of the $K_cB\;or\;NK_cB$ revealed characteristic $K_cB$ signature amino acid pattern comprised of 13 amino acid residues. The $K_cB$ signature amino acid residues were critical in separating the $K_cB$ ftom the $NK_cB$, since substitution of the $NK_cB$ sequences with $K_cB$ signature amino acids relocated them to the Koran clade, and vice versa. Synonymous and nonsynonymous substitution rate study suggested positive selection event for the $K_cB$.

• Journal of Microbiology
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• v.44 no.6
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• pp.655-659
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• 2006

Phylogenetic studies of nef, pol, and env gene sequences of HIV-1 isolated from Koreans suggested the presence of a Korean clade in which Korean sequences are clustered to the exclusion of foreign sequences. We attempted to identify and characterize the Korean clade using all vif gene sequences isolated from Koreans registered in the NCBI GenBank database (n = 233). Most (77 %) of the Korean isolates belonged to the Korean clade as a large subcluster in subtype B, designated the Korean clade subtype B ($K_{C}B$). $K_{C}B$ sequences were relatively homogenous compared to Korean subtype B sequences that did not belong to the $K_{C}B$ (non-Korean clade subtype B; $NK_{C}B$). Comparison of amino acid frequencies of $K_{C}B$ and $NK_{C}B$ sequences revealed several positions where the amino acid frequencies were significantly different. These amino acid residues were critical in separating $K_{C}B$ from $NK_{C}B$ or from foreign sequences, since substitution of these amino acids in $K_{C}B$ with the $NK_{C}B$ amino acids relocated the $K_{C}B$ sequences to $NK_{C}B$, and vice versa. Further analyses of $K_{C}B$ will help us to understand the origin and evolutionary history of $K_{C}B$.

• Journal of the Korea Convergence Society
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• v.8 no.12
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• pp.343-349
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• 2017

In this study, the factors of the industrial complexes were analyzed in a comprehensive review, and the research model was developed and related variables were adopted to the purpose of this study. Also, the determinants of location are analyzed by three factors of infrastructure stabilization, industrial resource access, and residential neighborhood factors. For the analysis of this study, the hypothesis was analyzed through the path analysis of the SEM through the set hypotheses based on the research model. As a result of analysis, it is analyzed that TI factors and RA factors of infrastructure, IF group, are both influenced by industrial location. In addition, there is a statistically significant correlation in the analysis between the parameters of the NEF and the determinants of industrial location. The results of this study are expected to provide useful guidelines for industrial infrastructure development and industrial complex development projects at national and local government.

• Clinical and Experimental Pediatrics
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• v.48 no.12
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• pp.1389-1389
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• 2005

The long arm duplication of chromosome 3 was reported for the first time in 1966 by Falek et al., and Hirschhorn et al. came to identify the duplication of 3q21${\rightarrow}$qter region in 1973. In most cases of duplication 3q syndrome patients, pure duplication of 3qter is believed to be rare and is often reported accompanied with deletion of another segment of the chromosome. Approximately 75 percent of parents of the patient in the meantime have been demonstrated to have unbalanced translocations or inversions of the chromosome. Partial deletion of the distal part of the short arm of chromosome 3 was first reported by Verjaal and De Nef in 1978 and terminal deletion of chromosome 3 (3p25-qter) has been observed in most cases. In karyotyping of chromosomes of immature infants showing the manifestations of flat occiputs, low set ears, hypertelorism, broad nasal roots, thin lips, web necks, hypotonia, hypertrichosis skin, cryptorchidism etc, we experienced a case diagnosed as 46,XY, rec(3)dup(3)(q21)del(3)(p25)inv(3)(p25q21).