• Parasites, Hosts and Diseases
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• 제51권6호
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• pp.735-738
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• 2013

Eosinophilic meningitis, caused by the nematode Angiostrongylus cantonensis, is prevalent in northeastern Thailand, most commonly in adults. Data regarding clinical manifestations of this condition in children is limited and may be different those in adults. A chart review was done on 19 eosinophilic meningitis patients aged less than 15 years in Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. Clinical manifestations and outcomes were reported using descriptive statistics. All patients had presented with severe headache. Most patients were males, had fever, nausea or vomiting, stiffness of the neck, and a history of snail ingestion. Six patients had papilledema or cranial nerve palsies. It was shown that the clinical manifestations of eosinophilic meningitis due to A. cantonensis in children are different from those in adult patients. Fever, nausea, vomiting, hepatomegaly, neck stiffness, and cranial nerve palsies were all more common in children than in adults.

• 대한기관식도과학회지
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• 제9권1호
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• pp.60-66
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• 2003

Although there is a wide range of diseases caused by gastric acid reflux and the number of cases is on the rise, it is difficult for the laryngologist to make the correct diagnosis. The treatment for laryngopharyngeal reflux can be grouped into 3 categories - changes in lifestyle, medication, and surgery. The medication used to treat laryngopharyngeal reflux are prokinetic agents and acid supressive agents such as antacids, H2 blockers, and PPIs(Proton pump inhibitor). Rabeprazole sodium($Pariet^{\circledR}$) is a newly developed agent belonging to the PPI group, but in contrast with the existing drugs such as omeprazole, lansoprazole, pantoprazole, has a low dependency on CYP2C19 during the metabolic cycle. Thus, it is known to have a quick but fixed antiacid effect and less individual differences. We analyzed 2166 patients from 32 hospitals who were prescribed $Pariet^{\circledR}$ from May, 2001 to April, 2002. The patients were divided into 4 groups according to the duration of treatment - Group 1: 1-14 days, Group 2: 15-28 days, group 3: 29-56 days, Group 4: more than 56 days. The cases were then analyzed for improvement of 8 symptoms(heart bum, regurgitation, chronic cough, hoarseness, globus sensation, chronic throat clearing, sore throat, and dysphagia), improvement on laryngoscope, usefulness to the doctor, and complication development. Of the total of 2116 patients, 1627(75.1%) cases showed at least 50% improvement of symptoms and the amount of improvement increased according to the duration of medical treatment. Most of the patients showed objective improvement on the laryngoscope, with 32.9% showing significant improvement and 38.7% showing moderate improvement. 37.6% of the doctors questioned replied that $Pariet^{\circledR}$ was very useful and 50.3% said it was useful, showing that most were satisfied with the treatment results. The complications known to develop after taking PPI are headache, nausea, diarrhea, abdominal pain, constipation, dizziness, fatigue, and of these, only a small percentage of the patients complained of mild headache. $Pariet^{\circledR}$ has shown to be a relatively safe and effective drug for the treatment of laryngopharyngeal reflux.

• 척추신경추나의학회지
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• 제1권1호
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• pp.45-50
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• 2006

Objectives : A rare case of dural tear ensuing after a cervical Chuna Manipulation Treatment leading to cerebrospinal fluid (CSF) leakage in the lower cervical and upper thoracic spine was found, so we report it. Methods : A 32-year-old woman presented with back and neck pain in 1 days earlier. The patient undertook a cervical Chuna Manipulation Treatment. After this maneuver, the patient complained of an orthostatic headache with nausea. The patient's headache worsened, and lying down gave the only measure of limited relief. In Brain CT and MRI study, nonspecific finding was detected. In Cistemography study, CSF leakage at lower cervical or upper thoracic area was detected. Results and Conclusions : It is supposed that this patient suffered a dural tear and CSF leakage secondarily due to a cervical Chuna Manipulation Treatment. From this case, we can understand the etiology of dural tear to some extent and consider the complication of Chuna Manipulation Treatment. In the future, more study, research and prospective trial for complications of a cervical Chuna Manipulation Treatment is needed.

• Journal of Preventive Medicine and Public Health
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• 제23권1호
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• pp.57-64
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• 1990

Since the reservoir of leptospires organism is consisted of a broad spectrum of animals, the best method of prevention is vaccination. The clinical trial of leptospires vaccine conducted on human volunteer for its immunogenicity and safety. Summarized results are as following : 1. The Oral temperature among vaccinated group ranged from $36.7{\pm}0.46^{\circ}C\;to\;37.0{\pm}0.34^{\circ}C$, while in placebo injected group it ranged from $36.4{\pm}0.46^{\circ}C\;to\;36.7{\pm}0.53^{\circ}C$. There was no association between vaccination and fever (p>0.05) 2. Mild local reactions revealed in vaccinees were swelling (50-75% ), Redness($75{\sim}90%$), and induration ($25{\sim}40%$). Placebo injected group revealed only redness in 12.5% in 1st injection and 37.5% in second injection. The duration local reactions on injection site for th vaccinees and place groups disappeared within 48 hours. 3. Generalized Symptoms complained by the vaccinees were myalgia (25%), back pain(15%), headache (15%), pruritus(15%), and abdominal pain(10%), whereas placebo group complained of headache (25%), myalgia(12.5%), back pain(12.5%), pain in eyes(12.5%), abdominal pain(12.5%) pruritus (12.5%) and nausea(12.5%). 4. The serological test(MAT) of vaccinees showed geometric mean antibody titer as follows : a. L. icterohemorrhagiae lai 1 week after 1st vaccination : 22.45 1 week after 2nd vaccination : 111.23 3 week after 2nd vaccination : 266.64 b. L. canicola canicola 1 week after 1st vaccination : 24.62 1 week after 2nd vaccination : 123.92 3 week after 2nd vaccination : 276.55 c. L. icterohemorrhagiae copenhageni 1 week after 1st vaccination : 28.28 1 week after 2nd vaccination : 128.55 3 week after 2nd vaccination : 247.88 Whereas all of the place injected group showed below 1:20 titers. The sero-conversion rate of vaccinees were 100 percent.

• Journal of Hospice and Palliative Care
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• 제7권2호
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• pp.248-257
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• 2004

목적: 전향적 임상시험을 통해 중등도 이상의 오심, 구토를 유발하는 항암화학요법제 투여로 인한 급성 및 지연성 오심, 구토의 예방에 있어서 dolasetron mesylate의 유효성 및 안정성을 평가하고자 하였다. 방법: 단일 기관에서 공개형, 단일군 임상시험으로 시행되었다. Dolasetron (1.8 mg/kg)과 dexmamethosone 10 mg을 항함화학요법 시작전에 투여하고 나서 이후 24시간 후부터 4일 연속 경구형 dolasetron(200 mg, 1일 1회)을 투여하였다. 구토의 빈도 오심의 중증도, $5-HT_3$ 이외의 구제 항구토제의 사용여부를 화학요법 시작 제1일부터 5일까지 매일 평가하였다. 결과: 30명의 환자가 연구에 참여하였고, 이 중 28명이 유효성 평가가 가능하였다. 28명 중 4명이 5일동안 구제항구토제를 전혀 사용하지 않는 오심, 구토의 완전 조절을 보였다. 완전 조절을 보이는 환자비율은 제 1일에서 5일로 가면서 17.9/46.4/42.9/53.6/60.7%로 시간이 경과하면서 향상되었다. Cisplatin 포함 화학요법과 비포함 화학요법 모두에서 오심보다는 구토가 보다 잘 조절되었다. Dolasetron에 의한 이상반응은 경증에서 중등도의 두통, 설사, 발열 등이었고, 대개 저절로 회복되었다. 결론: Dolasetron은 중등도 이상의 오심, 구토를 유발하는 항암화학요법에서 급성 및 지연성 오심, 구토의 예방에 있어 기존의 반응률 50%에 상당하는 반응률을 보였으며, 안전성면에서도 수용할 만한 경미한 이상반응만을 보여 오심, 구토의 예방에 유용한 약제로 판단된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권3호
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• pp.168-174
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• 2008

Objectives: The purpose of this study was to develop the Korean Somatization Scale for Children (KSS-C) and to evaluate the reliability and validity of this scale. Methods: Sixty-five children and adolescents with somatic symptoms were evaluated the KSS-C, Child Version, the Children's Depression Inventory (CDI), and the State-Trait Anxiety Inventory for Children (STAIC). 65 parents of the subjects evaluated the KSS-C, Parent Version and Korean version of the Child Behavior Checklist (K-CBCL). Psychometric properties and associations with the internalizing symptoms were. Results: Three factors were extracted by factor analysis. KSS-C was significantly correlated with the CDI, the STAIC, and the internalization, externalization and somatization scale of the K-CBCL. The KSS-C, Parent Version was significantly correlated with the KSS-C, Child Version. Frequently reported somatic symptoms in children were fatigue, headache, low energy, stomachache, and nausea. Conclusion: Both KSS-C, Child Version and KSS-P, Parent Version were valid and reliable instrument assess somatic symptoms in Korean children and adolescents.

• 한방안이비인후피부과학회지
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• 제13권2호
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• pp.1-19
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• 2000

1. The furuncle is nail shaped, whitch tip is sharp and root is deep, very dangerous. It's progress is so rapid and it corresponds to the acute suppurative infection of western medicine. 2. The cause and pathology of the furuncle were divided into three parts, inappropriate care (improper diet and excessive sex), surgical trauma (epidernic infection by domestic animal as like cattle, hoarses, pigs, sheep etc), external evil. 3. The early syndrome of the furuncle is swollen pain, various change of color, fidgetiness, restlessness, aversion to cold, headache, nausea and vomitting etc. Though apply acupuncture, there is no pain and bleeding. There may be streak of blood, curdy of muscles and widen swolling. If it is progressed, its sphere becomes diffuse. This is called as the serious case of furuncle(정독주황). 4. The maim treatment of the furuncle is clear away heat and toxic materials. The method was moxibustion, sticking-plaster, purge blood, oral taking the medicine of detoxication and fire extinguishing etc. 5. The main prescriptionst are omisodokyum(五味消毒飮), hwangyeonheadoktang(黃連解毒湯), ohyangyeongyotang(五香連翹湯), hyeongbangpaedoksan(荊防敗毒散) and so on. The main external prescriptionst are okrhosan(玉露散), cheonchugo(千 膏), guildao(九一丹), palyidan(八二丹), taeyulgo(太乙膏), hongyugo(紅油膏) and so on.

• Journal of Korean Neurosurgical Society
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• 제57권1호
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• pp.50-53
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• 2015

Usually fungal infections caused by opportunistic and pathogenic fungi had been an important cause of morbidity and mortality among immunocompromised patients. However clinical data and investigations for immunocompetent pathogenic fungal infections had been rare and neglected into clinical studies. Especially Cryptococcal brainstem abscess cases mimicking brain tumors were also much more rare. So we report this unusual case. This 47-year-old man presented with a history of progressively worsening headache and nausea for 1 month and several days of vomituritions before admission. Neurological and laboratory examinations performed demonstrated no abnormal findings. Previously he was healthy and did not have any significant medical illnesses. A CT and MRI scan revealed enhancing $1.8{\times}1.7{\times}2.0$ cm mass lesion in the left pons having central necrosis and peripheral edema compressing the fourth ventricle. And also positron emission tomogram scan demonstrated a hot uptake of fluoro-deoxy-glucose on the brainstem lesion without any evidences of systemic metastasis. Gross total mass resection was achieved with lateral suboccipital approach with neuronavigation system. Postoperatively he recovered without any neurological deficits. Pathologic report confirmed Cryptococcus neoformans and he was successively treated with antifungal medications. This is a previously unreported rare case of brainstem Cryptococcal abscess mimicking brain tumors in immunocompetent host without having any apparent typical meningeal symptoms and signs with resultant good neurosurgical recovery.

• Journal of Korean Biological Nursing Science
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• 제12권3호
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• pp.166-174
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• 2010

Purpose: The purpose of this study was to compare the cardiac knowledge and symptoms recognition between men and women with acute coronary syndrome (ACS). Methods: Cross-sectional survey research design and convenience sampling were used in this study. 64 men and 42 women from a university medical center were participated in this study. Data collection were used with self reported questionnaires and medical records. Results: There was no difference in cardiac knowledge by gender. Women marked the higher score in symptoms recognition than men. Significant gender differences were observed in the reports of several symptoms (headache, nausea, palpitation, hand paresthesia, and leg numbness) and with ACS. There was significant correlation between cardiac knowledge and symptom recognition on both men and women. Conclusion: These findings suggest that health care professionals should pay attention to the differences in clinical symptoms between women and men. Furthermore, tailored information about possible symptoms of coronary artery disease according to the patient's gender is needed.

• Journal of Chest Surgery
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• 제40권12호
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• pp.878-881
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• 2007

흉강경적 종격동 종양 절제 후 발생하는 뇌공기증은 매우 드문 합병증으로, 척수근 주위 경막의 손상으로 인해 발생한 거미막하강-흉강 누공이 그 원인이다. 후종격동 종양으로 흉강경적 종양 절제술을 시행 받은 60세 환자가 수술 직후부터 지속적인 오심과 두통을 호소하여 시행한 뇌 전산화 단층 촬영에서 뇌공기증이 진단되었고, 보존적 치료로 호전되었기에 이를 보고하는 바이다.