• 과학교육연구지
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• 제33권2호
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• pp.184-192
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• 2009

과학의 본성에 대한 이해는 과학적 소양의 요소로서 그 중요성이 강조되고 있으며, 우리나라에서는 제5차 교육과정에 과학의 본성에 대한 이해가 과학교육의 목표로 제시되기 시작했다. 학교수업에서도 과학의 본성을 가르치려는 시도들이 이루어졌는데, 우리나라에서는 주로 과학사 소재를 수업에 도입하는 방법에 국한되어 진행되어 왔다. 이외에 과학의 본성을 가르치는데 있어 적합한 방법으로 실험수행을 들 수 있다. 또한, 반성적 접근 방법을 적용한 과학의 본성수업이 제안되고 있는데, 이것을 조합하여 현장에서 보편적으로 이루어지는 실험수업에서 실험에 대한 반성과 토의를 강조하면 학생들이 과학의 본성을 이해하는데 효과적일 것이라 예상하였다. 따라서 이 연구에서는 반성을 강조한 실험수업을 중학생들에게 적용하였고, 과학의 본성에 대한 설문지를 통해 과학실험 활동에서 적극적인 반성과 토의 과정이 과학의 본성의 대한 이해의 증진에 도움을 주는지 알아보았다. 연구 결과 반성을 강조한 실험수업은 관찰과 추론 관계, 자료 해석의 다양화, 탐구와 사회적 제반 상황과의 관련 영역에서 과학의 본성 이해에 특히 효과적이었으며, 그 외 과학적 탐구기능과 과학적 탐구의 사회성 모든 영역에 대한 학생의 이해에 효과적이었다. 연구 결과를 통해 반성을 강조한 실험 수업은 과학의 본성 이해에 효과가 있다고 말할 수 있다.

• International Journal of Stem Cells
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• 제16권2호
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• pp.156-167
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• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• 보존과학회지
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• 제37권4호
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• pp.391-401
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• 2021

Outdoor sculptures of modern art works are being damaged and deteriorated as they are exposed to the outdoor environment due to the nature of exhibition in the outdoor environment, but secure of basic data through the measures for conservation and advanced researches still remain in the early stage. The surface of "Conversion" which is exhibited in the Busan Cheonmasan Sculpture Park has been exfoliated and deteriorated due to outdoor exhibition for a long time, so systematic conservation and management of works are considered necessary. Prior to the conservation and management, this study conducted observation of cross section, analysis of inorganic components, FT-IR, Raman and Py-GC/Mass analysis to examine the nature and type of paints used for the work through a scientific analysis. As a result of analysis, paints used for the "Conversion" include paint mixed with silvery aluminium powder and white pigment, reddish paint mixed with toluidine red, bluish paint that mixed prussian blue and titanium white and mixture of phthalocyanine blue and titanium white. The result is expected to be used as basic data for selecting materials necessary for conservative treatment of and establishing a plan for conservative treatment of the "Conversion".

• Advances in Computational Design
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• 제7권2호
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• pp.153-171
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• 2022

The present study aimed to find a way to create forms that can simultaneously meet several architectural requirements by applying generative design methods specifically focused on cellular automata. In other words, it is tried to find various forms of architecture that all have common features. Because of the useful features of cellular automata, we decided to use it to generate various forms, but make a relation between the discrete nature of cellular automata and the continuous nature of architecture, was the major problem of our project. To achieve this goal, three consecutive stages were designed. In the first stage, independent variables including the location of the building, the height of the building, and the building area were considered as the inputs of the model. In the second stage, after locating the building, the building's main shell was designed as a hidden geometry for the cellular automata and then the cellular automata were determined based on this shell. The main result of this research is establishing a logical relationship between the discrete geometry of the cellular automata and the continuous search space such that it creates various optimized forms. Although we specify the site plan of this project at Iran-Tehran, this research can be generalized to various design sites as well as different projects, allowing the architectsto alter the cell dimensions, cell density, etc., based on their opinion and project needs.

• 한국초등과학교육학회지:초등과학교육
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• 제19권1호
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• pp.101-112
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• 2000

The purpose of this study was to develop the modular multimedia instructional materials emphasizing the particulate nature on the realm of matter in elementary science classes. Features of the material are as follows: 1 To be in focus on particulate model named 'phenomenal magnifying glasses' in order to change the student's belief system of continuous matter into the belief system of particulate matter . The 'phenomenal magnifying glasses' is a new instructional strategy designed to change into the view of particulate matter through facilitating the reflective thinking resulted from the simultaneous consideration of experimental phenomena(macroscopic world) and particulate model(microscopic world). 2. To introduce modular system into the instructional materials, which was consisted of 14 subunits according to the sequential instruction unit of 'molecule and molecular motion'. Each subunit was composed of 5 types of modules(module 1: motivation, module 2: experimental result, module 3: discussion, module 4: phenomenal magnifying glasses, module 5: related experiment) 3. The multimedia program was composed of 36 kinds of experimental animation and 59 kinds of computer animation materials combined with text resources, photographic materials and sounds.

• 보건행정학회지
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• 제1권1호
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• pp.153-160
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• 1991

Hospital Management, as a branch of science, is now in a formative period in Korea. Proper understanding on the scienctific nature and issues of the subject, therefore, is important for both its developement and education of the students. As an academic subject, Hospital Management can be pointed out to have three characteristics, Firstly, when looking it in teleological viewpoint, it is a branch of health science. Ultimate goal of the hospital lies in promoting and keeping health of the people residing in the catchment area in which it places, Secondly, in terms of its contents, Hospital Management can be divided into tow subsubjects ; hospital administrative management and hospital business management. The former stands at the point of looking the hospital as the object of goverment administration, while the latter as the subject of organizational operation. Flanlly, Hospital Management, in its academic appoach, is a science that adopts management theories, what is called, traditional and/or modern. For the settlement and development of the Hospital Management, four major issues were suggested for discussion now and in the future. They include ; (1) boundary between Hospital Management and its related academic fields (2) subdivision of the subject and its contents, (3) activation of study, theortical and empirical, and (4) distinction of the level of lecture among lecfnical, four-year and gradudate courses.

• Mycobiology
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• 제30권3호
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• pp.146-153
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• 2002

Two types of mycorrhizae, orchid(OM) and arbuscular mycorrhizae(AM), were observed in the cortical cells of Botrychium ternatum roots. The vesicles or arbuscules of AM fungi were examined and the fresh or digestive pelotons by other species of basidiomycetes were also observed in the roots under light microscope. These symbioses were, as the genomic DNAs extracted from roots of B. ternatum reacted with the specific primers, confirmed with PCR technique, being added to more strong evidences. These discoveries were rarely happened in the roots, especially a fern in nature. OM was observed in the roots of B. ternatum collected from the nationwide areas, whereas AM was only in the roots of B. ternatum collected from Chung-Buk areas. It is speculated that OM are associated with the nitrogen cycle in Islands and the growth of B. ternatum in the inland of Central Korea is related to both the phosphate and nitrogen cycle in the nature. The results suggest that B. ternatum is a typical species with two types of mycorrhizae under various growing conditions.

• 한국수산과학회지
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• 제40권1호
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• pp.16-23
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• 2007

Nonylphenol (NP) is an estrogen-mimicking compound or xenoestrogen. This study investigated the effects of nonylphenol on the reproductive status of the equilateral venus Gomphina veneriformis. The experiment lasted 24 weeks, Experimental groups consisted of a control and three nonylphenol exposures ($1.0,\;2.5,\;and\;5.0\;{\mu}g\;NP/L$). Mortality did not differ significantly between the control and the exposure groups. The sex ratio (F:M) was 1:1 in nature and 1:1.03 in the control group. However, it changed to 1:3.5 with $5.0\;{\mu}g\;NP/L$ exposure. Gonad maturity in females was higher in the nonylphenol exposure groups than in the control group. By contrast, in males, it was lower in the nonylphenol exposure groups. Intersex individuals constituted 0% in nature, 3.08% in the control group, and 23.6% in the group exposed to nonylphenol, with female characteristics more prevalent than male. As the concentration of nonylphenol increased, the accumulation of lipofuscin increased in the mid-gut gland.

• 한국화재소방학회논문지
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• 제15권2호
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• pp.20-30
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• 2001

The science and technology of seismic hazard mitigation are increasingly being shared among scientists and policy makers around the world. Administrative expertise is also being shared. While there is still tremendous unevenness in technical and administrative capacities and resources, a global community of emergency managers is developing and there is a globalization of expertise. Hazards are better understood, tools for risk assessment are improving, techniques for hazard mitigation are being perfected, and communities and states are implementing more comprehensive disaster preparedness, response, and recovery programs. Priorities are also emerging and hazard mitigation has emerged as the priority of choice in North America and Europe. An increasingly important component of hazard mitigation is resilience, in terms of increased capacities for disaster mitigation and recovery at the community and even individual levels. Each year, more is known about the locations and natures of seismic hazards, although there are still unknown and poorly understood fault lines and limited understanding of related disasters such as tsunamis and landslides. More is known about the impact of earthquakes on the built environment, although nature still provides surprises to confound man's best extorts to reduce risk. More is known about human nature and how people respond to uncertain risk and when confronted by certain catastrophe. However, despite the increased understanding of seismic phenomena and how to protect people and property, there is much that needs to be done to reduce the risk, particularly in major metropolitan areas.

• 통합자연과학논문집
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• 제1권2호
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• pp.160-179
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• 2008

Field classes are necessary to grow the ability of and an attitude toward exploring nature and to shape the basic concept of natural science. I tried to develop a site for field classes and the old road Naori's hill is an ideal place with convenient traffic and established youth camps. As a result the vegetation was divided into five associations and communities. The vegetation units obtained in the present study were as follow: Quercus acutissima community, Pinus densiflora community, Pinus densiflora-Quercus acutissima community, Quercus acutissima-Pinus densiflora community, and Quercus mongolica community. In all survey areas 100 family 336 genus 587 species of palants was found. Furthermore, it provides lots of plants throughout the seasons. Not only the flora but also flowering phenology, variety of floral color and growth habits can be used as teaching items. Incorporation of diverse knowledge of plants at the old road Naori's hill into biology teaching will give students academic stimuli and teachers an opportunity of retraining. With a combination of use of visual instruments, the purpose of conceptual and exploring biology is more easily achieved.