• 대한한의학회지
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• 제39권1호
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• pp.95-103
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• 2018

Objectives: This study was designed to investigate antihypertensive effect by single adminstration of Chunghyul-dan in stroke patients. Methods: This is a 31-patient case series from retrospective chart review of inpatients who diagnosed with stroke at a Kyung Hee University Korean Medicine Hospital (Seoul) between October 2016 to October 2017. We reviewed patient's charts with transient and sudden increases in blood pressure who were treated with Chunghyul-dan and analyzed blood pressure over time. In addition we classified patients by using the standardized predictive models for Korean medical diagnostic pattern-identification to find out if there are some differences in responder ratios. Results: Thirty one patients who took Chunghyul-dan were identified. 60 minutes, 120 minutes after 1200mg administration, systolic and diastolic blood pressure decreased significantly compared to baseline. We could not identify the difference between the groups of each pattern-identification because of small number of some groups. Conclusions: Although limited by its retrospective nature, this study suggests that Chunghyul-dan may be effective as short term antihypertensive method for stroke patient.

• 동의생리병리학회지
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• 제27권4호
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• pp.362-366
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• 2013

We are building an Korean Medicine ontology and disassembling indication terms of medicinal materials and formulas. When we disassemble these terms, an expert can disagree about another expert's result, so participants have to consider another opinion and verify each other concurrently. To achieve this, we have developed a web-based tool that support users in refining terms, disassembling them into the minimum meaning efficiently. With this tool, plural participants refer to each other and make use of this as a verification method. This would have enabled participants to achieve consensus. Due to the nature of the traditional Korean Medicine knowledge which have rich implications and is complicated,E there would be a various result of refinement, disassembly, analysis and another processing. This tool assists users in minimizing the differences and maintaining objectivity by agreement. We have refined and analyzed 4,756 terms from materials and formulas indication in Korean Medicine ontology using this tool. And we concluded that disassembled data increases the percentage of linkage between diseases and medicinal treatments and established an infrastructure for the extensible knowledge.

• 동의생리병리학회지
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• 제18권3호
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• pp.774-782
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• 2004

The water extract of Dancheonhwan (DCH) has been used to treat ischemic brain and heart damage in oriental medicine. However, little is known about the mechanism by which the water extract of DCH rescues cells from ischemic damage. Therefore, this study was designed to investigate the protective mechanisms of DCH on the H₂O₂-induced toxicity in H9c2 cardiomyoblast cells. Treatment of H₂O₂ markedly decreased the viability of H9c2 cardiomyoblast in a dose-dependent and time-dependent manner. The nature of H₂O₂-induced toxicity of H9c2 cells resulted from apoptotic death confirmed with genomic DNA fragmentation. DCH increased the viability of H₂O₂-treated H9c2 cells by about 23%, and partially suppressed the genomic DNA fragmentation and PARP cleavage. H₂O₂ also activated caspase-3 protease and -9 protease, but not both caspase-6 protease and -8 protease. H₂O₂ induced the mitochondria dysfunction, including mitochondria membrane permeability transition (MPT) and cytosolic release of cytochrome c from mitochondria, which was prevented in part by pretreatment of DCH. N-acetylcystein (NAC), a free-radical scavenger, alone increased the viability of H₂O₂-treated H9c2 cells in a dose-dependent manner. Furthermore, the combination of NAC with DCH significantly increased the viability of the H₂O₂-treated H9c2 cells in a dose-dependent manner. These data indicate that DCH has the protective effect on ROS-induced apoptosis of cadiomyoblast H9c2 cells.

• 동의생리병리학회지
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• 제16권4호
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• pp.626-629
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• 2002

In Oriental medicine, Five Mental is a concept for understanding of man's mental structure. Spirit and body is inseparable relation in Oriental Medicine. Function of spirit and body is regarded as one in Oriental Medical physiology. Spirit is the essence of a function which an organism reveal, and it is regarded in the same with life. For this reason, identification spirit with life is special feature of Oriental Medicine. In Confucianism, Li(理) refers to nature's discipline, which everything under the sun shares. It is similar to the concept of Shin(神) in a broad sense and Sung(性) is similar to that of Shin(神) in a narrow sense. Confucianism's principle is similar to Oriental medicine's, in that they classify Sung(性) into Gi-Jil-Ji-Sung(氣質之性) and Bon-Yeon-Ji-Sung(本然之性), that Sung(性) acts upon man differently according to his disposition, and that materials have an effect on Shin(神)'s action. According to mind's action, there are Human mind(人心) and Moral mind(道心). Human mind(人心) is defined as a mental action of higher degree and Moral mind(道心) is conceived as a mental action related to body. It is similar to Oriental medicine's principle in which Shin(神) is classified into Hun(魂) and Beak(魄) according to its action. Yi(意) is self-control and application, and Zhi(志) is a conscious state in which basic acts towards the object are fixed regularly. Those are similar to the concepts of Oriental medicine.

• 감성과학
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• 제14권2호
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• pp.207-220
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• 2011

친환경 감성단어를 '환경/자연, 소재/섬유, 인간, 형용사/기타' 등의 4가지 영역으로 분류하고 각 단어에 대하여 그 출현시점, 빈도를 1999~2010년 상반기 간의 인터넷 섬유패션 신문 및 잡지를 중심으로 조사한 결과, 다음과 같은 결론을 얻었다. 가장 빈번히 출현한 단어는 '자연, 환경, 면, 천연섬유, 건강, 신선한, 맑은, 보존, 하모니, 옥수수섬유, 로하스' 등이었다. '친환경' 관련 감성단어의 출현시점을 살펴보면, 2000년도 이전부터 '에코, 형상기억소재, 오가닉, 스파' 등이 사용되어왔으며, 2000-1년도에 '자연환경, 친환경, 스트레치소재, 웰빙의, 대체가능한, 재생가능한' 등이 등장하였다. 2002-3년도에 '스마트소재, 친환경소재, 그린' 등이 사용되기 시작하였고, 2004-5년도에 '쿨비즈, 로하스, 자연염색' 등이 처음으로 사용되었다 2006-7년도에 '한방, 지속가능한, 웜비즈' 등이 사용되었고, 2008-9년도에 '그린슈머, 그린라이프, 태양에너지, 삼림욕' 등이 섬유패션 분야에서 처음 사용되었다. 친환경 감성단어의 출현 양상을 살펴보면, 친환경 감성단어의 출현은 과거 어느 때보다 2008-09년도에 가장 많이 등장하고 있었는데 2000년도 초반에는 비교적 많이 등장하였으나 이후 다소 주춤하였고 이는 근래에 들어 다시 출현빈도가 높아졌다. 영역별로 살펴보면 '환경/자연' 관련 친환경 감성 단어가 과거보다 최근에 두드러지게 빈번히 사용되고 있으며, 이에 비해 '인간' 관련 단어는 주춤하여 약간 감소세이거나 동일한 빈도를 나타내고 있다. 또 '형용사/기타' 관련 단어는 약간 증가세이거나 과거와 동일한 빈도를 나타내고 있었다. '소재/섬유' 관련 단어는 패션잡지에서는 최근에 그 빈도가 줄어드는 경향을 보이는 반면 인터넷 신문에서는 약간 증가하는 추세를 보였다.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제20권4호
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• pp.235-240
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• 2018

The safety and feasibility of simple coil embolization and stent deployment for the treatment of posterior inferior cerebellar artery (PICA) aneurysms, as well as their radiologic and clinical results, have not been adequately understood. Especially, if dissecting aneurysm of proximal PICA is associated with small caliber PICA and stenosis of ipsilateral vertebral artery orifice (VAO), endovascular coiling with saving of PICA is not always easy. This 64-year-old man presented with subarachnoid hemorrhage due to a ruptured dissecting aneurysm of left proximal PICA. The aneurysm was irregularly fusiform in nature with a shallow PICA orifice (1.4 mm) and narrow caliber (0.9-1.5 mm). Moreover, the ipsilateral VAO showed severe stenosis (1.8 mm). We performed bifemoral puncture and chose additional route from right vertebral artery to left vertebrobasilar junction for retrograde approach and deployment of LVIS Jr. intraluminal support at proximal PICA. And then, the antegrade approach and coiling of aneurysm was done. Despite of transient thrombus of PICA, the aneurysm was successfully secured with preservation of whole PICA course. For preservation of narrow PICA with ipsilateral VAO stenosis, the contralateral approach and deployment of LVIS Jr. intraluminal support may be considered.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.217-223
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• 1995

Adenosine 5'-tetraphosphate (ATPP) was identified and quantified in extracts of rabbit platelets by elution of extracts containing authentic adenosine 5'-tetraphosphate and comparison of retention time with nucleotide standards using high-performance liquid chromatography technique. The amount of adenosine 5'-tetraphosphate was $0.62\;nmoles/10^{9}$ cells which was 62-fold lower than that of ATP but only 10-fold lower than that of ADP. During platelet aggregation induced by thrombin, adenosine 5'-tetraphosphate was released to a relatively high extent. The degradation rates and halflives of adenosine 5'-tetraphosphate were measured during incubation of platelets in whole blood, erythrocyte suspension and plasma, respectively. The results suggest that plasma contributes more than blood cells to the catabolism of adenosine 5'-tetraphosphate. The pattern of degradation indicates that ATPP may be degraded mainly to AMP by soluble enzymes in plasma and very slowly to ADP and/or AMP by ectoenzymes on blood cells such as erythrocyte. The nature of the enzymes responsible fer the degradation of adenosine 5'-tetraphosphate is yet to be identified.

• 사상체질의학회지
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• 제12권2호
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• pp.1-7
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• 2000

Greeting the 100 year celebration of the death of Master Dong-mu, through investigating his thoght on Scholarship and Philosophy, and his new view of human being based on Sasang, I tried to reevaluate him as a Confucianist of practical mind. The conclusions were as followings ; 1. Dong-mu's recognition system of things is that based on the mind of summarizing things in view of Affair-Mind-Body-Object originated from Confucianism, and It developed 'the Marvel of Easiness & simpleness based on Yin-yang' into 'the Marvel of Easiness & simpleness based on Sasang' 2 Through understanding old Confucianism newly, Dong-mu summarized human being as having a natural character in view of Nature and Order and an autonomical character in view of Knowledge and Deed, and emphasized an autonomical character in view of Knowledge and Deed 3. In view of Knowledge and Deed, Dong-mu presented How to Say and Behave, and took it as a model of behavior in the new Confucianism. Also he presented the view of Knowledge and Deed based on Constitutions, and took it as a new mind of treatment. 4. Dong-mu can be estimated highly, in that he completed a new confucian view-point of Human being in the period of philosophic chaos, and executed the mind of General health maintenance and the mind of control others through a confucian self-control.

• Annals of Clinical Neurophysiology
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• 제19권1호
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• pp.40-45
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• 2017

Background: Telbivudine is a nucleoside analogue used for the treatment of chronic hepatitis B, but it often develops mitochondrial toxicity leading to symptomatic myopathy. In this study, three patients with telbivudine induced myopathy were enrolled in order to investigate the nature and pathogenesis of mitochondrial toxicity caused by long-term use of telbivudine. Methods: Clinical features, laboratory findings, muscle pathology, and quantitation of mitochondrial DNA were studied in three patients. Results: Patients presented with progressive muscle weakness with high serum creatine kinase levels. Light microscopic findings of muscle pathology showed ragged red fibers that reacted strongly with succinate dehydrogenase stain, but negative for cytochrome c oxidase activities. Electron microscopy revealed abnormal mitochondrial accumulation with rod shaped inclusions. The quantitative peroxidase chain reaction showed a depletion of mitochondrial DNA in skeletal muscle of the patients. Conclusions: Nucleoside analogues including telbivudine are potent inhibitors of viral DNA polymerases. However, they are not specific for viral DNA and can disturb mitochondrial replication at the same time. All nucleotide analogues should be used with close clinical observation in order to avoid development of mitochondrial myopathy.

• 대한한의학원전학회지
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• 제18권2호통권29호
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• pp.45-69
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• 2005

The condition contrary to the physiological conditions obtained by the normal functioning of seven constituents of the body is defined as disease. The primary causes of the disease are emotional defilements of desire, hatred and delusion. The secondary causes of diseases are seasonal climatic changes, the agency of harmful demons, and improper diet or conduct. Once a disease occurs, it brings the disfunctioning of the three humors of wind, bile, and phlegm. Therefore all the disease should be examined and determined which of theses three humors effect its nature the most. There are five main techniques of external therapy, namely bloodletting, which extract the impure blood produced by disease of heat; moxibustion, which debilitates cold diseases, medicinal compresses, fomentation, massage with ointment, and minor surgery. Among these, the former three are the mild treatment and the latter three the severe ones because of the pain the patient has to suffer during the whole procedure.