• Biomolecules & Therapeutics
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• 제26권4호
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• pp.343-349
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• 2018

Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural products with minimal unwanted effects have been preferred for the treatment of acute and/or mild insomnia, with additional benefits of overall health-promotion. Basic and clinical researches on the mechanisms of action of natural products have been carried out so far in insomnia treatments. Recent studies have been focusing on diverse chemical components available in natural products, with an interest of developing drugs that can improve sleep duration and quality. In the last 15 years, our co-workers have been actively looking for candidate substances from natural products that can relieve insomnia. This review is, therefore, intended to bring pharmacological data regarding to the effects of natural products on sleep duration and quality, mainly through the activation of $GABA_A$ receptors. It is imperative that phytochemicals will provide useful information during electroencephalography (EEG) analysis and serve as an alternative medications for insomnia patients who are reluctant to use conventional drugs.

• Natural Product Sciences
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• 제8권4호
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• pp.155-161
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• 2002

The mistletoe lectins are major active components in the extract of European mistletoe (Viscum album L) that have been widely used in adjuvant chemotherapy of cancer. This study was performed to investigate the antitumor activity of extract of Korean mistletoe (Viscum album var. coloratum) modified with Korean mistletoe lectin (Viscum album var. coloratum agglutinin, VCA). Compared with the results of VCA, survival rate was increased and experimental lung metastasis was reduced by treatment of modified extract (VCM). In addition, the treatment of VCM reduced angiogenesis and VCA-induced toxicity measured by a CAM assay. And VCM inhibited proliferation and induced apoptosis in vitro in tumor cells originated from tissues which are possible to apply topically without surgery. Taken together, the antitumor activities of VCM-treated group outperformed the activities of the VCA-treated group.

• 한국유기농업학회지
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• 제10권4호
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• pp.37-45
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• 2002

$GB_{10}$, chitofarm 및 왕겨숯과 왕겨숯액을 天然物質을 가을 배추 栽培圃場에 種子處理, 土壤處理 및 葉面撤布를 實施하여 收量과 成分分析을 遂行한 實驗成績은 아래와 같다. 1. 배추 生育特性中 株重, 球重, 球長, 球莖, 葉長, 葉幅 및 糖度에 있어서 Chitofarm 等 天然物質處理區가 無處理區에 비하여 大部分 有意差가 있었으나 天然物質 相互間에는 有意差가 없었다. 2. 배추 收量에 있어서는 $GB_{10}$ 土壤處理區+$GB_{10}$ 1% 葉面撤布區가 3.27kg으로 check區 보다 53% 增收되었다. 3. 배추 植物體 成分分析 結果 T-N, $P_2O_5$, $K_2O$, CaO, MgO, $Na_2O$, 및 Mn 等의 含量에서 天然物質 無處理區보다 check區 보다 多量이었으므로 品質向上에 效果的이었다.

• Composites Research
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• 제35권6호
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• pp.456-462
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• 2022

천연섬유는 가연성이 높아 난연화가 쉽지않으며, 친환경적인 특성을 활용하기 위해서는 친환경적으로 난연화시키는 것이 필요하다. 본 연구에서는 자연으로부터 유래한 난연 후보물질인 Phytic acid, APTES, Thiourea를 기반으로 하는 액상 난연제를 제조하고 대나무 섬유의 난연처리 및 난연성 평가를 통하여 그 성능을 입증하고자 하였다. 액상 난연제를 사용할 경우 대량의 천연섬유에 대한 난연처리가 가능하다. 다구찌 시험계획법에 따라 9종류의 난연처리된 대나무 섬유를 준비하였다. 그후 난연성 평가를 위하여 수직 연소시험 및 마이크로칼로리미터 시험을 수행하였으며, SEM을 이용하여 난연처리 전후의 천연섬유 표면을 비교하였다. 시험결과 Phytic acid가 천연섬유의 난연성 향상에 매우 큰 효과가 있음을 알 수 있었으며 미세구조 분석을 통하여 난연제가 천연섬유 표면에 균일하게 부착되는데 도움을 주는 것을 알 수 있었다. 이와 같은 연구성과를 활용할 경우 대량의 천연섬유를 친환경적인 방법으로 고난연화 하는 것이 가능하여 시제품 적용에 유리할 것으로 기대된다.

• Journal of Plant Biotechnology
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• 제50권
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• pp.115-126
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• 2023

A hydroponics experiment was performed to study the physiological and biochemical changes in Moroccan barley (Hordeum vulgare L.) varieties cultivated under salt stress conditions. Four barley varieties were grown under exposure to three salt concentrations, including 0, 200, and 300 mM NaCl. The ANOVA for both salt stress-sensitive and resistant varieties indicated that salt treatment represented the main source of variability in all studied traits. Salt treatment significantly reduced root and shoot dry weight (RDW and SDW), relative water content (RWC), and chlorophyll content (Chl a, Chl b, and Chl T). However, increases in electrolyte leakage (EL) along with proline and total soluble sugar (TSS) contents were recorded. In addition, large variations in all measured traits were found between varieties. The 'Massine' and 'Laanaceur' varieties displayed relatively higher RDW and SDW values. The 'Amira' and 'Adrar' varieties showed lower RWC values and Chl contents than those of the controls indicating their relative sensitivity to salt stress. Principal component analysis revealed that most of the variation was captured by PC1 (72% of the total variance) which grouped samples into three categories according to salt treatment. Correlation analyses highlighted significant associations between most parameters. Positive relationships were found between RDW, SDW, RWC, Chl content, and soluble proteins contents, while all of these parameters were negatively associated with EL intensity, proline content, and TSS content. The results from this study showed that the 'Massine' and 'Laanaceur' varieties were relatively salt-tolerant. These two salt-tolerant varieties present a good genetic background for breeding of barley varieties showing high salt tolerance.

• 한국의상디자인학회지
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• 제5권3호
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• pp.15-23
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• 2003

Chestnut trees have been used as a dyeing material, which are grow naturally, are cultivated all the area of Korea. So, there is abundant amount of the materials and they have better colorfastness than other natural dyeing materials. But chestnut husk extract is good at silk and wool fabrics, not cotton fabrics. That's why many methods using chestnut extraction for dyeing are being studied. But most of them depend on treatment method with chemical material which doesn't fit with the aim, using natural materials. Therefore in this research, we used protein pre-treatment method which is dyeing chestnut husk extract after treating at cotton fabrics with bean sap. And we studied the effect of dyeability of chestnut husk extract to cotton fabrics. As a result of pre-treatment of bean sap at cotton fabrics, dyeability was increased. Besides laundering fastness, dry cleaning fastness, perspiration fastness and light fastness were almost increased.

• 상하수도학회지
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• 제27권3호
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• pp.373-382
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• 2013

In this study, a biological odor treatment system was proposed to remove odor(foul smell) materials causing several problems in the closed sewage treatment plant. This odor treatment system was composed of a two-step biofilter system in one reactor. The two-step biofilter reactor was constructed with natural purification layer in upper part and artificial purification layer in lower part. The reed grasses of water purification plants were planted in the surface area and mixed porous ceramic media were filled with the lower part of biofilter reactor. By using the above experimental apparatus, the ammonia gas removal efficiency was attained to 98.3 % and the hydrogen sulfide gas removal efficiency was appeared more than 97.7 % which shows more effective than the conventional odor removal process.

• 설비공학논문집
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• 제18권5호
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• pp.451-457
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• 2006

Conjugate heat transfer (CHT) is the simultaneous, coupled heat transfer within a fluid and an adjoining solid, and the interface treatment plays an important role in its analysis, particularly when using unstructured grid system. In the present paper a new solid-fluid interface treatment in CHT analysis is presented and applied to two typical CHT problems, i.e. natural convections in both concentric thick-walled cylinders and cavity with a centered solid body. The present interface treatment for unstructured mesh clearly demonstrates the same accuracy and robustness as that for typical structured mesh.

• The Korean Journal of Physiology and Pharmacology
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• 제22권4호
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• pp.427-436
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• 2018

The objective of this study was to analyze the concurrent treatment effects of ursolic acid (UA) and low-intensity treadmill exercise and to confirm the effectiveness of UA as an exercise mimetic to safely improve muscle atrophy-related diseases using Sprague-Dawley (SD) rats with skeletal muscle atrophy. Significant muscle atrophy was induced in male SD rats through hind limb immobilization using casting for 10 days. The muscle atrophy-induced SD rats were group into four: SED, sedentary; UA, daily intraperitoneal UA injection, 5 mg/kg; EX, low-intensity (10-12 m/min, $0^{\circ}$ grade) treadmill exercise; and UEX, daily intraperitoneal UA injection, 5 mg/kg, and low-intensity (10-12 m/min, $0^{\circ}$ grade) treadmill exercise. After 8 weeks of treatment, endurance capacity was analyzed using a treadmill, and tissues were extracted for analysis of visceral fat mass, body weight, muscle mass, expression of muscle atrophy- and hypertrophy-related genes, and endurance capacity. Although the effects of body weight gain control, muscle mass increase, and endurance capacity improvement were inadequate in the UA group, significant results were confirmed in the UEX group. The UEX group had significantly reduced body weight and visceral fat, significantly improved mass of tibialis anterior and gastrocnemius muscles, and significantly decreased atrophy-related gene expression of MuRF1 and atrogin-1, but did not have significant change in hypertrophy-related gene expression of Akt and mTOR. The endurance capacity was significantly improved in the EX and UEX groups. These data suggest that concurrent treatment with low-intensity exercise and UA is effective for atrophy-related physical dysfunctions.

• Animal cells and systems
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• 제4권3호
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• pp.279-285
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• 2000

Vitamin E-succinate (VES) treatment of U937 human monoblasts induced cells to undergo apoptosis. After 96 h of VES treatment at 10 $\mu$/ml, more than 80% of cells appeared apoptotic. Evidence for apoptosis by VES was based on propidium iodide staining for detection of chromatin condensational fragmentation and electrophoretic DNA ladder formation. Western blot analyses showed a transient increase in Fas and p21 protein levels up to 48 h alter the VES treatment. Protein expression and activity of CDK1 and lamin B degradation were remarkably induced by VES, following the cleavage of caspase-3 after 48 h. The VES-induced apoptosis was found to involve activation of PKC as shown by increases in membrane translocation of PKC$\beat$II and PKC activity. Pretreatment of GF109203X (PKC inhibitor) prior to VES treatment almost completely inhibited the induction of apoptosis as assessed by blockage of VES-induced caspase-3 activity and DNA fragmentation. However, GF109203X h8d no effect on the VES-induced nitric oxide synthesis, which was required for monocvtic differentiation in our previous report (J Cell Sci 111, 435, 1998). Taken together, our data suggest that induction of apoptosis by VES in U937 cells occurs through activation of PKC-$\beat$II resulting in the activation of caspase-3 cascade and is independent of nitric oxide.