• 한국수학사학회지
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• 제27권1호
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• pp.47-57
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• 2014

This paper aims to evaluate works of Frege and G$\ddot{o}$del, who play the trigger role in development of logic, by Knowledge Change Model. It identifies where their positions are in the model respectively. For this purpose I suggest types of knowledge change and their criteria for the evaluation. Knowledge change are classified into five types according to the degree of its change: improvement, weak glorious revolution, glorious revolution, strong glorious revolution, and total revolution. Criteria to evaluate the change are its contents, influence, pervasive effects, and so forth. The Knowledge Change Model consists of the types and the criteria. I argue that in the model Frege belongs to the total revolution and G$\ddot{o}$del to the weak glorious revolution. If we accept that the revolution in logic initiated by Frege was completed by G$\ddot{o}$del, it is a natural conclusion.

• 대한치과의사협회지
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• 제13권9호
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• pp.820-822
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• 1975

• 방재저널
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• 제14권3호
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• pp.104-105
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• 2012

• 방재저널
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• 제15권4호
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• pp.144-145
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• 2013

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.101-108
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• 2018

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

• 환경생물
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• 제27권2호
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• pp.176-182
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• 2009

전나무의 천연갱신 형태를 임분의 특성과 연관하여 내설악 길골 총 30지역에서 조사하였다. 임학적 의미의 천연갱신은 주로 예전에 인공적 교란이 있었던 곳에서 나타나며 자연림의 특성이 강할수록 오히려 의미를 상실한다. 이것은 인공적 교란이 천연갱신에 더 나은 환경조건을 제공하기 때문으로 보인다. 이와는 달리 자연림에서 갱신단계는 인공림처럼 명확할 수 없고 잠시 나타났다 사라지는 상태이며 세대교체는 임분구조 변화의 일부라는 표현이 적합하다. 특히 patch dynamic이 임분구조를 결정하고 주 구성수종이 음수인 전나무 자연림에서는 인공림에서 사용되는 천연갱신 개념은 원천적으로 의미를 상실할 것으로 보인다.

• 한국자기공명학회논문지
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• 제15권2호
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• pp.137-145
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• 2011

Hsp33, a prokaryotic molecular chaperone, exerts holdase activity in response to oxidative stress. In this study, the stepwise conformational change of Hsp33 upon oxidation was monitored by NMR. In order to overcome its high molecular weight (33 kDa as a monomer and 66 kDa as a dimer), spectra were simplified using a selectively [$^{15}N$]His-labeled protein. All of the eight histidines were observed in the TROSY spectrum of the reduced Hsp33. Among them, three peaks showed dramatic resonance shifts dependent on the stepwise oxidation, indicating a remarkable conformational change. The results suggest that unfolding of the linker domain is associated with dimerization, but not entire region of the linker domain is unfolded.

• 접착 및 계면
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• 제3권2호
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• pp.30-39
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• 2002

실리카로 보강된 천연고무 가황물에서 가황촉진제의 양이 열노화에 의한 가교밀도의 변화에 미치는 영향에 대해 연구하였다. 또한 실란커플링제의 영향도 조사하였다. 가황촉진제로는 N-tert-butyl-2-benzothiazole sulfenamide(TBBS)를 실란 커플링제로는 bis-(3-(triethoxysilyl)-propyl)-tetrasulfide(TESPT)를 사용하였다. 가황물을 열노화 시키면 가교밀도는 증가하였고 노화 온도가 높을수록 그 변화 정도는 컸다. 실란 커플링제가 포함되지 않은 가황물의 가교밀도 변화가 실란 커플링제를 포함한 것에 비해 더 크게 나타났다. 실란 커플링제가 포함되지 않은 가황물의 경우에는 가교밀도의 변화에 대한 활성화 에너지가 가황촉진제의 함량이 증가할수록 순차적으로 낮아지는 경향을 보였다.

• 한국환경과학회지
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• 제19권7호
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• pp.843-848
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• 2010

This study focused on the characteristics of change soil water with respect to soil thickness and soil mixture ratio, in order to effectively carry out an afforestation system for a roof with a low level of management and a light weight. Soil hardness tended to increase as sand particle was increase regardless soil thickness and soil porosity had more higher artificial soil than natural soil mixture. In case of soil pH, natural soil mixture had between 6.7 and 7.4, and artificial soil mixture had 6.0~6.8. Organic matter, electrical conductance and exchangeable content were highest in $L_{10}$, which it had the highest leafmold ratio. Soil moisture tension(kPa) in 15cm soil thickness was observed natural soil mixture had a considerable change but artificial soil mixture had a gradual change when non-rainfall kept on. In the experimental $L_{10}$, $S_{10}$, $S_7L_3$ and $S_5L_5$ object, the amount of moisture tended to rapidly decrease. However, in the experimental $P_7P_1L_2$, $P_6P_2L_2$, $P_5P_3L_2$ and $P_4P_4L_2$ objects, which contained pearlite and peat moss, the amount of moisture tended to gradually decrease. As a result, the use of a artificial soil mixture soil seems to be required for the afforestation of a roof for a low level of management.

• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1647-1652
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• 2012

With the objective to design and synthesis of Schiff's base symmetrical liquid crystal dimmers and to study the effect of molecular structure variation ($o-ortho$, $m-meta$, $p-para$) and change in alkoxy terminal chain length on mesomorphic properties of liquid crystals, We have synthesized Schiff base dimers from dialdehyde derivative containing 2-hydroxy-1,3-dioxypropylene as short spacer with aniline derivatives having different lengths of terminal alkoxy chains ($n$ = 5, 7, 9). The chemical structure of the final products was characterized by proton nuclear magnetic resonance ($^1H$ NMR) spectroscopy and fourier transform infrared (FT-IR) spectroscopy. The mesomorphic properties and optical textures of the resultant dimers were characterized by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). The existence of smectic A phase transition was confirmed by the observation of batonnets and fan shaped textures in optical microscopy when compound were heated from crystalline phase. All of the dimers of this series, with the exception of $\mathbf{2S_5}$ -ortho, -meta, -para, were thermotropic liquid crystal. The compound $\mathbf{2S_9}$ -meta was monotropic, while the rest were enantiotropic. It was found that the change in terminal alkoxy chain length has pronounced effect on the mesomorphic properties. The temperature range of smectic A phase window widens with increasing alkoxy chain length.