• 한국과학교육학회지
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• 제13권2호
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• pp.210-218
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• 1993

Scientific literacy for all became a new goal and introducing STS issues into science curriculum shows new trends in science education. The educational importance of natural environment of a region is increasing because it can serve as a vehicle to meet the new goal and trends of science education. The opportunity to learn about Korean natural environment in schools was investigated. The characteristics and unique patterns of Korean natural environment are not well reflected in the intended curriculum. School teachers mostly believe that education of Korean natural environment will greatly contribute to the students' learning of the subject matter they teach and environmental problems. However, they have limited opportunity to teach Korean natural environment. Various elective courses dealing with our natural environment should be provided in schools, especially for non-science majors. Out-of-school activities and facilities for Korean natural environment should be made available.

• 한국환경교육학회지:환경교육
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• 제22권2호
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• pp.92-106
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• 2009

We assumed that natural history museums have rooms for functioning as institutions for the environmental education, especially in aspects of multi-disciplinary, informal education. So we set goals of this research as finding 1) how much environmental education contents are reflected in exhibits of natural history museums, and 2) what those characteristics in aspects of dimension, range, and topic are. First, we developed a framework for analyzing of environmental education contents. Second, we applied the framework to seven major natural history museums. As the result, environmental education contents are reflected by 69.1% totally. Especially, the 'knowledge' dimension covered mostly, and among them the range of 'elements of Ecosystem' occupied more than other ranges. With inferring our results, we suggested that characteristics of natural history museums in environmental education are followed; spatial-temporal expansion of bio-diversity concept, visualizing impacts of human activity against nature.

• 한국과학교육학회지
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• 제24권1호
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• pp.63-75
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• 2004

The purpose of this study is to explore characteristics of on-line teaching materials on websites of natural history museums, particularly with regard to educational perspectives and the nature of science. The target resources were selected from the websites of the Natural History Museum in London, the Australian Museum in Sydney, the Field Museum of Natural History in Chicago, and the Smithsonian Museum in Washington D.C.. A total of twelve on-line resources from these museums used in this study were selected as representative informal science teaching materials. For the investigation, this study developed a checklist with a total of nine items that were grounded on mostly reviewing previous literature and articles focusing on educational perspectives of natural history museums and science centers. Exciting and positive results were found in all four museums. The analyses, however, indicated weaknesses as well as strengths in on-line resources regarding their usages as informal science teaching venues.

• 한국환경교육학회지:환경교육
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• 제21권1호
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• pp.45-56
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• 2008

This study is to consider the fundamental perceptions of pre-service elementary school teachers to natural environments. The recognition items of questionnaire for those environments include ones of water, atmospheric, soil, biologic and oceanic environments constituting of the earth system. From the results of the study, they affirmatively recognized biologic environment, but they showed highly negative recognitions to others. In other side, it is considered that their recognitions to natural environments were probably transferred by the things which involve press media, curricula and real lives. On the basis of the study results, systematic teaching-learning for natural environments is essential because the encouragement of eco-friendly attitude, one of main goal for environmental education, is budded from basic understandings to natural environments. Affirmatively environmental worldviews for elementary school students are important for reasons why teacher's quality and practice will is fundamental, and then teacher could change the views of the students for environmental education. So, preparing balanced attitudes, right concepts and connection to applicable knowledges for natural environments, pre-service elementary school teachers in environmental education must be pointed to organized education between human and natural environment.

• Journal of Ginseng Research
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• 제46권6호
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• pp.738-749
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• 2022

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.

• 대한지구과학교육학회지
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• 제6권2호
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• pp.145-151
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• 2013

The aim of this research is clarify the relationship between concept understanding degree about the environment and environmental sensitivity and heighten understanding of environmental education target to pre-service elementary teacher. The subjects of this study are science education intensive course 65 students of B educational university. Concept understanding degree about the environment was separately investigated by 'the definition of environmental education', 'Write The positive concept of the natural environment education and briefly describe.''The negative concept of the natural environment education and briefly describe'. Next clarify the relationship between concept understanding degree about the environment and environmental sensitivity target to pre-service elementary teacher. Based on these results, propose an alternative to cultivate pre-service elementary teacher's knowledge about environmental education. Degree of understanding of the concept environmental education research results are as follows. First, Cognition degree about definition of environmental education of pre-service elementary teacher is correctly recognized generally. Second, They do not think deeply about natural environment when it comes to the positive concept of the natural environment of pre-service elementary teacher. Third, They have only a little interest in natural environment when it comes to the negative concept of the natural environment of pre-service elementary teacher. Correlation research results of degree of understanding of the concept of environmental and environmental sensitivity are as follows. High understanding degree of environmental education is high environmental sensitivity. Heighten environmental sensitivity of pre-service elementary teacher will be sustainable environmental education so education is necessary for environmental Sensitivity training.

• 한국보육학회지
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• 제18권4호
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• pp.227-245
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• 2018

본 연구는 자연재해의 발생이 급증하는 현상을 반영하여 자연재해 안전교육의 중요성을 강조하고자 교육 활동을 구성하였으며, 유아의 안전문제해결사고와 환경 친화적 태도를 향상 시키는데 목적이 있다. 행정안전부와 충청북도 교육청에서 다루고 있는 자연재해 종류를 참고하여 지진, 황사, 폭염, 홍수, 태풍, 낙뢰, 화재, 폭설, 지구온난화를 교육내용으로 포함시켜 자연재해 안전교육 활동을 20회기로 계획하였다. 연구대상은 충청북도 C시에 위치한 K병설 유치원 만 4세 유아 20명을 실험집단으로, N병설 유치원 만 4세 유아 20명을 통제집단으로 선정하였다. 실험집단의 경우 본 연구 활동을 진행하였고 통제집단의 경우 누리과정 생활주제에 기초한 일상적인 활동을 실시하였다. 연구결과 자연재해 안전교육을 실시한 실험집단 유아들이 통제집단 유아들보다 안전문제해결사고와 환경 친화적 태도가 향상되었다. 이를 통해 본 연구에서 이루어진 자연재해 안전교육이 유아의 안전문제해결사고와 환경 친화적 태도 향상에 효과를 줄 수 있는 교육활동으로 밝혀졌다. 따라서 본 연구는 실제로 유아교육현장에서 자연재해 안전교육을 실시하고자 하는 현장 교사들에게 구체적인 정보를 제공할 수 있을 것으로 기대된다.

• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.2165-2168
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• 2014

• 한국수학교육학회지시리즈D:수학교육연구
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• 제8권1호
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• pp.31-37
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• 2004

This study explores the relations between mathematics and the natural human language. At the very outset, a general definition of language was, given while it was attempted to make some comparisons between the words of natural language and mathematical symbols at that. Besides, the occupation of natural language functions within mathematics was handled. Consequently, it was tried to manifest that the language of mathematics enjoys the features of natural language as well. Mathematics makes use of many functional and structural features. The fact that fundamental ingredient of mathematics is symbols does not change this reality.

• Bulletin of the Korean Chemical Society
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• 제30권11호
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• pp.2779-2781
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• 2009