• BMB Reports
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• 제51권6호
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• pp.265-273
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• 2018

Tau protein is encoded in the microtubule-associated protein tau (MAPT) gene and contributes to the stability of microtubules in axons. Despite of its basic isoelectric point and high solubility, tau is often found in intraneuronal filamentous inclusions such as paired helical filaments (PHFs), which are the primary constituent of neurofibrillary tangles (NFTs). This pathological feature is the nosological entity termed "tauopathies" which notably include Alzheimer's disease (AD). A proteinaceous signature of all tauopathies is hyperphosphorylation of the accumulated tau, which has been extensively studied as a major pharmacological target for AD therapy. However, in addition to phosphorylation events, tau undergoes a number of diverse posttranslational modifications (PTMs) which appear to be controlled by complex crosstalk. It remains to be elucidated which of the PTMs or their combinations have pro-aggregation or anti-aggregation properties. In this review, we outline the consequences of and communications between several key PTMs of tau, such as acetylation, phosphorylation, and ubiquitination, focusing on their roles in aggregation and degradation. We place emphasis on the structure of tau protofilaments from the human AD brain, which may be good targets to modulate etiological PTMs which cause tau aggregation.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2003년도 Proceedings of the international symposium on the fusion technology
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• pp.676-683
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• 2003

A laboratory experiment using artificial fracture rocks was used to understand the 3-dimensional dispersion of a tracer and the mixing process in a fractured network. In this experiment, 12cm polystyrene foam cubes with two electrodes for monitoring electric conductivity (EC) were used as artificial fractured rocks. Distilled water with 0.5mS/m was used as a tracer in water with 35mS/m and the difference of EC between the tracer and the water was monitored by a multipoint simultaneous measurement system of electrical resistance. The results showed that even if the fracture arrangement pattern was not straight in the direction of the flow, the tracer did not diffuse along individual fractures and an oval tracer plume, which was the distribution of tracer concentrations, tended to be form in the direction of the flow. The vertical cross section of the tracer distribution showed small diffusivity in the vertical direction. The calculated total tracer volume passing through each measurement point in the horizontal cross section showed while that the solute passed through measurement points near the direction of hydraulic gradient and in other directions, the passed tracer volumes were small. Using Peclet number as a criterion, it was found that the mass distribution at the fracture intersection was controlled in the stage of transition between the complete mixing model and the streamline routing model.

• 한국작물학회지
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• 제50권1호
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• pp.60-66
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• 2005

Pod shape of twenty soybean (Glycine max L. Merrill) genotypes was evaluated quantitatively by image analysis using elliptic Fourier descriptors and their principal components. The closed contour of each pod projection was extracted, and 80 elliptic Fourier coefficients were calculated for each contour. The Fourier coefficients were standardized so that they were invariant of size, rotation, shift, and chain code starting point. Then, the principal components on the standardized Fourier coefficients were evaluated. The cumulative contribution at the fifth principal component was higher than $95\%$, indicating that the first, second, third, fourth, and fifth principal components represented the aspect ratio of the pod, the location of the pod centroid, the sharpness of the two pod tips and the roundness of the base in the pod contour, respectively. Analysis of variance revealed significant genotypic differences in these principal components and seed number per pod. As the principal components for pod shape varied continuously, pod shape might be controlled by polygenes. It was concluded that principal component scores based on elliptic Fourier descriptors yield seemed to be useful in quantitative parameters not only for evaluating soybean pod shape in a soybean breeding program but also for describing pod shape for evaluating soybean germplasm.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 B
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• pp.994-995
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• 2006

This paper presents a grid-connected photovoltaic (PV) system with direct coupled power quality control (PQC) algorithm, which uses an inner current control loop (PRT : polarized ramp time) and outer feedback control loop to improve grid power quality and maximum power point tracking (MPPT) of PV arrays. To reduce the complexity, cost and number of power conversions, which results in higher efficiency, single stage CCVSI (Current Controlled Voltage Source Inverter) is used. The proposed system operation has been divided into two modes (sunny and night). In night mode, the proposed system operates to compensate the reactive power demanded by nonlinear or variation in loads. in sunny mode, the proposed system performs PQC to reduce harmonic current and improve power factor as well as MPPT to supply active power from the PV arrays simultaneously. it is shown that the proposed system improves the system utilization factor to 100% which is generally low for PV system (20%). To verify the proposed system, a comprehensive evaluation with theoretical analysis and simulation results are presented.

• 천문학회보
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• 제39권1호
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• pp.45.2-45.2
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• 2014

We carry out the first survey for globular clusters (GCs) of three galaxies in cosmic voids using Hubble Space Telescope (HST) Advanced Camera for Survey archival F606W and F814W images. While all sample galaxies are classified as early-type galaxies based on ground-based imaging, the high resolution HST images reveal that they are actually spiral galaxies. We identify the point sources with red colors typical for GCs as GC candidates in the color-magnitude diagrams. As a result, we find a significant number of GC candidates. The spatial and radial distribution of GCs show central concentration on each galaxy region. Their mean colors are similar to that of the Milky Way and M31 GCs. The void GCs are somewhat bluer by, and than cluster and field GCs in early-type galaxies with similar luminosity to our samples, but the discrepancy is not significant. We also estimate the specific frequencies of GCs in these galaxies and the values are consistent with those in field and cluster galaxies with similar luminosity. From these results, we suggest that the formation process of void GCs is similar to that of GCs in other environments. The further implications will be discussed.

• 대한치과보철학회지
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• 제38권4호
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• pp.461-471
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• 2000

This study evaluated the effect of degassing on the ceramic bond strength of two Ni-Cr alloys under varying holding time at the upper limit temperature and atmospheric conditions. Metal specimens were divided into 5 groups for each alloy according to degassing conditions prior to porcelain application no degassing, degassing under vacuum without hold, degassing under vacuum with hold for 5 min. and 10 min. respectively at the upper limit temperature and degassing in air. Total number of metal ceramic specimens was eighty and each group had eight specimens. The ceramic bond strength was measured by four-point flexural test using Instron and the fractured surface was examined under SEM. The results obtained were as follows. 1. Degassing in air improved the ceramic bond strength of Ni-Cr alloys. 2. In degassing under vacuum, hold at the upper limit temperature was advantageous to the ceramic bonding of Ni-Cr alloys. 3. After ceramic metal bond test, metal surfaces were partially covered with the thin porcelain layer, and the cohesive failures in porcelain were predominant in groups showing higher ceramic bond strength.

• 한국멀티미디어학회논문지
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• 제25권2호
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• pp.257-268
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• 2022

When there is a missing value in the raw data, if ignore the missing values and proceed with the analysis, the accuracy decrease due to the decrease in the number of sample. The method of imputation and analyzing patterns and significant values can compensate for the problem of lower analysis quality and analysis accuracy as a result of bias rather than simply removing missing values. In this study, we proposed to study irregular data patterns and missing processing methods of data using machine learning techniques for the study of correction of missing values. we would like to propose a plan to replace the missing with data from a similar past point in time by finding the situation at the time when the missing data occurred. Unlike previous studies, data correction techniques present new algorithms using DNN and KNN-MLE techniques. As a result of the performance evaluation, the ANAE measurement value compared to the existing missing section correction algorithm confirmed a performance improvement of about 0.041 to 0.321.

• 대한수의학회지
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• 제39권1호
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• pp.34-44
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• 1999

Ischemic damage in the selectively vulnerable populations of neurons is thought to be caused by an abnormal accumulation of intracellular calcium. It has been reported that the neurons, expressing specific calcium binding proteins, might effectively control intracellular calcium concentrations because of a high capacity to buffer intracellular calcium in the brain ischemic condition. It is uncertain that parvalbumin, one of the calcium binding proteins, can protect the neurons from the cerebral ischemic damage. Recently, treatment of kappa opioid agonists increased survival rate, improved neurological function, and decreased tissue damage under the cerebral ischemic condition. Many evidences indicate that these therapeutic effects might result from regulation of calcium concentration. This study was designed to analyze the changes of number in parvalbumin-positive neurons after cerebral ischemic damage according to timepoints after cerebral ischemic induction. In addition, we evaluated the effect of GR89696 (kappa opioid agonist) or naltrexone(non selective opioid antagonist) on the changes of number in parvalbumin expressing neurons under ischemic condition. Cerebral ischemia was induced by occluding the common carotid artery of experimental animals. The hippocampal areas were morphometrically analyzed at different time point after ischemic induction(1, 3, 5 days) by using immuno-histochemical technique and imaging analysis system. The number of parvalbumin-positive neurons in hippocampus was significantly reduced at 1 day after ischemia(p<0.05). Furthermore, the number of parvalbumin-immunoreactive neurons was dramatically reduced at 3 and 5 days after cerebral ischemic induction(p<0.05) as compared to 1 day group after ischemia, as well as sham control group. Significant reduction of parvalbumin positive neurons in CA1 region of hippocampus was observed at 1 day after cerebral ischemic induction. However, significant loss of MAP2 immunoreactivity was observed at 3 day after cerebral ischemia. The loss of parvalbumin-positive neurons and MAP2 immunoreactivity in CA1 region was prevented by pre-administration of GR89696 compared to that of saline-treated ischemic group. Furthermore, protective effect of GR89696 partially reversed by pre-treatment of naltrexone. These data indicate that parvalbumin-positive neurons more sensitively responded to cerebral ischemic damage than MAP2 protein. Moreover, this loss of parvalbumin-positive neurons was effectively prevented by the pretreatment of kappa opioid agonist. It was also suggested that the changes of number in parvalbumin-positive neurons could be used as the specific marker to analyze the degree of ischemic neuronal damage.

• 한국건설관리학회논문집
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• 제23권4호
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• pp.57-64
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• 2022

식물공장은 통제된 공간에서 인공적인 환경을 조성과 자동화 설비를 통해 식물을 계획적으로 생산하는 시설이다. 하지만 식물공장은 내부 환경 제어 기술에 비해 재배 과정의 자동화 도입이 미비한 상황이다. 이는 다수의 근로자 투입으로 인한 운영비용 상승의 문제를 초래한다. 따라서 본 연구는 식물공장의 재배 과정에 자동화 도입 전후를 비교하여 경제성을 평가하고자 하였다. 첫째, 자동화 도입이 필요한 작업을 선정하기 위해 식물공장의 작업 과정을 파악하였다. 파악된 작업 과정은 재배 식물의 생육 과정을 중심으로 나열하고 자동화를 도입할 작업을 선정하였다. 둘째, 선정된 작업에 방안별 투입과 산출을 비교할 경제성 평가 방법을 설정하였다. 셋째, 방안별 소요비용의 계산에 필요한 변수를 설정하였다. 넷째, 방안별 소요비용의 산정을 위한 계산 식을 도출하였다. 마지막으로 작업별 손익분기점을 분석하고 전체 작업에 대한 손익분기점을 통해 운영 기간에 따른 자동화 도입의 적절성을 확인하였다. 분석 결과, 식물 재배를 위한 6가지 작업에 자동화를 도입할 경우 손익분기점은 3.4년으로 분석되었다. 이는 대상 식물공장을 3.4년 이상 운영할 경우 자동화 도입은 경제성 측면에서 우수하다고 판단할 수 있다. 본 연구는 식물공장에 자동화 도입에 따른 손익분기점을 분석함으로써 국내외 다양한 식물공장의 자동화 도입에 따른 경제성 분석을 위한 기초 자료로 활용 가능할 것으로 판단된다. 향후 수행될 연구는 자동화 도입에 적절한 식물공장의 기준을 선정하고 효율적인 자동화 도입 방안을 수립하는 연구가 필요할 것으로 판단된다.

• Child Health Nursing Research
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• 제6권2호
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• pp.249-261
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• 2000

The purpose of this study were to identify the quality of life for the mothers of hospitalized chronic pediatric patients, and to explore the factors affecting the QOL of those mothers. The subjects were 201 mothers whose children had hospitalized at one University hospital with chronic diseases. Data were collected from the December, 1997 to December, 1998. We used a revised QOL instrument consisting of 34 items, 5 point likert scale based on the Noh's QOL instrument. The revised QOL consists of six subscales, those are physical status and function, self esteem, emotional status, economic status, relationship with family members, and relationship with neighborhood. Data were analyzed by t-test, ANOVA, Pearson's correlation using SPSS-PC. The results were as follows: 1. The mean score of quality of life for the mothers of chronic pediatric patients was 100.31, and item mean was 2.95. In subscale analysis, item mean of economic status was the lowest, and that of relationship with family members was the highest. 2. Correlations between characteristics of chronic pediatric patients, their mothers and QOL of mothers were as follows; 1) Total QOL of mothers had a significant positive relationship with progressing time relapse after diagnosing and age of mothers. There was a significant negative relationship between the total QOL of mothers and number of hospitalization of their children. 2) QOL on self esteem and economic status had a significant relationship with age of pediatric patients, the time relapse after diagnosis, and age of mothers. Total number of family members and QOL on economic status showed a significant positive relationship. QOL on emotional status, economic status, and relationship with family members of mothers showed negative correlations with the number of hospitalization of their children. 3. Followings were the result of difference in QOL among different demographic cha- racteristics of the subjects. 1) QOL on economic status of mothers was significantly higher when fathers of pediatric patients had jobs. 2) Total QOL score, QOL on emotional status, and QOL on relationship with neighborhood were significantly higher when mothers of pediatric patients had spouses. 3) QOL on self esteem of mothers was significantly higher when mothers had religion. 4. Followings were the result of difference in QOL among different diagnosis of the children. 1) Total QOL score of mothers whose children had congenital heart disease was higher than that of mothers whose children had leukemia and cancer. 2) QOL on emotional status, economic status, and relationship with family members of mothers whose children had congenital heart disease were higher than those of mothers whose children had leukemia, cancer, and epilepsy.