• Applied Chemistry for Engineering
• /
• v.30 no.4
• /
• pp.487-492
• /
• 2019

Nano flexible vesicles encapsulating an adenosine, an active ingredient for anti-wrinkle, were prepared for the transdermal delivery. The nano flexible vesicle is usually composed of phospholipid, ethanol, and lysolecithin, which is a type of liquid crystalline one made by dispersing the liquid crystalline phase formed through a hydration process into a water phase. In this study, the Taguchi method, one of the experimental design methods, was applied to investigate the factors affecting the vesicle droplet size. Signal to noise (S/N) ratios for the smaller the better characteristics of vesicle droplet size were calculated using the Taguchi orthogonal array. The composition of ethanol and lysolecithin in the vesicle constituents and the amount of aqueous solution added in the hydration process were main factors that had a great effect on the vesicle droplet size and ANOVA test showed that these factors were significant at 95% confidence level.