• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2019-2022
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• 2013

Purpose: To investigate the safety and efficacy of pemetrexed combined with chemotherapy as second or third line in patients with stage IV colorectal cancer (CRC). Patients and Methods: This trial was conducted to evaluate the effectiveness and safety of pemetrexed given to patients with recurrent or metastatic colorectal carcinoma who previously received 5-FU-based chemotherapy. All patients were required to have a histological diagnosis of colorectal adenocarcinoma with measurable metastatic disease and prior chemotherapy. Patients received pemetrexed at a dose of 500 $mg/m^2$ by 10 minute infusion on day 1, repeated every 21 days. Doses were modified depending on nadir counts. Combined chemotherapy included Oxaliplatin, Irinotecan and cis-platinum. Results: Thirty patients were enrolled and twenty-nine were evaluable for response. One patient did not have repeat radiological testing to determine response because he went off study after only one cycle of treatment for economic reasons. For 29 evaluable patients, 1 partial response, 6 stable disease and 22 progressive disease were recorded. Response rate was 3.45% (1/29). All responses occurred in patients receiving a starting dose of pemetrexed 500 $mg/m^2$. Median time to progression for all eligible patients was 2.5 months. The most common toxicities experienced were mild to moderate fever, hepatic damage, myelosuppression, nausea, vomiting, constipation, abdominal pain, diarrhea, and skin rash. Conclusion: Pemetrexed at 500 $mg/m^2$ given every three weeks combined with chemotherapy is associated with moderate response and good tolerability in patients with stage IV CRC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.8009-8013
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• 2015

Background: Orthotopic organ transplantation, a treatment option for irreversible organ dysfunction according to organ failure, severe damaged organ or malignancy in situ, was usually accompanied with massive blood loss thus transfusion was required. We aimed to evaluate the adverse impact of blood transfusion on solid organ transplantation. Materials and Methods: From January, 2009 to December, 2014, patients who received orthotopic organ transplantation at Far Eastern Memorial Hospital medical center were enrolled. Clinical data regarding anemia status and red blood cell (RBC) transfusion before, during and after operation, as well as patient outcomes were collected for further univariate analysis. Results: A total of 105 patients who underwent orthotopic transplantation, including liver, kidney and small intestine were registered. The mean hemoglobin (Hb) level upon admission and before operation were $11.6{\pm}1.8g/dL$ and $11.7{\pm}1.7g/dL$, respectively; and the nadir Hb level post operation and the final Hb level before discharge were $8.3{\pm}1.6g/dL$ and $10.2{\pm}1.6g/dL$, respectively. The median units (interquartile range) of RBC transfusion in pre-operative, peri-operative and post-operative periods were 0 (0-0), 2 (0-12), and 2 (0-6) units, respectively. Furthermore, the median (interquartile range) length of hospital stay (LHS) from admission to discharge and from operation to discharge were 28 (17-44) and 24 (16-37) days, respectively. Both peri-operative and post-operative RBC transfusion were associated with longer LHS from admission to discharge and from operation to discharge. Furthermore, it increased the risk of post-operative septicemia. While peri-operative RBC transfusion elevated the risk of acute graft rejection in patients who received orthotopic transplantation. Conclusions: Worse outcome could be anticipated in those who had received massive RBC transfusion in transplantation operation. Hence, peri-operative RBC transfusion should be avoided as much as possible.

• Asian-Australasian Journal of Animal Sciences
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• 제23권2호
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• pp.188-196
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• 2010

The objective of this study was to characterize the litter sizes in Huanghuai goats with high prolificacy (HP, five or more kids born per litter on at least one occasion), and to compare their peripheral blood concentrations of progesterone and estradiol with those of goats with poor prolificacy (PP, up to three kids born per litter on any occasion). The circulating concentrations of progesterone and estradiol were measured by radioimmunoassay from daily blood samples taken during natural estrus cycles and at 1-5 days after ovariectomy. Estrus was synchronized using two doses of a prostaglandin analog. Litter size for the HP goats increased up to a parity of five and decreased thereafter. The percentage of goats with litter sizes of $\geq$4 from parities 3 to 6 ranged from 44.5% to 58.3%. Although small differences in litter size were obtained for goats of parities three, four and six relative to five, parity five does had the highest mean litter size. Progesterone concentrations began to rise earlier and were higher in the HP than in the PP goats on most days of the luteal phase, but not during the follicular phase of the cycle or after ovariectomy. There was a significant difference between the two groups (p<0.05) in the magnitude of the progesterone plateau. Mean estradiol concentrations in the HP group remained significantly higher than in the PP group (p<0.05) during the estrus cycle. There were two estradiol peaks in the HP goats during the early luteal phase, but only one in the PP group. Measurements of individual corpora lutea (CL) in vitro showed that there was a greater prevalence of small CL (<6 mm in diameter) in the HP group than in the PP group (p<0.05). After ovariectomy, the estradiol level on day 1 was significantly higher than at the nadir during the estrus cycle in both the HP (p<0.01) and PP (p<0.05) goats, while levels decreased by 12.3% and 26.2% respectively compared with the mid-luteal period in HP and PP goats (p<0.05). The overall mean estradiol concentrations in HP goats were lower than in the PP group, but no significant differences were found between groups at 1-5 days after ovariectomy.

• Asian-Australasian Journal of Animal Sciences
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• 제5권1호
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• pp.101-106
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• 1992

Secretory patterns of serum tri-iodothyronine, thyroxin and testosterone were analysed by specific radioimmunoassay in Kaghani (n = 42), Rambouilet (n = 42) and Kaghani ${\times}$ Rambouillet (n = 42) male sheep to determine age and breed related changes. Animals were examined at 1-2 wk, 8, 10, 12, 20, 22 and 24 months of age (n = 6/age group). All animals were maintained under standard conditions of feeding and management. $T_3$ and $T_4$ concentrations were maximal (p < 0.01) in 1-2 wk old lambs of all breeds studied ($207.4{\pm}14.9-276.8{\pm}20.4ng/dl$ and $5.76{\pm}0.3-7.23{\pm}0.9{\mu}g/dl$, respectively). For all the breeds, concentrations of $T_3$ declined markedly (p < 0.01) at 8 month of age and then varied in a narrow range ($44.5{\pm}14.0-87.0{\pm}4.8ng/dl$) up to the age of 24 month. While, serum $T_4$ concentrations decreased (p < 0.01) to nadir ($0.97{\pm}0.1-1.43{\pm}0.3{\mu}g/dl$) at 10 months of age in all the 3 breeds. Afterwards, $T_4$ levels increased gradually and attained a small peak at 20 months before declining again at 22 and 24 months of age. Serum $T_3$ and $T_4$ concentrations were correlated significantly (p < 0.05) and their ratio was constant at all ages in the different breeds. Age significantly (p < 0.01) influenced the secretion of testosterone in the breeds examined but the breed differences were comparable. Mean serum concentrations of testosterone were low from 1-2 wk to 10 months of age in the Kaghani, Rambouillet and Kaghani ${\times}$ Rambouillet animals. Peak testosterone levels were noted in the 12 months old Kaghani ($1.75{\pm}0.4ng/ml$), Rambouillet ($1.30{\pm}0.2ng/ml$) and their $T_3$ cross animals ($1.16{\pm}0.08ng/ml$). Mean testosterone levels, thereafter, decreased at 20 months and then at 22 and 24 months remained variable but higher than observed at 1-2 wk -10 months of age. The findings of the present study indicate a significant influence of age but not of breed on the peripheral concentrations of thyroid hormones and testosterone. Serum concentrations of $T_3$ and $T_4$ were not related to testosterone levels. High thyroid secretory activity observed at prenatal phase of development may play an important role in preparing the lambs to extrauterine environments.

• Asian-Australasian Journal of Animal Sciences
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• 제17권4호
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• pp.460-466
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• 2004

This study was undertaken with the aim to establish a reliable radioimmunoassay (RIA) system for urinary pregnanediol glucuronide (PdG) and to employ it for monitoring the reproductive status of dairy cows. Urine and blood samples were collected from the Holstein cows both pregnant and non-pregnant. The samples were then investigated for evaluating the relationship between progesterone ($P_{4}$) in blood and PdG in urine adjusted with or without urinary creatinine basis. Biweekly urine collection was employed for three cows in estrous and those artificially inseminated, while urine from pregnant cows was collected on a monthly basis. P_{4}$ and PdG levels were measured by enzymeimmunoassay (EIA) and RIA techniques, respectively. Our results indicated the sensitivity of PdG for RIA being 35 pg/tube and the recovery rate of 100%. Urinary creatinine concentrations also fluctuated within a day, but change at midday was not noteworthy. Regardless of the time of urination the change in concentrations of PdG was relatively smaller and did not vary significantly. The urinary PdG concentration showed periodic changes as that with serum P_{4}$ levels during the cow's estrus cycle. The correlation coefficient rose when creatinine level in urine was adjusted but the change was also not significant. The concentrations of PdG during the luteal phase were detected between 8.2 and 17.4 ng/ml, three to five times higher than that in the follicular phase. The concentration of PdG from pregnant cows (21 days after conception) was three to four times higher than in the nonpregnant cows. Our finding suggests that the determination of urinary PdG could be reliably employed for early pregnancy detection. The urinary PdG level continued to raise until 30 days pre-partum while the concentration reached its peak at 30 ng/ml, after which it started to fall 18 to 30 days before parturition and finally fell to its nadir value one week after parturition. As the correlation coefficient between the urinary PdG and serum P_{4}$ was higher than that corrected by urinary creatinine it can be suggested that the adjustment is not needed. The concentrations of urinary PdG could be maintained stably for 2 days in urine samples stored at room temperature and extended to 8 days when the samples were pretreated by boiling for 30 minutes. In conclusion urinary PdG concentration even without the need for creatinine basis adjustment can be used directly for monitoring the reproductive status of dairy cows.

• Journal of Astronomy and Space Sciences
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• 제14권2호
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• pp.330-346
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• 1997

다목적 실용위성 1호 (KOMPSAT I)는 지도 제작, 해양관측, 우주 과학실험 등에 활용할 태양도기 저궤도용 위성으로 1999년 8~9월에 발사될 예정이다. 본 위성에 탑재될 고해상도 전자광학 카메라(Electro-Optical Camera: EOC)의 주임무는 한반도 표준지도 제작을 위한 위성영상정보의 획득이다. EOC 센서는 가시광선 영역의 흑백 단일 채널(510~730mm)을 통해 수직 촬영 시 최소 15km 이상의 폭과 궤도 800km의 길이를 지상 해상도 6.6m로 촬영한다. 본 연구에서는 아리랑 1호의 한반도 통과 시각을 결정하기 위하여 한반도 지역에 있어 EOC 영상에 커다란 영향을 미치는 태양 변수와 구름과 시정의 일변를 조사하였다. 조사 결과는 다음과 같다. 1) 동지의 경우 대략 오전 10시 30분 이후 태양 천장 각 의 $70^{\circ}$보다 작고, 예상되는 EOC 스펙트럼 밴드의 flux 값은 맑은 날씨 육지에서 약 $2.4mW/cm^2$보다 크다. 2) 낮 동안의 구름의 분포 (맑은 하늘의 분포)는 오전 11시경에 최소값(최대값)을 보이며, 비록 안개에 의한 악 시정의 발생 빈도는 정오로 갈수록 감소하나 맑은 하늘의 분포에 미치는 영향은 미약하다. 이러한 결과로부터 EOC 관측을 위해서는 다목적 실용위성 1호의 한반도 통과 시각을 오전 10시 30분에서 11시 30분 사이에서 결정하는 것이 적합하다고 판단된다.

• Childhood Kidney Diseases
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• 제16권2호
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• pp.138-141
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• 2012

리툭시맙(Rituximab)은 CD20에 대한 키메라형 IgG1 단클론 항체로 스테로이드 의존성 또는 난치성 신증후군에 대한 새로운 치료약제로 이용되고 있다. 그러나 리툭시맙의 약제 부작용에 대해서는 아직까지 더 많은 연구가 필요하다. 저자들은 스테로이드 의존성 신증후군을 앓고 있던 9세 남아에서 수차례의 리툭시맙 사용 후 기쿠치병(Kikuchi-Fujimoto disease)이 병발한 증례를 보고하는 바이다. 기쿠치병은 자연 회복의 양성 경과를 보이는 조직구 괴사성 림프절염으로 아직 원인은 알려져 있지 않다. 이 증례에서는 환자의 말초 혈액 B 면역세포 수치가 매우 감소되었을 때 발병하였으며, 이후 환자의 B 면역세포가 회복되면서 서서히 자연 소실되었다. 이 증례는 비록 병리 조직학적 진단은 뒷받침되지 못하였지만 임상적으로 진단된 기쿠치병이 리툭시맙 사용의 부작용으로 발생할 수 있다는 연관성을 시사하는 첫 번째 보고로써, 소아 신증후군에서 리툭시맙 사용의 안전성에 대한 이해의 폭을 넓히고자 하였다.

• 대한공간정보학회지
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• 제22권3호
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• pp.113-119
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• 2014

GNSS는 다양한 오차요소에 의해 좌표 정확도가 저하되는데, 그중 고정밀 측위에서 간과하기 쉬운 것이 안테나의 위상중심변동이다. 이를 보정하기 위해 IGS에서는 위상중심변동 보정정보를 기록한 ANTEX 파일을 제공하고 있다. 하지만 수신기 안테나의 경우 방위각과 고도각마다 $5^{\circ}$ 간격으로, 위성 안테나의 경우 천저각에 대해 $1^{\circ}$ 간격으로 PCV 보정정보가 제공되기 때문에 사용자 입장에서는 충분하지 않다. 따라서 어떠한 각도에서도 PCV 보정정보를 정확하게 보간하기 위한 연구를 수행하였다. 이 연구에서는 방위각과 고도각을 모두 변수로 사용할 수 있는 구면조화함수를 수신기 안테나 PCV 보정정보를 보간하는데 사용해 최적차수를 구하였다. 그 결과 정확도를 우선적으로 고려한다면 구면조화함수 8차가 최적차수가 되며, 구동시간을 우선적으로 고려한다면 허용되는 오차 내에서 구면조화함수 1차와 5차를 제외한 가장 낮은 차수가 최적차수가 된다.

• 한국항공우주학회지
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• 제33권9호
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• pp.73-80
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• 2005

본 논문은 피치 바이어스 모멘텀 방식을 사용하는 HAUSAT-2 위성의 모멘텀 휠 초기구동(Start-up)을 위한 방안을 연구 분석하고 초소형위성 HAUSAT-2에 적합한 새로운 초기구동 방법을 제안하였다. HAUSAT-2는 25kg급의 나노 위성으로 모멘텀 휠과 마그네틱 토커를 사용하여 3축 제어를 수행한다. 자세제어를 위해 모멘텀 휠은 공칭 속도로 회전하거나 회전속도가 변하게 된다. 모멘텀 휠을 장착한 위성에서 휠의 초기구동방법은 휠을 발사 전에 미리 일정한 속도로 회전하게 하거나, 궤도상에서 추력기와 같은 구동기로 자세를 안정화 시킨 이후에 휠을 공칭속도에 도달하게 하는 방법이 있다. 하지만 HAUSAT-2와 같은 초소형위성의 경우 전력제한으로 발사 전 휠을 구동하기 힘들며, 궤도상에서 자세 안정화 이후 휠을 구동하기 위해서는 자기토커만으로 자세를 안정화 해야 하는데 이 경우 시간이 오래 걸리는 단점이 있다. 따라서 본 논문에서는 좀더 빠르고 효율적으로 휠의 초기구동과 자세안정화를 하기 위해서 모멘텀 휠 구동 방안을 제안하였다. 이 방법은 위성이 발사체에서 분리된 후 초기 각속도 제어를 할 때 일정한 속도 증가율로 모멘텀 휠의 속도를 올려주어 공칭 속도에 도달하게 하며, 이 후 자세 안정화를 수행하게 된다. 이 방식을 사용하면 약 4 궤도 이내에 휠 초기구동과 자세 안정화를 성공적으로 이룰 수 있음을 확인 할 수 있었다.

• 한국산림과학회지
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• 제78권3호
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• pp.263-273
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• 1989

우리나라 국토(國土)의 65%를 차지하는 삼림(森林)은 국민경제적(國民經濟的) 측면(側面)과 국토보전적(國土保全的) 측면(側面)에서 모두 중요하다. 따라서 삼림(森林)의 내용(內容)과 현황(現況)을 정확히 조사하여 평가(評價)하는 일은 큰 의미를 가지며, 그 목적(目的)을 위해서 항공사진(航空寫眞)이나 원격탐사기술(遠隔探査技術)이 효과적으로 이용(利用)된다. Landsat 4호(號)와 5호(號)에 탑재(搭載)되어 있는 TM은 지상해상능력(地上解像能力)이 뛰어나고 넓은 범위의 파장영역(波長領域)을 해석(解析)할 수 있는 능력이 있다. 본(本) 연구(硏究)에서는 Landsat-5에서 수신(受信)한 TM data를 사용하여 경상북도(慶尙北道)의 한 지역(地域)을 대상으로 하여 토지(土地)의 이용형태(利用形態)와 임상구분(林相區分)을 실시(實施)하였고, 흑백적외선(黑白赤外線) 항공사진(航空寫眞)을 판독(判讀)하여 제작(製作)한 임상도(林相圖)와 분류(分類) 결과(結果)를 비교하였다. 그 결과(結果) TM data는 전반적인 토지이용분류(土地利用分類)의 측면(側面)에서 효과가 높았으며, 임상구분(林相區分)은 항공사진(航空寫眞)을 판독(判讀) 결과(結果)와 비교하여 차이가 있었다. 복잡하고 변화(變化)가 심한 삼림지역(森林地域)의 계절(季節)에 따른 반사특성(反射特性)을 이해하고, 임상간(林相間) 분리도(分離度)를 크게 하는 band의 선정(選定)과 조합(調合) 방법(方法)이 앞으로 해결해야 한 문제점(問題點)으로 제기되었다.