• Journal of electromagnetic engineering and science
• /
• v.12 no.2
• /
• pp.166-170
• /
• 2012

This paper presents a tunable composite right/left-handed (CRLH) delay line for a delay line discriminator that linearizes modulated frequency sweep in a frequency modulated continuous wave (FMCW) radar transmitter. The tunable delay line consists of 8 cascaded unit cells with series varactor diodes and shunt inductors. The reverse bias voltage of the varactor diode controlled the group delay through its junction capacitance. The measured results demonstrate a group delay of 8.12 ns and an insertion loss of 4.5 dB at 250 MHz, while a control voltage can be used to adjust the group delay by approximately 15 ns. A group delay per unit cell of approximately 1 ns was obtained, which is very large when compared with previously published results. This group delay can be used effectively in FMCW radar transmitters.

• Korean Journal of Organic Agriculture
• /
• v.19 no.spc
• /
• pp.165-168
• /
• 2011

An organic apple (Malus ${\times}$ domestics Borkh.) orchard was established to study the interaction effects of ground cover management systems (GMS) and nutrient sources (NS) on soil and tree nutrient status and tree growth. Trees received one of four GMS: 1) green compost (GC), 2) wood chips (WC), 3) shredded paper (SP), and 4) mow-and-blow (MB). Across all GMS, one of three NS was applied: A) a commercial organic fertilizer (CF), B) poultry litter (PL), and C) control (NF). Overall, GMS had greater effects on the variables than did NS. GC mulch supplied greater nutrients, followed by WC, SP, and MB mulches. SP trees had lower foliar [N] in the first two years than the GC and WC trees. GC-and WC-treated trees had larger trunk cross sectional area than the SP and MB trees.

• Proceedings of the IEEK Conference
• /
• 1998.06a
• /
• pp.526-529
• /
• 1998

This paper describes new sense amplifier with fast sensing delay time of 0.54ns and 32kb CMOS embedded SRAM with 4.67ns access time for a 3-V powr supply. It was achieved using the sense amplifier with multiple point sensing scheme and high speed bit-line scheme. The sense amplifier saves 25% of the power dissipation compared with the conventional one while maintaining a very short sensing delay. The SRAM uses 0.5.mu.m double-polysilicon and triplemetal CMOS process technology. A die size is 1.78mm*2.13mm.

• Journal of Electrical Engineering and information Science
• /
• v.3 no.3
• /
• pp.300-305
• /
• 1998

This paper describes new sense amplifier with fast sensing delay time of 0.54ns and 32kb CMOS embedded SRAM with 4.67 ns access time for a 3-V power supply. It was achieved using the sense amplifier with multiple point sensing scheme and highs peed bit-line scheme. The sense amplifier saves 25% of the power dissipation compared with the conventional one while maintaining a very short sensing delay. The SRAM uses 0.5m double-polysilicon and triple-metal CMOS process technology. A die size is 1.78${\times}$mm2.13mm.

• Journal of Acupuncture Research
• /
• v.21 no.4
• /
• pp.197-206
• /
• 2004

Objective : This study was designed to find out whether NS(normal saline) is able to be constituted as an appropriate control group for HHT(Hwangryunhaedoktang herbal acupuncture) and HP(Homnis Placenta herbal acupuncture). Methods : NS and two herbal acupuncture were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared the subjective acupuncture sensation between the two groups. Results : As for HHT seven items of the acupuncture sensation were significantly different from NS. In case of HP just two items were significantly different from NS. Conclusion : We found that NS may be able to be an placebo herbal acupuncture for HP. Further study is needed for the appropriate placebo herbal acupuncture.

• BMB Reports
• /
• v.38 no.1
• /
• pp.104-110
• /
• 2005

We extended the measurable time scale of DNA dynamics to microsecond using $[Ru(phen)_2(dppz)]^{2+}$ (phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) (RuPD), which displays a mean lifetime near 500 ns. To evaluate the usefulness of this luminophore (RuPD) for probing nucleic acid dynamics, its intensity and anisotropy decays when intercalated into supercoiled and linear pBluescript (pBS) II SK(+) phagemids were examined using frequency-domain fluorometry with a blue light-emitting diode (LED) as the modulated light source. The mean lifetime for the supercoiled phagemids (< $\tau$ > = 489.7 ns) was somewhat shorter than that for the linear phagemids (< $\tau$ > = 506.4 ns), suggesting a more efficient shielding from water by the linear phagemids. The anisotropy decay data also showed somewhat shorter slow rotational correlation times for supercoiled phagemids (997.2 ns) than for the linear phagemids (1175.6 ns). The slow and fast rotational correlation times appear to be consistent with the bending and torsional motions of the phagemids, respectively. These results indicate that RuPD can have applications in studies of both bending and torsional dynamics of nucleic acids.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.3 no.1
• /
• pp.1-8
• /
• 1999

Dynamic elastoplastic LPM (lumped parameter mass) analyses are carried out in order to investigate the seismic resistant performance of a typical high-rise shear wall apartment subjected to several earthquakes. Three-dimensional nonlinear pushover analysis is adopted to estimate initial elastic stiffness, yielding strength and post-yielding stiffness of each story for the time history analysis of LPM shear model. For the hysteresis of each story, Clough and bilinear models are used with the input of four recorded earthquake ground motions of EI Centro 1940 NS, Taft 1952 EW, Hachinohe 1968 NS and Kobe 1995 NS, of which the amplitudes are scaled down to have the same maximum ground velocity of 12 kine. The result shows that yieldings take place in most storys of the building, i.e. the earthquake resistant capacity of this high-rise shear wall apartment is not sufficient at the event of earthquake M=5~6.

• Korean journal of food and cookery science
• /
• v.14 no.4
• /
• pp.380-387
• /
• 1998

The stability of red pepper seed oils during storage at 20${\pm}$3$^{\circ}C$, 40${\pm}$3$^{\circ}C$ and heating at 140${\pm}$3$^{\circ}C$ or 180${\pm}$3$^{\circ}C$ were measured to evaluate red pepper seed oil as a cooking oil. Two species of red pepper seeds (native, improved) were dried by either sunlight or heating to prepare the oil samples of NS (native, sunlight-dried), IS (improved, sunlight-dried), NF (native, heated), and IF (improved, heated). During storage at 20${\pm}$3$^{\circ}C$ or 40${\pm}$ 3$^{\circ}C$, acid values (AV) of all red pepper seed oils were higher than that of soy bean oil (SBO), however, peroxide values (POV) were similar to SBO. Antioxidative stability of NS was better than SBO but IF was not. By the heat treatments at 140${\pm}$3$^{\circ}C$ or 180${\pm}$3$^{\circ}C$, NS was identified to have better antioxidative stability than SBO and IF was the lowest. In sensory evaluation of each deep-fat fried potato-chip at 180${\pm}$5$^{\circ}C$, potato-chips fried in NS were better than that of SBO for color, taste, and flavor. NS-fried potato-chips got the highest score in overall acceptance (p<0.05), however, those of IF showed little acceptance. When blended oils (SBO: NOS, 0, 25, 50, 75%) were used, 50% blended oil was the best for taste, color, flavor, cripness, and total acceptance.

• Genomics & Informatics
• /
• v.14 no.3
• /
• pp.104-111
• /
• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• Clinical and Experimental Pediatrics
• /
• v.62 no.7
• /
• pp.274-280
• /
• 2019

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children's Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were positive for mutations of the PTPN11, RAF1, and SOS1 genes. The five genes undetected (FGU) group was negative for PTPN11, RAF1, SOS1, KRAS, and BRAF gene mutations. The influence of genotype was retrospectively analyzed by comparing the growth parameters after GH therapy. Results: The mean chronological age at the start of GH treatment was $5.85{\pm}2.67years$. At the beginning of the GH treatment, the height standard deviation score (SDS), growth velocity (GV), and lower levels of insulin-like growth factor-1 (IGF)-1 levels were not statistically different among the groups. All the 23 NS patients had significantly increased height SDS and serum IGF-1 level during the 3 years of treatment. GV was highest during the first year of treatment. During the 3 years of GH therapy, the PTPN11, RAF1, and SOS1 groups showed less improvement in height SDS, IGF-1 SDS, and GV, and less increase in bone age-to-chronological age ratio than the FGU group. Conclusion: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. The FGU group showed a better response to recombinant human GH therapy than the PTPN11, RAF1, and SOS1 groups.