• 산업기술연구
• /
• 제42권1호
• /
• pp.13-18
• /
• 2022

Diabetes mellitus is an abnormally high glucose level in the bloodstream. Several pharmaceuticals are administered to diabetic patients to control their glucose levels. Early diagnosis and proper glycemic management are essential in this situation to prevent further progression and complications. Biosensor-based detection has progressed and shown potential in portable and inexpensive daily assessment of glucose levels because of its simplicity, low cost, and convenient operation without sophisticated instrumentation. This review discusses various systemic aspects of non-invasive glucose monitoring, including materials for monitoring and managing diabetes.

• 대한화장품학회지
• /
• 제28권3호
• /
• pp.63-90
• /
• 2002

멜라닌의 정량은 인체에서 화장품의 미백효과를 평가하기 위한 가장 좋은 방법이지만 인체의 멜라닌 측정을 위한 높은 정확성을 가진 non-invasive방법은 아직 확립되지 않은 실정이다. 피부에서 화장품의 미백효과는 피부색의 밝기로 나타낼 수 있으므로 화장품의 미백효력 평가를 위한 재현성있는 방법으로는 피부색측정을 하는 것이 합리적이다 이에 colorimeter, mexameter와 전문가의 육안평가같은 여러 기기나 분석법이 사용되었다. 이 강연에서는 미백효과에 대한 평가를 위한 다양한 평가방법에 대해 자세히 보고하고 각 방법에 대하여 토의하게 될 것이다 그리고 간단히 임상시험에 대한 결과를 보고하고 마지막으로 melanocyte를 정량하는 새로운 non-invasive방법에 대한 model을 제시하려고 한다.

• 대한의용생체공학회:의공학회지
• /
• 제31권5호
• /
• pp.351-358
• /
• 2010

In the automatic non-invasive blood pressure measurement device, the oscillometric method iswidely used. In the oscillometric method, the step-wise deflation has the advantage of the robustness for the motion artifacts than the linear deflation method. But it has the disadvantage of its longer measurement time because we need to detect two or more pulses in a certain cuff pressure step. In this study, we suggest the modified step-wise deflation method to overcome this limitation while maintaining the general concept of step-wise deflation. Using one valid pulse in each step and the deflating valve control during the diastolic period, the measurement time could be reduced. In order to verify the accuracy of the proposed algorithm, we compared the blood pressure values from the suggested method and the blood pressure values from the conventional auscultation method. The mean and standard deviation were -0.50${\pm}$5.3mmHg and 2.08${\pm}$4.75mmHg, for systolic and diastolic blood pressure respectively. The measurement time can be reduced up to the half of conventional step-wise deflation method.

• Journal of the Optical Society of Korea
• /
• 제19권2호
• /
• pp.123-129
• /
• 2015

A pulse is generated when the heart pumps blood into the arterial system. The heart pumps blood only when it contracts, not when it relaxes; therefore, blood enters the arterial system in a cyclical form. Artery beating is visible in some parts of the body surface, such as the radial artery of the wrist. This paper mainly uses the feature in which near-infrared spectroscopy penetrates skin to construct a non-invasive measurement system that can measure small vibration in the subcutaneous tissue of the human body, and then uses it for the pulse measurement. This measurement system uses the optical moir$\acute{e}$ principle, together with the fringe displacement made by small vibration in the subcutaneous tissue, and an image analysis program to calculate the height variation from small vibrations in the subcutaneous tissue. It completes a measurement system that records height variation with time, and that together with a fast Fourier transform (FFT) program, they can convert the pulse waveform generated by vibration (time-amplitude) to heartbeat frequency (frequency-amplitude). This is a new and non-invasive medical assistance system for measuring the pulse of the human body, with the advantages of being simple, fast, safe and objective.

• 한국감성과학회:학술대회논문집
• /
• 한국감성과학회 2000년도 춘계 학술대회 및 국제 감성공학 심포지움 논문집 Proceeding of the 2000 Spring Conference of KOSES and International Sensibility Ergonomics Symposium
• /
• pp.99-103
• /
• 2000

There are two approaches in the study of emotion in the physiological psychology. The first is to clarify the brain mechanism of emotion, and the second is to evaluate objectively emotions using physiological responses along with our feeling experience. The method presented here belongs to the second one. Our method is based on the "level-crossing point detection" method. which involves the analysis of frequency fluctuations of EEG and is characterized by estimation of emotionality using coefficients of slopes in the log-power spectra of frequency fluctuation in alpha waves on both the left and right frontal lobe. In this paper we introduce a new theory of estimation on an individual's emotional state by using our non-invasive and easy measurement apparatus.

• 대한의용생체공학회:의공학회지
• /
• 제33권3호
• /
• pp.114-127
• /
• 2012

Recent technical advancement allows noninvasive measurement of blood glucose. In this literature, we reviewed various noninvasive techniques for measuring glucose concentration. Optical or electrical methods have been investigated. Optical techniques include near-infrared spectroscopy, Raman spectroscopy, optical coherence technique, polarization, fluorescence, occlusion spectroscopy, and photoacoustic spectroscopy. Electrical methods include reverse iontophoresis, impedance spectroscopy, and electromagnetic sensing. Ultrasound, detection from breath, or fluid harvesting technique can be used to measure blood glucose level. Combination of various methods is also promising. Although there are many interesting and promising technologies and devices, there need further researches until a commercially available non-invasive glucometer is popular.

• 대한의용생체공학회:의공학회지
• /
• 제18권4호
• /
• pp.407-412
• /
• 1997

In this paper, we present a new method to diagnose the characteristics of the soft tissue, especially a liver. In order to diagnose the characteristics of a liver, it is necessary to evaluate the propagation delay time and propagation velocity of bending vibration In a liver. For this purpose, we measure the propagation velocity of bending vibration in a liver for low frequency forced vibration using a standard ultrasonic Doppler diagnosis equipment. We have carried out preliminary experiments by using an ultrasonic probe of 3.5MHz and obtained some results. This new measurement method developed here can be applied to new research and medical fields for acoustic non-invasive diagnosis of soft tissue.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2018년도 춘계학술대회
• /
• pp.188-192
• /
• 2018

대뇌혈류를 증가 시키는 수술은 뇌경색의 치료방법중 하나이다. 그러나 수술과 같은 침습적인 방법은 환자에게 수술 후유증 또는 부작용을 부담하게 한다. 이러한 침습적인 방법을 보완하기 위해 사람의 혈압을 이용해, 사지에 압박을 가하여 대뇌 혈류를 증가 시키는 비 침습적인 장치도 등장하였다. 그러나 속도와 정확성이 떨어지는 문제점이 제기되었다. 본 논문에서는, 정확한 측정과 측정하는 데에 걸리는 시간을 기존의 장치보다 개선하기 위해, Blood Oxygen Level Sensor를 이용하여, 양팔에 압력을 주면서 각 팔의 Perfusion Index를 측정하여, Perfusion Index가 일정 값 이하로 떨어지는 순간의 75% 압력을 팔에 가하고, 다리에는 팔에서 구해진 압력 값을 이용해 계산하여 얻은 압력을 가한다. 기존의 혈압 측정식 대뇌혈류증가 장치와 같이, 혈류량을 20%이상 증가시킬 수 있고, 또한 측정 시간도 단축한 결과를 얻어 뇌경색 환자에게 선택적으로 사용할 수 있다.

• 한국정밀공학회지
• /
• 제24권3호
• /
• pp.7-15
• /
• 2007

• 한국가축번식학회지
• /
• 제19권3호
• /
• pp.161-169
• /
• 1995

To investigate the metabolism of various substrates in preimplantation bovine embryos, uptake of glucose and pyruvate, and lactate production were measured in single IVF-derived bovine embryos by a non-invasive method. When the embryos were incubated for 5 h in culture medium supplemented with 1 mM glucose and 0.4mM pyruvate as substrates at each developmental stage, glucose uptake was increased with more advanced developmental stages while pyruvate uptake was decreased. Total lactate producton of 2-cell embryos was significantly higher than that of blastocysts (p<0.05). Both of glucose uptake and lactate production in normal morulae produced in vitro was significantly high compared to the degenerated embryos(p<0.05). The results obtained in the study suggest that pyruvate as an exogenous substrate may be support in bovine embryos until 8-cell stage, whereas glucose may be effective as an energy source after morula stage. In addition, it was proven thatlactate was not effective as an energy source in preimplantation development of IVF-derived bovine embryos.