• 한방재활의학과학회지
• /
• 제23권4호
• /
• pp.169-176
• /
• 2013

Objectives To investigate correlation between anthropometric data (neck circumference (NC), waist circumference (WC), body mass index (BMI), and body shape indexes) and radiological parameters of lumbosacrum. Methods The data of college students living in Seoul (n=24) were analyzed retrospectively. Anthropometric data of NC, WC, and BMI were measured. Lumbar spine X-ray film was taken to measure lumbar lordotic angle, Ferguson's angle. To evaluate body shape of participants, three indexes of neck-to-waist ratio (NWR), neck-to-height ratio (NHR), and waist-to-height ratio (WHR) were used. Anthropometric data's correlations with radiological parameters of lumbosacrum were investigated. Results Anthropometric data of NC, WC, and BMI had no significant correlation with radiological parameters of lumbosacrum. NWR had significant positive correlation with lumbar lordotic angle and Ferguson's angle. NHR and WHR had no significant correlation with radiological parameters of lumbosacrum. Conclusions The results suggest that NWR-related fat distribution in neck has significant correlation with radiological parameters of lumbosacrum regardless of obesity.

• 대한후두음성언어의학회지
• /
• 제28권2호
• /
• pp.84-88
• /
• 2017

Background and Objectives : The purpose of this study was to compare the usefulness of Cepstral peak prominence (CPP) with parameter of Multiple Dimensional Voice Program (MDVP) in evaluating unilateral vocal fold paraylsis patients with subjective voice impairment. Materials and Methods : From July 2014 to August 2016, 37 patients with unilateral vocal fold paralysis who had been diagnosed with unilateral vocal fold paralysis and had received two or more voice tests before and after the diagnosis were evaluated for maximum phonation time (MPT), MDVP and CPP. Respectively. Voice tests were performed with short vowel /a/ and paragraph reading. Results : The CPP-a (CPP with vowel /a/) and CPP-s (CPP with paragraph reading) of the Cepstrum were statistically negatively correlated with G, R, B, and A before the voice therapy. Jitter, Shimmer, and NHR of MDVP were positively correlated with G, R, B. Jitter, Shimmer, and NHR of the MDVP were significantly correlated with the Cepstrum index. G, B, A and CPP-a and CPP-s showed a statistically significant negative correlation and a somewhat higher correlation coefficient between 0.5 and 0.78. On the other hand, in MDVP index, there was a positive correlation with G and B only with Jitter of 0.4. Conclusion : CPP can be an important evaluation tool in the evaluation of speech in the unilateral vocal cord paralysis when speech energy changes or the cycle is not constant during speech.

• 대한후두음성언어의학회지
• /
• 제26권1호
• /
• pp.40-45
• /
• 2015

Objectives:This study aims to investigate the correlation between the measurements of Praat as an acoustic evaluation and those of GRBAS and CAPE-V as perceptual rating tool respectively. Through this, it also tries to find out parameters to which attention should be paid when an evaluator, who is untrained in auditory-perceptual voice evaluation, conducts voice evaluation with objective tool. Materials and Methods:Voice samples of this study were 33 vocal polyp patients(23 males and 10 females) who visited our Department of Otorhinolaryngology. They sustained vowel voices of 'e' were recorded and acoustically analyzed. Results:As the results of correlation analysis between GRBAS and Praat measurements, G scale and R scale showed statistically significant correlation with Jitt, Shim and NHR. And it is found that B scale represented significant correlation with Jitt, S scale with Shim. As the results of analysis on correlation with CAPE-V and Praat measurements, OS scale and R scale showed statistically significant correlation with Jitt, Shim and NHR. B scale represented significant correlation with Jitt, S scale with Shim. Conclusion:Although, both GRBAS and CAPE-V were highly reliable, in comparison between CAPE-V and Pratt, more parameters that showed statistically significant correlation are observed, which implies that VAS has more potential to make detailed evaluation than ORD.

• 대한후두음성언어의학회지
• /
• 제26권2호
• /
• pp.104-111
• /
• 2015

Background and Objectives : Acoustic analysis of voice could be influenced so much by the quality of voice files which were recorded by recording device. In clinical practice, voice files that were recorded by analysis program directly or portable digital recording device were analyzed mostly. This study examined the feasibility of using Galaxy smartphone recordings for acoustic analysis of voice. Materials and Methods : Acoustic measures were compared between voice signals recorded from 30 normal speakers (15 males and 15 females) through Galaxy smartphone, portable digital recording device and CSL. Fo, jitter, shimmer, NHR (Noise-Harmony ratio) and Formant frequencies were analyzed by MDVP. Results : Fo, Jitter, Shimmer, NHR and formant frequencies from 3 devices were no significantly difference. The intraclass correlation coefficient (ICC) was higher between each of the voice perturbation measures. Conclusion : The findings indicated that Galaxy smartphone recording system was useful device for acoustic analysis of voice. Furthermore, Galaxy smartphone can be applied widely in various way for acoustic analysis of voice.

• 한국전문물리치료학회지
• /
• 제16권2호
• /
• pp.16-23
• /
• 2009

The purpose of this study was to investigate the effects postural changes on respiratory muscles and acoustic parameters of the children with spastic cerebral palsy. Nine children with spastic cerebral palsy who required assistance when walking were selected. The ages of the children ranged from 6 to 9 years old. The phonation of the sustained vowel /a/ and the voice qualities of each child such as fundamental frequency($F_0$; Hz), pitch variation (Jitter; %), amplitude variation (Shimmer; %) and noise to harmonic ratio (NHR) were analyzed by Multi-Dimensional Voice Program (MDVP). The muscle activity of three major respiratory muscles: pectoralis major muscle, upper trapezius muscle and rectus abdorminalis muscle, were measured by examining the root mean square (RMS) of the surface EMG to investigate the impact of changes in the adjusted sitting posture of each subject. However, the RMS of pectoralis major muscle showed a significant differences (p<.05). Secondly, there were no significant differences in $F_0$, Jitter and Shimmer between pre and post posture change, but there was a significant difference in NHR (p<.05). The data were collected in each individual; once prior and once after the sitting posture change. The data were analyzed by Wilcoxon signed ranks-test using SPSS version 14.0 for Windows. The findings of this study were as follows; Firstly, the RMS of upper trapezius and rectus abdorminalis muscle were not significant different between pre and post sitting posture changes. From the result, it is concluded that changes in the adjusted sitting posture decreases the abnormal respiratory patterns in the children with spastic cerebral palsy which is characterized by the hyperactivity of the respiratory muscles in breathing. Also, there is increased on the voice qualities in children with spastic cerebral palsy.

• 말소리와 음성과학
• /
• 제2권2호
• /
• pp.37-42
• /
• 2010

The purpose of this study is to first discriminate and assess those infants who appear healthy in appearance but who could face possible risk factors in the future and, secondly, to identify those infants who may have difficulties in their developmental stages. The subjects of this study consisted of 35 full-term infants (39-40 weeks) and 33 pre-term infants (34-35 weeks). The infants' voices were recorded for three minutes, for which EDIROL by Roland and a stand-type microphone made by SONY were used. This was done to discern the value of the Breath unit (B-unit) and the fundamental frequencies ($F_0$). It was found that there were significant differences in terms of F0 since the pre-term infants had higher F0 than the full-term infants, showing a result of 436.4 Hz for the full-term infants and 460 Hz for the pre-term infants (p<.05) There was an average rate of 4.01 for the full-term infants and 4.02 (SD=1.69) for the pre-term infants in shimmer. For NHR, it was observed .44 for the full-term infants and .50 for the pre-term infants, thus revealing no significant differences in these observations. This study shows that the crying of newborn babies is related to their physical conditions and it is a sensatory response to these conditions. Furthermore, this study could be helpful for the early detection and measurement of newborn babies who look clinically healthy but could be at risk through acoustic and physiological analyses.

• 대한화장품학회지
• /
• 제34권1호
• /
• pp.1-8
• /
• 2008

피부장벽을 포함한 표피층은 인체의 조직 가운데에서도 가장 역동적인 기관이다. 다시 말해서 끊임없이 새로운 표피세포의 형성, 분화 및 탈각과정이 반복되면서 표피항상성(epidermal homeostasis)을 유지한다. 표피항상성은 피부기능 가운데 가장 주요한 기능인 permeability barrier homeostasis의 확립으로 연결된다. Permeability barrier homeostasis는 각질층에서 이루어지며 이를 형성하고 유지하기 위해 매우 정교하게 조절되어야 한다. 표피항상성을 조절하는 핵심 조절인자로서 nuclear hormone receptor(NHR)가 중심에 있음이 최근 다양한 연구를 통해 입증되었다. 이들은 각질세포 특이적인 단백질, 즉, involucrin, loricrin 및 trans-glutaminase 1(TG 1) 등의 발현을 유전자 수준에서 조절할 뿐 아니라 표피 지질성분의 생합성을 증가시키는 등 피부장벽을 구성하는 brick 및 mortar의 생성과 유지에 핵심적 역할을 하는 것으로 알려졌다. NHR 가운데 peroxisome proliferator activator receptor(PPAR)와 liver X receptor(LXR)의 activator/ligands가 리놀레인산 등 지방산, leukotriene, prostanoid 및 oxygenated sterol 등이 지질대사과정에서 형성된 지질 종류인 까닭에 liposensor로도 알려지고 있다. 따라서 liposensor들을 비롯한 PPAR과 LXR activator/ligands들은 피부장벽기능이 저해된 아토피성 피부를 포함하여 건조피부를 관리하는 epidermotherapy의 수단으로서 잠재적 가능성이 있다고 생각된다.

• 말소리와 음성과학
• /
• 제10권4호
• /
• pp.155-161
• /
• 2018

The purpose of this study was to evaluate the efficacy of a multiple voice therapy technique ($SKMVTT^{(R)}$) using laughter for the treatment of various benign vocal fold lesions. To achieve this, 23 female patients diagnosed with vocal nodules, vocal polyp, and muscle tension dysphonia through videostroboscopy were enrolled in vocal hygiene and $SKMVTT^{(R)}$. All of the patients were treated once a week for 4 to 12 sessions. The GRBAS scale was used to confirm the changes in voice quality before and after the treatment. Acoustic analysis was performed to evaluate jitter, shimmer, NHR, fundamental frequency variation, amplitude variation, PFR, and dB range. Videostroboscopy was performed to confirm the changes in the laryngeal features before and after the treatment. After the $SKMVTT^{(R)}$, the results of the perceptual evaluation demonstrated that the G, R, and B scales significantly improved. An acoustic evaluation also demonstrated that jitter, shimmer, NHR, vAm, vFo, PFR, and dB range also significantly improved after the $SKMVTT^{(R)}$. In comparison to the videostroboscopic findings, the size of the vocal nodules and vocal polyp decreased or disappeared after the treatment. In addition, the size of the cuneiform tubercles decreased, the length of the aryepiglottic folds became longer, and the laryngeal findings of the supraglottic compressions improved after the $SKMVTT^{(R)}$. These results suggest that the $SKMVTT^{(R)}$ is effective in improving the vocal quality of patients with benign vocal fold lesions. In conclusion, it seems that laughter and inspiratory phonation suppressed abnormal laryngeal elevation and lowered laryngeal height, which seems to have the effect of improving hyperfunctional phonation.

• Nuclear Engineering and Technology
• /
• 제54권8호
• /
• pp.3095-3105
• /
• 2022

Solid Microencapsulated Fuel (SMF) is a type of solid fuel rod design that disperses TRISO coated fuel particles directly into a kind of matrix. SMF is expected to provide improved performance because of the elimination of cladding tube and associated failure mechanisms. This study focused on the neutronics and some of the fuel cycle characteristics of SMF by using OpenMC. Two kinds of SMFs have been designed and evaluated - fuel particles dispersed into a silicon carbide matrix and fuel particles dispersed into a zirconium matrix. A 7×7 fuel assembly with increased rod diameter transformed from the standard NHR200-II 9×9 array was also introduced to increase the heavy metal inventory. A preliminary study of two kinds of burnable poisons (Erbia & Gadolinia) in two forms (BISO and QUADRISO particles) was also included. This study found that SMF requires about 12% enriched UN TRISO particles to match the cycle length of standard fuel when loaded in NHR200-II, which is about 7% for SMF with increased rod diameter. Feedback coefficients are less negative through the life of SMF than the reference. And it is estimated that the average center temperature of fuel kernel at fuel rod centerline is about 60 K below that of reference in this paper.

• Journal of Ginseng Research
• /
• 제47권4호
• /
• pp.524-533
• /
• 2023

Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.