• 제목/요약/키워드: N-substitutes-5-hydroxyanthranilic axids

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N-치환 5-Hydroxyanthranilic acid의 합성 (Synthesis of N-Substituted 5-Hydroxyanthranilic Acid)

  • 문정술;이강노;임중기;우원식;박상우
    • 약학회지
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    • 제37권3호
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    • pp.243-246
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    • 1993

  • Six N-substituted-5-hydroxyanthranilic acids were synthesized by the coupling reaction of 5-tosyloxyanthranilic acid ethyl ester with corresponding acid chlorides. The structure of the obtained compounds was proved by NMR and IR. These compounds did not inhibit the growth of micro-organisms while suppressed HSV-1 replication in vero cell at 100 $\mu\textrm{g}$/ml.

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