• Bulletin of the Korean Chemical Society
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• 제26권7호
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• pp.1112-1116
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• 2005

• Bulletin of the Korean Chemical Society
• /
• 제28권8호
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• pp.1401-1404
• /
• 2007

An efficient Pictet-Spengler type reaction of N,O-acetal TMS ethers for the practical synthesis of 1-substituted tetrahydroquinolines, medicinally important alkaloids, has been accomplished. To demonstrate the versatility of this novel procedure, the total synthesis of calycotomine, a representative 1-hydroxymethyl substituted tetrahydroisoquinoline, is also described.