• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.7 no.1
• /
• pp.33-48
• /
• 1997

Korean diffusive sampler (KDS) and charcoal tube (CT) were used for sampling n-hexane, trichloroethylene and toluene in air KDS was made by Department of Environmental Health, SNU-SPH in 1995. Surveys were conducted at ten industrial plants with organic solvents. The relationship between two sampling methods was examined by linear regression analysis, and concentrations by two sampling methods were compared using paired t-test. The results are as follows: 1. The geometric means by CT and KDS methods were 3.26ppm and 3.32ppm for n-hexane, 5.07ppm and 6.34ppm for toluene, and 7.18ppm and 7.90ppm for toluene, respectively. There was no significant difference between results by CT and KDS methods in three organic vapors (p>0.05). When linear regression analysis was performed, two sampling methods were highly related ; correlation coefficients were 0.98, 0.90 and 0.96 for n-hexane, toluene and trichloroethylene, respectively. 2. Airborne concentrations of n-hexane (n=21) were below 0.5 TLV level. The GM by two methods were almost same (3.09 ppm). And there was no significant difference between results by two methods (p>0.05). 3. Since toluene and trichloroethylene concentrations showed several levels, appropriate sampling rates were applied for each level. The GM of toluene concentrations by two methods at 0.5 TLV level were 3.75ppm and 5.48ppm. The KDS method overestimated the toluene concentrations at 0.5 TLV level (p<0.05). The GM values of toluene concentrations at 1 TLV level were 31.80ppm and 25.38ppm and at 2 TLV level were 64.13 ppm and 51.37 ppm. The KDS method underestimated concentration at both level (p<0.05). For trichloroethylene, the GM at 0.5 TLV level were 4.97 ppm and 7.11ppm. The KDS method overestimated the concentration of trichloroethylene (p<0.05). In conclusion, concentrations of three organic vapors measured by CT and KDS were not significantly different and results by two methods were highly related. But at contain concentrations, the levels by method were significantly different. Therefore, it is suggested that sampling rate of KDS should be studied simultaneously using CT method for organic vapors.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.25 no.2
• /
• pp.31-38
• /
• 2019

Background: The purpose of this study was to investigate the effects of Progressive muscle relaxation training on pain, Korean version of Oswestry disability index (ODI) and psychological level in chronic low back pain patients with somatization. Methods: A total of 30 subjects were treated with the experimental group (n=15) and conservative physical therapy (n=15). The experimental group was trained with progressive muscle relaxation (PMR), and the control group was treated with conservative physical therapy. Physical factor treatment was applied for 60 minutes by hot pack, electrotherapy and ultrasound. Both groups performed three times a week for six weeks. VAS, ODI, psychological level measurements were taken before and after intervention. Results: There was a significant difference in VAS (p<.05) and ODI (p<.01) between experimental and control group. At the psychological level, there were significant differences in somatization (p<0.01) and depression scales (p<.01), but not in anxiety. Conclusion: As a result of this study, the degree of pain was decreased, the level of back pain dysfunction was improved, and the somatization scale and depression scale were decreased by gradual muscle relaxation therapy.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.31 no.4
• /
• pp.465-469
• /
• 1986

This study was conducted to investigate the proper fertilizer application level and top-dressing method of Lycium chinense MILL in 1984 and 1985. The results obtained were summerized as follows; Stem length was 4cm longer, leaf area was 45-490$\textrm{cm}^2$ larger, dry matter weight per plant was 1.6-5g heavier and average yield of dry fruit of two years was higher as 183kg per l0a in double amount of potassium( 14kg/l0a) application than in standard level of potassium(7kg/l0a). Highly positive correlation was found between absorption amount of inorganic elements of phosporus(l%), nitrogen, potassium(5%) and dry matter weight. Proper fertilizer application level was 13.8kg(N), 14.2kg(P) and 14.3kg(K) per l0a. Dry fruit yield of top-dress-ing plot was 20% heigher than that of basal dressing plot through increase of leaf area per plant and dry matter weight per plant.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.7
• /
• pp.3261-3265
• /
• 2014

Background: To evaluate serum VEGF-A levels in squamous cell carcinoma of head and neck (SCCHN) patients and relationships with response to therapy. Materials and Methods: Serum VEGF-A levels in patients (n=72) treated with radiotherapy (RT) or radio-chemotherapy (RCT) and controls (n=40) were measured by ELISA. Results: Serum VEGF-A levels of the SCCHN cases were significantly higher (p=0.001) than in healthy controls, and in patients with positive as compared to negative lymph node status (p=0.004). Similarly, patients with advanced stage (Stage III-IV) disease had more greatly elevated levels of serum VEGF-A level than their early stage (Stage I-II) counterparts (p=0.001). In contrast, there was no significant difference (p=0.57) in serum level of VEGF-A in patients with advanced T-stage (T3-4) as compared to early stage (T1-2). Similarly, patients with distant metastasis had no significant (p=0.067) elevation in serum VEGF-A level as compared to non-metastatic disease. However, the non-responder patients had significantly higher serum VEGF-A level as compared to responders (p=0.001). Conclusions: Our results suggest that the serum VEGF-A level may be a useful biomarker for the prediction of response to therapy in SCCHN.

• Archives of Pharmacal Research
• /
• v.9 no.2
• /
• pp.81-86
• /
• 1986

The effect of imperatorin on hepatic microsomal mixed function oxidases (MF0) was investigated. On acute treatment, imperatorin (30 mg/kg, i.p) caused a significant reduction in activities of hepatic aminopyrine N-demethylase, hexobarbital hydroxylase and aniline hydroxylase as well as cytochrome p0450 content in rats and mice. Kinetic studies on rat liver enzymes revealed that imperatorin appeared to be a competitive inhibitor of aminopyrine N-demethylase (Ki,0.007 mM), whereas a non-competitive inhibitor of hexobarbital hydroxylase (Ki, 0.0148 mM). Imperatorin also inhibited non-competitively aniline metabolism (Ki 0.2 mM). Imperatorin binds to phenobarbital-induced cytochrome p-450 to give a typical type 1 binding sepctrum (max. 388nm, min 422 nm). Multiple administrations of imperatorin (30 mg/kg. i. p. daily for 7 days) to mice shortended markedly the duration of hexobarbital narcosis and increased activities of hepatic aminopyrine N-demethylase and hexobarbital hydroxylase and the level of cytochrome p-450 where as aniline hydroxylase activity was unaffected.

• Radiation Oncology Journal
• /
• v.37 no.2
• /
• pp.110-116
• /
• 2019

Purpose: This study aimed to identify prognostic factors for locoregional recurrence (LRR) in pT3N0 rectal cancer patients who were treated with surgery alone and had negative resection margin including circumferential resection margin (CRM) for optimal indication of adjuvant radiotherapy. Materials and Methods: We reviewed patients with pT3N0 rectal cancer who were treated via upfront surgery and had no other adjuvant treatment from January 2003 to December 2012. In total, 122 patients who had negative resection margin including negative CRM were included in the analysis. Results: The median follow-up period after surgery was 60 months (range, 3 to 161 months). During this time, 6 patients (4.9%) experienced LRR at the anastomotic site (4 patients), and regional lymphatic area (2 patients). The estimated 5-year rates of overall survival, recurrence-free survival, and LRR-free survival were 96.7%, 84.6%, and 94.0%, respectively. Multivariate analysis showed that level of tumor ≤5 cm was a significant prognostic factor for LRR-free survival (LRRFS) (p = 0.04; hazard ratio = 7.08; 95% confidence interval, 1.06-47.30). Patients with level of tumor ≤5 cm had an estimated 5-year LRRFS of 66.8%, which was much higher than 2.3% in patients with level of tumor >5 cm. There was no significant factor for recurrence-free survival or overall survival. Conclusion: In T3N0 rectal cancer, adjuvant chemoradiotherapy should be recommended in patients with level of tumor ≤5 cm for better local control. However, in patients with pT3N0 disease, negative resection margin, and level of tumor >5 cm, adjuvant chemoradiotherapy should be carefully suggested.

• Korean Journal of Soil Science and Fertilizer
• /
• v.42 no.4
• /
• pp.301-306
• /
• 2009

This study was conducted to determine the physiological differences betweenhealthy and wilted plants with respect to nitrate assimilation and ascorbic acid content. Wilting was artificially induced in spinach plants by treating the seeds with nutrient solution containing high nitrogen and low potassium. The plants were cultured in different plots 4 types of media: 1N-1P-1K (control), 6N-1P-0K (0K), 6N-1P-0.5K (0.5K), and 6N-1P-2K (2K). The rate of wilting among the plants was as follows: control, 0%; 2K, 10%; 0.5K, 40%; and 0K, 70%. This shows that under high nitrogen conditions, the lower the amount of potassium provided, higher was the rate of wilting. There were no differences in plant growth among the plants treated with different levels of potassium under high nitrogen conditions.The nitrate content in both the leaves and the roots was higher in plants grown under high nitrogen media than those in the control. Furthermore, the nitrate level decreased with increasing potassium concentration. The ascorbic acid content of spinach under high nitrogen conditions was lower than those of the control.

• Asian-Australasian Journal of Animal Sciences
• /
• v.31 no.3
• /
• pp.363-368
• /
• 2018

Objective: The objective of the study was to determine the effect of fermented spent coffee ground (FSCG) on nutrient digestibility and nitrogen utilization in sheep. Methods: Fermentation of spent coffee ground (SCG) was conducted using Lactobacillus plantrum. Fermentation was performed at moisture content of 70% and temperature of $39^{\circ}C$ with anaerobic air tension for 48 h. Four adult rams (initial body weight = $56.8{\pm}0.4kg$) were housed in a respiration-metabolism chamber and the treatments were: i) control (Basal diet; 0% SCG or FSCG), ii) 10% level of SCG, iii) 10% level of FSCG, and iv) 20% level of FSCG in $4{\times}4$ Latin square design. Each dietary experiment period lasted for 18-d with a 14-d of adaptation period and a 4-d of sample collection period. Results: In SCG fermentation experimental result, acid detergent insoluble nitrogen (ADIN) concentration of FSCG (64.5% of total N) was lower than that of non-fermented SCG (78.8% of total N). Digestibility of dry matter and organic matter was similar among treatment groups. Although crude protein (CP) digestibility of the control was greater than FSCG groups (p<0.05), the 10% FSCG group showed greater CP digestibility and nitrogen retention than non-fermented 10% SCG group (p<0.05). Body weight gain and average daily gain were linearly decreased with increasing FSCG feeding level (p<0.05). When the feeding level of FSCG was increased, water intake was linearly increased (p<0.05). With an increasing FSCG level, dry matter intake did not differ among groups, although the gain to feed ratio tended to decrease with increasing level of FSCG (p<0.10). Conclusion: Microbial fermentation of SCG can improve protein digestibility, thereby increasing CP digestibility and nitrogen utilization in sheep. Fermentation using microorganisms in feed ingredients with low digestibility could have a positive effect on improving the quality of raw feed.

• Journal of Animal Science and Technology
• /
• v.50 no.4
• /
• pp.561-572
• /
• 2008

Responses of real-time control parameters, such as ORP, DO and pH, to the conditions of biological animal wastewater treatment process were examined to evaluate the stability of real-time control using each parameter. Also an optimum index for supplemental carbon source addition based on NOx-N level was determined under a consideration of denitrification rate by endogenous respiration of microorganism and residual organic matter in liquor. Experiment was performed with lab-scale sequencing batch reactor(SBR) and working volume of the process was 45L. The distinctive nitrogen break point(NBP) on ORP-and DO-time profiles, which mean the termination of nitrification, started disappearing with the maintenance of low NH4-N loading rate. Also the NBP on ORP-and DO-time profiles was no longer observed when high NOx-N was loaded into the reactor, and the sensitivity of ORP became dull with the increase of NOx-N level. However, the distinctive NBP was constantly occurred on pH(mV)-time profile, maintaining unique profile patterns. This stable occurrence of NBP on pH(mV)-time profile was lasted even at very high NOx-N:NH4-N ratio(over 80:1) in reactor, and the specific point could be easily detected by tracking moving slope change(MSC) of the curve. Revelation of NBP on pH(mV)-time profile and recognition of the realtime control point using MSC were stable at a condition of over 300mg/L NOx-N level in reactor. The occurrence of distinctive NBP was persistent on pH(mV)-time profile even at a level of 10,000mg/L STOC(soluble total organic carbon) and the recognition of NBP was feasible by tracing MSC, but that point on ORP and DO-time profiles began to disappear with the increase of STOC level in reactor. The denitrfication rate by endogenous respiration and residual organic matter was about 0.4mg/L.hr., and it was found that 0.83 would be accepted as an index for supplemental carbon source addition when 0.1 of safety factor was applied.

• Perspectives in Nursing Science
• /
• v.9 no.1
• /
• pp.51-60
• /
• 2012

Purpose: The purpose of this study was to develop a self-directed e-learning program for ICU nurses and to evaluate how the proposed e-learning program affects the level of knowledge, nursing performance and job satisfaction of ICU nurses. Methods: The e-learning program was developed with the Computer Assisted Instruction Design Model using sources of self-efficacy which included the inactive attainment, vicarious experience, and verbal persuasion of ICU nurses. The program was evaluated by experts. Following the revision of the program, it was applied to a total of 59 ICU nurses (experimental group n=29, control group n=30) from three hospitals. Four weeks later, we measured the level of knowledge, nursing performance and job satisfaction. Results: The level of knowledge significantly improved in the experimental group (t=5.691, p<.001). Moreover, the level of nursing performance significantly increased in the areas of circulatory diagnostic test (t=2.143, p=.039), EKG (t=2.911, p=.006), aortic balloon pump (t=2.491, p=.017), and nebulizer therapy (t=2.085, p=.044). Overall, job satisfaction did not significantly increase (t=1.664, p=.105); however, job satisfaction in terms of relationships with coworkers (t=2.371, p=.023) and the needs of nursing performance (t=2.940, p=.006) were significantly increased. Conclusion: The results showed that the proposed e-learning program using sources of self-efficacy from ICU nurses was an effective learning method to increase the level of knowledge and nursing performance. The propose de-learning program would be a useful teaching tool for ICU nurses improving the quality of ICU patient care.