• Journal of Hospice and Palliative Care
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• 제4권1호
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• pp.41-46
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• 2001

목적 : 경구로 투여되는 진통제 중에서 $Myprodol^{(R)}$은 codeine, ibuprofen과 paracetamol이 복합 처방된 진통제로서 최근에 임상에 사용되기 시작한 약제이다. 본 연구는 실제로 임상에서 $Myprodol^{(R)}$이 사용되고 있는 질환의 종류, 부작용과 진통 효과 등을 알아보기 위하여 수행되었다. 방법 : 부산대학교병원에서 $Myprodol^{(R)}$을 사용한 적이 있는 183명의 환자의 병력기록지를 조사하여 통증의 원인이 된 질환의 종류와 통증의 유형, 병원에 내원하여 최초로 $Myprodol^{(R)}$이 투여되었을 때까지의 통증의 기간 $Myprodol^{(R)}$을 투여한 기간, $Myprodol^{(R)}$의 투여 이후에 나타난 부작용, 통증에 대한 $Myprodol^{(R)}$의 통증 조절 정도를 통증시각등급(VAS)의 변화 등을 분석하였다. 결과 : $Myprodol^{(R)}$을 사용한 환자의 질환은 각종 암성 통증으로 인한 경우가 64.3%이었고, 비암성 통증으로 인한 경우가 35.7%이었다. 투여 중에 나타난 부작용에는 암성 통증 환자에서 메스꺼움, 변비, 전신부종이 있었고, 비암성 통증 환자에서는 위복부통, 변비 등이 있었다. 비암성 통증 관리측면에서 $Myprodol^{(R)}$은 암성 통증 치료에서보다 더 효과가 있었다. 결론 : $Myprodol^{(R)}$은 약한 초기 암성 통증에 비교적 적은 부작용으로 진통효과를 나타내었다. 비암성 통증 환자에서는 흉통, 요통, 치과 수술 후에 주로 사용되었고 적은 부작용으로 진통효과를 나타내었다.

• The Korean Journal of Pain
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• 제11권1호
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• pp.74-80
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• 1998

Background: Myprodol, a newly introduced combination analgesics with codeine, ibuprofen and paracetamol was evaluated in the dental surgery patients for its efficacy and side effects. Methods: Total 60 ASA I or II outpatients dental surgical patients were randomly assigned into three groups(n=20 each). After various oral procedures, one of three oral analgesics, myprodol, ibuprofen or codeine, was prescribed to each patients in double blind fashion for three days. Each patient was followed carefully by daily phone calls for verbal analog pain scale, side effects and patient's satisfaction level. Results: Demographic data and duration of surgery revealed no statistical differences in all three groups. Myprodol group showed better verbal analgesic scores consistently for the study period than ibuprofen or codeine group. Adverse effects were minimal. Patients' satisfaction level was high in all three groups. Conclusion: We conclude that myprodol is an excellent oral analgesic for day-surgery based dental procedure patients. This effect appears to be synergistic among different analgesics rather than additive.

• Journal of Periodontal and Implant Science
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• 제30권1호
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• pp.1-11
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• 2000

Although various analgesics have been administrated for postoperative pain control, postoperative pain has not been adequately controlled . The purpose of this study was to evaluate the effects and patient's satisfaction of $Myprodol^{(R)}$(combination analgesics with codeine, ibuprofen, paracetamol) compared to Acetamionphen and placebo drug after periodontal surgery and dental implant surgery. We studied 98 cases of outpatients which were composed of 67 cases of flap operation(which separated to 3 groups: Placebo group(n=25), $Myprodol^{(R)}$ group(n=22), Acetaminophen group(n=20)) and 21 cases of dental implant surgery(which separated to 3 groups : Placebo group(n=10), $Myprodol^{(R)}$ group(n=12), Acetaminophen group(n=9)). We evaluated the postoperative pain(Pain 1), Pain after first drug administraion(Pain 2), the degrees of pain reduction(pain 3), patient's satisfaction for drug, and side-effects. We obtained following results; 1. In Pain 1, making a comparison among groups, there was no significant difference in both cases of flap operation-group and dental implant surgery-group 2. In Pain 2, establishing a comparison among groups, there was no significant difference in flap operation-group, but significant difference was seen between placebo group and $Myprodol^{(R)}$ group in cases of dental implant surgery group(P<0.05). 3. In Pain 3, making a comparison among groups, $Myprodol^{(R)}$ group showed significant differences compared to placebo group and Acetaminophen group in both cases of flap operation group and dental implant surgery group(P<0.05). 4. In patient's satisfactory score, making a comparison among groups, there were significant differences between placebo group and $Myprodol^{(R)}$ group in cases of flap operation group and between $Myprodol^{(R)}$ group and Acetaminophen group in cases of dental implant surgery group(P<0.05). 5. Making a comparison in side-dffect, no significant differrence was seen. Our conclusion is that $Myprodol^{(R)}$ is a effective oral analgesics to the patients who underwent periodontal surgery or implant surgery for it's synergism among three dugs.